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PubMed:10224278 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT.
T2 108-209 Sentence denotes We molecularly cloned a new Grb2 family member, named Grf40, containing the common SH3-SH2-SH3 motif.
T3 210-290 Sentence denotes Expression of Grf40 is predominant in hematopoietic cells, particularly T cells.
T4 291-410 Sentence denotes Grf40 binds to the SH2 domain-containing leukocyte protein of 76 kD (SLP-76) via its SH3 domain more tightly than Grb2.
T5 411-507 Sentence denotes Incidentally, Grf40 binds to linker for activation of T cells (LAT) possibly via its SH2 domain.
T6 508-845 Sentence denotes Overexpression of wild-type Grf40 in Jurkat cells induced a significant increase of SLP-76-dependent interleukin (IL)-2 promoter and nuclear factor of activated T cell (NF-AT) activation upon T cell receptor (TCR) stimulation, whereas the COOH-terminal SH3-deleted Grf40 mutant lacked any recognizable increase in IL-2 promoter activity.
T7 846-1031 Sentence denotes Furthermore, the SH2-deleted Grf40 mutant led to a marked inhibition of these regulatory activities, the effect of which is apparently stronger than that of the SH2-deleted Grb2 mutant.
T8 1032-1185 Sentence denotes Our data suggest that Grf40 is an adaptor molecule involved in TCR-mediated signaling through a more efficient interaction than Grb2 with SLP-76 and LAT.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-5 protein denotes Grf40
T2 15-33 protein denotes Grb2 family member
T3 92-98 protein denotes SLP-76
T4 103-106 protein denotes LAT
T5 136-154 protein denotes Grb2 family member
T6 162-167 protein denotes Grf40
T7 191-208 protein denotes SH3-SH2-SH3 motif
T8 224-229 protein denotes Grf40
T9 248-267 cell_type denotes hematopoietic cells
T10 282-289 cell_type denotes T cells
T11 291-296 protein denotes Grf40
T12 310-349 protein denotes SH2 domain-containing leukocyte protein
T13 360-366 protein denotes SLP-76
T14 405-409 protein denotes Grb2
T15 425-430 protein denotes Grf40
T16 440-472 protein denotes linker for activation of T cells
T17 474-477 protein denotes LAT
T18 496-506 protein denotes SH2 domain
T19 526-541 protein denotes wild-type Grf40
T20 545-557 cell_line denotes Jurkat cells
T21 592-636 DNA denotes SLP-76-dependent interleukin (IL)-2 promoter
T22 641-675 protein denotes nuclear factor of activated T cell
T23 677-682 protein denotes NF-AT
T24 700-715 protein denotes T cell receptor
T25 717-720 protein denotes TCR
T26 747-785 protein denotes COOH-terminal SH3-deleted Grf40 mutant
T27 822-835 DNA denotes IL-2 promoter
T28 863-887 protein denotes SH2-deleted Grf40 mutant
T29 1007-1030 protein denotes SH2-deleted Grb2 mutant
T30 1054-1059 protein denotes Grf40
T31 1066-1082 protein denotes adaptor molecule
T32 1095-1098 protein denotes TCR
T33 1160-1164 protein denotes Grb2
T34 1170-1176 protein denotes SLP-76
T35 1181-1184 protein denotes LAT

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-107 Sentence denotes Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT.
S2 108-209 Sentence denotes We molecularly cloned a new Grb2 family member, named Grf40, containing the common SH3-SH2-SH3 motif.
S3 210-290 Sentence denotes Expression of Grf40 is predominant in hematopoietic cells, particularly T cells.
S4 291-410 Sentence denotes Grf40 binds to the SH2 domain-containing leukocyte protein of 76 kD (SLP-76) via its SH3 domain more tightly than Grb2.
S5 411-507 Sentence denotes Incidentally, Grf40 binds to linker for activation of T cells (LAT) possibly via its SH2 domain.
S6 508-845 Sentence denotes Overexpression of wild-type Grf40 in Jurkat cells induced a significant increase of SLP-76-dependent interleukin (IL)-2 promoter and nuclear factor of activated T cell (NF-AT) activation upon T cell receptor (TCR) stimulation, whereas the COOH-terminal SH3-deleted Grf40 mutant lacked any recognizable increase in IL-2 promoter activity.
S7 846-1031 Sentence denotes Furthermore, the SH2-deleted Grf40 mutant led to a marked inhibition of these regulatory activities, the effect of which is apparently stronger than that of the SH2-deleted Grb2 mutant.
S8 1032-1185 Sentence denotes Our data suggest that Grf40 is an adaptor molecule involved in TCR-mediated signaling through a more efficient interaction than Grb2 with SLP-76 and LAT.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-5 NP denotes Grf40
C2 7-33 NP denotes A novel Grb2 family member
C4 92-98 NP denotes SLP-76
C5 103-106 NP denotes LAT
C3 92-106 NP denotes SLP-76 and LAT
C6 130-154 NP denotes a new Grb2 family member
C7 162-167 NP denotes Grf40
C8 224-229 NP denotes Grf40
C9 282-289 NP denotes T cells
C10 291-296 NP denotes Grf40
C11 306-367 NP denotes the SH2 domain-containing leukocyte protein of 76 kD (SLP-76)
C12 372-375 NP denotes its
C13 425-430 NP denotes Grf40
C14 440-478 NP denotes linker for activation of T cells (LAT)
C15 492-495 NP denotes its
C16 545-557 NP denotes Jurkat cells
C17 859-887 NP denotes the SH2-deleted Grf40 mutant
C18 947-957 NP denotes the effect
C19 961-966 NP denotes which
C20 995-999 NP denotes that
C21 1054-1059 NP denotes Grf40
C23 1170-1176 NP denotes SLP-76
C24 1181-1184 NP denotes LAT
C22 1170-1184 NP denotes SLP-76 and LAT
R1 C2 C1 coref-appos A novel Grb2 family member,Grf40
R2 C6 C1 coref-ident a new Grb2 family member,Grf40
R3 C7 C6 coref-ident Grf40,a new Grb2 family member
R4 C8 C7 coref-ident Grf40,Grf40
R5 C10 C8 coref-ident Grf40,Grf40
R6 C11 C4 coref-ident the SH2 domain-containing leukocyte protein of 76 kD (SLP-76),SLP-76
R7 C12 C10 coref-pron its,Grf40
R8 C13 C10 coref-ident Grf40,Grf40
R9 C14 C5 coref-ident linker for activation of T cells (LAT),LAT
R10 C15 C13 coref-pron its,Grf40
R11 C16 C9 coref-ident Jurkat cells,T cells
R12 C19 C17 coref-pron which,the SH2-deleted Grf40 mutant
R13 C20 C18 coref-pron that,the effect
R14 C21 C13 coref-ident Grf40,Grf40
R15 C23 C11 coref-ident SLP-76,the SH2 domain-containing leukocyte protein of 76 kD (SLP-76)
R16 C24 C14 coref-ident LAT,linker for activation of T cells (LAT)
R17 C22 C3 coref-ident SLP-76 and LAT,SLP-76 and LAT

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-5 protein_molecule denotes Grf40
T2 15-33 protein_family_or_group denotes Grb2 family member
T3 50-66 other_name denotes T cell signaling
T4 92-98 protein_molecule denotes SLP-76
T5 103-106 protein_molecule denotes LAT
T6 136-154 protein_family_or_group denotes Grb2 family member
T7 162-167 protein_molecule denotes Grf40
T8 224-229 protein_molecule denotes Grf40
T9 248-267 cell_type denotes hematopoietic cells
T10 282-289 cell_type denotes T cells
T11 291-296 protein_molecule denotes Grf40
T12 310-320 protein_domain_or_region denotes SH2 domain
T13 360-366 protein_molecule denotes SLP-76
T14 405-409 protein_family_or_group denotes Grb2
T15 425-430 protein_molecule denotes Grf40
T16 440-464 protein_molecule denotes linker for activation of
T17 465-472 cell_type denotes T cells
T18 474-477 protein_molecule denotes LAT
T19 496-506 protein_domain_or_region denotes SH2 domain
T20 526-535 protein_molecule denotes wild-type
T21 536-541 protein_molecule denotes Grf40
T22 545-557 cell_line denotes Jurkat cells
T23 592-598 protein_molecule denotes SLP-76
T24 641-675 protein_molecule denotes nuclear factor of activated T cell
T25 677-682 protein_molecule denotes NF-AT
T26 700-715 protein_family_or_group denotes T cell receptor
T27 717-720 protein_family_or_group denotes TCR
T28 747-772 protein_molecule denotes COOH-terminal SH3-deleted
T29 773-778 protein_molecule denotes Grf40
T30 822-826 protein_molecule denotes IL-2
T31 863-874 protein_molecule denotes SH2-deleted
T32 875-880 protein_molecule denotes Grf40
T33 1007-1018 protein_molecule denotes SH2-deleted
T34 1019-1023 protein_family_or_group denotes Grb2
T35 1054-1059 protein_molecule denotes Grf40
T36 1066-1082 protein_family_or_group denotes adaptor molecule
T37 1095-1098 protein_family_or_group denotes TCR
T38 1160-1164 protein_family_or_group denotes Grb2
T39 1170-1176 protein_molecule denotes SLP-76
T40 1181-1184 protein_molecule denotes LAT