PubMed:10212226
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 221-232 | Cell | denotes | tumor cells | http://purl.obolibrary.org/obo/CL:0001063 |
| T2 | 939-950 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
| T3 | 1228-1240 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T4 | 1479-1490 | Cell | denotes | tumor cells | http://purl.obolibrary.org/obo/CL:0001063 |
GGDB-2020
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 123-134 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T2 | 263-270 | https://acgg.asia/db/ggdb/info/gg073 | denotes | Lewis a |
| T3 | 263-270 | https://acgg.asia/db/ggdb/info/gg003 | denotes | Lewis a |
| T4 | 530-537 | https://acgg.asia/db/ggdb/info/gg073 | denotes | Lewis a |
| T5 | 530-537 | https://acgg.asia/db/ggdb/info/gg003 | denotes | Lewis a |
| T6 | 595-606 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T7 | 846-857 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T8 | 973-984 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T9 | 1055-1062 | https://acgg.asia/db/ggdb/info/gg073 | denotes | Lewis a |
| T10 | 1055-1062 | https://acgg.asia/db/ggdb/info/gg003 | denotes | Lewis a |
| T11 | 1180-1191 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T12 | 1295-1306 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T13 | 1323-1334 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T14 | 1523-1534 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T15 | 1629-1636 | https://acgg.asia/db/ggdb/info/gg073 | denotes | Lewis a |
| T16 | 1629-1636 | https://acgg.asia/db/ggdb/info/gg003 | denotes | Lewis a |
ggdb-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 123-134 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T2 | 263-270 | https://acgg.asia/db/ggdb/info/gg073 | denotes | Lewis a |
| T3 | 263-270 | https://acgg.asia/db/ggdb/info/gg003 | denotes | Lewis a |
| T4 | 530-537 | https://acgg.asia/db/ggdb/info/gg073 | denotes | Lewis a |
| T5 | 530-537 | https://acgg.asia/db/ggdb/info/gg003 | denotes | Lewis a |
| T6 | 595-606 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T7 | 846-857 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T8 | 973-984 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T9 | 1055-1062 | https://acgg.asia/db/ggdb/info/gg073 | denotes | Lewis a |
| T10 | 1055-1062 | https://acgg.asia/db/ggdb/info/gg003 | denotes | Lewis a |
| T11 | 1180-1191 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T12 | 1295-1306 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T13 | 1323-1334 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T14 | 1523-1534 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| T15 | 1629-1636 | https://acgg.asia/db/ggdb/info/gg073 | denotes | Lewis a |
| T16 | 1629-1636 | https://acgg.asia/db/ggdb/info/gg003 | denotes | Lewis a |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 72-91 | Glycan_Motif | denotes | N-acetylglucosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP |
| T2 | 256-270 | Glycan_Motif | denotes | sialyl Lewis a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81971FM|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00053MO |
| T4 | 263-270 | Glycan_Motif | denotes | Lewis a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G39023AU|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00047MO |
| T6 | 523-537 | Glycan_Motif | denotes | sialyl Lewis a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81971FM|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00053MO |
| T8 | 530-537 | Glycan_Motif | denotes | Lewis a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G39023AU|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00047MO |
| T10 | 1048-1062 | Glycan_Motif | denotes | sialyl Lewis a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81971FM|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00053MO |
| T12 | 1055-1062 | Glycan_Motif | denotes | Lewis a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G39023AU|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00047MO |
| T14 | 1115-1134 | Glycan_Motif | denotes | lacto-N-neotetraose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48059CD|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G45827GY |
| T16 | 1622-1636 | Glycan_Motif | denotes | sialyl Lewis a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81971FM|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00053MO |
| T18 | 1629-1636 | Glycan_Motif | denotes | Lewis a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G39023AU|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00047MO |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-251 | Sentence | denotes | Cloning, expression, and characterization of a novel UDP-galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom. |
| T2 | 252-402 | Sentence | denotes | The sialyl Lewis a antigen is a well known tumor marker, CA19-9, which is frequently elevated in the serum in gastrointestinal and pancreatic cancers. |
| T3 | 403-546 | Sentence | denotes | UDP-galactose:N-acetylglucosamine beta1, 3-galactosyltransferase(s) (beta3Gal-Ts) are required for the synthesis of the sialyl Lewis a epitope. |
| T4 | 547-768 | Sentence | denotes | In the present study, a novel beta3Gal-T, named beta3Gal-T5, was isolated from a Colo205 cDNA library using a degenerate primer strategy based on the amino acid sequences of the four human beta3Gal-T genes cloned to date. |
| T5 | 769-903 | Sentence | denotes | Transfection experiments demonstrated that HCT-15 cells transfected with the beta3Gal-T5 gene expressed all the type 1 Lewis antigens. |
| T6 | 904-1072 | Sentence | denotes | In gastrointestinal and pancreatic cancer cell lines, the amounts of beta3Gal-T5 transcripts were quite well correlated with the amounts of the sialyl Lewis a antigens. |
| T7 | 1073-1312 | Sentence | denotes | The beta1,3Gal-T activity toward agalacto-lacto-N-neotetraose was also well correlated with the amounts of beta3Gal-T5 transcripts in a series of cultured cancer cells, and in Namalwa and HCT-15 cells transfected with the beta3Gal-T5 gene. |
| T8 | 1313-1509 | Sentence | denotes | Thus, the beta3Gal-T5 gene is the most probable candidate responsible for the synthesis of the type 1 Lewis antigens in gastrointestinal and pancreatic epithelia and tumor cells derived therefrom. |
| T9 | 1510-1645 | Sentence | denotes | In addition, beta3Gal-T5 is a key enzyme that determines the amounts of the type 1 Lewis antigens including the sialyl Lewis a antigen. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 72-91 | https://glytoucan.org/Structures/Glycans/G64581RP | denotes | N-acetylglucosamine |
| T2 | 256-270 | https://glytoucan.org/Structures/Glycans/G00053MO | denotes | sialyl Lewis a |
| T3 | 256-270 | https://glytoucan.org/Structures/Glycans/G81971FM | denotes | sialyl Lewis a |
| T4 | 263-270 | https://glytoucan.org/Structures/Glycans/G00047MO | denotes | Lewis a |
| T5 | 263-270 | https://glytoucan.org/Structures/Glycans/G39023AU | denotes | Lewis a |
| T6 | 523-537 | https://glytoucan.org/Structures/Glycans/G00053MO | denotes | sialyl Lewis a |
| T7 | 523-537 | https://glytoucan.org/Structures/Glycans/G81971FM | denotes | sialyl Lewis a |
| T8 | 530-537 | https://glytoucan.org/Structures/Glycans/G00047MO | denotes | Lewis a |
| T9 | 530-537 | https://glytoucan.org/Structures/Glycans/G39023AU | denotes | Lewis a |
| T10 | 1048-1062 | https://glytoucan.org/Structures/Glycans/G00053MO | denotes | sialyl Lewis a |
| T11 | 1048-1062 | https://glytoucan.org/Structures/Glycans/G81971FM | denotes | sialyl Lewis a |
| T12 | 1055-1062 | https://glytoucan.org/Structures/Glycans/G00047MO | denotes | Lewis a |
| T13 | 1055-1062 | https://glytoucan.org/Structures/Glycans/G39023AU | denotes | Lewis a |
| T14 | 1115-1134 | https://glytoucan.org/Structures/Glycans/G45827GY | denotes | lacto-N-neotetraose |
| T15 | 1115-1134 | https://glytoucan.org/Structures/Glycans/G48059CD | denotes | lacto-N-neotetraose |
| T16 | 1622-1636 | https://glytoucan.org/Structures/Glycans/G00053MO | denotes | sialyl Lewis a |
| T17 | 1622-1636 | https://glytoucan.org/Structures/Glycans/G81971FM | denotes | sialyl Lewis a |
| T18 | 1629-1636 | https://glytoucan.org/Structures/Glycans/G00047MO | denotes | Lewis a |
| T19 | 1629-1636 | https://glytoucan.org/Structures/Glycans/G39023AU | denotes | Lewis a |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 256-270 | http://www.glycoepitope.jp/epitopes/EP0008 | denotes | sialyl Lewis a |
| T2 | 263-270 | http://www.glycoepitope.jp/epitopes/EP0007 | denotes | Lewis a |
| T3 | 523-537 | http://www.glycoepitope.jp/epitopes/EP0008 | denotes | sialyl Lewis a |
| T4 | 530-537 | http://www.glycoepitope.jp/epitopes/EP0007 | denotes | Lewis a |
| T5 | 1048-1062 | http://www.glycoepitope.jp/epitopes/EP0008 | denotes | sialyl Lewis a |
| T6 | 1055-1062 | http://www.glycoepitope.jp/epitopes/EP0007 | denotes | Lewis a |
| T7 | 1115-1134 | http://www.glycoepitope.jp/epitopes/EP0350 | denotes | lacto-N-neotetraose |
| T8 | 1622-1636 | http://www.glycoepitope.jp/epitopes/EP0008 | denotes | sialyl Lewis a |
| T9 | 1629-1636 | http://www.glycoepitope.jp/epitopes/EP0007 | denotes | Lewis a |
glycogenes
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoGenes20190927-B_T1 | 123-134 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| PD-GlycoGenes20190927-B_T2 | 595-606 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| PD-GlycoGenes20190927-B_T3 | 846-857 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| PD-GlycoGenes20190927-B_T4 | 973-984 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| PD-GlycoGenes20190927-B_T5 | 1180-1191 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| PD-GlycoGenes20190927-B_T6 | 1295-1306 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| PD-GlycoGenes20190927-B_T7 | 1323-1334 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
| PD-GlycoGenes20190927-B_T8 | 1523-1534 | https://acgg.asia/db/ggdb/info/gg073 | denotes | beta3Gal-T5 |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 1180-1191 | gene:10317 | denotes | beta3Gal-T5 |
| T1 | 1228-1234 | disease:C0006826 | denotes | cancer |
| T2 | 1180-1191 | gene:10317 | denotes | beta3Gal-T5 |
| T3 | 1228-1234 | disease:C1306459 | denotes | cancer |
| R1 | T0 | T1 | associated_with | beta3Gal-T5,cancer |
| R2 | T2 | T3 | associated_with | beta3Gal-T5,cancer |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 295-300 | HP_0002664 | denotes | tumor |
| T2 | 383-401 | HP_0002894 | denotes | pancreatic cancers |
| T3 | 394-401 | HP_0002664 | denotes | cancers |
| T4 | 928-945 | HP_0002894 | denotes | pancreatic cancer |
| T5 | 939-945 | HP_0002664 | denotes | cancer |
| T6 | 1228-1234 | HP_0002664 | denotes | cancer |
| T7 | 1454-1484 | HP_0002894 | denotes | pancreatic epithelia and tumor |
| T8 | 1479-1484 | HP_0002664 | denotes | tumor |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 221-226 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 295-300 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 383-401 | Phenotype | denotes | pancreatic cancers | HP:0002894 |
| T4 | 928-945 | Phenotype | denotes | pancreatic cancer | HP:0002894 |
| T5 | 1228-1234 | Phenotype | denotes | cancer | HP:0002664 |
| T6 | 1479-1484 | Phenotype | denotes | tumor | HP:0002664 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 221-226 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T2 | 295-300 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T3 | 383-401 | Disease | denotes | pancreatic cancers | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T5 | 928-945 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T7 | 1228-1234 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T8 | 1479-1484 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 256-270 | Glycan | denotes | sialyl Lewis a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T2 | 523-537 | Glycan | denotes | sialyl Lewis a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T3 | 1048-1062 | Glycan | denotes | sialyl Lewis a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T4 | 1115-1134 | Glycan | denotes | lacto-N-neotetraose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48059CD |
| T5 | 1622-1636 | Glycan | denotes | sialyl Lewis a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 256-270 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis a | http://www.glycoepitope.jp/epitopes/EP0008 |
| T2 | 523-537 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis a | http://www.glycoepitope.jp/epitopes/EP0008 |
| T3 | 1048-1062 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis a | http://www.glycoepitope.jp/epitopes/EP0008 |
| T4 | 1115-1134 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lacto-N-neotetraose | http://www.glycoepitope.jp/epitopes/EP0350 |
| T5 | 1622-1636 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis a | http://www.glycoepitope.jp/epitopes/EP0008 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 221-226 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 295-300 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 383-401 | Phenotype | denotes | pancreatic cancers | HP:0002894 |
| T4 | 928-945 | Phenotype | denotes | pancreatic cancer | HP:0002894 |
| T5 | 1228-1234 | Phenotype | denotes | cancer | HP:0002664 |
| T6 | 1479-1484 | Phenotype | denotes | tumor | HP:0002664 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 221-226 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T2 | 295-300 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T3 | 383-401 | Disease | denotes | pancreatic cancers | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T5 | 928-945 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T7 | 1228-1234 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T8 | 1479-1484 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 730-735 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 221-232 | Cell | denotes | tumor cells | http://purl.obolibrary.org/obo/CL:0001063 |
| T2 | 939-950 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
| T3 | 1228-1240 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T4 | 1479-1490 | Cell | denotes | tumor cells | http://purl.obolibrary.org/obo/CL:0001063 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-251 | Sentence | denotes | Cloning, expression, and characterization of a novel UDP-galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom. |
| T2 | 252-402 | Sentence | denotes | The sialyl Lewis a antigen is a well known tumor marker, CA19-9, which is frequently elevated in the serum in gastrointestinal and pancreatic cancers. |
| T3 | 403-546 | Sentence | denotes | UDP-galactose:N-acetylglucosamine beta1, 3-galactosyltransferase(s) (beta3Gal-Ts) are required for the synthesis of the sialyl Lewis a epitope. |
| T4 | 547-768 | Sentence | denotes | In the present study, a novel beta3Gal-T, named beta3Gal-T5, was isolated from a Colo205 cDNA library using a degenerate primer strategy based on the amino acid sequences of the four human beta3Gal-T genes cloned to date. |
| T5 | 769-903 | Sentence | denotes | Transfection experiments demonstrated that HCT-15 cells transfected with the beta3Gal-T5 gene expressed all the type 1 Lewis antigens. |
| T6 | 904-1072 | Sentence | denotes | In gastrointestinal and pancreatic cancer cell lines, the amounts of beta3Gal-T5 transcripts were quite well correlated with the amounts of the sialyl Lewis a antigens. |
| T7 | 1073-1312 | Sentence | denotes | The beta1,3Gal-T activity toward agalacto-lacto-N-neotetraose was also well correlated with the amounts of beta3Gal-T5 transcripts in a series of cultured cancer cells, and in Namalwa and HCT-15 cells transfected with the beta3Gal-T5 gene. |
| T8 | 1313-1509 | Sentence | denotes | Thus, the beta3Gal-T5 gene is the most probable candidate responsible for the synthesis of the type 1 Lewis antigens in gastrointestinal and pancreatic epithelia and tumor cells derived therefrom. |
| T9 | 1510-1645 | Sentence | denotes | In addition, beta3Gal-T5 is a key enzyme that determines the amounts of the type 1 Lewis antigens including the sialyl Lewis a antigen. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-251 | Sentence | denotes | Cloning, expression, and characterization of a novel UDP-galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom. |
| T2 | 252-402 | Sentence | denotes | The sialyl Lewis a antigen is a well known tumor marker, CA19-9, which is frequently elevated in the serum in gastrointestinal and pancreatic cancers. |
| T3 | 403-546 | Sentence | denotes | UDP-galactose:N-acetylglucosamine beta1, 3-galactosyltransferase(s) (beta3Gal-Ts) are required for the synthesis of the sialyl Lewis a epitope. |
| T4 | 547-768 | Sentence | denotes | In the present study, a novel beta3Gal-T, named beta3Gal-T5, was isolated from a Colo205 cDNA library using a degenerate primer strategy based on the amino acid sequences of the four human beta3Gal-T genes cloned to date. |
| T5 | 769-903 | Sentence | denotes | Transfection experiments demonstrated that HCT-15 cells transfected with the beta3Gal-T5 gene expressed all the type 1 Lewis antigens. |
| T6 | 904-1072 | Sentence | denotes | In gastrointestinal and pancreatic cancer cell lines, the amounts of beta3Gal-T5 transcripts were quite well correlated with the amounts of the sialyl Lewis a antigens. |
| T7 | 1073-1312 | Sentence | denotes | The beta1,3Gal-T activity toward agalacto-lacto-N-neotetraose was also well correlated with the amounts of beta3Gal-T5 transcripts in a series of cultured cancer cells, and in Namalwa and HCT-15 cells transfected with the beta3Gal-T5 gene. |
| T8 | 1313-1509 | Sentence | denotes | Thus, the beta3Gal-T5 gene is the most probable candidate responsible for the synthesis of the type 1 Lewis antigens in gastrointestinal and pancreatic epithelia and tumor cells derived therefrom. |
| T9 | 1510-1645 | Sentence | denotes | In addition, beta3Gal-T5 is a key enzyme that determines the amounts of the type 1 Lewis antigens including the sialyl Lewis a antigen. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 256-270 | Glycan | denotes | sialyl Lewis a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T2 | 523-537 | Glycan | denotes | sialyl Lewis a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T3 | 1048-1062 | Glycan | denotes | sialyl Lewis a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T4 | 1115-1134 | Glycan | denotes | lacto-N-neotetraose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48059CD |
| T5 | 1622-1636 | Glycan | denotes | sialyl Lewis a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 256-270 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis a | http://www.glycoepitope.jp/epitopes/EP0008 |
| T2 | 523-537 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis a | http://www.glycoepitope.jp/epitopes/EP0008 |
| T3 | 1048-1062 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis a | http://www.glycoepitope.jp/epitopes/EP0008 |
| T4 | 1115-1134 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lacto-N-neotetraose | http://www.glycoepitope.jp/epitopes/EP0350 |
| T5 | 1622-1636 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis a | http://www.glycoepitope.jp/epitopes/EP0008 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 730-735 | OrganismTaxon | denotes | human | 9606 |