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PubMed:10216071 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-38 protein denotes E2A-HLF chimeric protein
T2 144-163 DNA denotes E2A-HLF fusion gene
T3 178-195 DNA denotes t(17;19)(q22;p13)
T4 245-274 protein denotes chimeric transcription factor
T5 288-312 protein denotes trans-activating domains
T6 316-319 protein denotes E2A
T7 337-373 protein denotes DNA-binding and dimerization domains
T8 377-400 protein denotes hepatic leukemic factor
T9 402-405 protein denotes HLF
T10 484-491 protein denotes E2A-HLF
T11 498-522 DNA denotes Ig enhancer and promoter
T12 751-761 cell_type denotes thymocytes
T13 815-825 cell_type denotes thymocytes
T14 896-915 cell_type denotes splenic lymphocytes
T15 1121-1128 protein denotes E2A-HLF
T16 1505-1519 cell_type denotes lymphoid cells
T17 1531-1538 protein denotes E2A-HLF
T18 1601-1608 protein denotes E2A-HLF

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-139 Sentence denotes Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia.
S2 140-407 Sentence denotes The E2A-HLF fusion gene, generated by t(17;19)(q22;p13) in acute lymphoblastic leukemia (ALL), encodes a chimeric transcription factor in which the trans-activating domains of E2A are fused to the DNA-binding and dimerization domains of hepatic leukemic factor (HLF).
S3 408-601 Sentence denotes To investigate its biological role, we generated transgenic mice expressing E2A-HLF using Ig enhancer and promoter, which direct transgene expression in cells committed to the lymphoid lineage.
S4 602-712 Sentence denotes The transgenic mice exhibited abnormal development in the thymus and spleen and were susceptible to infection.
S5 713-852 Sentence denotes The thymus contained small numbers of thymocytes, and TUNEL staining showed that higher population of thymocytes were undergoing apoptosis.
S6 853-1072 Sentence denotes The spleen exhibited a marked reduction in splenic lymphocytes and the flow cytometric analyses and the in vitro colony formation assays showed that the B-cell maturation was blocked at a very early developmental stage.
S7 1073-1283 Sentence denotes These findings indicated that the expression of E2A-HLF induced T-cell apoptosis and B-cell maturation arrest in vivo and that the susceptibility of the transgenic mice to infection was due to immunodeficiency.
S8 1284-1539 Sentence denotes Moreover, several transgenic mice developed acute leukemia, classified as T-ALL based on the surface marker analysis and DNA rearrangements, suggesting that an additional event is required for malignant transformation of lymphoid cells expressing E2A-HLF.
S9 1540-1669 Sentence denotes Our findings provide insight into the biological function of E2A-HLF in lymphoid development and also its role in leukemogenesis.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 110-138 NP denotes acute lymphoblastic leukemia
C2 140-163 NP denotes The E2A-HLF fusion gene
C3 199-233 NP denotes acute lymphoblastic leukemia (ALL)
C4 243-274 NP denotes a chimeric transcription factor
C5 278-283 NP denotes which
C6 423-426 NP denotes its
C7 484-491 NP denotes E2A-HLF
C8 498-522 NP denotes Ig enhancer and promoter
C9 524-529 NP denotes which
C10 602-621 NP denotes The transgenic mice
C11 702-711 NP denotes infection
C12 751-761 NP denotes thymocytes
C13 815-825 NP denotes thymocytes
C14 1073-1087 NP denotes These findings
C15 1121-1128 NP denotes E2A-HLF
C16 1222-1241 NP denotes the transgenic mice
C17 1245-1254 NP denotes infection
C18 1531-1538 NP denotes E2A-HLF
C19 1540-1552 NP denotes Our findings
C20 1601-1608 NP denotes E2A-HLF
C21 1642-1645 NP denotes its
R1 C3 C1 coref-ident acute lymphoblastic leukemia (ALL),acute lymphoblastic leukemia
R2 C5 C4 coref-relat which,a chimeric transcription factor
R3 C6 C2 coref-pron its,The E2A-HLF fusion gene
R4 C9 C8 coref-relat which,Ig enhancer and promoter
R5 C13 C12 coref-ident thymocytes,thymocytes
R6 C15 C7 coref-ident E2A-HLF,E2A-HLF
R7 C16 C10 coref-ident the transgenic mice,The transgenic mice
R8 C17 C11 coref-ident infection,infection
R9 C18 C15 coref-ident E2A-HLF,E2A-HLF
R10 C19 C14 coref-ident Our findings,These findings
R11 C20 C18 coref-ident E2A-HLF,E2A-HLF
R12 C21 C20 coref-pron its,E2A-HLF

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-38 protein_molecule denotes E2A-HLF chimeric protein
T2 47-63 other_name denotes T-cell apoptosis
T3 65-89 other_name denotes B-cell maturation arrest
T4 110-138 other_name denotes acute lymphoblastic leukemia
T5 144-163 DNA_domain_or_region denotes E2A-HLF fusion gene
T6 178-195 DNA_domain_or_region denotes t(17;19)(q22;p13)
T7 199-227 other_name denotes acute lymphoblastic leukemia
T8 229-232 other_name denotes ALL
T9 245-274 protein_family_or_group denotes chimeric transcription factor
T10 288-312 protein_domain_or_region denotes trans-activating domains
T11 316-319 protein_molecule denotes E2A
T12 377-400 protein_molecule denotes hepatic leukemic factor
T13 402-405 protein_molecule denotes HLF
T14 457-472 other_artificial_source denotes transgenic mice
T15 484-491 protein_molecule denotes E2A-HLF
T16 606-621 other_artificial_source denotes transgenic mice
T17 660-666 body_part denotes thymus
T18 671-677 body_part denotes spleen
T19 702-711 other_name denotes infection
T20 717-723 body_part denotes thymus
T21 751-761 cell_type denotes thymocytes
T22 767-781 other_name denotes TUNEL staining
T23 815-825 cell_type denotes thymocytes
T24 842-851 other_name denotes apoptosis
T25 857-863 body_part denotes spleen
T26 896-915 cell_type denotes splenic lymphocytes
T27 924-948 other_name denotes flow cytometric analyses
T28 957-989 other_name denotes in vitro colony formation assays
T29 1006-1023 other_name denotes B-cell maturation
T30 1046-1071 other_name denotes early developmental stage
T31 1121-1128 protein_molecule denotes E2A-HLF
T32 1137-1143 other_name denotes T-cell
T33 1144-1153 other_name denotes apoptosis
T34 1165-1182 other_name denotes maturation arrest
T35 1226-1241 other_artificial_source denotes transgenic mice
T36 1245-1254 other_name denotes infection
T37 1266-1282 other_name denotes immunodeficiency
T38 1302-1317 other_artificial_source denotes transgenic mice
T39 1328-1342 other_name denotes acute leukemia
T40 1360-1363 other_name denotes ALL
T41 1377-1400 other_name denotes surface marker analysis
T42 1405-1423 other_name denotes DNA rearrangements
T43 1477-1501 other_name denotes malignant transformation
T44 1505-1519 cell_type denotes lymphoid cells
T45 1531-1538 protein_molecule denotes E2A-HLF
T46 1601-1608 protein_molecule denotes E2A-HLF
T47 1612-1632 other_name denotes lymphoid development
T48 1654-1668 other_name denotes leukemogenesis

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 199-227 HP_0006721 denotes acute lymphoblastic leukemia
T2 219-227 HP_0001909 denotes leukemia
T3 687-711 HP_0002719 denotes susceptible to infection
T4 1266-1282 HP_0002721 denotes immunodeficiency
T5 1328-1342 HP_0002488 denotes acute leukemia
T6 1334-1342 HP_0001909 denotes leukemia