> top > docs > PubMed:10224130 > annotations

PubMed:10224130 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-140 Sentence denotes Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells.
T2 141-277 Sentence denotes The activity of the transcription factor NF-kappaB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules.
T3 278-386 Sentence denotes Here we present evidence of a second mechanism of regulation acting on NF-kappaB after release from IkappaB.
T4 387-567 Sentence denotes In endothelial cells this mechanism involves phosphorylation of the RelA subunit of NF-kappaB through a pathway involving activation of protein kinase Czeta (PKCzeta) and p21(ras).
T5 568-730 Sentence denotes We show that transcriptional activity of RelA is dependent on phosphorylation of the N-terminal Rel homology domain but not the C-terminal transactivation domain.
T6 731-899 Sentence denotes Inhibition of phosphorylation by dominant negative mutants of PKCzeta or p21(ras) results in loss of RelA transcriptional activity without interfering with DNA binding.
T7 900-1049 Sentence denotes Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation.

bionlp-st-pc-2013-training

Id Subject Object Predicate Lexical cue
T1 14-23 Complex denotes NF-kappaB
T2 24-28 Gene_or_gene_product denotes RelA
T3 77-80 Gene_or_gene_product denotes p21
T4 81-84 Gene_or_gene_product denotes ras
T5 90-110 Gene_or_gene_product denotes protein kinase Czeta
T6 182-191 Complex denotes NF-kappaB
T7 234-245 Cellular_component denotes cytoplasmic
T8 259-266 Gene_or_gene_product denotes IkappaB
T9 349-358 Complex denotes NF-kappaB
T10 378-385 Gene_or_gene_product denotes IkappaB
T11 455-459 Gene_or_gene_product denotes RelA
T12 471-480 Complex denotes NF-kappaB
T13 523-543 Gene_or_gene_product denotes protein kinase Czeta
T14 545-552 Gene_or_gene_product denotes PKCzeta
T15 558-561 Gene_or_gene_product denotes p21
T16 562-565 Gene_or_gene_product denotes ras
T17 609-613 Gene_or_gene_product denotes RelA
T18 664-667 Gene_or_gene_product denotes Rel
T19 793-800 Gene_or_gene_product denotes PKCzeta
T20 804-807 Gene_or_gene_product denotes p21
T21 808-811 Gene_or_gene_product denotes ras
T22 832-836 Gene_or_gene_product denotes RelA
T23 900-903 Gene_or_gene_product denotes Raf
T24 904-907 Gene_or_gene_product denotes MEK
T25 924-953 Gene_or_gene_product denotes phosphatidylinositol 3-kinase
T26 959-990 Gene_or_gene_product denotes stress-activated protein kinase

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 122-139 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T2 234-245 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T3 390-407 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 122-139 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T2 390-407 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115