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PubMed:10229324 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 38-72 protein denotes IL-2R associated JAK/STAT proteins
T2 81-138 cell_line denotes HTLV-I(+), IL-2-independent and IL-2-dependent cell lines
T3 143-168 cell_type denotes uncultured leukemic cells
T4 258-263 protein denotes IL-2R
T5 276-284 protein denotes Jak/STAT
T6 301-322 cell_line denotes HTLV-I infected cells
T7 364-368 protein denotes Jak3
T8 370-375 protein denotes STAT3
T9 381-386 protein denotes STAT5
T10 398-420 cell_line denotes HTLV-I(+) T-cell lines
T11 428-455 cell_type denotes uncultured leukemic T cells
T12 561-565 protein denotes Jak3
T13 580-585 protein denotes STAT3
T14 590-595 protein denotes STAT5
T15 621-648 cell_line denotes IL-2-independent cell lines
T16 682-707 cell_line denotes IL-2-dependent cell lines
T17 769-773 protein denotes Jak3
T18 778-783 protein denotes STAT5
T19 791-805 cell_type denotes leukemic cells
T20 880-884 protein denotes IL-2
T21 897-901 protein denotes Jak3
T22 906-911 protein denotes STAT5
T23 936-955 cell_type denotes leukemic ATLL cells
T24 960-980 cell_line denotes IL-2-dependent lines
T25 1009-1026 protein denotes SHP-1 phosphatase
T26 1060-1077 protein denotes cytokine receptor
T27 1106-1133 cell_line denotes IL-2 independent cell lines
T28 1164-1174 cell_type denotes ATLL cells
T29 1195-1217 cell_line denotes HTLV-I(+) T-cell lines
T30 1245-1267 cell_line denotes HTLV-I(-) T-cell lines
T31 1424-1428 protein denotes Jak3
T32 1430-1435 protein denotes STAT3
T33 1441-1446 protein denotes STAT5
T34 1568-1572 protein denotes IL-2
T35 1600-1605 protein denotes IL-2R
T36 1606-1614 protein denotes Jak/STAT
T37 1723-1728 protein denotes SHP-1

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-219 Sentence denotes Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia.
S2 220-522 Sentence denotes To determine activation status of the IL-2R-associated (Jak/STAT) pathway in the HTLV-I infected cells, we examined tyrosine phosphorylation of Jak3, STAT3, and STAT5 in several HTLV-I(+) T-cell lines and in uncultured leukemic T cells isolated from patients with adult T-cell lymphoma/leukemia (ATLL).
S3 523-708 Sentence denotes Constitutive basal phosphorylation of Jak3 and, usually, STAT3 and STAT5 was detected in all four IL-2-independent cell lines tested, but in none of the three IL-2-dependent cell lines.
S4 709-853 Sentence denotes Similarly, there was no detectable basal phosphorylation of Jak3 and STAT5 in the leukemic cells from ATLL patients (0/8 and 0/3, respectively).
S5 854-981 Sentence denotes However, stimulation with IL-2 resulted in Jak3 and STAT5 phosphorylation in both leukemic ATLL cells and IL-2-dependent lines.
S6 982-1181 Sentence denotes Furthermore, expression of SHP-1 phosphatase which is a negative regulator of cytokine receptor signaling, was lost in most IL-2 independent cell lines (3/4) but not in the leukemic ATLL cells (0/3).
S7 1182-1321 Sentence denotes Finally, the HTLV-I(+) T-cell lines (313) but not the control, HTLV-I(-) T-cell lines were resistant to rapamycin and its novel analog RAD.
S8 1322-1772 Sentence denotes We conclude that (1) HTLV-I infection per se does not result in a constitutive phosphorylation of the Jak3, STAT3, and STAT5 proteins; (2) malignant transformation in at least some cases of ATLL does not require the constitutive, but may require IL-2-induced, activation of the IL-2R Jak/STAT pathway; and (3) there are major differences in T-cell immortalization mechanism(s) which appear to involve SHP-1 and target molecules for rapamycin and RAD.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 188-218 NP denotes adult T-cell lymphoma/leukemia
C1 174-218 NP denotes patients with adult T-cell lymphoma/leukemia
C3 254-293 NP denotes the IL-2R-associated (Jak/STAT) pathway
C5 364-368 NP denotes Jak3
C6 370-375 NP denotes STAT3
C7 381-386 NP denotes STAT5
C4 364-386 NP denotes Jak3, STAT3, and STAT5
C9 484-521 NP denotes adult T-cell lymphoma/leukemia (ATLL)
C8 470-521 NP denotes patients with adult T-cell lymphoma/leukemia (ATLL)
C10 561-565 NP denotes Jak3
C11 580-585 NP denotes STAT3
C12 590-595 NP denotes STAT5
C13 769-773 NP denotes Jak3
C14 778-783 NP denotes STAT5
C16 811-824 NP denotes ATLL patients
C15 787-824 NP denotes the leukemic cells from ATLL patients
C17 1009-1026 NP denotes SHP-1 phosphatase
C18 1027-1032 NP denotes which
C19 1151-1174 NP denotes the leukemic ATLL cells
C20 1232-1243 NP denotes the control
C21 1245-1267 NP denotes HTLV-I(-) T-cell lines
C23 1286-1295 NP denotes rapamycin
C24 1300-1303 NP denotes its
C22 1286-1320 NP denotes rapamycin and its novel analog RAD
C25 1420-1456 NP denotes the Jak3, STAT3, and STAT5 proteins;
C26 1512-1516 NP denotes ATLL
C27 1596-1623 NP denotes the IL-2R Jak/STAT pathway;
C28 1663-1698 NP denotes T-cell immortalization mechanism(s)
C29 1699-1704 NP denotes which
C31 1754-1763 NP denotes rapamycin
C30 1754-1771 NP denotes rapamycin and RAD
R1 C9 C2 coref-ident adult T-cell lymphoma/leukemia (ATLL),adult T-cell lymphoma/leukemia
R2 C8 C1 coref-ident patients with adult T-cell lymphoma/leukemia (ATLL),patients with adult T-cell lymphoma/leukemia
R3 C10 C5 coref-ident Jak3,Jak3
R4 C11 C6 coref-ident STAT3,STAT3
R5 C12 C7 coref-ident STAT5,STAT5
R6 C13 C10 coref-ident Jak3,Jak3
R7 C14 C12 coref-ident STAT5,STAT5
R8 C16 C8 coref-ident ATLL patients,patients with adult T-cell lymphoma/leukemia (ATLL)
R9 C18 C17 coref-relat which,SHP-1 phosphatase
R10 C19 C15 coref-ident the leukemic ATLL cells,the leukemic cells from ATLL patients
R11 C21 C20 coref-appos HTLV-I(-) T-cell lines,the control
R12 C24 C23 coref-pron its,rapamycin
R13 C25 C4 coref-ident "the Jak3, STAT3, and STAT5 proteins;","Jak3, STAT3, and STAT5"
R14 C26 C9 coref-ident ATLL,adult T-cell lymphoma/leukemia (ATLL)
R15 C27 C3 coref-ident the IL-2R Jak/STAT pathway;,the IL-2R-associated (Jak/STAT) pathway
R16 C29 C28 coref-relat which,T-cell immortalization mechanism(s)
R17 C31 C23 coref-ident rapamycin,rapamycin
R18 C30 C22 coref-ident rapamycin and RAD,rapamycin and its novel analog RAD

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 38-72 protein_family_or_group denotes IL-2R associated JAK/STAT proteins
T2 143-168 cell_type denotes uncultured leukemic cells
T3 174-182 multi_cell denotes patients
T4 188-218 other_name denotes adult T-cell lymphoma/leukemia
T5 258-263 protein_molecule denotes IL-2R
T6 276-284 protein_family_or_group denotes Jak/STAT
T7 301-322 cell_line denotes HTLV-I infected cells
T8 336-360 other_name denotes tyrosine phosphorylation
T9 364-368 protein_molecule denotes Jak3
T10 370-375 protein_molecule denotes STAT3
T11 381-386 protein_molecule denotes STAT5
T12 398-420 cell_line denotes HTLV-I(+) T-cell lines
T13 428-455 cell_type denotes uncultured leukemic T cells
T14 470-478 multi_cell denotes patients
T15 484-514 other_name denotes adult T-cell lymphoma/leukemia
T16 516-520 other_name denotes ATLL
T17 561-565 protein_molecule denotes Jak3
T18 580-585 protein_molecule denotes STAT3
T19 590-595 protein_molecule denotes STAT5
T20 621-625 protein_molecule denotes IL-2
T21 682-686 protein_molecule denotes IL-2
T22 769-773 protein_molecule denotes Jak3
T23 778-783 protein_molecule denotes STAT5
T24 791-805 cell_type denotes leukemic cells
T25 811-815 other_name denotes ATLL
T26 816-824 multi_cell denotes patients
T27 880-884 protein_molecule denotes IL-2
T28 897-901 protein_molecule denotes Jak3
T29 906-911 protein_molecule denotes STAT5
T30 936-944 cell_type denotes leukemic
T31 945-949 other_name denotes ATLL
T32 960-964 protein_molecule denotes IL-2
T33 1009-1026 protein_molecule denotes SHP-1 phosphatase
T34 1060-1077 protein_family_or_group denotes cytokine receptor
T35 1106-1110 protein_molecule denotes IL-2
T36 1164-1168 other_name denotes ATLL
T37 1195-1217 cell_line denotes HTLV-I(+) T-cell lines
T38 1245-1267 cell_line denotes HTLV-I(-) T-cell lines
T39 1286-1295 other_organic_compound denotes rapamycin
T40 1317-1320 other_organic_compound denotes RAD
T41 1343-1349 virus denotes HTLV-I
T42 1388-1416 other_name denotes constitutive phosphorylation
T43 1424-1428 protein_molecule denotes Jak3
T44 1430-1435 protein_molecule denotes STAT3
T45 1441-1446 protein_molecule denotes STAT5
T46 1512-1516 other_name denotes ATLL
T47 1568-1572 protein_molecule denotes IL-2
T48 1600-1605 protein_molecule denotes IL-2R
T49 1606-1614 protein_family_or_group denotes Jak/STAT
T50 1663-1695 other_name denotes T-cell immortalization mechanism
T51 1723-1728 protein_molecule denotes SHP-1
T52 1754-1763 other_organic_compound denotes rapamycin
T53 1768-1771 other_organic_compound denotes RAD

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 490-505 HP_0012190 denotes T-cell lymphoma
T2 490-514 HP_0005517 denotes T-cell lymphoma/leukemia
T3 497-505 HP_0002665 denotes lymphoma
T4 506-514 HP_0001909 denotes leukemia