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PubMed:10217534 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 80-96 DiseaseOrPhenotypicFeature denotes hypersensitivity 0000605|0005271
T3 245-261 DiseaseOrPhenotypicFeature denotes hypersensitivity 0000605|0005271
T5 1210-1219 DiseaseOrPhenotypicFeature denotes sensitive 0000605
T6 1677-1680 DiseaseOrPhenotypicFeature denotes can 0012833
T7 1711-1727 DiseaseOrPhenotypicFeature denotes hypersensitivity 0000605|0005271

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 528-545 cell_type denotes white blood cells
T2 718-746 cell_type denotes human peripheral blood cells
T3 800-810 protein denotes ubiquitous
T4 1165-1176 cell_type denotes Lymphocytes
T5 1267-1278 cell_type denotes neutrophils
T6 1313-1328 cell_type denotes red blood cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-97 Sentence denotes Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity.
S2 98-262 Sentence denotes 1. Bioactivation of sulphamethoxazole (SMX) to chemically-reactive metabolites and subsequent protein conjugation is thought to be involved in SMX hypersensitivity.
S3 263-379 Sentence denotes We have therefore examined the cellular metabolism, disposition and conjugation of SMX and its metabolites in vitro.
S4 380-546 Sentence denotes 2. Flow cytometry revealed binding of N-hydroxy (SMX-NHOH) and nitroso (SMX-NO) metabolites of SMX, but not of SMX itself, to the surface of viable white blood cells.
S5 547-621 Sentence denotes Cellular haptenation by SMX-NO was reduced by exogenous glutathione (GSH).
S6 622-837 Sentence denotes 3. SMX-NHOH and SMX-NO were rapidly reduced back to the parent compound by cysteine (CYS), GSH, human peripheral blood cells and plasma, suggesting that this is an important and ubiquitous bioinactivation mechanism.
S7 838-967 Sentence denotes 4. Fluorescence HPLC showed that SMX-NHOH and SMX-NO depleted CYS and GSH in buffer, and to a lesser extent, in cells and plasma.
S8 968-1164 Sentence denotes 5. Neutrophil apoptosis and inhibition of neutrophil function were induced at lower concentrations of SMX-NHOH and SMX-NO than those inducing loss of membrane viability, with SMX having no effect.
S9 1165-1279 Sentence denotes Lymphocytes were significantly (P<0.05) more sensitive to the direct cytotoxic effects of SMX-NO than neutrophils.
S10 1280-1401 Sentence denotes 6. Partitioning of SMX-NHOH into red blood cells was significantly (P<0.05) lower than with the hydroxylamine of dapsone.
S11 1402-1558 Sentence denotes 7. Our results suggest that the balance between oxidation of SMX to its toxic metabolites and their reduction is an important protective cellular mechanism.
S12 1559-1728 Sentence denotes If an imbalance exists, haptenation of the toxic metabolites to bodily proteins including the surface of viable cells can occur, and may result in drug hypersensitivity.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 24-41 NP denotes sulphamethoxazole
C3 46-49 NP denotes its
C1 24-61 NP denotes sulphamethoxazole and its metabolites
C4 118-141 NP denotes sulphamethoxazole (SMX)
C6 346-349 NP denotes SMX
C7 354-357 NP denotes its
C5 346-369 NP denotes SMX and its metabolites
C9 475-478 NP denotes SMX
C8 418-478 NP denotes N-hydroxy (SMX-NHOH) and nitroso (SMX-NO) metabolites of SMX
C10 491-501 NP denotes SMX itself
C11 571-577 NP denotes SMX-NO
C12 593-620 NP denotes exogenous glutathione (GSH)
C14 625-633 NP denotes SMX-NHOH
C15 638-644 NP denotes SMX-NO
C13 625-644 NP denotes SMX-NHOH and SMX-NO
C16 713-716 NP denotes GSH
C17 751-757 NP denotes plasma
C19 871-879 NP denotes SMX-NHOH
C20 884-890 NP denotes SMX-NO
C18 871-890 NP denotes SMX-NHOH and SMX-NO
C21 960-966 NP denotes plasma
C23 1070-1078 NP denotes SMX-NHOH
C24 1083-1089 NP denotes SMX-NO
C22 1070-1089 NP denotes SMX-NHOH and SMX-NO
C25 1255-1261 NP denotes SMX-NO
C26 1299-1307 NP denotes SMX-NHOH
C27 1463-1466 NP denotes SMX
C29 1470-1473 NP denotes its
C28 1470-1491 NP denotes its toxic metabolites
C30 1496-1501 NP denotes their
C31 1598-1619 NP denotes the toxic metabolites
R1 C3 C2 coref-pron its,sulphamethoxazole
R2 C4 C2 coref-ident sulphamethoxazole (SMX),sulphamethoxazole
R3 C6 C4 coref-ident SMX,sulphamethoxazole (SMX)
R4 C7 C6 coref-pron its,SMX
R5 C5 C1 coref-ident SMX and its metabolites,sulphamethoxazole and its metabolites
R6 C9 C6 coref-ident SMX,SMX
R7 C10 C9 coref-ident SMX itself,SMX
R8 C15 C11 coref-ident SMX-NO,SMX-NO
R9 C13 C8 coref-ident SMX-NHOH and SMX-NO,N-hydroxy (SMX-NHOH) and nitroso (SMX-NO) metabolites of SMX
R10 C16 C12 coref-ident GSH,exogenous glutathione (GSH)
R11 C19 C14 coref-ident SMX-NHOH,SMX-NHOH
R12 C20 C15 coref-ident SMX-NO,SMX-NO
R13 C18 C13 coref-ident SMX-NHOH and SMX-NO,SMX-NHOH and SMX-NO
R14 C21 C17 coref-ident plasma,plasma
R15 C23 C19 coref-ident SMX-NHOH,SMX-NHOH
R16 C24 C20 coref-ident SMX-NO,SMX-NO
R17 C22 C18 coref-ident SMX-NHOH and SMX-NO,SMX-NHOH and SMX-NO
R18 C25 C24 coref-ident SMX-NO,SMX-NO
R19 C26 C23 coref-ident SMX-NHOH,SMX-NHOH
R20 C27 C10 coref-ident SMX,SMX itself
R21 C29 C27 coref-pron its,SMX
R22 C30 C28 coref-pron their,its toxic metabolites
R23 C31 C28 coref-ident the toxic metabolites,its toxic metabolites

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-20 other_name denotes Cellular disposition
T2 24-41 other_organic_compound denotes sulphamethoxazole
T3 50-61 other_organic_compound denotes metabolites
T4 63-96 other_name denotes implications for hypersensitivity
T5 118-135 other_organic_compound denotes sulphamethoxazole
T6 137-140 other_organic_compound denotes SMX
T7 165-176 other_organic_compound denotes metabolites
T8 192-211 other_name denotes protein conjugation
T9 241-244 other_organic_compound denotes SMX
T10 346-349 other_organic_compound denotes SMX
T11 358-369 other_organic_compound denotes metabolites
T12 475-478 other_organic_compound denotes SMX
T13 491-494 other_organic_compound denotes SMX
T14 528-545 cell_type denotes white blood cells
T15 571-574 other_organic_compound denotes SMX
T16 603-614 peptide denotes glutathione
T17 616-619 peptide denotes GSH
T18 625-628 other_organic_compound denotes SMX
T19 638-641 other_organic_compound denotes SMX
T20 697-705 amino_acid_monomer denotes cysteine
T21 707-710 amino_acid_monomer denotes CYS
T22 713-716 peptide denotes GSH
T23 718-746 cell_type denotes human peripheral blood cells
T24 800-810 protein_family_or_group denotes ubiquitous
T25 841-858 other_name denotes Fluorescence HPLC
T26 871-874 other_organic_compound denotes SMX
T27 884-887 other_organic_compound denotes SMX
T28 900-903 amino_acid_monomer denotes CYS
T29 908-911 peptide denotes GSH
T30 960-966 tissue denotes plasma
T31 971-991 other_name denotes Neutrophil apoptosis
T32 1010-1029 other_name denotes neutrophil function
T33 1070-1073 other_organic_compound denotes SMX
T34 1083-1086 other_organic_compound denotes SMX
T35 1143-1146 other_organic_compound denotes SMX
T36 1165-1176 cell_type denotes Lymphocytes
T37 1234-1251 other_name denotes cytotoxic effects
T38 1255-1258 other_organic_compound denotes SMX
T39 1267-1278 cell_type denotes neutrophils
T40 1299-1302 other_organic_compound denotes SMX
T41 1313-1328 cell_type denotes red blood cells
T42 1376-1389 other_organic_compound denotes hydroxylamine
T43 1393-1400 other_organic_compound denotes dapsone
T44 1463-1466 other_organic_compound denotes SMX
T45 1583-1594 other_name denotes haptenation
T46 1602-1619 other_organic_compound denotes toxic metabolites
T47 1706-1727 other_name denotes drug hypersensitivity