PubMed:10221658
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-5 | protein | denotes | CIITA |
| T2 | 28-50 | DNA | denotes | MHC class II promoters |
| T3 | 106-144 | protein | denotes | promoter-bound multi-protein complexes |
| T4 | 168-180 | cell_type | denotes | MHC class II |
| T5 | 256-270 | protein | denotes | transactivator |
| T6 | 271-276 | protein | denotes | CIITA |
| T7 | 338-355 | DNA | denotes | MHC class II gene |
| T8 | 430-452 | DNA | denotes | MHC class II promoters |
| T9 | 497-520 | protein | denotes | multi-protein complexes |
| T10 | 522-525 | protein | denotes | RFX |
| T11 | 527-531 | protein | denotes | X2BP |
| T12 | 536-540 | protein | denotes | NF-Y |
| T13 | 684-689 | protein | denotes | CIITA |
| T14 | 693-712 | cell_line | denotes | MHC class II- cells |
| T15 | 829-834 | protein | denotes | CIITA |
| T16 | 923-956 | protein | denotes | DNA-bound multi-protein complexes |
| T17 | 997-1002 | protein | denotes | CIITA |
| T18 | 1086-1089 | protein | denotes | RFX |
| T19 | 1091-1095 | protein | denotes | X2BP |
| T20 | 1100-1104 | protein | denotes | NF-Y |
| T21 | 1141-1146 | protein | denotes | CIITA |
| T22 | 1196-1205 | DNA | denotes | chromatin |
| T23 | 1254-1276 | DNA | denotes | MHC class II promoters |
| T24 | 1294-1299 | protein | denotes | CIITA |
| T25 | 1428-1433 | protein | denotes | CIITA |
| T26 | 1477-1482 | protein | denotes | CIITA |
| T27 | 1524-1546 | DNA | denotes | MHC class II promoters |
| T28 | 1550-1563 | cell_type | denotes | B lymphocytes |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-145 | Sentence | denotes | CIITA-induced occupation of MHC class II promoters is independent of the cooperative stabilization of the promoter-bound multi-protein complexes. |
| S2 | 146-251 | Sentence | denotes | Precise regulation of MHC class II expression plays a crucial role in the control of the immune response. |
| S3 | 252-415 | Sentence | denotes | The transactivator CIITA behaves as a master controller of constitutive and inducible MHC class II gene activation, but its exact mechanism of action is not known. |
| S4 | 416-542 | Sentence | denotes | Activation of MHC class II promoters requires binding of at least three distinct multi-protein complexes (RFX, X2BP and NF-Y). |
| S5 | 543-651 | Sentence | denotes | It is known that the stability of this binding results from cooperative interactions between these proteins. |
| S6 | 652-769 | Sentence | denotes | We show here that expression of CIITA in MHC class II- cells triggers occupation of the promoters by these complexes. |
| S7 | 770-957 | Sentence | denotes | This observation raised the possibility that the effect of CIITA on promoter occupation is mediated by an effect on the cooperative stabilization of the DNA-bound multi-protein complexes. |
| S8 | 958-1105 | Sentence | denotes | We show, however, that the presence of CIITA does not affect the stability of the higher-order protein complex formed on DNA by RFX, X2BP and NF-Y. |
| S9 | 1106-1277 | Sentence | denotes | This suggests other mechanisms for CIITA-induced promoter occupancy, such as an effect on chromatin structure leading to increased accessibility of MHC class II promoters. |
| S10 | 1278-1386 | Sentence | denotes | This ability of CIITA to facilitate promoter occupation is undissociable from its transactivation potential. |
| S11 | 1387-1564 | Sentence | denotes | Finally, we conclude that this effect of CIITA is cell-type specific, since expression of CIITA is not required for normal occupation of MHC class II promoters in B lymphocytes. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 28-50 | NP | denotes | MHC class II promoters |
| C2 | 252-276 | NP | denotes | The transactivator CIITA |
| C3 | 372-375 | NP | denotes | its |
| C4 | 430-452 | NP | denotes | MHC class II promoters |
| C6 | 473-541 | NP | denotes | at least three distinct multi-protein complexes (RFX, X2BP and NF-Y) |
| C5 | 462-541 | NP | denotes | binding of at least three distinct multi-protein complexes (RFX, X2BP and NF-Y) |
| C7 | 577-589 | NP | denotes | this binding |
| C8 | 636-650 | NP | denotes | these proteins |
| C9 | 684-689 | NP | denotes | CIITA |
| C10 | 736-749 | NP | denotes | the promoters |
| C11 | 753-768 | NP | denotes | these complexes |
| C12 | 794-809 | NP | denotes | the possibility |
| C13 | 810-814 | NP | denotes | that |
| C14 | 829-834 | NP | denotes | CIITA |
| C15 | 838-857 | NP | denotes | promoter occupation |
| C16 | 997-1002 | NP | denotes | CIITA |
| C17 | 1086-1104 | NP | denotes | RFX, X2BP and NF-Y |
| C18 | 1254-1276 | NP | denotes | MHC class II promoters |
| C19 | 1294-1299 | NP | denotes | CIITA |
| C20 | 1314-1333 | NP | denotes | promoter occupation |
| C21 | 1356-1359 | NP | denotes | its |
| C22 | 1428-1433 | NP | denotes | CIITA |
| C23 | 1477-1482 | NP | denotes | CIITA |
| C24 | 1524-1546 | NP | denotes | MHC class II promoters |
| R1 | C3 | C2 | coref-pron | its,The transactivator CIITA |
| R2 | C4 | C1 | coref-ident | MHC class II promoters,MHC class II promoters |
| R3 | C7 | C5 | coref-ident | this binding,"binding of at least three distinct multi-protein complexes (RFX, X2BP and NF-Y)" |
| R4 | C8 | C6 | coref-ident | these proteins,"at least three distinct multi-protein complexes (RFX, X2BP and NF-Y)" |
| R5 | C9 | C2 | coref-ident | CIITA,The transactivator CIITA |
| R6 | C10 | C4 | coref-ident | the promoters,MHC class II promoters |
| R7 | C11 | C8 | coref-ident | these complexes,these proteins |
| R8 | C13 | C12 | coref-relat | that,the possibility |
| R9 | C14 | C9 | coref-ident | CIITA,CIITA |
| R10 | C16 | C14 | coref-ident | CIITA,CIITA |
| R11 | C17 | C11 | coref-ident | "RFX, X2BP and NF-Y",these complexes |
| R12 | C18 | C10 | coref-ident | MHC class II promoters,the promoters |
| R13 | C19 | C16 | coref-ident | CIITA,CIITA |
| R14 | C20 | C15 | coref-ident | promoter occupation,promoter occupation |
| R15 | C21 | C19 | coref-pron | its,CIITA |
| R16 | C22 | C19 | coref-ident | CIITA,CIITA |
| R17 | C23 | C22 | coref-ident | CIITA,CIITA |
| R18 | C24 | C18 | coref-ident | MHC class II promoters,MHC class II promoters |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-5 | protein_molecule | denotes | CIITA |
| T2 | 28-40 | cell_type | denotes | MHC class II |
| T3 | 106-144 | protein_complex | denotes | promoter-bound multi-protein complexes |
| T4 | 168-180 | cell_type | denotes | MHC class II |
| T5 | 235-250 | other_name | denotes | immune response |
| T6 | 256-270 | protein_family_or_group | denotes | transactivator |
| T7 | 271-276 | protein_molecule | denotes | CIITA |
| T8 | 338-350 | cell_type | denotes | MHC class II |
| T9 | 430-442 | cell_type | denotes | MHC class II |
| T10 | 497-520 | protein_complex | denotes | multi-protein complexes |
| T11 | 522-525 | protein_complex | denotes | RFX |
| T12 | 527-531 | protein_complex | denotes | X2BP |
| T13 | 536-540 | protein_complex | denotes | NF-Y |
| T14 | 684-689 | protein_molecule | denotes | CIITA |
| T15 | 693-705 | cell_type | denotes | MHC class II |
| T16 | 829-834 | protein_molecule | denotes | CIITA |
| T17 | 838-857 | other_name | denotes | promoter occupation |
| T18 | 923-956 | protein_complex | denotes | DNA-bound multi-protein complexes |
| T19 | 997-1002 | protein_molecule | denotes | CIITA |
| T20 | 1086-1089 | protein_complex | denotes | RFX |
| T21 | 1091-1095 | protein_complex | denotes | X2BP |
| T22 | 1100-1104 | protein_complex | denotes | NF-Y |
| T23 | 1141-1146 | protein_molecule | denotes | CIITA |
| T24 | 1196-1205 | DNA_molecule | denotes | chromatin |
| T25 | 1254-1266 | cell_type | denotes | MHC class II |
| T26 | 1294-1299 | protein_molecule | denotes | CIITA |
| T27 | 1428-1433 | protein_molecule | denotes | CIITA |
| T28 | 1477-1482 | protein_molecule | denotes | CIITA |
| T29 | 1524-1536 | cell_type | denotes | MHC class II |
| T30 | 1550-1563 | cell_type | denotes | B lymphocytes |