PubMed:10232385 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	14-35	protein	denotes	tumor necrosis factor
T2	122-125	protein	denotes	TNF
T3	140-149	protein	denotes	cytokines
T4	226-236	cell_line	denotes	cell lines
T5	309-312	protein	denotes	TNF
T6	350-360	cell_line	denotes	cell lines
T7	409-412	protein	denotes	TNF
T8	445-455	cell_line	denotes	cell lines
T9	500-518	protein	denotes	cytotoxic proteins
T10	531-540	cell_line	denotes	LAK cells
T11	563-566	protein	denotes	TNF
T12	626-646	protein	denotes	transcription factor
T13	647-656	protein	denotes	NF-kappaB
T14	756-767	cell_type	denotes	tumor cells
T15	793-802	cell_line	denotes	LAK cells

Id	Subject	Object	Predicate	Lexical cue
S1	0-121	Sentence	denotes	Resistance to tumor necrosis factor induced apoptosis in vitro correlates with high metastatic capacity of cells in vivo.
S2	122-193	Sentence	denotes	TNF is one of the cytokines secreted by the cells of the immune system.
S3	194-340	Sentence	denotes	Our data demonstrate that those cell lines lacking capability to form metastatic tumors in vivo are susceptible to TNF induced apoptosis in vitro.
S4	341-422	Sentence	denotes	However, cell lines with high metastatic potential are resistant to TNF in vitro.
S5	423-541	Sentence	denotes	Furthermore, the same cell lines were resistant to cytolytic action of other cytotoxic proteins secreted by LAK cells.
S6	542-657	Sentence	denotes	Our data showed that TNF resistance in vitro correlates with the increased level of transcription factor NF-kappaB.
S7	658-803	Sentence	denotes	This finding may provide a tool to improve current protocols of immunotherapy and insights to how tumor cells are or are not killed by LAK cells.

Id	Subject	Object	Predicate	Lexical cue
C1	14-62	NP	denotes	tumor necrosis factor induced apoptosis in vitro
C2	122-125	NP	denotes	TNF
C3	309-339	NP	denotes	TNF induced apoptosis in vitro
C4	350-391	NP	denotes	cell lines with high metastatic potential
C5	409-412	NP	denotes	TNF
C6	436-455	NP	denotes	the same cell lines
C7	531-540	NP	denotes	LAK cells
C8	793-802	NP	denotes	LAK cells
R1	C3	C1	coref-ident	TNF induced apoptosis in vitro,tumor necrosis factor induced apoptosis in vitro
R2	C5	C2	coref-ident	TNF,TNF
R3	C6	C4	coref-ident	the same cell lines,cell lines with high metastatic potential
R4	C8	C7	coref-ident	LAK cells,LAK cells

Id	Subject	Object	Predicate	Lexical cue
T1	14-35	protein_family_or_group	denotes	tumor necrosis factor
T2	44-53	other_name	denotes	apoptosis
T3	79-103	other_name	denotes	high metastatic capacity
T4	122-125	protein_family_or_group	denotes	TNF
T5	140-149	protein_family_or_group	denotes	cytokines
T6	179-192	body_part	denotes	immune system
T7	226-236	cell_line	denotes	cell lines
T8	264-281	tissue	denotes	metastatic tumors
T9	309-312	protein_family_or_group	denotes	TNF
T10	321-330	other_name	denotes	apoptosis
T11	350-360	cell_line	denotes	cell lines
T12	366-391	other_name	denotes	high metastatic potential
T13	409-412	protein_family_or_group	denotes	TNF
T14	445-455	cell_line	denotes	cell lines
T15	474-490	other_name	denotes	cytolytic action
T16	500-518	protein_family_or_group	denotes	cytotoxic proteins
T17	531-540	cell_line	denotes	LAK cells
T18	563-566	protein_family_or_group	denotes	TNF
T19	626-646	protein_family_or_group	denotes	transcription factor
T20	647-656	protein_complex	denotes	NF-kappaB
T21	722-735	other_name	denotes	immunotherapy
T22	756-767	cell_type	denotes	tumor cells
T23	793-802	cell_line	denotes	LAK cells

Id	Subject	Object	Predicate	Lexical cue
T1	275-281	HP_0002664	denotes	tumors
T2	756-761	HP_0002664	denotes	tumor