PubMed:10228008 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10228008","sourcedb":"PubMed","sourceid":"10228008","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10228008","text":"The evolutionarily conserved sequence upstream of the human Ig heavy chain S gamma 3 region is an inducible promoter: synergistic activation by CD40 ligand and IL-4 via cooperative NF-kappa B and STAT-6 binding sites.\nGermline C gamma gene transcription is a crucial event in the process that leads to switch DNA recombination to IgG, but its regulation in the human is poorly understood. We took advantage of our monoclonal model of germinal center B cell differentiation, IgM+ IgD+ CL-01 cells, to define the role of the I gamma 3 evolutionarily conserved sequence (ECS) in the germline transcriptional activation of the human C gamma 3 gene. The I gamma 3 ECS lies upstream of the major I gamma 3 transcription initiation site and displays more than 90% identity with the corresponding human I gamma 1, I gamma 2, and I gamma 4 regions. Reporter luciferase gene vectors containing the human gamma 3 ECS were used to transfect CL-01 cells, which have been shown to undergo Smu--\u003eS gamma 3 DNA recombination, upon engagement of CD40 by CD40 ligand (CD40L) and exposure to IL-4. In these transfected CL-01 cells, CD40:CD40L engagement and exposure to IL-4 synergistically induced gamma 3 ECS-dependent luciferase reporter gene activation. Targeted mutational analysis demonstrated that a tandem NF-kappa B/Rel binding motif is critical for the gamma 3 ECS responsiveness to both CD40L and IL-4, while a STAT-6-binding site is additionally required for IL-4 inducibility. Electrophoretic mobility shift assays showed that p50/p65/c-Rel and STAT-6 are effectively induced by CD40L and IL-4, respectively, and bind to specific DNA motifs within the ECS. These partially overlapping CD40L and IL-4 responsive elements are functionally cooperative as the disruption of one of them prevents synergistic promoter activation. Thus, the gamma 3 ECS is an inducible promoter containing cis elements that critically mediate CD40L and IL-4-triggered transcriptional activation of the human C gamma 3 gene.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C2","span":{"begin":144,"end":155},"obj":"NP"},{"id":"C3","span":{"begin":160,"end":164},"obj":"NP"},{"id":"C1","span":{"begin":144,"end":164},"obj":"NP"},{"id":"C4","span":{"begin":218,"end":253},"obj":"NP"},{"id":"C5","span":{"begin":257,"end":287},"obj":"NP"},{"id":"C6","span":{"begin":288,"end":292},"obj":"NP"},{"id":"C7","span":{"begin":339,"end":342},"obj":"NP"},{"id":"C8","span":{"begin":410,"end":472},"obj":"NP"},{"id":"C9","span":{"begin":474,"end":495},"obj":"NP"},{"id":"C10","span":{"begin":519,"end":572},"obj":"NP"},{"id":"C11","span":{"begin":619,"end":643},"obj":"NP"},{"id":"C12","span":{"begin":645,"end":662},"obj":"NP"},{"id":"C13","span":{"begin":884,"end":905},"obj":"NP"},{"id":"C14","span":{"begin":929,"end":940},"obj":"NP"},{"id":"C15","span":{"begin":942,"end":947},"obj":"NP"},{"id":"C16","span":{"begin":1037,"end":1056},"obj":"NP"},{"id":"C18","span":{"begin":1073,"end":1077},"obj":"NP"},{"id":"C17","span":{"begin":1061,"end":1077},"obj":"NP"},{"id":"C20","span":{"begin":1151,"end":1155},"obj":"NP"},{"id":"C19","span":{"begin":1139,"end":1155},"obj":"NP"},{"id":"C21","span":{"begin":1374,"end":1393},"obj":"NP"},{"id":"C23","span":{"begin":1573,"end":1578},"obj":"NP"},{"id":"C24","span":{"begin":1583,"end":1587},"obj":"NP"},{"id":"C22","span":{"begin":1573,"end":1587},"obj":"NP"},{"id":"C25","span":{"begin":1679,"end":1713},"obj":"NP"},{"id":"C26","span":{"begin":1771,"end":1775},"obj":"NP"},{"id":"C27","span":{"begin":1824,"end":1839},"obj":"NP"},{"id":"C28","span":{"begin":1876,"end":1888},"obj":"NP"},{"id":"C29","span":{"begin":1889,"end":1893},"obj":"NP"},{"id":"C30","span":{"begin":1968,"end":1992},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-relat","subj":"C6","obj":"C5"},{"id":"R2","pred":"coref-pron","subj":"C7","obj":"C4"},{"id":"R3","pred":"coref-appos","subj":"C9","obj":"C8"},{"id":"R4","pred":"coref-ident","subj":"C12","obj":"C10"},{"id":"R5","pred":"coref-relat","subj":"C15","obj":"C14"},{"id":"R6","pred":"coref-ident","subj":"C16","obj":"C2"},{"id":"R7","pred":"coref-ident","subj":"C18","obj":"C3"},{"id":"R8","pred":"coref-ident","subj":"C20","obj":"C18"},{"id":"R9","pred":"coref-ident","subj":"C19","obj":"C17"},{"id":"R10","pred":"coref-ident","subj":"C21","obj":"C1"},{"id":"R11","pred":"coref-ident","subj":"C23","obj":"C16"},{"id":"R12","pred":"coref-ident","subj":"C24","obj":"C20"},{"id":"R13","pred":"coref-ident","subj":"C22","obj":"C21"},{"id":"R14","pred":"coref-pron","subj":"C26","obj":"C25"},{"id":"R15","pred":"coref-ident","subj":"C27","obj":"C13"},{"id":"R16","pred":"coref-relat","subj":"C29","obj":"C28"},{"id":"R17","pred":"coref-ident","subj":"C30","obj":"C11"}],"attributes":[{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C12","pred":"source","obj":"genia-medco-coref"},{"subj":"C13","pred":"source","obj":"genia-medco-coref"},{"subj":"C14","pred":"source","obj":"genia-medco-coref"},{"subj":"C15","pred":"source","obj":"genia-medco-coref"},{"subj":"C16","pred":"source","obj":"genia-medco-coref"},{"subj":"C18","pred":"source","obj":"genia-medco-coref"},{"subj":"C17","pred":"source","obj":"genia-medco-coref"},{"subj":"C20","pred":"source","obj":"genia-medco-coref"},{"subj":"C19","pred":"source","obj":"genia-medco-coref"},{"subj":"C21","pred":"source","obj":"genia-medco-coref"},{"subj":"C23","pred":"source","obj":"genia-medco-coref"},{"subj":"C24","pred":"source","obj":"genia-medco-coref"},{"subj":"C22","pred":"source","obj":"genia-medco-coref"},{"subj":"C25","pred":"source","obj":"genia-medco-coref"},{"subj":"C26","pred":"source","obj":"genia-medco-coref"},{"subj":"C27","pred":"source","obj":"genia-medco-coref"},{"subj":"C28","pred":"source","obj":"genia-medco-coref"},{"subj":"C29","pred":"source","obj":"genia-medco-coref"},{"subj":"C30","pred":"source","obj":"genia-medco-coref"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":4,"end":37},"obj":"DNA"},{"id":"T2","span":{"begin":54,"end":91},"obj":"protein"},{"id":"T3","span":{"begin":98,"end":116},"obj":"DNA"},{"id":"T4","span":{"begin":144,"end":155},"obj":"protein"},{"id":"T5","span":{"begin":160,"end":164},"obj":"protein"},{"id":"T6","span":{"begin":181,"end":216},"obj":"DNA"},{"id":"T7","span":{"begin":330,"end":333},"obj":"protein"},{"id":"T8","span":{"begin":434,"end":456},"obj":"cell_type"},{"id":"T9","span":{"begin":474,"end":495},"obj":"cell_line"},{"id":"T10","span":{"begin":523,"end":532},"obj":"protein"},{"id":"T11","span":{"begin":533,"end":566},"obj":"DNA"},{"id":"T12","span":{"begin":568,"end":571},"obj":"DNA"},{"id":"T13","span":{"begin":580,"end":588},"obj":"DNA"},{"id":"T14","span":{"begin":623,"end":643},"obj":"DNA"},{"id":"T15","span":{"begin":649,"end":658},"obj":"protein"},{"id":"T16","span":{"begin":659,"end":662},"obj":"DNA"},{"id":"T17","span":{"begin":684,"end":729},"obj":"DNA"},{"id":"T18","span":{"begin":789,"end":804},"obj":"DNA"},{"id":"T19","span":{"begin":806,"end":815},"obj":"DNA"},{"id":"T20","span":{"begin":821,"end":830},"obj":"DNA"},{"id":"T21","span":{"begin":840,"end":872},"obj":"DNA"},{"id":"T22","span":{"begin":888,"end":905},"obj":"DNA"},{"id":"T23","span":{"begin":929,"end":940},"obj":"cell_line"},{"id":"T24","span":{"begin":1029,"end":1033},"obj":"protein"},{"id":"T25","span":{"begin":1037,"end":1048},"obj":"protein"},{"id":"T26","span":{"begin":1050,"end":1055},"obj":"protein"},{"id":"T27","span":{"begin":1073,"end":1077},"obj":"protein"},{"id":"T28","span":{"begin":1100,"end":1111},"obj":"cell_line"},{"id":"T29","span":{"begin":1118,"end":1123},"obj":"protein"},{"id":"T30","span":{"begin":1151,"end":1155},"obj":"protein"},{"id":"T31","span":{"begin":1202,"end":1226},"obj":"DNA"},{"id":"T32","span":{"begin":1295,"end":1323},"obj":"DNA"},{"id":"T33","span":{"begin":1344,"end":1355},"obj":"DNA"},{"id":"T34","span":{"begin":1379,"end":1384},"obj":"protein"},{"id":"T35","span":{"begin":1389,"end":1393},"obj":"protein"},{"id":"T36","span":{"begin":1403,"end":1422},"obj":"DNA"},{"id":"T37","span":{"begin":1452,"end":1456},"obj":"protein"},{"id":"T38","span":{"begin":1521,"end":1534},"obj":"protein"},{"id":"T39","span":{"begin":1539,"end":1545},"obj":"protein"},{"id":"T40","span":{"begin":1573,"end":1578},"obj":"protein"},{"id":"T41","span":{"begin":1583,"end":1587},"obj":"protein"},{"id":"T42","span":{"begin":1624,"end":1634},"obj":"DNA"},{"id":"T43","span":{"begin":1646,"end":1649},"obj":"DNA"},{"id":"T44","span":{"begin":1679,"end":1713},"obj":"DNA"},{"id":"T45","span":{"begin":1828,"end":1839},"obj":"DNA"},{"id":"T46","span":{"begin":1876,"end":1888},"obj":"DNA"},{"id":"T47","span":{"begin":1913,"end":1918},"obj":"protein"},{"id":"T48","span":{"begin":1923,"end":1927},"obj":"protein"},{"id":"T49","span":{"begin":1972,"end":1992},"obj":"DNA"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"},{"subj":"T19","pred":"source","obj":"jnlpba-st-training"},{"subj":"T20","pred":"source","obj":"jnlpba-st-training"},{"subj":"T21","pred":"source","obj":"jnlpba-st-training"},{"subj":"T22","pred":"source","obj":"jnlpba-st-training"},{"subj":"T23","pred":"source","obj":"jnlpba-st-training"},{"subj":"T24","pred":"source","obj":"jnlpba-st-training"},{"subj":"T25","pred":"source","obj":"jnlpba-st-training"},{"subj":"T26","pred":"source","obj":"jnlpba-st-training"},{"subj":"T27","pred":"source","obj":"jnlpba-st-training"},{"subj":"T28","pred":"source","obj":"jnlpba-st-training"},{"subj":"T29","pred":"source","obj":"jnlpba-st-training"},{"subj":"T30","pred":"source","obj":"jnlpba-st-training"},{"subj":"T31","pred":"source","obj":"jnlpba-st-training"},{"subj":"T32","pred":"source","obj":"jnlpba-st-training"},{"subj":"T33","pred":"source","obj":"jnlpba-st-training"},{"subj":"T34","pred":"source","obj":"jnlpba-st-training"},{"subj":"T35","pred":"source","obj":"jnlpba-st-training"},{"subj":"T36","pred":"source","obj":"jnlpba-st-training"},{"subj":"T37","pred":"source","obj":"jnlpba-st-training"},{"subj":"T38","pred":"source","obj":"jnlpba-st-training"},{"subj":"T39","pred":"source","obj":"jnlpba-st-training"},{"subj":"T40","pred":"source","obj":"jnlpba-st-training"},{"subj":"T41","pred":"source","obj":"jnlpba-st-training"},{"subj":"T42","pred":"source","obj":"jnlpba-st-training"},{"subj":"T43","pred":"source","obj":"jnlpba-st-training"},{"subj":"T44","pred":"source","obj":"jnlpba-st-training"},{"subj":"T45","pred":"source","obj":"jnlpba-st-training"},{"subj":"T46","pred":"source","obj":"jnlpba-st-training"},{"subj":"T47","pred":"source","obj":"jnlpba-st-training"},{"subj":"T48","pred":"source","obj":"jnlpba-st-training"},{"subj":"T49","pred":"source","obj":"jnlpba-st-training"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":217},"obj":"Sentence"},{"id":"S2","span":{"begin":218,"end":388},"obj":"Sentence"},{"id":"S3","span":{"begin":389,"end":644},"obj":"Sentence"},{"id":"S4","span":{"begin":645,"end":839},"obj":"Sentence"},{"id":"S5","span":{"begin":840,"end":1078},"obj":"Sentence"},{"id":"S6","span":{"begin":1079,"end":1238},"obj":"Sentence"},{"id":"S7","span":{"begin":1239,"end":1470},"obj":"Sentence"},{"id":"S8","span":{"begin":1471,"end":1650},"obj":"Sentence"},{"id":"S9","span":{"begin":1651,"end":1817},"obj":"Sentence"},{"id":"S10","span":{"begin":1818,"end":1993},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S7","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S8","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S9","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S10","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":4,"end":37},"obj":"DNA_domain_or_region"},{"id":"T2","span":{"begin":54,"end":91},"obj":"protein_domain_or_region"},{"id":"T3","span":{"begin":98,"end":116},"obj":"DNA_domain_or_region"},{"id":"T4","span":{"begin":144,"end":155},"obj":"protein_molecule"},{"id":"T5","span":{"begin":160,"end":164},"obj":"protein_molecule"},{"id":"T6","span":{"begin":218,"end":253},"obj":"other_name"},{"id":"T7","span":{"begin":330,"end":333},"obj":"protein_family_or_group"},{"id":"T8","span":{"begin":361,"end":366},"obj":"multi_cell"},{"id":"T9","span":{"begin":434,"end":456},"obj":"cell_type"},{"id":"T10","span":{"begin":474,"end":495},"obj":"cell_line"},{"id":"T11","span":{"begin":523,"end":532},"obj":"protein_molecule"},{"id":"T12","span":{"begin":533,"end":566},"obj":"DNA_domain_or_region"},{"id":"T13","span":{"begin":568,"end":571},"obj":"DNA_domain_or_region"},{"id":"T14","span":{"begin":580,"end":588},"obj":"DNA_domain_or_region"},{"id":"T15","span":{"begin":623,"end":643},"obj":"DNA_domain_or_region"},{"id":"T16","span":{"begin":649,"end":658},"obj":"protein_molecule"},{"id":"T17","span":{"begin":659,"end":662},"obj":"DNA_domain_or_region"},{"id":"T18","span":{"begin":684,"end":689},"obj":"DNA_domain_or_region"},{"id":"T19","span":{"begin":690,"end":699},"obj":"protein_molecule"},{"id":"T20","span":{"begin":789,"end":804},"obj":"DNA_domain_or_region"},{"id":"T21","span":{"begin":806,"end":815},"obj":"DNA_domain_or_region"},{"id":"T22","span":{"begin":821,"end":830},"obj":"DNA_domain_or_region"},{"id":"T23","span":{"begin":840,"end":872},"obj":"DNA_family_or_group"},{"id":"T24","span":{"begin":888,"end":901},"obj":"DNA_domain_or_region"},{"id":"T25","span":{"begin":902,"end":905},"obj":"DNA_domain_or_region"},{"id":"T26","span":{"begin":929,"end":940},"obj":"cell_line"},{"id":"T27","span":{"begin":991,"end":1008},"obj":"other_name"},{"id":"T28","span":{"begin":1029,"end":1033},"obj":"protein_molecule"},{"id":"T29","span":{"begin":1037,"end":1048},"obj":"protein_molecule"},{"id":"T30","span":{"begin":1050,"end":1055},"obj":"protein_molecule"},{"id":"T31","span":{"begin":1073,"end":1077},"obj":"protein_molecule"},{"id":"T32","span":{"begin":1100,"end":1111},"obj":"cell_line"},{"id":"T33","span":{"begin":1113,"end":1118},"obj":"other_name"},{"id":"T34","span":{"begin":1118,"end":1123},"obj":"protein_molecule"},{"id":"T35","span":{"begin":1151,"end":1155},"obj":"protein_molecule"},{"id":"T36","span":{"begin":1180,"end":1201},"obj":"other_name"},{"id":"T37","span":{"begin":1202,"end":1226},"obj":"DNA_domain_or_region"},{"id":"T38","span":{"begin":1295,"end":1305},"obj":"protein_complex"},{"id":"T39","span":{"begin":1344,"end":1355},"obj":"DNA_domain_or_region"},{"id":"T40","span":{"begin":1379,"end":1384},"obj":"protein_molecule"},{"id":"T41","span":{"begin":1389,"end":1393},"obj":"protein_molecule"},{"id":"T42","span":{"begin":1403,"end":1422},"obj":"DNA_domain_or_region"},{"id":"T43","span":{"begin":1452,"end":1456},"obj":"protein_molecule"},{"id":"T44","span":{"begin":1471,"end":1508},"obj":"other_name"},{"id":"T45","span":{"begin":1521,"end":1534},"obj":"protein_molecule"},{"id":"T46","span":{"begin":1539,"end":1545},"obj":"protein_molecule"},{"id":"T47","span":{"begin":1573,"end":1578},"obj":"protein_molecule"},{"id":"T48","span":{"begin":1583,"end":1587},"obj":"protein_molecule"},{"id":"T49","span":{"begin":1624,"end":1634},"obj":"DNA_domain_or_region"},{"id":"T50","span":{"begin":1646,"end":1649},"obj":"DNA_domain_or_region"},{"id":"T51","span":{"begin":1785,"end":1816},"obj":"other_name"},{"id":"T52","span":{"begin":1828,"end":1839},"obj":"DNA_domain_or_region"},{"id":"T53","span":{"begin":1876,"end":1888},"obj":"DNA_family_or_group"},{"id":"T54","span":{"begin":1913,"end":1918},"obj":"protein_molecule"},{"id":"T55","span":{"begin":1923,"end":1927},"obj":"protein_molecule"},{"id":"T56","span":{"begin":1972,"end":1992},"obj":"DNA_domain_or_region"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"},{"subj":"T28","pred":"source","obj":"GENIAcorpus"},{"subj":"T29","pred":"source","obj":"GENIAcorpus"},{"subj":"T30","pred":"source","obj":"GENIAcorpus"},{"subj":"T31","pred":"source","obj":"GENIAcorpus"},{"subj":"T32","pred":"source","obj":"GENIAcorpus"},{"subj":"T33","pred":"source","obj":"GENIAcorpus"},{"subj":"T34","pred":"source","obj":"GENIAcorpus"},{"subj":"T35","pred":"source","obj":"GENIAcorpus"},{"subj":"T36","pred":"source","obj":"GENIAcorpus"},{"subj":"T37","pred":"source","obj":"GENIAcorpus"},{"subj":"T38","pred":"source","obj":"GENIAcorpus"},{"subj":"T39","pred":"source","obj":"GENIAcorpus"},{"subj":"T40","pred":"source","obj":"GENIAcorpus"},{"subj":"T41","pred":"source","obj":"GENIAcorpus"},{"subj":"T42","pred":"source","obj":"GENIAcorpus"},{"subj":"T43","pred":"source","obj":"GENIAcorpus"},{"subj":"T44","pred":"source","obj":"GENIAcorpus"},{"subj":"T45","pred":"source","obj":"GENIAcorpus"},{"subj":"T46","pred":"source","obj":"GENIAcorpus"},{"subj":"T47","pred":"source","obj":"GENIAcorpus"},{"subj":"T48","pred":"source","obj":"GENIAcorpus"},{"subj":"T49","pred":"source","obj":"GENIAcorpus"},{"subj":"T50","pred":"source","obj":"GENIAcorpus"},{"subj":"T51","pred":"source","obj":"GENIAcorpus"},{"subj":"T52","pred":"source","obj":"GENIAcorpus"},{"subj":"T53","pred":"source","obj":"GENIAcorpus"},{"subj":"T54","pred":"source","obj":"GENIAcorpus"},{"subj":"T55","pred":"source","obj":"GENIAcorpus"},{"subj":"T56","pred":"source","obj":"GENIAcorpus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#93ecd4","default":true},{"id":"jnlpba-st-training","color":"#ecba93"},{"id":"pubmed-sentences-benchmark","color":"#a093ec"},{"id":"GENIAcorpus","color":"#9fec93"}]}]}}