PubMed:10215834 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10215834","sourcedb":"PubMed","sourceid":"10215834","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10215834","text":"Gastrointestinal stromal sarcomas.\nBACKGROUND: Gastrointestinal stromal sarcomas are a rare group of malignancies originating in the bowel wall.\nMETHODS: The treatment of 12 patients with gastrointestinal stromal sarcoma who underwent operation between 1994 and 1998 was reviewed.\nRESULTS: Eight tumours originated in the stomach; others were in the small bowel or rectum. Five of the tumours were of myogenic origin, two were gastrointestinal autonomic nerve tumours, one was a mixed neural-myoid tumour, and four could not be differentiated. Complete resection was possible in ten patients; in two of the ten en bloc resection of adjacent organs was required to ensure adequate margins. The tumours in the remaining two patients were irresectable because of diffuse intra-abdominal metastatic disease. All patients who underwent complete resection were alive after 4-48 (median 14) months. Two of the ten patients developed recurrence, which was reresected completely. The patients with metastatic disease died less than 1 year after operation.\nCONCLUSION: Aggressive surgical resection, achieving complete resection, can lead to prolongation of life and may be a potential cure for patients with gastrointestinal stromal 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