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PubMed:10228011 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-11 protein denotes HLA class I
T2 62-70 DNA denotes cyclin E
T3 125-128 protein denotes E2F
T4 252-267 protein denotes HLA class I Ags
T5 347-368 protein denotes HLA class I molecules
T6 401-419 cell_type denotes aortic endothelial
T7 431-450 cell_type denotes smooth muscle cells
T8 480-491 protein denotes HLA class I
T9 569-579 protein denotes Rb protein
T10 587-605 cell_line denotes T cell line Jurkat
T11 617-647 cell_type denotes human aortic endothelial cells
T12 649-660 protein denotes HLA class I
T13 686-688 protein denotes Rb
T14 722-738 protein denotes neutralizing Abs
T15 742-772 protein denotes basic fibroblast growth factor
T16 774-778 protein denotes bFGF
T17 803-816 protein denotes FGF receptors
T18 861-882 protein denotes HLA class I molecules
T19 891-899 DNA denotes cyclin E
T20 941-968 cell_type denotes quiescent endothelial cells
T21 1014-1016 protein denotes Rb
T22 1061-1093 DNA denotes dominant-negative cdk2 construct
T23 1104-1115 protein denotes HLA class I
T24 1141-1143 protein denotes Rb
T25 1158-1200 DNA denotes dominant-negative cdk4 and cdk6 constructs
T26 1254-1280 protein denotes cyclin D-associated kinase
T27 1295-1306 protein denotes HLA class I
T28 1333-1358 protein denotes cyclin E-dependent kinase
T29 1377-1379 protein denotes Rb
T30 1405-1408 protein denotes E2F

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-138 Sentence denotes HLA class I-mediated induction of cell proliferation involves cyclin E-mediated inactivation of Rb function and induction of E2F activity.
S2 139-251 Sentence denotes Chronic rejection of transplanted organs is manifested as atherosclerosis of the blood vessels of the allograft.
S3 252-451 Sentence denotes HLA class I Ags have been implicated to play a major role in this process, since signaling via HLA class I molecules can induce the proliferation of aortic endothelial as well as smooth muscle cells.
S4 452-648 Sentence denotes In this study, we show that HLA class I-mediated induction of cell proliferation correlates with inactivation of the Rb protein in the T cell line Jurkat as well as human aortic endothelial cells.
S5 649-842 Sentence denotes HLA class I-mediated inactivation of Rb can be inhibited specifically by neutralizing Abs to basic fibroblast growth factor (bFGF), suggesting a role for FGF receptors in the signaling process.
S6 843-1017 Sentence denotes Signaling through HLA class I molecules induced cyclin E-associated kinase activity within 4 h in quiescent endothelial cells, and appeared to mediate the inactivation of Rb.
S7 1018-1215 Sentence denotes A cdk2 inhibitor, Olomoucine, as well as a dominant-negative cdk2 construct prevented HLA class I-mediated inactivation of Rb; in contrast, dominant-negative cdk4 and cdk6 constructs had no effect.
S8 1216-1443 Sentence denotes Furthermore, there was no increase in cyclin D-associated kinase activity upon HLA class I ligation, suggesting that cyclin E-dependent kinase activity mediates Rb inactivation, leading to E2F activation and cell proliferation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 34-52 NP denotes cell proliferation
C1 0-52 NP denotes HLA class I-mediated induction of cell proliferation
C3 333-368 NP denotes signaling via HLA class I molecules
C5 514-532 NP denotes cell proliferation
C4 480-532 NP denotes HLA class I-mediated induction of cell proliferation
C6 565-579 NP denotes the Rb protein
C8 686-688 NP denotes Rb
C7 649-688 NP denotes HLA class I-mediated inactivation of Rb
C9 843-882 NP denotes Signaling through HLA class I molecules
C11 1014-1016 NP denotes Rb
C10 994-1016 NP denotes the inactivation of Rb
C12 1018-1034 NP denotes A cdk2 inhibitor
C13 1036-1046 NP denotes Olomoucine
C15 1141-1144 NP denotes Rb;
C14 1104-1144 NP denotes HLA class I-mediated inactivation of Rb;
C16 1377-1392 NP denotes Rb inactivation
C17 1424-1442 NP denotes cell proliferation
R1 C5 C2 coref-ident cell proliferation,cell proliferation
R2 C4 C1 coref-ident HLA class I-mediated induction of cell proliferation,HLA class I-mediated induction of cell proliferation
R3 C8 C6 coref-ident Rb,the Rb protein
R4 C9 C3 coref-ident Signaling through HLA class I molecules,signaling via HLA class I molecules
R5 C11 C8 coref-ident Rb,Rb
R6 C13 C12 coref-appos Olomoucine,A cdk2 inhibitor
R7 C15 C11 coref-ident Rb;,Rb
R8 C14 C7 coref-ident HLA class I-mediated inactivation of Rb;,HLA class I-mediated inactivation of Rb
R9 C16 C10 coref-ident Rb inactivation,the inactivation of Rb
R10 C17 C5 coref-ident cell proliferation,cell proliferation

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-11 protein_family_or_group denotes HLA class I
T2 34-52 other_name denotes cell proliferation
T3 62-70 DNA_domain_or_region denotes cyclin E
T4 96-107 other_name denotes Rb function
T5 125-128 protein_molecule denotes E2F
T6 197-212 other_name denotes atherosclerosis
T7 220-233 body_part denotes blood vessels
T8 241-250 other_name denotes allograft
T9 252-267 protein_family_or_group denotes HLA class I Ags
T10 347-368 protein_family_or_group denotes HLA class I molecules
T11 401-419 cell_type denotes aortic endothelial
T12 431-450 cell_type denotes smooth muscle cells
T13 480-491 protein_family_or_group denotes HLA class I
T14 514-532 other_name denotes cell proliferation
T15 569-579 protein_molecule denotes Rb protein
T16 587-605 cell_line denotes T cell line Jurkat
T17 617-647 cell_type denotes human aortic endothelial cells
T18 649-660 protein_family_or_group denotes HLA class I
T19 686-688 protein_molecule denotes Rb
T20 722-738 protein_family_or_group denotes neutralizing Abs
T21 742-772 protein_molecule denotes basic fibroblast growth factor
T22 774-778 protein_family_or_group denotes bFGF
T23 803-816 protein_family_or_group denotes FGF receptors
T24 861-882 protein_family_or_group denotes HLA class I molecules
T25 891-899 DNA_domain_or_region denotes cyclin E
T26 941-968 cell_type denotes quiescent endothelial cells
T27 1014-1016 protein_molecule denotes Rb
T28 1020-1034 other_organic_compound denotes cdk2 inhibitor
T29 1036-1046 other_organic_compound denotes Olomoucine
T30 1061-1093 DNA_molecule denotes dominant-negative cdk2 construct
T31 1104-1115 protein_family_or_group denotes HLA class I
T32 1141-1143 protein_molecule denotes Rb
T33 1254-1280 protein_molecule denotes cyclin D-associated kinase
T34 1295-1306 protein_family_or_group denotes HLA class I
T35 1333-1358 protein_family_or_group denotes cyclin E-dependent kinase
T36 1377-1379 protein_molecule denotes Rb
T37 1405-1408 protein_molecule denotes E2F
T38 1424-1442 other_name denotes cell proliferation

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 197-212 HP_0002621 denotes atherosclerosis