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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-141 Sentence denotes Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2.
T2 142-247 Sentence denotes In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2.
T3 248-392 Sentence denotes This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor.
T4 393-584 Sentence denotes These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation.
T5 585-823 Sentence denotes We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes.
T6 824-943 Sentence denotes In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression.
T7 944-1085 Sentence denotes We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha.
T8 1086-1200 Sentence denotes Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased.
T9 1201-1264 Sentence denotes Trifluoromethylketones ameliorate chronic inflammation in vivo.
T10 1265-1425 Sentence denotes Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription.
T1 0-141 Sentence denotes Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2.
T2 142-247 Sentence denotes In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2.
T3 248-392 Sentence denotes This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor.
T4 393-584 Sentence denotes These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation.
T5 585-823 Sentence denotes We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes.
T6 824-943 Sentence denotes In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression.
T7 944-1085 Sentence denotes We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha.
T8 1086-1200 Sentence denotes Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased.
T9 1201-1264 Sentence denotes Trifluoromethylketones ameliorate chronic inflammation in vivo.
T10 1265-1425 Sentence denotes Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-35 protein denotes nuclear factor-kappaB
T2 61-83 cell_type denotes mononuclear leukocytes
T3 114-140 protein denotes cytosolic phospholipase A2
T4 145-154 cell_type denotes monocytes
T5 220-246 protein denotes cytosolic phospholipase A2
T6 436-457 protein denotes transcription factors
T7 476-490 DNA denotes cytokine genes
T8 517-543 protein denotes cytosolic phospholipase A2
T9 651-677 protein denotes cytosolic phospholipase A2
T10 753-822 cell_type denotes lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes
T11 983-1005 RNA denotes interleukin-1beta mRNA
T12 1062-1084 protein denotes inhibitor-kappaB alpha
T13 1163-1184 protein denotes nuclear factor-kappaB
T14 1332-1353 protein denotes nuclear factor-kappaB
T15 1361-1368 cell_type denotes cytosol
T16 1388-1405 protein denotes interleukin-1beta

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-141 Sentence denotes Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2.
S2 142-247 Sentence denotes In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2.
S3 248-392 Sentence denotes This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor.
S4 393-584 Sentence denotes These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation.
S5 585-823 Sentence denotes We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes.
S6 824-943 Sentence denotes In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression.
S7 944-1085 Sentence denotes We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha.
S8 1086-1200 Sentence denotes Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased.
S9 1201-1264 Sentence denotes Trifluoromethylketones ameliorate chronic inflammation in vivo.
S10 1265-1425 Sentence denotes Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 14-35 NP denotes nuclear factor-kappaB
C2 114-140 NP denotes cytosolic phospholipase A2
C3 213-246 NP denotes 85-kDa cytosolic phospholipase A2
C4 248-259 NP denotes This enzyme
C6 314-323 NP denotes membranes
C7 324-329 NP denotes which
C5 269-391 NP denotes arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor
C8 393-414 NP denotes These lipid mediators
C9 517-543 NP denotes cytosolic phospholipase A2
C10 651-677 NP denotes cytosolic phospholipase A2
C11 839-865 NP denotes the subcellular mechanisms
C12 883-888 NP denotes which
C13 889-911 NP denotes trifluoromethylketones
C14 958-962 NP denotes they
C15 1163-1184 NP denotes nuclear factor-kappaB
C16 1201-1223 NP denotes Trifluoromethylketones
R1 C3 C2 coref-ident 85-kDa cytosolic phospholipase A2,cytosolic phospholipase A2
R2 C4 C3 coref-ident This enzyme,85-kDa cytosolic phospholipase A2
R3 C7 C6 coref-relat which,membranes
R4 C8 C5 coref-ident These lipid mediators,arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor
R5 C9 C4 coref-ident cytosolic phospholipase A2,This enzyme
R6 C10 C9 coref-ident cytosolic phospholipase A2,cytosolic phospholipase A2
R7 C12 C11 coref-relat which,the subcellular mechanisms
R8 C14 C13 coref-pron they,trifluoromethylketones
R9 C15 C1 coref-ident nuclear factor-kappaB,nuclear factor-kappaB
R10 C16 C13 coref-ident Trifluoromethylketones,trifluoromethylketones

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-35 protein_complex denotes nuclear factor-kappaB
T2 39-57 lipid denotes lipopolysaccharide
T3 61-83 cell_type denotes mononuclear leukocytes
T4 114-140 protein_molecule denotes cytosolic phospholipase A2
T5 145-154 cell_type denotes monocytes
T6 156-174 lipid denotes lipopolysaccharide
T7 220-246 protein_molecule denotes cytosolic phospholipase A2
T8 269-285 other_organic_compound denotes arachidonic acid
T9 290-308 lipid denotes lyso-phospholipids
T10 349-360 other_organic_compound denotes eicosanoids
T11 365-391 other_organic_compound denotes platelet-activating-factor
T12 436-457 protein_family_or_group denotes transcription factors
T13 476-490 DNA_family_or_group denotes cytokine genes
T14 517-543 protein_molecule denotes cytosolic phospholipase A2
T15 547-566 other_name denotes signal transduction
T16 571-583 other_name denotes inflammation
T17 615-647 other_organic_compound denotes trifluoromethylketone inhibitors
T18 651-677 protein_molecule denotes cytosolic phospholipase A2
T19 719-743 other_name denotes steady-state mRNA levels
T20 753-771 lipid denotes lipopolysaccharide
T21 800-822 cell_type denotes mononuclear leukocytes
T22 843-865 other_name denotes subcellular mechanisms
T23 889-911 other_organic_compound denotes trifluoromethylketones
T24 927-942 other_organic_compound denotes gene expression
T25 983-1005 RNA_family_or_group denotes interleukin-1beta mRNA
T26 1062-1084 protein_molecule denotes inhibitor-kappaB alpha
T27 1100-1120 other_name denotes cytosolic activation
T28 1122-1143 other_name denotes nuclear translocation
T29 1163-1184 protein_complex denotes nuclear factor-kappaB
T30 1201-1223 other_organic_compound denotes Trifluoromethylketones
T31 1235-1242 other_name denotes chronic
T32 1243-1255 other_name denotes inflammation
T33 1332-1353 protein_complex denotes nuclear factor-kappaB
T34 1361-1368 cell_type denotes cytosol
T35 1388-1405 protein_molecule denotes interleukin-1beta