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PubMed:10224223 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 51-69 cell_type denotes monoblastoid cells
T2 81-90 protein denotes TNF-alpha
T3 136-155 cell_type denotes mononucleated cells
T4 444-461 cell_type denotes endothelial cells
T5 466-477 cell_type denotes osteoblasts
T6 479-488 protein denotes TNF-alpha
T7 552-565 cell_type denotes myeloid cells
T8 624-633 protein denotes TNF-alpha
T9 659-686 cell_line denotes monoblastoid U937 cell line
T10 768-777 protein denotes TNF-alpha
T11 823-852 cell_line denotes PMA-differentiated U937 cells
T12 1129-1210 RNA denotes estrogen receptor alpha (ER-alpha), ER-beta, and progesterone receptor (PR) mRNAs
T13 1216-1224 protein denotes ER-alpha
T14 1466-1488 cell_type denotes undifferentiated cells
T15 1635-1659 cell_line denotes PMA-differentiated cells
T16 1701-1710 protein denotes TNF-alpha
T17 2037-2063 protein denotes proapoptotic Nip-2 protein
T18 2122-2132 cell_line denotes U937 cells
T19 2216-2218 protein denotes ER
T20 2223-2225 protein denotes PR
T21 2320-2329 protein denotes TNF-alpha
T22 2351-2361 cell_line denotes U937 cells
T23 2404-2428 protein denotes female steroid receptors
T24 2505-2523 cell_type denotes monoblastoid cells
T25 2722-2740 cell_type denotes monoblastoid cells
T26 2752-2761 protein denotes TNF-alpha

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-109 Sentence denotes Estrogen and progesterone induction of survival of monoblastoid cells undergoing TNF-alpha-induced apoptosis.
S2 110-235 Sentence denotes Induction of apoptosis of mononucleated cells is a physiological process for regulating the intensity of the immune response.
S3 236-478 Sentence denotes The female steroid hormones estrogen (E2) and progesterone (Prog) are known to modulate the reactivity of the immune system; recently it has been demonstrated that they can regulate induction of apoptosis of endothelial cells and osteoblasts.
S4 479-566 Sentence denotes TNF-alpha-mediated induction of apoptosis has been well characterized in myeloid cells.
S5 567-687 Sentence denotes We investigated whether E2 and Prog could interfere with TNF-alpha-induced apoptosis of the monoblastoid U937 cell line.
S6 688-1007 Sentence denotes Treatment with E2 or Prog increased survival and prevented apoptosis induced by TNF-alpha in both undifferentiated and macrophage-like PMA-differentiated U937 cells, as assessed by trypan blue exclusion cell counting, thymidine incorporation, AnnexinV labeling, followed by flow cytometry and DNA fragmentation studies.
S7 1008-1289 Sentence denotes This effect can be associated with the activation of specific hormone receptors, since we observed the expression of the estrogen receptor alpha (ER-alpha), ER-beta, and progesterone receptor (PR) mRNAs; the ER-alpha protein expression was confirmed by immunocytochemical analysis.
S8 1290-1556 Sentence denotes In addition, hormone-mediated survival against apoptosis was concentration dependent, reaching the half-maximal effect at 10 nM and blocked by the ER antagonist ICI 182,780 in undifferentiated cells, further supporting a receptor-mediated mechanism of cell survival.
S9 1557-1942 Sentence denotes Other steroid receptor drugs such as Raloxifene, RU486, or the ICI 182,780 in PMA-differentiated cells displayed agonist activity by preventing TNF-alpha-induced apoptosis as efficiently as the hormones alone, providing further evidence to the notion that steroid receptor drugs may manifest agonist or antagonist activities depending on the cellular context in which they are studied.
S10 1943-2174 Sentence denotes Treatment with E2 was also associated with a time-dependent decrease in the mRNA level of the proapoptotic Nip-2 protein, supporting the hypothesis that hormone responsiveness of U937 cells is mediated by target gene transcription.
S11 2175-2362 Sentence denotes Together, these results demonstrate that ER and PR can be activated by endogenous or exogenous ligands to induce a genetic response that impairs TNF-alpha-induced apoptosis in U937 cells.
S12 2363-2617 Sentence denotes The data presented here suggest that the female steroid receptors play a role in regulation of the immune response by preventing apoptosis of monoblastoid cells; this effect might have important consequences in the clinical use of steroid receptor drugs.
S13 2618-2670 Sentence denotes --Vegeto, E., Pollio, G., Pellicciari, C., Maggi, A.
S14 2671-2779 Sentence denotes Estrogen and progesterone induction of survival of monoblastoid cells undergoing TNF-alpha-inuced apoptosis.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 81-108 NP denotes TNF-alpha-induced apoptosis
C1 0-108 NP denotes Estrogen and progesterone induction of survival of monoblastoid cells undergoing TNF-alpha-induced apoptosis
C3 215-234 NP denotes the immune response
C4 236-301 NP denotes The female steroid hormones estrogen (E2) and progesterone (Prog)
C5 400-404 NP denotes they
C6 511-520 NP denotes apoptosis
C8 591-593 NP denotes E2
C9 598-602 NP denotes Prog
C7 591-602 NP denotes E2 and Prog
C10 703-705 NP denotes E2
C11 709-713 NP denotes Prog
C12 1337-1346 NP denotes apoptosis
C13 1701-1728 NP denotes TNF-alpha-induced apoptosis
C14 1797-1807 NP denotes the notion
C15 1808-1812 NP denotes that
C16 1813-1835 NP denotes steroid receptor drugs
C17 1895-1915 NP denotes the cellular context
C18 1919-1924 NP denotes which
C19 1925-1929 NP denotes they
C20 1958-1960 NP denotes E2
C21 2076-2090 NP denotes the hypothesis
C22 2091-2095 NP denotes that
C23 2122-2132 NP denotes U937 cells
C24 2288-2306 NP denotes a genetic response
C25 2307-2311 NP denotes that
C26 2351-2361 NP denotes U937 cells
C27 2458-2477 NP denotes the immune response
C28 2594-2616 NP denotes steroid receptor drugs
C30 2752-2778 NP denotes TNF-alpha-inuced apoptosis
C29 2671-2778 NP denotes Estrogen and progesterone induction of survival of monoblastoid cells undergoing TNF-alpha-inuced apoptosis
R1 C5 C4 coref-pron they,The female steroid hormones estrogen (E2) and progesterone (Prog)
R2 C7 C4 coref-ident E2 and Prog,The female steroid hormones estrogen (E2) and progesterone (Prog)
R3 C10 C8 coref-ident E2,E2
R4 C11 C9 coref-ident Prog,Prog
R5 C12 C6 coref-ident apoptosis,apoptosis
R6 C13 C2 coref-ident TNF-alpha-induced apoptosis,TNF-alpha-induced apoptosis
R7 C15 C14 coref-relat that,the notion
R8 C18 C17 coref-relat which,the cellular context
R9 C19 C16 coref-pron they,steroid receptor drugs
R10 C20 C10 coref-ident E2,E2
R11 C22 C21 coref-relat that,the hypothesis
R12 C25 C24 coref-relat that,a genetic response
R13 C26 C23 coref-ident U937 cells,U937 cells
R14 C27 C3 coref-ident the immune response,the immune response
R15 C28 C16 coref-ident steroid receptor drugs,steroid receptor drugs
R16 C30 C13 coref-ident TNF-alpha-inuced apoptosis,TNF-alpha-induced apoptosis
R17 C29 C1 coref-ident Estrogen and progesterone induction of survival of monoblastoid cells undergoing TNF-alpha-inuced apoptosis,Estrogen and progesterone induction of survival of monoblastoid cells undergoing TNF-alpha-induced apoptosis

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-8 lipid denotes Estrogen
T2 13-25 lipid denotes progesterone
T3 51-69 cell_type denotes monoblastoid cells
T4 81-90 protein_molecule denotes TNF-alpha
T5 136-155 cell_type denotes mononucleated cells
T6 219-234 other_name denotes immune response
T7 240-263 lipid denotes female steroid hormones
T8 264-272 lipid denotes estrogen
T9 274-276 lipid denotes E2
T10 282-294 lipid denotes progesterone
T11 296-300 lipid denotes Prog
T12 346-359 body_part denotes immune system
T13 431-440 other_name denotes apoptosis
T14 444-461 cell_type denotes endothelial cells
T15 466-477 cell_type denotes osteoblasts
T16 479-488 protein_molecule denotes TNF-alpha
T17 511-520 other_name denotes apoptosis
T18 552-565 cell_type denotes myeloid cells
T19 591-593 lipid denotes E2
T20 598-602 lipid denotes Prog
T21 624-633 protein_molecule denotes TNF-alpha
T22 642-651 other_name denotes apoptosis
T23 659-686 cell_line denotes monoblastoid U937 cell line
T24 703-705 lipid denotes E2
T25 709-713 lipid denotes Prog
T26 747-756 other_name denotes apoptosis
T27 768-777 protein_molecule denotes TNF-alpha
T28 823-852 cell_line denotes PMA-differentiated U937 cells
T29 869-904 other_name denotes trypan blue exclusion cell counting
T30 906-915 amino_acid_monomer denotes thymidine
T31 931-939 other_organic_compound denotes AnnexinV
T32 962-976 other_name denotes flow cytometry
T33 981-1006 other_name denotes DNA fragmentation studies
T34 1216-1224 protein_molecule denotes ER-alpha
T35 1261-1288 other_name denotes immunocytochemical analysis
T36 1337-1346 other_name denotes apoptosis
T37 1437-1450 other_organic_compound denotes ER antagonist
T38 1451-1462 other_organic_compound denotes ICI 182,780
T39 1466-1488 cell_type denotes undifferentiated cells
T40 1563-1585 other_organic_compound denotes steroid receptor drugs
T41 1594-1604 other_organic_compound denotes Raloxifene
T42 1606-1611 other_organic_compound denotes RU486
T43 1620-1631 other_organic_compound denotes ICI 182,780
T44 1635-1659 cell_line denotes PMA-differentiated cells
T45 1701-1710 protein_molecule denotes TNF-alpha
T46 1719-1728 other_name denotes apoptosis
T47 1813-1835 other_organic_compound denotes steroid receptor drugs
T48 1860-1881 other_name denotes antagonist activities
T49 1958-1960 lipid denotes E2
T50 2019-2029 other_name denotes mRNA level
T51 2037-2063 protein_molecule denotes proapoptotic Nip-2 protein
T52 2096-2118 other_name denotes hormone responsiveness
T53 2122-2132 cell_line denotes U937 cells
T54 2216-2218 protein_molecule denotes ER
T55 2223-2225 protein_molecule denotes PR
T56 2320-2329 protein_molecule denotes TNF-alpha
T57 2351-2361 cell_line denotes U937 cells
T58 2404-2428 protein_family_or_group denotes female steroid receptors
T59 2462-2477 other_name denotes immune response
T60 2492-2501 other_name denotes apoptosis
T61 2505-2523 cell_type denotes monoblastoid cells
T62 2594-2616 other_organic_compound denotes steroid receptor drugs
T63 2671-2679 lipid denotes Estrogen
T64 2684-2696 lipid denotes progesterone
T65 2722-2740 cell_type denotes monoblastoid cells
T66 2752-2761 protein_molecule denotes TNF-alpha

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 466-477 HP_0011846 denotes osteoblasts