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PubMed:10231345 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-163 Sentence denotes Glucocorticoid receptors are down-regulated in inflamed colonic mucosa but not in peripheral blood mononuclear cells from patients with inflammatory bowel disease.
T2 164-175 Sentence denotes BACKGROUND:
T3 176-363 Sentence denotes Growing evidence indicates that the immune system and the hypothalamic-pituitary-adrenal system are linked by several mechanisms, for example intracellular glucocorticoid receptors (hGR).
T4 364-460 Sentence denotes Glucocorticoids are the standard treatment of acute attacks of inflammatory bowel disease (IBD).
T5 461-573 Sentence denotes Binding of glucocorticoids to hGR down-regulates the transcription of inflammatory genes that can propagate IBD.
T6 574-901 Sentence denotes PATIENTS AND METHODS: IBD patients were either treated with 5-60 mg of prednisolone for more than 1 week or were without glucocorticoid treatment for more than 4 weeks. hGR levels were determined from isolated cytosol of peripheral blood mononuclear cells (PBMCs) or mucosal biopsies using a radioassay with [3H]-dexamethasone.
T7 902-989 Sentence denotes Interleukin (IL) 6 levels were determined by enzyme-linked immunosorbent assay (ELISA).
T8 990-998 Sentence denotes RESULTS:
T9 999-1331 Sentence denotes The systemic (PBMC) hGR levels of corticosteroid-treated IBD patients were significantly lower than those of control subjects (59.6 +/- 57.1 dpm mg-1 cytosol protein vs. 227.0 +/- 90.8 dpm mg-1 cytosol protein, P = 0.007) and IBD patients not receiving glucocorticoid treatment (179.7 +/- 171.3 dpm mg-1 cytosol protein, P = 0.002).
T10 1332-1438 Sentence denotes Systemic hGR levels in untreated IBD patients did not differ significantly from those in control subjects.
T11 1439-1579 Sentence denotes In patients with connective tissue diseases, systemic hGR levels were also found to be decreased in the absence of glucocorticoid treatment.
T12 1580-1813 Sentence denotes Systemic hGR levels in patients with Crohn's disease (CD) treated with steroids (66.6 +/- 61.0 dpm mg-1 cytosol protein) were not different from those in patients with ulcerative colitis (UC) (56.1 +/- 51.6 dpm mg-1 cytosol protein).
T13 1814-2071 Sentence denotes In contrast to these findings, mucosal hGR levels were significantly decreased in both steroid-treated (18.0 +/- 15.5) and not steroid-treated (37.8 +/- 30.5) patients compared with control subjects (125.6 +/- 97.1; P = 0.00009 and P = 0.0008 respectively).
T14 2072-2188 Sentence denotes IL-6 levels in all IBD groups with and without steroids were significantly different from those in control subjects.
T15 2189-2200 Sentence denotes CONCLUSION:
T16 2201-2354 Sentence denotes In IBD there is no difference in systemic hGR levels between not steroid-treated patients and control subjects, in spite of inflammatory activity (IL-6).
T17 2355-2510 Sentence denotes Mucosal hGR levels were decreased independently of treatment, probably leading to a decreased protection against NF-kappaB action in the intestinal mucosa.
T1 0-163 Sentence denotes Glucocorticoid receptors are down-regulated in inflamed colonic mucosa but not in peripheral blood mononuclear cells from patients with inflammatory bowel disease.
T2 164-175 Sentence denotes BACKGROUND:
T3 176-363 Sentence denotes Growing evidence indicates that the immune system and the hypothalamic-pituitary-adrenal system are linked by several mechanisms, for example intracellular glucocorticoid receptors (hGR).
T4 364-460 Sentence denotes Glucocorticoids are the standard treatment of acute attacks of inflammatory bowel disease (IBD).
T5 461-573 Sentence denotes Binding of glucocorticoids to hGR down-regulates the transcription of inflammatory genes that can propagate IBD.
T6 574-901 Sentence denotes PATIENTS AND METHODS: IBD patients were either treated with 5-60 mg of prednisolone for more than 1 week or were without glucocorticoid treatment for more than 4 weeks. hGR levels were determined from isolated cytosol of peripheral blood mononuclear cells (PBMCs) or mucosal biopsies using a radioassay with [3H]-dexamethasone.
T7 902-989 Sentence denotes Interleukin (IL) 6 levels were determined by enzyme-linked immunosorbent assay (ELISA).
T8 990-998 Sentence denotes RESULTS:
T9 999-1331 Sentence denotes The systemic (PBMC) hGR levels of corticosteroid-treated IBD patients were significantly lower than those of control subjects (59.6 +/- 57.1 dpm mg-1 cytosol protein vs. 227.0 +/- 90.8 dpm mg-1 cytosol protein, P = 0.007) and IBD patients not receiving glucocorticoid treatment (179.7 +/- 171.3 dpm mg-1 cytosol protein, P = 0.002).
T10 1332-1438 Sentence denotes Systemic hGR levels in untreated IBD patients did not differ significantly from those in control subjects.
T11 1439-1579 Sentence denotes In patients with connective tissue diseases, systemic hGR levels were also found to be decreased in the absence of glucocorticoid treatment.
T12 1580-1813 Sentence denotes Systemic hGR levels in patients with Crohn's disease (CD) treated with steroids (66.6 +/- 61.0 dpm mg-1 cytosol protein) were not different from those in patients with ulcerative colitis (UC) (56.1 +/- 51.6 dpm mg-1 cytosol protein).
T13 1814-2071 Sentence denotes In contrast to these findings, mucosal hGR levels were significantly decreased in both steroid-treated (18.0 +/- 15.5) and not steroid-treated (37.8 +/- 30.5) patients compared with control subjects (125.6 +/- 97.1; P = 0.00009 and P = 0.0008 respectively).
T14 2072-2188 Sentence denotes IL-6 levels in all IBD groups with and without steroids were significantly different from those in control subjects.
T15 2189-2200 Sentence denotes CONCLUSION:
T16 2201-2354 Sentence denotes In IBD there is no difference in systemic hGR levels between not steroid-treated patients and control subjects, in spite of inflammatory activity (IL-6).
T17 2355-2510 Sentence denotes Mucosal hGR levels were decreased independently of treatment, probably leading to a decreased protection against NF-kappaB action in the intestinal mucosa.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-24 protein denotes Glucocorticoid receptors
T2 82-116 cell_type denotes peripheral blood mononuclear cells
T3 332-356 protein denotes glucocorticoid receptors
T4 358-361 protein denotes hGR
T5 491-494 protein denotes hGR
T6 531-549 DNA denotes inflammatory genes
T7 743-746 protein denotes hGR
T8 795-829 cell_type denotes peripheral blood mononuclear cells
T9 831-836 cell_type denotes PBMCs
T10 1019-1022 protein denotes hGR
T11 1149-1164 protein denotes cytosol protein
T12 1193-1208 protein denotes cytosol protein
T13 1303-1318 protein denotes cytosol protein
T14 1341-1344 protein denotes hGR
T15 1493-1496 protein denotes hGR
T16 1589-1592 protein denotes hGR
T17 1684-1699 protein denotes cytosol protein
T18 1796-1811 protein denotes cytosol protein
T19 1853-1856 protein denotes hGR
T20 2243-2246 protein denotes hGR
T21 2348-2352 protein denotes IL-6
T22 2363-2366 protein denotes hGR
T23 2468-2477 protein denotes NF-kappaB

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-163 Sentence denotes Glucocorticoid receptors are down-regulated in inflamed colonic mucosa but not in peripheral blood mononuclear cells from patients with inflammatory bowel disease.
S2 164-363 Sentence denotes BACKGROUND: Growing evidence indicates that the immune system and the hypothalamic-pituitary-adrenal system are linked by several mechanisms, for example intracellular glucocorticoid receptors (hGR).
S3 364-460 Sentence denotes Glucocorticoids are the standard treatment of acute attacks of inflammatory bowel disease (IBD).
S4 461-573 Sentence denotes Binding of glucocorticoids to hGR down-regulates the transcription of inflammatory genes that can propagate IBD.
S5 574-742 Sentence denotes PATIENTS AND METHODS: IBD patients were either treated with 5-60 mg of prednisolone for more than 1 week or were without glucocorticoid treatment for more than 4 weeks.
S6 743-901 Sentence denotes hGR levels were determined from isolated cytosol of peripheral blood mononuclear cells (PBMCs) or mucosal biopsies using a radioassay with [3H]-dexamethasone.
S7 902-989 Sentence denotes Interleukin (IL) 6 levels were determined by enzyme-linked immunosorbent assay (ELISA).
S8 990-1331 Sentence denotes RESULTS: The systemic (PBMC) hGR levels of corticosteroid-treated IBD patients were significantly lower than those of control subjects (59.6 +/- 57.1 dpm mg-1 cytosol protein vs. 227.0 +/- 90.8 dpm mg-1 cytosol protein, P = 0.007) and IBD patients not receiving glucocorticoid treatment (179.7 +/- 171.3 dpm mg-1 cytosol protein, P = 0.002).
S9 1332-1438 Sentence denotes Systemic hGR levels in untreated IBD patients did not differ significantly from those in control subjects.
S10 1439-1579 Sentence denotes In patients with connective tissue diseases, systemic hGR levels were also found to be decreased in the absence of glucocorticoid treatment.
S11 1580-1813 Sentence denotes Systemic hGR levels in patients with Crohn's disease (CD) treated with steroids (66.6 +/- 61.0 dpm mg-1 cytosol protein) were not different from those in patients with ulcerative colitis (UC) (56.1 +/- 51.6 dpm mg-1 cytosol protein).
S12 1814-2071 Sentence denotes In contrast to these findings, mucosal hGR levels were significantly decreased in both steroid-treated (18.0 +/- 15.5) and not steroid-treated (37.8 +/- 30.5) patients compared with control subjects (125.6 +/- 97.1; P = 0.00009 and P = 0.0008 respectively).
S13 2072-2188 Sentence denotes IL-6 levels in all IBD groups with and without steroids were significantly different from those in control subjects.
S14 2189-2354 Sentence denotes CONCLUSION: In IBD there is no difference in systemic hGR levels between not steroid-treated patients and control subjects, in spite of inflammatory activity (IL-6).
S15 2355-2510 Sentence denotes Mucosal hGR levels were decreased independently of treatment, probably leading to a decreased protection against NF-kappaB action in the intestinal mucosa.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 136-162 NP denotes inflammatory bowel disease
C1 122-162 NP denotes patients with inflammatory bowel disease
C3 318-362 NP denotes intracellular glucocorticoid receptors (hGR)
C4 364-379 NP denotes Glucocorticoids
C5 427-459 NP denotes inflammatory bowel disease (IBD)
C6 472-487 NP denotes glucocorticoids
C7 491-494 NP denotes hGR
C8 510-549 NP denotes the transcription of inflammatory genes
C9 550-554 NP denotes that
C10 569-572 NP denotes IBD
C11 596-608 NP denotes IBD patients
C12 999-1029 NP denotes The systemic (PBMC) hGR levels
C13 1099-1104 NP denotes those
C14 1108-1124 NP denotes control subjects
C16 1252-1276 NP denotes glucocorticoid treatment
C15 1225-1276 NP denotes IBD patients not receiving glucocorticoid treatment
C17 1332-1351 NP denotes Systemic hGR levels
C18 1355-1377 NP denotes untreated IBD patients
C19 1412-1417 NP denotes those
C20 1421-1437 NP denotes control subjects
C21 1484-1503 NP denotes systemic hGR levels
C22 1554-1578 NP denotes glucocorticoid treatment
C23 1580-1599 NP denotes Systemic hGR levels
C24 1651-1659 NP denotes steroids
C25 1725-1730 NP denotes those
C26 1845-1863 NP denotes mucosal hGR levels
C27 1996-2012 NP denotes control subjects
C28 2072-2083 NP denotes IL-6 levels
C29 2119-2127 NP denotes steroids
C30 2162-2167 NP denotes those
C31 2171-2187 NP denotes control subjects
C32 2204-2207 NP denotes IBD
C33 2234-2253 NP denotes systemic hGR levels
C34 2295-2311 NP denotes control subjects
C35 2355-2373 NP denotes Mucosal hGR levels
R1 C5 C2 coref-ident inflammatory bowel disease (IBD),inflammatory bowel disease
R2 C6 C4 coref-ident glucocorticoids,Glucocorticoids
R3 C7 C3 coref-ident hGR,intracellular glucocorticoid receptors (hGR)
R4 C9 C8 coref-relat that,the transcription of inflammatory genes
R5 C10 C5 coref-ident IBD,inflammatory bowel disease (IBD)
R6 C11 C1 coref-ident IBD patients,patients with inflammatory bowel disease
R7 C13 C12 coref-pron those,The systemic (PBMC) hGR levels
R8 C17 C12 coref-ident Systemic hGR levels,The systemic (PBMC) hGR levels
R9 C18 C15 coref-ident untreated IBD patients,IBD patients not receiving glucocorticoid treatment
R10 C19 C17 coref-pron those,Systemic hGR levels
R11 C20 C14 coref-ident control subjects,control subjects
R12 C21 C17 coref-ident systemic hGR levels,Systemic hGR levels
R13 C22 C16 coref-ident glucocorticoid treatment,glucocorticoid treatment
R14 C23 C21 coref-ident Systemic hGR levels,systemic hGR levels
R15 C25 C23 coref-pron those,Systemic hGR levels
R16 C27 C20 coref-ident control subjects,control subjects
R17 C29 C24 coref-ident steroids,steroids
R18 C30 C28 coref-pron those,IL-6 levels
R19 C31 C27 coref-ident control subjects,control subjects
R20 C32 C10 coref-ident IBD,IBD
R21 C33 C23 coref-ident systemic hGR levels,Systemic hGR levels
R22 C34 C31 coref-ident control subjects,control subjects
R23 C35 C26 coref-ident Mucosal hGR levels,mucosal hGR levels

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-24 protein_family_or_group denotes Glucocorticoid receptors
T2 47-70 tissue denotes inflamed colonic mucosa
T3 82-116 cell_type denotes peripheral blood mononuclear cells
T4 122-130 multi_cell denotes patients
T5 136-162 other_name denotes inflammatory bowel disease
T6 212-225 body_part denotes immune system
T7 234-271 other_name denotes hypothalamic-pituitary-adrenal system
T8 332-356 protein_family_or_group denotes glucocorticoid receptors
T9 358-361 protein_family_or_group denotes hGR
T10 364-379 lipid denotes Glucocorticoids
T11 427-453 other_name denotes inflammatory bowel disease
T12 455-458 other_name denotes IBD
T13 491-494 protein_family_or_group denotes hGR
T14 531-549 DNA_family_or_group denotes inflammatory genes
T15 569-572 other_name denotes IBD
T16 596-599 other_name denotes IBD
T17 600-608 multi_cell denotes patients
T18 645-657 lipid denotes prednisolone
T19 695-709 lipid denotes glucocorticoid
T20 743-746 protein_family_or_group denotes hGR
T21 775-791 cell_component denotes isolated cytosol
T22 795-829 cell_type denotes peripheral blood mononuclear cells
T23 831-836 cell_type denotes PBMCs
T24 882-900 lipid denotes [3H]-dexamethasone
T25 947-980 other_name denotes enzyme-linked immunosorbent assay
T26 982-987 other_name denotes ELISA
T27 1003-1018 other_name denotes systemic (PBMC)
T28 1019-1022 protein_family_or_group denotes hGR
T29 1033-1055 multi_cell denotes corticosteroid-treated
T30 1056-1059 other_name denotes IBD
T31 1060-1068 multi_cell denotes patients
T32 1108-1124 multi_cell denotes control subjects
T33 1149-1164 protein_family_or_group denotes cytosol protein
T34 1193-1208 protein_family_or_group denotes cytosol protein
T35 1225-1228 other_name denotes IBD
T36 1229-1237 multi_cell denotes patients
T37 1252-1266 lipid denotes glucocorticoid
T38 1303-1318 protein_family_or_group denotes cytosol protein
T39 1341-1344 protein_family_or_group denotes hGR
T40 1365-1368 other_name denotes IBD
T41 1369-1377 multi_cell denotes patients
T42 1421-1437 multi_cell denotes control subjects
T43 1442-1450 multi_cell denotes patients
T44 1484-1492 other_name denotes systemic
T45 1493-1496 protein_family_or_group denotes hGR
T46 1554-1568 lipid denotes glucocorticoid
T47 1580-1588 other_name denotes Systemic
T48 1589-1592 protein_family_or_group denotes hGR
T49 1603-1611 multi_cell denotes patients
T50 1651-1659 lipid denotes steroids
T51 1684-1699 protein_family_or_group denotes cytosol protein
T52 1734-1742 multi_cell denotes patients
T53 1748-1766 other_name denotes ulcerative colitis
T54 1796-1811 protein_family_or_group denotes cytosol protein
T55 1845-1852 other_name denotes mucosal
T56 1853-1856 protein_family_or_group denotes hGR
T57 1973-1981 multi_cell denotes patients
T58 1996-2012 multi_cell denotes control subjects
T59 2091-2094 other_name denotes IBD
T60 2119-2127 lipid denotes steroids
T61 2171-2187 multi_cell denotes control subjects
T62 2204-2207 other_name denotes IBD
T63 2234-2242 other_name denotes systemic
T64 2243-2246 protein_family_or_group denotes hGR
T65 2282-2290 multi_cell denotes patients
T66 2295-2311 multi_cell denotes control subjects
T67 2325-2346 other_name denotes inflammatory activity
T68 2348-2352 protein_molecule denotes IL-6
T69 2363-2366 protein_family_or_group denotes hGR
T70 2439-2459 other_name denotes decreased protection
T71 2468-2477 protein_complex denotes NF-kappaB
T72 2492-2509 tissue denotes intestinal mucosa