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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 108-114 DiseaseOrPhenotypicFeature denotes asthma 0004979
T2 329-349 DiseaseOrPhenotypicFeature denotes inflammatory disease 0021166
T3 909-927 DiseaseOrPhenotypicFeature denotes chronic bronchitis 0005607
T4 1393-1413 DiseaseOrPhenotypicFeature denotes inflammatory disease 0021166
T5 1479-1485 DiseaseOrPhenotypicFeature denotes asthma 0004979
T6 1646-1653 DiseaseOrPhenotypicFeature denotes allergy 0005271

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-115 Sentence denotes Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma.
T2 116-350 Sentence denotes Cytokine effects on immunity and inflammation often depend on the transcription factors termed signal transducers and activators of transcription (STATs), so STAT signaling pathways are candidates for influencing inflammatory disease.
T3 351-703 Sentence denotes We reasoned that selective IFN responsiveness of the first STAT family member (Stat1) and Stat1-dependent immune-response genes such as intercellular adhesion molecule-1 (ICAM-1), IFN regulatory factor-1 (IRF-1), and Stat1 itself in airway epithelial cells provides a basis for detecting cytokine signaling abnormalities in inflammatory airway disease.
T4 704-937 Sentence denotes On the basis of nuclear localization and phosphorylation, we found that epithelial Stat1 (but not other control transcription factors) was invariably activated in asthmatic compared with normal control or chronic bronchitis subjects.
T5 938-1139 Sentence denotes Furthermore, epithelial levels of activated Stat1 correlated with levels of expression for epithelial ICAM-1, IRF-1, and Stat1, and in turn, ICAM-1 levels correlated with T-cell accumulation in tissue.
T6 1140-1254 Sentence denotes However, only low levels of IFN-gamma or IFN-gamma-producing cells were detected in airway tissue in all subjects.
T7 1255-1414 Sentence denotes The results therefore provide initial evidence linking abnormal behavior of STAT pathways for cytokine signaling to the development of an inflammatory disease.
T8 1415-1705 Sentence denotes In that context, the results also change the current scheme for asthma pathogenesis to one that must include a localized gain in transcriptional signal ordinarily used for a T helper 1-type cytokine (IFN-gamma) in combination with allergy-driven overproduction of T helper 2-type cytokines.
T1 0-115 Sentence denotes Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma.
T2 116-350 Sentence denotes Cytokine effects on immunity and inflammation often depend on the transcription factors termed signal transducers and activators of transcription (STATs), so STAT signaling pathways are candidates for influencing inflammatory disease.
T3 351-703 Sentence denotes We reasoned that selective IFN responsiveness of the first STAT family member (Stat1) and Stat1-dependent immune-response genes such as intercellular adhesion molecule-1 (ICAM-1), IFN regulatory factor-1 (IRF-1), and Stat1 itself in airway epithelial cells provides a basis for detecting cytokine signaling abnormalities in inflammatory airway disease.
T4 704-937 Sentence denotes On the basis of nuclear localization and phosphorylation, we found that epithelial Stat1 (but not other control transcription factors) was invariably activated in asthmatic compared with normal control or chronic bronchitis subjects.
T5 938-1139 Sentence denotes Furthermore, epithelial levels of activated Stat1 correlated with levels of expression for epithelial ICAM-1, IRF-1, and Stat1, and in turn, ICAM-1 levels correlated with T-cell accumulation in tissue.
T6 1140-1254 Sentence denotes However, only low levels of IFN-gamma or IFN-gamma-producing cells were detected in airway tissue in all subjects.
T7 1255-1414 Sentence denotes The results therefore provide initial evidence linking abnormal behavior of STAT pathways for cytokine signaling to the development of an inflammatory disease.
T8 1415-1705 Sentence denotes In that context, the results also change the current scheme for asthma pathogenesis to one that must include a localized gain in transcriptional signal ordinarily used for a T helper 1-type cytokine (IFN-gamma) in combination with allergy-driven overproduction of T helper 2-type cytokines.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 91-95 protein denotes STAT
T2 116-124 protein denotes Cytokine
T3 182-203 protein denotes transcription factors
T4 211-261 protein denotes signal transducers and activators of transcription
T5 263-268 protein denotes STATs
T6 274-278 protein denotes STAT
T7 378-381 protein denotes IFN
T8 410-428 protein denotes STAT family member
T9 430-435 protein denotes Stat1
T10 441-478 DNA denotes Stat1-dependent immune-response genes
T11 487-520 protein denotes intercellular adhesion molecule-1
T12 522-528 protein denotes ICAM-1
T13 531-554 protein denotes IFN regulatory factor-1
T14 556-561 protein denotes IRF-1
T15 568-573 protein denotes Stat1
T16 584-607 cell_type denotes airway epithelial cells
T17 639-647 protein denotes cytokine
T18 776-792 protein denotes epithelial Stat1
T19 816-837 protein denotes transcription factors
T20 982-987 protein denotes Stat1
T21 1029-1046 protein denotes epithelial ICAM-1
T22 1048-1053 protein denotes IRF-1
T23 1059-1064 protein denotes Stat1
T24 1079-1085 protein denotes ICAM-1
T25 1168-1177 protein denotes IFN-gamma
T26 1181-1206 cell_type denotes IFN-gamma-producing cells
T27 1331-1335 protein denotes STAT
T28 1349-1357 protein denotes cytokine
T29 1589-1613 protein denotes T helper 1-type cytokine
T30 1615-1624 protein denotes IFN-gamma
T31 1679-1704 protein denotes T helper 2-type cytokines

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-115 Sentence denotes Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma.
S2 116-350 Sentence denotes Cytokine effects on immunity and inflammation often depend on the transcription factors termed signal transducers and activators of transcription (STATs), so STAT signaling pathways are candidates for influencing inflammatory disease.
S3 351-703 Sentence denotes We reasoned that selective IFN responsiveness of the first STAT family member (Stat1) and Stat1-dependent immune-response genes such as intercellular adhesion molecule-1 (ICAM-1), IFN regulatory factor-1 (IRF-1), and Stat1 itself in airway epithelial cells provides a basis for detecting cytokine signaling abnormalities in inflammatory airway disease.
S4 704-937 Sentence denotes On the basis of nuclear localization and phosphorylation, we found that epithelial Stat1 (but not other control transcription factors) was invariably activated in asthmatic compared with normal control or chronic bronchitis subjects.
S5 938-1139 Sentence denotes Furthermore, epithelial levels of activated Stat1 correlated with levels of expression for epithelial ICAM-1, IRF-1, and Stat1, and in turn, ICAM-1 levels correlated with T-cell accumulation in tissue.
S6 1140-1254 Sentence denotes However, only low levels of IFN-gamma or IFN-gamma-producing cells were detected in airway tissue in all subjects.
S7 1255-1414 Sentence denotes The results therefore provide initial evidence linking abnormal behavior of STAT pathways for cytokine signaling to the development of an inflammatory disease.
S8 1415-1705 Sentence denotes In that context, the results also change the current scheme for asthma pathogenesis to one that must include a localized gain in transcriptional signal ordinarily used for a T helper 1-type cytokine (IFN-gamma) in combination with allergy-driven overproduction of T helper 2-type cytokines.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 329-349 NP denotes inflammatory disease
C2 400-436 NP denotes the first STAT family member (Stat1)
C3 1059-1064 NP denotes Stat1
C4 1255-1266 NP denotes The results
C5 1390-1413 NP denotes an inflammatory disease
C6 1432-1443 NP denotes the results
C7 1502-1505 NP denotes one
C8 1506-1510 NP denotes that
R1 C3 C2 coref-ident Stat1,the first STAT family member (Stat1)
R2 C5 C1 coref-ident an inflammatory disease,inflammatory disease
R3 C6 C4 coref-ident the results,The results
R4 C8 C7 coref-relat that,one

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 76-91 other_name denotes transcription (
T2 91-95 protein_family_or_group denotes STAT
T3 108-114 other_name denotes asthma
T4 116-124 protein_family_or_group denotes Cytokine
T5 136-144 other_name denotes immunity
T6 149-161 other_name denotes inflammation
T7 182-203 protein_family_or_group denotes transcription factors
T8 211-261 protein_family_or_group denotes signal transducers and activators of transcription
T9 263-268 protein_family_or_group denotes STATs
T10 274-278 protein_family_or_group denotes STAT
T11 329-349 other_name denotes inflammatory disease
T12 378-381 protein_family_or_group denotes IFN
T13 410-428 protein_family_or_group denotes STAT family member
T14 430-435 protein_molecule denotes Stat1
T15 441-446 protein_molecule denotes Stat1
T16 487-520 protein_molecule denotes intercellular adhesion molecule-1
T17 522-528 protein_molecule denotes ICAM-1
T18 531-554 protein_molecule denotes IFN regulatory factor-1
T19 556-561 protein_molecule denotes IRF-1
T20 568-573 protein_molecule denotes Stat1
T21 584-607 cell_type denotes airway epithelial cells
T22 639-647 protein_family_or_group denotes cytokine
T23 675-702 other_name denotes inflammatory airway disease
T24 720-740 other_name denotes nuclear localization
T25 745-760 other_name denotes phosphorylation
T26 776-786 protein_molecule denotes epithelial
T27 787-792 protein_molecule denotes Stat1
T28 816-837 protein_family_or_group denotes transcription factors
T29 867-876 multi_cell denotes asthmatic
T30 909-927 other_name denotes chronic bronchitis
T31 951-968 other_name denotes epithelial levels
T32 982-987 protein_molecule denotes Stat1
T33 1029-1039 protein_molecule denotes epithelial
T34 1040-1046 protein_molecule denotes ICAM-1
T35 1048-1053 protein_molecule denotes IRF-1
T36 1059-1064 protein_molecule denotes Stat1
T37 1079-1085 protein_molecule denotes ICAM-1
T38 1109-1128 other_name denotes T-cell accumulation
T39 1168-1177 protein_molecule denotes IFN-gamma
T40 1181-1190 protein_molecule denotes IFN-gamma
T41 1224-1237 tissue denotes airway tissue
T42 1331-1335 protein_family_or_group denotes STAT
T43 1349-1357 protein_family_or_group denotes cytokine
T44 1393-1413 other_name denotes inflammatory disease
T45 1479-1485 other_name denotes asthma
T46 1544-1566 other_name denotes transcriptional signal
T47 1589-1613 protein_family_or_group denotes T helper 1-type cytokine
T48 1615-1624 protein_molecule denotes IFN-gamma
T49 1646-1675 other_name denotes allergy-driven overproduction
T50 1679-1704 protein_family_or_group denotes T helper 2-type cytokines

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 909-927 HP_0004469 denotes chronic bronchitis
T2 917-927 HP_0012387 denotes bronchitis
T3 1310-1327 HP_0000708 denotes abnormal behavior
T4 1479-1485 HP_0002099 denotes asthma
T5 1646-1653 HP_0012393 denotes allergy