PubMed:10226884 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	24-37	DNA	denotes	cytokine gene
T2	77-85	protein	denotes	Cytokine
T3	219-249	cell_type	denotes	naive CD4+ T helper (Th) cells
T4	269-302	cell_line	denotes	cytokine-producing effector cells
T5	378-386	protein	denotes	cytokine
T6	435-439	protein	denotes	IL-2
T7	444-453	protein	denotes	IFN-gamma
T8	463-472	cell_line	denotes	Th2 cells
T9	481-485	protein	denotes	IL-4
T10	487-491	protein	denotes	IL-5
T11	493-497	protein	denotes	IL-6
T12	499-504	protein	denotes	IL-10
T13	510-515	protein	denotes	IL-13
T14	801-823	protein	denotes	Th1/Th2-like cytokines

Id	Subject	Object	Predicate	Lexical cue
S1	0-76	Sentence	denotes	Molecular regulation of cytokine gene expression during the immune response.
S2	77-185	Sentence	denotes	Cytokine expression by immune system cells plays an important role in the regulation of the immune response.
S3	186-303	Sentence	denotes	On first encounter with antigen, naive CD4+ T helper (Th) cells differentiate into cytokine-producing effector cells.
S4	304-416	Sentence	denotes	Two types of effector cells characterized by their distinct expression of cytokine profiles have been described.
S5	417-516	Sentence	denotes	Th1 cells produce IL-2 and IFN-gamma, whereas Th2 cells produce IL-4, IL-5, IL-6, IL-10, and IL-13.
S6	517-733	Sentence	denotes	In many pathological situations, the balance between Th1 and Th2 immune responses determines the outcome of diverse immunologically mediated clinical syndromes including infectious, autoimmune, and allergic diseases.
S7	734-845	Sentence	denotes	However, the molecular basis for the tissue-specific expression of Th1/Th2-like cytokines has remained elusive.
S8	846-1015	Sentence	denotes	In this review we evaluate the possible in vivo role of different transcription factors and transcriptional mechanisms in T cell differentiation and the immune response.

Id	Subject	Object	Predicate	Lexical cue
C1	56-75	NP	denotes	the immune response
C2	165-184	NP	denotes	the immune response
C3	304-331	NP	denotes	Two types of effector cells
C4	349-354	NP	denotes	their
C5	995-1014	NP	denotes	the immune response
R1	C2	C1	coref-ident	the immune response,the immune response
R2	C4	C3	coref-pron	their,Two types of effector cells
R3	C5	C2	coref-ident	the immune response,the immune response

Id	Subject	Object	Predicate	Lexical cue
T1	24-32	protein_family_or_group	denotes	cytokine
T2	60-75	other_name	denotes	immune response
T3	77-85	protein_family_or_group	denotes	Cytokine
T4	169-184	other_name	denotes	immune response
T5	219-249	cell_type	denotes	naive CD4+ T helper (Th) cells
T6	269-277	protein_family_or_group	denotes	cytokine
T7	378-386	protein_family_or_group	denotes	cytokine
T8	435-439	protein_molecule	denotes	IL-2
T9	444-453	protein_molecule	denotes	IFN-gamma
T10	463-472	cell_line	denotes	Th2 cells
T11	481-485	protein_molecule	denotes	IL-4
T12	487-491	protein_molecule	denotes	IL-5
T13	493-497	protein_molecule	denotes	IL-6
T14	499-504	protein_molecule	denotes	IL-10
T15	510-515	protein_molecule	denotes	IL-13
T16	633-676	other_name	denotes	immunologically mediated clinical syndromes
T17	771-797	other_name	denotes	tissue-specific expression
T18	801-823	protein_family_or_group	denotes	Th1/Th2-like cytokines
T19	938-964	other_name	denotes	transcriptional mechanisms
T20	968-990	other_name	denotes	T cell differentiation
T21	999-1014	other_name	denotes	immune response

Id	Subject	Object	Predicate	Lexical cue
T1	699-709	HP_0002960	denotes	autoimmune