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PubMed:10229841 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 22-47 protein denotes lymphotoxin-beta receptor
T2 118-142 protein denotes membrane-bound TNF-alpha
T3 270-278 protein denotes cytokine
T4 279-288 protein denotes TNF-alpha
T5 439-442 protein denotes TNF
T6 471-506 protein denotes lymphotoxin-beta (LT-beta) receptor
T7 508-516 protein denotes LT-betaR
T8 630-638 protein denotes LT-betaR
T9 643-663 protein denotes TNF receptor systems
T10 793-817 protein denotes membrane-bound TNF-alpha
T11 822-836 protein denotes LT-alpha1beta2
T12 952-983 protein denotes LT-beta and TNF-alpha receptors
T13 1102-1111 cell_type denotes monocytes
T14 1149-1163 protein denotes LT-alpha1beta2
T15 1185-1196 cell_line denotes T cell line
T16 1287-1301 protein denotes LT-alpha1beta2
T17 1366-1380 protein denotes LT-alpha1beta2
T18 1431-1445 protein denotes LT-alpha1beta2

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-143 Sentence denotes Signaling through the lymphotoxin-beta receptor stimulates HIV-1 replication alone and in cooperation with soluble or membrane-bound TNF-alpha.
S2 144-238 Sentence denotes The level of ongoing HIV-1 replication within an individual is critical to HIV-1 pathogenesis.
S3 239-390 Sentence denotes Among host immune factors, the cytokine TNF-alpha has previously been shown to increase HIV-1 replication in various monocyte and T cell model systems.
S4 391-552 Sentence denotes Here, we demonstrate that signaling through the TNF receptor family member, the lymphotoxin-beta (LT-beta) receptor (LT-betaR), also regulates HIV-1 replication.
S5 553-717 Sentence denotes Furthermore, HIV-1 replication is cooperatively stimulated when the distinct LT-betaR and TNF receptor systems are simultaneously engaged by their specific ligands.
S6 718-925 Sentence denotes Moreover, in a physiological coculture cellular assay system, we show that membrane-bound TNF-alpha and LT-alpha1beta2 act virtually identically to their soluble forms in the regulation of HIV-1 replication.
S7 926-1112 Sentence denotes Thus, cosignaling via the LT-beta and TNF-alpha receptors is probably involved in the modulation of HIV-1 replication and the subsequent determination of HIV-1 viral burden in monocytes.
S8 1113-1336 Sentence denotes Intriguingly, surface expression of LT-alpha1beta2 is up-regulated on a T cell line acutely infected with HIV-1, suggesting a positive feedback loop between HIV-1 infection, LT-alpha1beta2 expression, and HIV-1 replication.
S9 1337-1517 Sentence denotes Given the critical role that LT-alpha1beta2 plays in lymphoid architecture, we speculate that LT-alpha1beta2 may be involved in HIV-associated abnormalities of the lymphoid organs.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 18-47 NP denotes the lymphotoxin-beta receptor
C1 0-47 NP denotes Signaling through the lymphotoxin-beta receptor
C3 59-82 NP denotes HIV-1 replication alone
C5 435-465 NP denotes the TNF receptor family member
C6 467-517 NP denotes the lymphotoxin-beta (LT-beta) receptor (LT-betaR)
C4 417-517 NP denotes signaling through the TNF receptor family member, the lymphotoxin-beta (LT-beta) receptor (LT-betaR)
C7 534-551 NP denotes HIV-1 replication
C8 566-583 NP denotes HIV-1 replication
C9 617-663 NP denotes the distinct LT-betaR and TNF receptor systems
C10 694-699 NP denotes their
C12 822-836 NP denotes LT-alpha1beta2
C11 793-836 NP denotes membrane-bound TNF-alpha and LT-alpha1beta2
C13 866-871 NP denotes their
C14 907-924 NP denotes HIV-1 replication
C15 1026-1043 NP denotes HIV-1 replication
C16 1149-1163 NP denotes LT-alpha1beta2
C17 1318-1335 NP denotes HIV-1 replication
C18 1366-1380 NP denotes LT-alpha1beta2
C19 1431-1445 NP denotes LT-alpha1beta2
R1 C5 C2 coref-ident the TNF receptor family member,the lymphotoxin-beta receptor
R2 C6 C5 coref-appos the lymphotoxin-beta (LT-beta) receptor (LT-betaR),the TNF receptor family member
R3 C4 C1 coref-ident "signaling through the TNF receptor family member, the lymphotoxin-beta (LT-beta) receptor (LT-betaR)",Signaling through the lymphotoxin-beta receptor
R4 C7 C3 coref-ident HIV-1 replication,HIV-1 replication alone
R5 C8 C7 coref-ident HIV-1 replication,HIV-1 replication
R6 C10 C9 coref-pron their,the distinct LT-betaR and TNF receptor systems
R7 C13 C11 coref-pron their,membrane-bound TNF-alpha and LT-alpha1beta2
R8 C14 C8 coref-ident HIV-1 replication,HIV-1 replication
R9 C15 C14 coref-ident HIV-1 replication,HIV-1 replication
R10 C16 C12 coref-ident LT-alpha1beta2,LT-alpha1beta2
R11 C17 C15 coref-ident HIV-1 replication,HIV-1 replication
R12 C18 C16 coref-ident LT-alpha1beta2,LT-alpha1beta2
R13 C19 C18 coref-ident LT-alpha1beta2,LT-alpha1beta2

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 22-47 protein_molecule denotes lymphotoxin-beta receptor
T2 59-64 virus denotes HIV-1
T3 118-142 protein_molecule denotes membrane-bound TNF-alpha
T4 165-170 virus denotes HIV-1
T5 219-224 virus denotes HIV-1
T6 270-278 protein_family_or_group denotes cytokine
T7 279-288 protein_molecule denotes TNF-alpha
T8 327-332 virus denotes HIV-1
T9 356-364 other_name denotes monocyte
T10 369-389 other_name denotes T cell model systems
T11 439-442 protein_family_or_group denotes TNF
T12 471-506 protein_molecule denotes lymphotoxin-beta (LT-beta) receptor
T13 508-516 protein_molecule denotes LT-betaR
T14 534-539 virus denotes HIV-1
T15 566-571 virus denotes HIV-1
T16 630-638 protein_molecule denotes LT-betaR
T17 643-663 protein_family_or_group denotes TNF receptor systems
T18 747-778 other_name denotes coculture cellular assay system
T19 793-817 protein_molecule denotes membrane-bound TNF-alpha
T20 822-836 protein_molecule denotes LT-alpha1beta2
T21 907-912 virus denotes HIV-1
T22 1026-1031 virus denotes HIV-1
T23 1080-1085 virus denotes HIV-1
T24 1102-1111 cell_type denotes monocytes
T25 1149-1163 protein_molecule denotes LT-alpha1beta2
T26 1185-1196 cell_line denotes T cell line
T27 1219-1224 virus denotes HIV-1
T28 1270-1275 virus denotes HIV-1
T29 1287-1301 protein_molecule denotes LT-alpha1beta2
T30 1318-1335 other_name denotes HIV-1 replication
T31 1366-1380 protein_molecule denotes LT-alpha1beta2
T32 1431-1445 protein_molecule denotes LT-alpha1beta2
T33 1465-1468 virus denotes HIV
T34 1501-1516 body_part denotes lymphoid organs