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PubMed:10229815 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-6 protein denotes CTLA-4
T2 68-74 protein denotes CTLA-4
T3 89-93 protein denotes mAbs
T4 110-114 protein denotes CD28
T5 125-129 protein denotes IL-2
T6 233-239 protein denotes CTLA-4
T7 290-302 cell_type denotes CD4+ T cells
T8 327-333 protein denotes CTLA-4
T9 357-361 protein denotes CD28
T10 370-379 RNA denotes IL-2 mRNA
T11 407-411 protein denotes IL-2
T12 483-488 protein denotes NF-AT
T13 526-532 protein denotes CTLA-4
T14 571-575 protein denotes CD28
T15 602-611 RNA denotes IL-2 mRNA
T16 622-628 protein denotes CTLA-4
T17 717-726 protein denotes cyclin D3
T18 728-751 protein denotes cyclin-dependent kinase
T19 752-758 protein denotes (cdk)4
T20 764-768 protein denotes cdk6
T21 778-785 cell_type denotes T cells
T22 807-820 protein denotes anti-CD3/CD28
T23 830-838 protein denotes anti-CD3
T24 874-880 protein denotes CTLA-4
T25 942-946 protein denotes IL-2
T26 981-985 protein denotes IL-2
T27 1051-1055 protein denotes CD28

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-67 Sentence denotes CTLA-4-Mediated inhibition of early events of T cell proliferation.
S2 68-182 Sentence denotes CTLA-4 engagement by mAbs inhibits, while CD28 enhances, IL-2 production and proliferation upon T cell activation.
S3 183-326 Sentence denotes Here, we have analyzed the mechanisms involved in CTLA-4-mediated inhibition of T cell activation of naive CD4+ T cells using Ab cross-linking.
S4 327-516 Sentence denotes CTLA-4 ligation inhibited CD3/CD28-induced IL-2 mRNA accumulation by inhibiting IL-2 transcription, which appears to be mediated in part through decreasing NF-AT accumulation in the nuclei.
S5 517-612 Sentence denotes However, CTLA-4 ligation did not appear to affect the CD28-mediated stabilization of IL-2 mRNA.
S6 613-845 Sentence denotes Further, CTLA-4 engagement inhibited progression through the cell cycle by inhibiting the production of cyclin D3, cyclin-dependent kinase (cdk)4, and cdk6 when the T cells were stimulated with anti-CD3/CD28 and with anti-CD3 alone.
S7 846-1079 Sentence denotes These results indicate that CTLA-4 signaling inhibits events early in T cell activation both at IL-2 transcription and at the level of IL-2-independent events of the cell cycle, and does not simply oppose CD28-mediated costimulation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 164-181 NP denotes T cell activation
C2 327-342 NP denotes CTLA-4 ligation
C3 526-541 NP denotes CTLA-4 ligation
C4 670-684 NP denotes the cell cycle
C5 916-933 NP denotes T cell activation
C6 1008-1022 NP denotes the cell cycle
R1 C3 C2 coref-ident CTLA-4 ligation,CTLA-4 ligation
R2 C5 C1 coref-ident T cell activation,T cell activation
R3 C6 C4 coref-ident the cell cycle,the cell cycle

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-6 protein_molecule denotes CTLA-4
T2 46-66 other_name denotes T cell proliferation
T3 68-74 protein_molecule denotes CTLA-4
T4 89-93 protein_family_or_group denotes mAbs
T5 110-114 protein_molecule denotes CD28
T6 125-129 protein_molecule denotes IL-2
T7 145-158 other_name denotes proliferation
T8 164-181 other_name denotes T cell activation
T9 233-239 protein_molecule denotes CTLA-4
T10 263-280 other_name denotes T cell activation
T11 290-302 cell_type denotes CD4+ T cells
T12 309-325 other_name denotes Ab cross-linking
T13 327-333 protein_molecule denotes CTLA-4
T14 353-357 other_name denotes CD3/
T15 357-361 protein_molecule denotes CD28
T16 370-374 protein_molecule denotes IL-2
T17 407-411 protein_molecule denotes IL-2
T18 483-488 protein_molecule denotes NF-AT
T19 509-515 cell_component denotes nuclei
T20 526-532 protein_molecule denotes CTLA-4
T21 571-575 protein_molecule denotes CD28
T22 602-606 protein_molecule denotes IL-2
T23 622-628 protein_molecule denotes CTLA-4
T24 674-684 other_name denotes cell cycle
T25 717-726 protein_molecule denotes cyclin D3
T26 728-751 protein_molecule denotes cyclin-dependent kinase
T27 752-758 protein_molecule denotes (cdk)4
T28 764-768 protein_molecule denotes cdk6
T29 778-785 cell_type denotes T cells
T30 807-816 protein_family_or_group denotes anti-CD3/
T31 816-820 protein_molecule denotes CD28
T32 830-838 protein_family_or_group denotes anti-CD3
T33 874-880 protein_molecule denotes CTLA-4
T34 916-933 other_name denotes T cell activation
T35 942-946 protein_molecule denotes IL-2
T36 981-985 protein_molecule denotes IL-2
T37 1012-1022 other_name denotes cell cycle
T38 1051-1055 protein_molecule denotes CD28