PubMed:10228133
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 10-38 | protein | denotes | glucocorticoid receptor beta |
| T2 | 42-54 | cell_type | denotes | airway cells |
| T3 | 312-338 | RNA | denotes | GC receptor (GCR) pre-mRNA |
| T4 | 358-361 | protein | denotes | GCR |
| T5 | 370-377 | protein | denotes | GCRbeta |
| T6 | 462-465 | protein | denotes | GCR |
| T7 | 496-503 | protein | denotes | GCRbeta |
| T8 | 552-586 | cell_type | denotes | Bronchoalveolar lavage (BAL) cells |
| T9 | 608-625 | cell_type | denotes | mononuclear cells |
| T10 | 627-631 | cell_type | denotes | PBMC |
| T11 | 651-658 | protein | denotes | GCRbeta |
| T12 | 684-709 | protein | denotes | GCRbeta-specific antibody |
| T13 | 764-771 | protein | denotes | GCRbeta |
| T14 | 917-945 | cell_type | denotes | GCRbeta-immunoreactive cells |
| T15 | 1050-1057 | protein | denotes | GCRbeta |
| T16 | 1126-1133 | cell_type | denotes | T cells |
| T17 | 1240-1247 | protein | denotes | GCRbeta |
| T18 | 1353-1369 | cell_type | denotes | GCRbeta-positive |
| T19 | 1529-1536 | protein | denotes | GCRbeta |
| T20 | 1547-1554 | cell_type | denotes | T cells |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-92 | Sentence | denotes | Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma. |
| S2 | 93-231 | Sentence | denotes | Glucocorticoid (GC)-insensitive asthma is a challenging clinical problem that can be associated with life-threatening disease progression. |
| S3 | 232-283 | Sentence | denotes | The molecular basis of GC insensitivity is unknown. |
| S4 | 284-466 | Sentence | denotes | Alternative splicing of the GC receptor (GCR) pre-mRNA generates a second GCR, termed GCRbeta, which does not bind GC but antagonizes the transactivating activity of the classic GCR. |
| S5 | 467-551 | Sentence | denotes | Thus increased expression of GCRbeta could account for glucocorticoid insensitivity. |
| S6 | 552-742 | Sentence | denotes | Bronchoalveolar lavage (BAL) cells and peripheral blood mononuclear cells (PBMC) were examined for GCRbeta immunoreactivity using a GCRbeta-specific antibody by immunohistochemical staining. |
| S7 | 743-837 | Sentence | denotes | Cell localization of GCRbeta expression was performed using a double immunostaining technique. |
| S8 | 838-1036 | Sentence | denotes | Patients with GC-insensitive asthma expressed a significantly higher number of GCRbeta-immunoreactive cells in their BAL and peripheral blood than GC-sensitive asthmatics or normal control subjects. |
| S9 | 1037-1204 | Sentence | denotes | Furthermore, GCRbeta expression in GC-insensitive asthma was particularly high in airway T cells, which are thought to play a major role in the pathogenesis of asthma. |
| S10 | 1205-1314 | Sentence | denotes | We also examined the expression of GCRbeta in specimens from the airways of patients with chronic bronchitis. |
| S11 | 1315-1446 | Sentence | denotes | In chronic bronchitis, few cells were GCRbeta-positive and their numbers did not differ significantly from normal control subjects. |
| S12 | 1447-1555 | Sentence | denotes | We conclude that GC-insensitive asthma is associated with increased expression of GCRbeta in airway T cells. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 58-91 | NP | denotes | glucocorticoid-insensitive asthma |
| C2 | 93-131 | NP | denotes | Glucocorticoid (GC)-insensitive asthma |
| C3 | 135-165 | NP | denotes | a challenging clinical problem |
| C4 | 166-170 | NP | denotes | that |
| C5 | 255-271 | NP | denotes | GC insensitivity |
| C6 | 349-361 | NP | denotes | a second GCR |
| C7 | 370-377 | NP | denotes | GCRbeta |
| C8 | 379-384 | NP | denotes | which |
| C9 | 496-503 | NP | denotes | GCRbeta |
| C10 | 522-550 | NP | denotes | glucocorticoid insensitivity |
| C12 | 852-873 | NP | denotes | GC-insensitive asthma |
| C11 | 838-873 | NP | denotes | Patients with GC-insensitive asthma |
| C13 | 949-954 | NP | denotes | their |
| C14 | 1012-1035 | NP | denotes | normal control subjects |
| C15 | 1072-1093 | NP | denotes | GC-insensitive asthma |
| C16 | 1119-1133 | NP | denotes | airway T cells |
| C17 | 1240-1247 | NP | denotes | GCRbeta |
| C18 | 1295-1313 | NP | denotes | chronic bronchitis |
| C19 | 1318-1336 | NP | denotes | chronic bronchitis |
| C20 | 1338-1347 | NP | denotes | few cells |
| C21 | 1374-1379 | NP | denotes | their |
| C22 | 1422-1445 | NP | denotes | normal control subjects |
| C23 | 1464-1485 | NP | denotes | GC-insensitive asthma |
| C24 | 1529-1536 | NP | denotes | GCRbeta |
| C25 | 1540-1554 | NP | denotes | airway T cells |
| R1 | C2 | C1 | coref-ident | Glucocorticoid (GC)-insensitive asthma,glucocorticoid-insensitive asthma |
| R2 | C4 | C3 | coref-relat | that,a challenging clinical problem |
| R3 | C7 | C6 | coref-ident | GCRbeta,a second GCR |
| R4 | C8 | C7 | coref-relat | which,GCRbeta |
| R5 | C9 | C7 | coref-ident | GCRbeta,GCRbeta |
| R6 | C10 | C5 | coref-ident | glucocorticoid insensitivity,GC insensitivity |
| R7 | C12 | C2 | coref-ident | GC-insensitive asthma,Glucocorticoid (GC)-insensitive asthma |
| R8 | C13 | C11 | coref-pron | their,Patients with GC-insensitive asthma |
| R9 | C15 | C12 | coref-ident | GC-insensitive asthma,GC-insensitive asthma |
| R10 | C17 | C9 | coref-ident | GCRbeta,GCRbeta |
| R11 | C19 | C18 | coref-ident | chronic bronchitis,chronic bronchitis |
| R12 | C21 | C20 | coref-pron | their,few cells |
| R13 | C22 | C14 | coref-ident | normal control subjects,normal control subjects |
| R14 | C23 | C15 | coref-ident | GC-insensitive asthma,GC-insensitive asthma |
| R15 | C24 | C17 | coref-ident | GCRbeta,GCRbeta |
| R16 | C25 | C16 | coref-ident | airway T cells,airway T cells |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 10-24 | lipid | denotes | glucocorticoid |
| T2 | 42-54 | cell_type | denotes | airway cells |
| T3 | 58-72 | lipid | denotes | glucocorticoid |
| T4 | 93-109 | other_name | denotes | Glucocorticoid ( |
| T5 | 109-111 | lipid | denotes | GC |
| T6 | 194-230 | other_name | denotes | life-threatening disease progression |
| T7 | 255-257 | lipid | denotes | GC |
| T8 | 312-314 | lipid | denotes | GC |
| T9 | 325-328 | protein_molecule | denotes | GCR |
| T10 | 358-361 | protein_molecule | denotes | GCR |
| T11 | 370-377 | protein_molecule | denotes | GCRbeta |
| T12 | 399-401 | lipid | denotes | GC |
| T13 | 462-465 | protein_molecule | denotes | GCR |
| T14 | 496-503 | protein_molecule | denotes | GCRbeta |
| T15 | 522-536 | lipid | denotes | glucocorticoid |
| T16 | 552-586 | cell_type | denotes | Bronchoalveolar lavage (BAL) cells |
| T17 | 608-625 | cell_type | denotes | mononuclear cells |
| T18 | 627-631 | cell_type | denotes | PBMC |
| T19 | 651-658 | protein_molecule | denotes | GCRbeta |
| T20 | 684-691 | protein_molecule | denotes | GCRbeta |
| T21 | 713-741 | other_name | denotes | immunohistochemical staining |
| T22 | 764-771 | protein_molecule | denotes | GCRbeta |
| T23 | 805-836 | other_name | denotes | double immunostaining technique |
| T24 | 852-854 | lipid | denotes | GC |
| T25 | 917-924 | protein_molecule | denotes | GCRbeta |
| T26 | 985-987 | lipid | denotes | GC |
| T27 | 1012-1035 | multi_cell | denotes | normal control subjects |
| T28 | 1050-1057 | protein_molecule | denotes | GCRbeta |
| T29 | 1072-1093 | other_name | denotes | GC-insensitive asthma |
| T30 | 1126-1133 | cell_type | denotes | T cells |
| T31 | 1197-1203 | other_name | denotes | asthma |
| T32 | 1240-1247 | protein_molecule | denotes | GCRbeta |
| T33 | 1281-1289 | multi_cell | denotes | patients |
| T34 | 1295-1313 | other_name | denotes | chronic bronchitis |
| T35 | 1318-1336 | other_name | denotes | chronic bronchitis |
| T36 | 1353-1360 | protein_molecule | denotes | GCRbeta |
| T37 | 1422-1445 | multi_cell | denotes | normal control subjects |
| T38 | 1464-1466 | lipid | denotes | GC |
| T39 | 1529-1536 | protein_molecule | denotes | GCRbeta |
| T40 | 1547-1554 | cell_type | denotes | T cells |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 125-131 | HP_0002099 | denotes | asthma |
| T2 | 867-873 | HP_0002099 | denotes | asthma |
| T3 | 1087-1093 | HP_0002099 | denotes | asthma |
| T4 | 1197-1203 | HP_0002099 | denotes | asthma |
| T5 | 1295-1313 | HP_0004469 | denotes | chronic bronchitis |
| T6 | 1303-1313 | HP_0012387 | denotes | bronchitis |
| T7 | 1318-1336 | HP_0004469 | denotes | chronic bronchitis |
| T8 | 1326-1336 | HP_0012387 | denotes | bronchitis |
| T9 | 1479-1485 | HP_0002099 | denotes | asthma |