PubMed:10210645
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 12-21 | protein | denotes | NF-kappaB |
| T2 | 37-46 | protein | denotes | TNF-alpha |
| T3 | 58-73 | cell_type | denotes | human monocytes |
| T4 | 78-101 | protein | denotes | protein tyrosine kinase |
| T5 | 116-132 | protein | denotes | protein kinase C |
| T6 | 158-185 | protein | denotes | Tumor necrosis factor alpha |
| T7 | 187-196 | protein | denotes | TNF-alpha |
| T8 | 279-294 | cell_type | denotes | human monocytes |
| T9 | 318-340 | protein | denotes | nuclear factor-kappa B |
| T10 | 342-351 | protein | denotes | NF-kappaB |
| T11 | 357-366 | protein | denotes | TNF-alpha |
| T12 | 428-444 | protein | denotes | protein kinase C |
| T13 | 446-449 | protein | denotes | PKC |
| T14 | 455-479 | protein | denotes | protein tyrosine kinases |
| T15 | 481-484 | protein | denotes | PTK |
| T16 | 501-510 | protein | denotes | NF-kappaB |
| T17 | 526-535 | protein | denotes | TNF-alpha |
| T18 | 590-593 | protein | denotes | PKC |
| T19 | 597-600 | protein | denotes | PTK |
| T20 | 628-637 | protein | denotes | NF-kappaB |
| T21 | 654-663 | protein | denotes | TNF-alpha |
| T22 | 675-690 | cell_type | denotes | human monocytes |
| T23 | 715-730 | cell_type | denotes | Human monocytes |
| T24 | 823-854 | protein | denotes | serine/threonine protein kinase |
| T25 | 904-907 | protein | denotes | PKC |
| T26 | 964-967 | protein | denotes | PTK |
| T27 | 985-994 | protein | denotes | TNF-alpha |
| T28 | 1053-1062 | protein | denotes | NF-kappaB |
| T29 | 1153-1162 | protein | denotes | NF-kappaB |
| T30 | 1179-1188 | protein | denotes | TNF-alpha |
| T31 | 1200-1215 | cell_type | denotes | human monocytes |
| T32 | 1229-1243 | protein | denotes | protein kinase |
| T33 | 1265-1274 | protein | denotes | NF-kappaB |
| T34 | 1290-1299 | protein | denotes | TNF-alpha |
| T35 | 1324-1327 | protein | denotes | PKC |
| T36 | 1377-1386 | protein | denotes | NF-kappaB |
| T37 | 1402-1411 | protein | denotes | TNF-alpha |
| T38 | 1421-1424 | protein | denotes | PTK |
| T39 | 1473-1482 | protein | denotes | NF-kappaB |
| T40 | 1499-1508 | protein | denotes | TNF-alpha |
| T41 | 1523-1538 | cell_type | denotes | human monocytes |
| T42 | 1561-1564 | protein | denotes | PKC |
| T43 | 1587-1596 | protein | denotes | NF-kappaB |
| T44 | 1612-1621 | protein | denotes | TNF-alpha |
| T45 | 1636-1651 | cell_type | denotes | human monocytes |
| T46 | 1705-1714 | protein | denotes | NF-kappaB |
| T47 | 1730-1739 | protein | denotes | TNF-alpha |
| T48 | 1751-1766 | cell_type | denotes | human monocytes |
| T49 | 1786-1789 | protein | denotes | PKC |
| T50 | 1847-1850 | protein | denotes | PTK |
| T51 | 1879-1888 | protein | denotes | NF-kappaB |
| T52 | 1904-1913 | protein | denotes | TNF-alpha |
| T53 | 1925-1940 | cell_type | denotes | human monocytes |
semrep-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| E1-ti-1 | 0-3 | cui:C0023810 | denotes | LPS |
| E2-ti-1 | 4-11 | cui:C0205263 | denotes | Induced |
| E3-ti-1 | 12-21 | cui:C0079904 | denotes | NF-kappaB |
| E4-ti-1 | 37-46 | cui:C1448177 | denotes | TNF-alpha |
| E5-ti-1 | 58-63 | cui:C0020114 | denotes | human |
| E6-ti-1 | 64-73 | cui:C0026473 | denotes | monocytes |
| E7-ti-1 | 78-101 | cui:C0033681 | denotes | protein tyrosine kinase |
| E8-ti-1 | 116-132 | cui:C0033634 | denotes | protein kinase C |
| T1 | 22-32 | STIMULATES | denotes | activation |
| T2 | 22-32 | STIMULATES | denotes | activation |
| T3 | 58-73 | PART_OF | denotes | human monocytes |
| E1-ab-1 | 158-185 | cui:C1448177 | denotes | Tumor necrosis factor alpha |
| E2-ab-1 | 226-238 | cui:C0036983 | denotes | septic shock |
| E1-ab-2 | 240-249 | cui:C0014264 | denotes | Endotoxin |
| E2-ab-2 | 251-254 | cui:C0023810 | denotes | LPS |
| E3-ab-2 | 256-275 | cui:C0037083 | denotes | signal transduction |
| E4-ab-2 | 279-284 | cui:C0020114 | denotes | human |
| E5-ab-2 | 285-294 | cui:C0026473 | denotes | monocytes |
| E6-ab-2 | 318-340 | cui:C0079904 | denotes | nuclear factor-kappa B |
| E7-ab-2 | 357-366 | cui:C1456820 | denotes | TNF-alpha |
| T4 | 240-254 | ISA | denotes | Endotoxin (LPS |
| T5 | 279-294 | PART_OF | denotes | human monocytes |
| T6 | 276-278 | LOCATION_OF | denotes | in |
| T7 | 240-254 | LOCATION_OF | denotes | Endotoxin (LPS |
| E1-ab-3 | 376-384 | cui:C0205156 | denotes | Previous |
| E2-ab-3 | 385-392 | cui:C0008972 | denotes | studies |
| E3-ab-3 | 428-444 | cui:C0033634 | denotes | protein kinase C |
| E4-ab-3 | 455-479 | cui:C0033681 | denotes | protein tyrosine kinases |
| E5-ab-3 | 489-492 | cui:C0023810 | denotes | LPS |
| E6-ab-3 | 493-500 | cui:C0205263 | denotes | induced |
| E7-ab-3 | 501-510 | cui:C0079904 | denotes | NF-kappaB |
| E8-ab-3 | 526-535 | cui:C1448177 | denotes | TNF-alpha |
| E9-ab-3 | 536-546 | cui:C0033268 | denotes | production |
| T8 | 511-521 | STIMULATES | denotes | activation |
| T9 | 511-521 | STIMULATES | denotes | activation |
| T10 | 511-521 | STIMULATES | denotes | activation |
| E1-ab-4 | 590-593 | cui:C0033634 | denotes | PKC |
| E2-ab-4 | 597-600 | cui:C0033681 | denotes | PTK |
| E3-ab-4 | 616-619 | cui:C0023810 | denotes | LPS |
| E4-ab-4 | 620-627 | cui:C0205263 | denotes | induced |
| E5-ab-4 | 628-637 | cui:C0079904 | denotes | NF-kappaB |
| E6-ab-4 | 638-649 | cui:C1148673 | denotes | DNA binding |
| E7-ab-4 | 654-663 | cui:C1448177 | denotes | TNF-alpha |
| E8-ab-4 | 675-680 | cui:C0020114 | denotes | human |
| E9-ab-4 | 681-690 | cui:C0026473 | denotes | monocytes |
| T11 | 607-615 | INHIBITS | denotes | decrease |
| T12 | 607-615 | INHIBITS | denotes | decrease |
| T13 | 675-690 | PART_OF | denotes | human monocytes |
| E1-ab-5 | 692-701 | cui:C0520510 | denotes | MATERIALS |
| E2-ab-5 | 706-713 | cui:C0025663 | denotes | METHODS |
| E3-ab-5 | 715-720 | cui:C0020114 | denotes | Human |
| E4-ab-5 | 721-730 | cui:C0026473 | denotes | monocytes |
| E5-ab-5 | 752-755 | cui:C0048451 | denotes | PMA |
| E6-ab-5 | 776-779 | cui:C0023810 | denotes | LPS |
| E7-ab-5 | 811-822 | cui:C0750540 | denotes | nonspecific |
| E8-ab-5 | 823-854 | cui:C0072402 | denotes | serine/threonine protein kinase |
| E9-ab-5 | 855-864 | cui:C0243077 | denotes | inhibitor |
| E10-ab-5 | 865-878 | cui:C0075193 | denotes | staurosporine |
| E11-ab-5 | 904-917 | cui:C1514555 | denotes | PKC inhibitor |
| E12-ab-5 | 918-937 | cui:C0256431 | denotes | bisindolylmaleimide |
| E13-ab-5 | 951-960 | cui:C0243077 | denotes | inhibitor |
| E14-ab-5 | 964-967 | cui:C0033681 | denotes | PTK |
| E15-ab-5 | 968-977 | cui:C0061202 | denotes | genistein |
| T14 | 715-730 | PART_OF | denotes | Human monocytes |
| T15 | 736-746 | AUGMENTS | denotes | stimulated |
| T16 | 736-746 | AUGMENTS | denotes | stimulated |
| E1-ab-6 | 985-994 | cui:C1456820 | denotes | TNF-alpha |
| E2-ab-6 | 1006-1013 | cui:C0220814 | denotes | culture |
| E3-ab-6 | 1014-1026 | cui:C1550101 | denotes | supernatants |
| E4-ab-6 | 1046-1051 | cui:C0014441 | denotes | ELISA |
| E1-ab-7 | 1053-1062 | cui:C0079904 | denotes | NF-kappaB |
| E2-ab-7 | 1063-1074 | cui:C1148673 | denotes | DNA binding |
| E3-ab-7 | 1092-1128 | cui:C0949632 | denotes | electrophoretic mobility shift assay |
| E1-ab-8 | 1130-1137 | cui:C1274040 | denotes | RESULTS |
| E2-ab-8 | 1139-1142 | cui:C0023810 | denotes | LPS |
| E3-ab-8 | 1153-1162 | cui:C0079904 | denotes | NF-kappaB |
| E4-ab-8 | 1163-1174 | cui:C1148673 | denotes | DNA binding |
| E5-ab-8 | 1179-1188 | cui:C1456820 | denotes | TNF-alpha |
| E6-ab-8 | 1200-1205 | cui:C0020114 | denotes | human |
| E7-ab-8 | 1206-1215 | cui:C0026473 | denotes | monocytes |
| T17 | 1143-1152 | STIMULATES | denotes | increased |
| T18 | 1200-1215 | PART_OF | denotes | human monocytes |
| E1-ab-9 | 1217-1228 | cui:C0750540 | denotes | Nonspecific |
| E2-ab-9 | 1237-1243 | cui:C0031727 | denotes | kinase |
| E3-ab-9 | 1229-1254 | cui:C1514548 | denotes | protein kinase inhibition |
| E4-ab-9 | 1265-1274 | cui:C0079904 | denotes | NF-kappaB |
| E5-ab-9 | 1290-1299 | cui:C1448177 | denotes | TNF-alpha |
| E6-ab-9 | 1324-1327 | cui:C0033634 | denotes | PKC |
| E7-ab-9 | 1344-1347 | cui:C0256431 | denotes | Bis |
| E8-ab-9 | 1355-1361 | cui:C1280500 | denotes | effect |
| E9-ab-9 | 1365-1368 | cui:C0023810 | denotes | LPS |
| E10-ab-9 | 1369-1376 | cui:C0205263 | denotes | induced |
| E11-ab-9 | 1377-1386 | cui:C0079904 | denotes | NF-kappaB |
| E12-ab-9 | 1387-1398 | cui:C1148673 | denotes | DNA binding |
| E13-ab-9 | 1402-1411 | cui:C1448177 | denotes | TNF-alpha |
| T19 | 1275-1285 | STIMULATES | denotes | activation |
| E1-ab-10 | 1421-1424 | cui:C0033681 | denotes | PTK |
| E2-ab-10 | 1441-1444 | cui:C0061202 | denotes | Gen |
| E3-ab-10 | 1461-1464 | cui:C0023810 | denotes | LPS |
| E4-ab-10 | 1465-1472 | cui:C0205263 | denotes | induced |
| E5-ab-10 | 1473-1482 | cui:C0079904 | denotes | NF-kappaB |
| E6-ab-10 | 1483-1494 | cui:C1148673 | denotes | DNA binding |
| E7-ab-10 | 1499-1508 | cui:C1448177 | denotes | TNF-alpha |
| E8-ab-10 | 1509-1519 | cui:C0033268 | denotes | production |
| E9-ab-10 | 1523-1528 | cui:C0020114 | denotes | human |
| E10-ab-10 | 1529-1538 | cui:C0026473 | denotes | monocytes |
| T20 | 1425-1435 | INHIBITS | denotes | inhibition |
| T21 | 1445-1455 | INHIBITS | denotes | attenuated |
| T22 | 1523-1538 | PART_OF | denotes | human monocytes |
| T23 | 1520-1522 | LOCATION_OF | denotes | in |
| E1-ab-11 | 1561-1564 | cui:C0033634 | denotes | PKC |
| E2-ab-11 | 1570-1573 | cui:C0048451 | denotes | PMA |
| E3-ab-11 | 1587-1596 | cui:C0079904 | denotes | NF-kappaB |
| E4-ab-11 | 1612-1621 | cui:C1448177 | denotes | TNF-alpha |
| E5-ab-11 | 1622-1632 | cui:C0033268 | denotes | production |
| E6-ab-11 | 1636-1641 | cui:C0020114 | denotes | human |
| E7-ab-11 | 1642-1651 | cui:C0026473 | denotes | monocytes |
| T24 | 1547-1557 | STIMULATES | denotes | activation |
| T25 | 1547-1557 | STIMULATES | denotes | activation |
| T26 | 1636-1651 | PART_OF | denotes | human monocytes |
| E1-ab-12 | 1672-1679 | cui:C1274040 | denotes | results |
| E2-ab-12 | 1693-1696 | cui:C0023810 | denotes | LPS |
| E3-ab-12 | 1697-1704 | cui:C0205263 | denotes | induced |
| E4-ab-12 | 1705-1714 | cui:C0079904 | denotes | NF-kappaB |
| E5-ab-12 | 1730-1739 | cui:C1448177 | denotes | TNF-alpha |
| E6-ab-12 | 1751-1756 | cui:C0020114 | denotes | human |
| E7-ab-12 | 1757-1766 | cui:C0026473 | denotes | monocytes |
| E8-ab-12 | 1786-1798 | cui:C1150572 | denotes | PKC activity |
| T27 | 1751-1766 | PART_OF | denotes | human monocytes |
| E1-ab-13 | 1817-1824 | cui:C1274040 | denotes | results |
| E2-ab-13 | 1847-1850 | cui:C0033681 | denotes | PTK |
| E3-ab-13 | 1859-1863 | cui:C0035820 | denotes | role |
| E4-ab-13 | 1867-1870 | cui:C0023810 | denotes | LPS |
| E5-ab-13 | 1871-1878 | cui:C0205263 | denotes | induced |
| E6-ab-13 | 1879-1888 | cui:C0079904 | denotes | NF-kappaB |
| E7-ab-13 | 1904-1913 | cui:C1448177 | denotes | TNF-alpha |
| E8-ab-13 | 1925-1930 | cui:C0020114 | denotes | human |
| E9-ab-13 | 1931-1940 | cui:C0026473 | denotes | monocytes |
| E10-ab-13 | 1961-1970 | cui:C0237399 | denotes | potential |
| E11-ab-13 | 1971-1982 | cui:C0302350 | denotes | therapeutic |
| E12-ab-13 | 1983-1989 | cui:C1521840 | denotes | target |
| E13-ab-13 | 1993-2005 | cui:C0333348 | denotes | inflammatory |
| E14-ab-13 | 2006-2012 | cui:C1442792 | denotes | states |
| T28 | 1889-1899 | STIMULATES | denotes | activation |
| T29 | 1925-1940 | PART_OF | denotes | human monocytes |
| R1 | E7-ti-1 | T1 | subjectOf | protein tyrosine kinase,activation |
| R2 | E3-ti-1 | T1 | objectOf | NF-kappaB,activation |
| R3 | E8-ti-1 | T2 | subjectOf | protein kinase C,activation |
| R4 | E3-ti-1 | T2 | objectOf | NF-kappaB,activation |
| R5 | E6-ti-1 | T3 | subjectOf | monocytes,human monocytes |
| R6 | E5-ti-1 | T3 | objectOf | human,human monocytes |
| R7 | E2-ab-2 | T4 | subjectOf | LPS,Endotoxin (LPS |
| R8 | E1-ab-2 | T4 | objectOf | Endotoxin,Endotoxin (LPS |
| R9 | E5-ab-2 | T5 | subjectOf | monocytes,human monocytes |
| R10 | E4-ab-2 | T5 | objectOf | human,human monocytes |
| R11 | E5-ab-2 | T6 | subjectOf | monocytes,in |
| R12 | E1-ab-2 | T6 | objectOf | Endotoxin,in |
| R13 | E5-ab-2 | T7 | subjectOf | monocytes,Endotoxin (LPS |
| R14 | E2-ab-2 | T7 | objectOf | LPS,Endotoxin (LPS |
| R15 | E4-ab-3 | T8 | subjectOf | protein tyrosine kinases,activation |
| R16 | E7-ab-3 | T8 | objectOf | NF-kappaB,activation |
| R17 | E8-ab-3 | T9 | subjectOf | TNF-alpha,activation |
| R18 | E7-ab-3 | T9 | objectOf | NF-kappaB,activation |
| R19 | E3-ab-3 | T10 | subjectOf | protein kinase C,activation |
| R20 | E7-ab-3 | T10 | objectOf | NF-kappaB,activation |
| R21 | E2-ab-4 | T11 | subjectOf | PTK,decrease |
| R22 | E5-ab-4 | T11 | objectOf | NF-kappaB,decrease |
| R23 | E1-ab-4 | T12 | subjectOf | PKC,decrease |
| R24 | E5-ab-4 | T12 | objectOf | NF-kappaB,decrease |
| R25 | E9-ab-4 | T13 | subjectOf | monocytes,human monocytes |
| R26 | E8-ab-4 | T13 | objectOf | human,human monocytes |
| R27 | E4-ab-5 | T14 | subjectOf | monocytes,Human monocytes |
| R28 | E3-ab-5 | T14 | objectOf | Human,Human monocytes |
| R29 | E5-ab-5 | T15 | subjectOf | PMA,stimulated |
| R30 | E4-ab-5 | T15 | objectOf | monocytes,stimulated |
| R31 | E6-ab-5 | T16 | subjectOf | LPS,stimulated |
| R32 | E4-ab-5 | T16 | objectOf | monocytes,stimulated |
| R33 | E2-ab-8 | T17 | subjectOf | LPS,increased |
| R34 | E3-ab-8 | T17 | objectOf | NF-kappaB,increased |
| R35 | E7-ab-8 | T18 | subjectOf | monocytes,human monocytes |
| R36 | E6-ab-8 | T18 | objectOf | human,human monocytes |
| R37 | E7-ab-9 | T19 | subjectOf | Bis,activation |
| R38 | E4-ab-9 | T19 | objectOf | NF-kappaB,activation |
| R39 | E2-ab-10 | T20 | subjectOf | Gen,inhibition |
| R40 | E1-ab-10 | T20 | objectOf | PTK,inhibition |
| R41 | E2-ab-10 | T21 | subjectOf | Gen,attenuated |
| R42 | E5-ab-10 | T21 | objectOf | NF-kappaB,attenuated |
| R43 | E10-ab-10 | T22 | subjectOf | monocytes,human monocytes |
| R44 | E9-ab-10 | T22 | objectOf | human,human monocytes |
| R45 | E10-ab-10 | T23 | subjectOf | monocytes,in |
| R46 | E7-ab-10 | T23 | objectOf | TNF-alpha,in |
| R47 | E2-ab-11 | T24 | subjectOf | PMA,activation |
| R48 | E1-ab-11 | T24 | objectOf | PKC,activation |
| R49 | E4-ab-11 | T25 | subjectOf | TNF-alpha,activation |
| R50 | E1-ab-11 | T25 | objectOf | PKC,activation |
| R51 | E7-ab-11 | T26 | subjectOf | monocytes,human monocytes |
| R52 | E6-ab-11 | T26 | objectOf | human,human monocytes |
| R53 | E7-ab-12 | T27 | subjectOf | monocytes,human monocytes |
| R54 | E6-ab-12 | T27 | objectOf | human,human monocytes |
| R55 | E2-ab-13 | T28 | subjectOf | PTK,activation |
| R56 | E6-ab-13 | T28 | objectOf | NF-kappaB,activation |
| R57 | E9-ab-13 | T29 | subjectOf | monocytes,human monocytes |
| R58 | E8-ab-13 | T29 | objectOf | human,human monocytes |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-145 | Sentence | denotes | LPS-Induced NF-kappaB activation and TNF-alpha release in human monocytes are protein tyrosine kinase dependent and protein kinase C independent. |
| S2 | 146-239 | Sentence | denotes | BACKGROUND: Tumor necrosis factor alpha (TNF-alpha) is an important mediator of septic shock. |
| S3 | 240-375 | Sentence | denotes | Endotoxin (LPS) signal transduction in human monocytes leads to activation of nuclear factor-kappa B (NF-kappaB) and TNF-alpha release. |
| S4 | 376-547 | Sentence | denotes | Previous studies have implicated activation of both protein kinase C (PKC) and protein tyrosine kinases (PTK) in LPS-induced NF-kappaB activation and TNF-alpha production. |
| S5 | 548-691 | Sentence | denotes | We hypothesized that inhibition of either PKC or PTK would decrease LPS-induced NF-kappaB DNA binding and TNF-alpha release in human monocytes. |
| S6 | 692-984 | Sentence | denotes | MATERIALS AND METHODS: Human monocytes were stimulated with PMA (50 ng/ml) alone or LPS (100 ng/ml) with and without a nonspecific serine/threonine protein kinase inhibitor staurosporine (Stauro), a specific pan-PKC inhibitor bisindolylmaleimide (Bis), or an inhibitor of PTK genistein (Gen). |
| S7 | 985-1052 | Sentence | denotes | TNF-alpha release in culture supernatants was measured by an ELISA. |
| S8 | 1053-1129 | Sentence | denotes | NF-kappaB DNA binding was evaluated by electrophoretic mobility shift assay. |
| S9 | 1130-1216 | Sentence | denotes | RESULTS: LPS increased NF-kappaB DNA binding and TNF-alpha release in human monocytes. |
| S10 | 1217-1420 | Sentence | denotes | Nonspecific protein kinase inhibition inhibited NF-kappaB activation and TNF-alpha release, while specific PKC inhibition with Bis had no effect on LPS-induced NF-kappaB DNA binding or TNF-alpha release. |
| S11 | 1421-1539 | Sentence | denotes | PTK inhibition with Gen attenuated both LPS-induced NF-kappaB DNA binding and TNF-alpha production in human monocytes. |
| S12 | 1540-1652 | Sentence | denotes | Direct activation of PKC with PMA induced both NF-kappaB activation and TNF-alpha production by human monocytes. |
| S13 | 1653-1799 | Sentence | denotes | CONCLUSIONS: These results suggest that LPS-induced NF-kappaB activation and TNF-alpha release in human monocytes are independent of PKC activity. |
| S14 | 1800-2013 | Sentence | denotes | Furthermore, our results provide evidence that PTK plays a role in LPS-induced NF-kappaB activation and TNF-alpha release in human monocytes and thus could be a potential therapeutic target in inflammatory states. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C2 | 58-73 | NP | denotes | human monocytes |
| C1 | 0-73 | NP | denotes | LPS-Induced NF-kappaB activation and TNF-alpha release in human monocytes |
| C3 | 279-294 | NP | denotes | human monocytes |
| C5 | 357-374 | NP | denotes | TNF-alpha release |
| C4 | 304-374 | NP | denotes | activation of nuclear factor-kappa B (NF-kappaB) and TNF-alpha release |
| C6 | 590-593 | NP | denotes | PKC |
| C7 | 597-600 | NP | denotes | PTK |
| C8 | 675-690 | NP | denotes | human monocytes |
| C9 | 715-730 | NP | denotes | Human monocytes |
| C10 | 752-772 | NP | denotes | PMA (50 ng/ml) alone |
| C11 | 889-943 | NP | denotes | a specific pan-PKC inhibitor bisindolylmaleimide (Bis) |
| C12 | 948-983 | NP | denotes | an inhibitor of PTK genistein (Gen) |
| C13 | 1200-1215 | NP | denotes | human monocytes |
| C15 | 1290-1307 | NP | denotes | TNF-alpha release |
| C14 | 1265-1307 | NP | denotes | NF-kappaB activation and TNF-alpha release |
| C16 | 1344-1347 | NP | denotes | Bis |
| C17 | 1402-1419 | NP | denotes | TNF-alpha release |
| C18 | 1441-1444 | NP | denotes | Gen |
| C19 | 1523-1538 | NP | denotes | human monocytes |
| C20 | 1561-1564 | NP | denotes | PKC |
| C21 | 1570-1573 | NP | denotes | PMA |
| C22 | 1636-1651 | NP | denotes | human monocytes |
| C23 | 1666-1679 | NP | denotes | These results |
| C25 | 1751-1766 | NP | denotes | human monocytes |
| C24 | 1693-1766 | NP | denotes | LPS-induced NF-kappaB activation and TNF-alpha release in human monocytes |
| C26 | 1813-1824 | NP | denotes | our results |
| C27 | 1833-1841 | NP | denotes | evidence |
| C28 | 1842-1846 | NP | denotes | that |
| C29 | 1847-1850 | NP | denotes | PTK |
| C31 | 1925-1940 | NP | denotes | human monocytes |
| C30 | 1867-1940 | NP | denotes | LPS-induced NF-kappaB activation and TNF-alpha release in human monocytes |
| R1 | C3 | C2 | coref-ident | human monocytes,human monocytes |
| R2 | C8 | C3 | coref-ident | human monocytes,human monocytes |
| R3 | C9 | C8 | coref-ident | Human monocytes,human monocytes |
| R4 | C13 | C9 | coref-ident | human monocytes,Human monocytes |
| R5 | C15 | C5 | coref-ident | TNF-alpha release,TNF-alpha release |
| R6 | C14 | C4 | coref-ident | NF-kappaB activation and TNF-alpha release,activation of nuclear factor-kappa B (NF-kappaB) and TNF-alpha release |
| R7 | C16 | C11 | coref-ident | Bis,a specific pan-PKC inhibitor bisindolylmaleimide (Bis) |
| R8 | C17 | C15 | coref-ident | TNF-alpha release,TNF-alpha release |
| R9 | C18 | C12 | coref-ident | Gen,an inhibitor of PTK genistein (Gen) |
| R10 | C19 | C13 | coref-ident | human monocytes,human monocytes |
| R11 | C20 | C6 | coref-ident | PKC,PKC |
| R12 | C21 | C10 | coref-ident | PMA,PMA (50 ng/ml) alone |
| R13 | C22 | C19 | coref-ident | human monocytes,human monocytes |
| R14 | C25 | C22 | coref-ident | human monocytes,human monocytes |
| R15 | C24 | C1 | coref-ident | LPS-induced NF-kappaB activation and TNF-alpha release in human monocytes,LPS-Induced NF-kappaB activation and TNF-alpha release in human monocytes |
| R16 | C26 | C23 | coref-ident | our results,These results |
| R17 | C28 | C27 | coref-relat | that,evidence |
| R18 | C29 | C7 | coref-ident | PTK,PTK |
| R19 | C31 | C25 | coref-ident | human monocytes,human monocytes |
| R20 | C30 | C24 | coref-ident | LPS-induced NF-kappaB activation and TNF-alpha release in human monocytes,LPS-induced NF-kappaB activation and TNF-alpha release in human monocytes |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-3 | lipid | denotes | LPS |
| T2 | 12-21 | protein_complex | denotes | NF-kappaB |
| T3 | 37-46 | protein_molecule | denotes | TNF-alpha |
| T4 | 58-73 | cell_type | denotes | human monocytes |
| T5 | 78-85 | protein_family_or_group | denotes | protein |
| T6 | 86-94 | amino_acid_monomer | denotes | tyrosine |
| T7 | 116-132 | protein_molecule | denotes | protein kinase C |
| T8 | 158-185 | protein_molecule | denotes | Tumor necrosis factor alpha |
| T9 | 187-196 | protein_molecule | denotes | TNF-alpha |
| T10 | 226-238 | other_name | denotes | septic shock |
| T11 | 240-251 | other_name | denotes | Endotoxin ( |
| T12 | 251-254 | lipid | denotes | LPS |
| T13 | 279-294 | cell_type | denotes | human monocytes |
| T14 | 318-340 | protein_complex | denotes | nuclear factor-kappa B |
| T15 | 342-351 | protein_complex | denotes | NF-kappaB |
| T16 | 357-366 | protein_molecule | denotes | TNF-alpha |
| T17 | 428-444 | protein_molecule | denotes | protein kinase C |
| T18 | 446-449 | protein_molecule | denotes | PKC |
| T19 | 455-462 | protein_family_or_group | denotes | protein |
| T20 | 463-471 | amino_acid_monomer | denotes | tyrosine |
| T21 | 481-484 | protein_family_or_group | denotes | PTK |
| T22 | 489-492 | lipid | denotes | LPS |
| T23 | 501-510 | protein_complex | denotes | NF-kappaB |
| T24 | 526-535 | protein_molecule | denotes | TNF-alpha |
| T25 | 590-593 | protein_molecule | denotes | PKC |
| T26 | 597-600 | protein_family_or_group | denotes | PTK |
| T27 | 616-619 | lipid | denotes | LPS |
| T28 | 628-637 | protein_complex | denotes | NF-kappaB |
| T29 | 654-663 | protein_molecule | denotes | TNF-alpha |
| T30 | 675-690 | cell_type | denotes | human monocytes |
| T31 | 715-730 | cell_type | denotes | Human monocytes |
| T32 | 752-755 | other_organic_compound | denotes | PMA |
| T33 | 776-779 | lipid | denotes | LPS |
| T34 | 811-822 | other_organic_compound | denotes | nonspecific |
| T35 | 823-829 | amino_acid_monomer | denotes | serine |
| T36 | 829-839 | amino_acid_monomer | denotes | /threonine |
| T37 | 900-904 | other_organic_compound | denotes | pan- |
| T38 | 904-907 | protein_molecule | denotes | PKC |
| T39 | 939-942 | other_organic_compound | denotes | Bis |
| T40 | 964-967 | protein_family_or_group | denotes | PTK |
| T41 | 968-977 | other_organic_compound | denotes | genistein |
| T42 | 979-982 | other_organic_compound | denotes | Gen |
| T43 | 985-994 | protein_molecule | denotes | TNF-alpha |
| T44 | 1046-1051 | other_name | denotes | ELISA |
| T45 | 1053-1062 | protein_complex | denotes | NF-kappaB |
| T46 | 1092-1128 | other_name | denotes | electrophoretic mobility shift assay |
| T47 | 1139-1142 | lipid | denotes | LPS |
| T48 | 1153-1162 | protein_complex | denotes | NF-kappaB |
| T49 | 1179-1188 | protein_molecule | denotes | TNF-alpha |
| T50 | 1200-1215 | cell_type | denotes | human monocytes |
| T51 | 1217-1228 | other_name | denotes | Nonspecific |
| T52 | 1229-1243 | protein_family_or_group | denotes | protein kinase |
| T53 | 1265-1274 | protein_complex | denotes | NF-kappaB |
| T54 | 1290-1299 | protein_molecule | denotes | TNF-alpha |
| T55 | 1324-1327 | protein_molecule | denotes | PKC |
| T56 | 1344-1347 | other_organic_compound | denotes | Bis |
| T57 | 1365-1368 | lipid | denotes | LPS |
| T58 | 1377-1386 | protein_complex | denotes | NF-kappaB |
| T59 | 1402-1411 | protein_molecule | denotes | TNF-alpha |
| T60 | 1421-1424 | protein_family_or_group | denotes | PTK |
| T61 | 1441-1444 | other_organic_compound | denotes | Gen |
| T62 | 1461-1464 | lipid | denotes | LPS |
| T63 | 1473-1482 | protein_complex | denotes | NF-kappaB |
| T64 | 1499-1508 | protein_molecule | denotes | TNF-alpha |
| T65 | 1523-1538 | cell_type | denotes | human monocytes |
| T66 | 1561-1564 | protein_molecule | denotes | PKC |
| T67 | 1570-1573 | other_organic_compound | denotes | PMA |
| T68 | 1587-1596 | protein_complex | denotes | NF-kappaB |
| T69 | 1612-1621 | protein_molecule | denotes | TNF-alpha |
| T70 | 1636-1651 | cell_type | denotes | human monocytes |
| T71 | 1693-1696 | lipid | denotes | LPS |
| T72 | 1705-1714 | protein_complex | denotes | NF-kappaB |
| T73 | 1730-1739 | protein_molecule | denotes | TNF-alpha |
| T74 | 1751-1766 | cell_type | denotes | human monocytes |
| T75 | 1786-1789 | protein_molecule | denotes | PKC |
| T76 | 1847-1850 | protein_family_or_group | denotes | PTK |
| T77 | 1867-1870 | lipid | denotes | LPS |
| T78 | 1879-1888 | protein_complex | denotes | NF-kappaB |
| T79 | 1904-1913 | protein_molecule | denotes | TNF-alpha |
| T80 | 1925-1940 | cell_type | denotes | human monocytes |
| T81 | 1961-1989 | other_name | denotes | potential therapeutic target |
| T82 | 1993-2012 | other_name | denotes | inflammatory states |
metamap-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T9 | 59-64 | C0086418 | denotes | uman |
| T12 | 117-133 | C0033634 | denotes | rotein kinase C |
| T16 | 79-102 | C0033681 | denotes | rotein tyrosine kinase |
| T24 | 38-47 | C1456820 | denotes | NF-alpha |
| T33 | 65-74 | C0026473 | denotes | onocytes |
| T42 | 13-22 | C0079904 | denotes | F-kappaB |
| T43 | 103-112 | C0851827 | denotes | ependent |
| T44 | 134-145 | C0085862 | denotes | ndependent. |
| T51 | 48-55 | C1283071 | denotes | elease |
| T57 | 23-33 | C1879547 | denotes | ctivation |
| T62 | 38-47 | C2003941 | denotes | NF-alpha |
| T70 | 5-12 | C0205263 | denotes | nduced |
| T80 | 1-4 | C2697656 | denotes | PS- |
| T1 | 2013-691 | C0086418 | denotes | |
| T2 | 2013-691 | C0086418 | denotes | |
| T3 | 2013-691 | C0086418 | denotes | |
| T4 | 2013-691 | C0086418 | denotes | |
| T5 | 2013-691 | C0086418 | denotes | |
| T6 | 2013-691 | C0086418 | denotes | |
| T7 | 676-681 | C0086418 | denotes | uman |
| T8 | 280-285 | C0086418 | denotes | uman |
| T10 | 2013-691 | C0033634 | denotes | |
| T11 | 591-594 | C0033634 | denotes | KC |
| T13 | 2013-691 | C0033681 | denotes | |
| T14 | 2013-691 | C0033681 | denotes | |
| T15 | 598-601 | C0033681 | denotes | TK |
| T17 | 2013-691 | C1456820 | denotes | |
| T18 | 2013-691 | C1456820 | denotes | |
| T19 | 2013-691 | C1456820 | denotes | |
| T20 | 2013-691 | C1456820 | denotes | |
| T21 | 655-664 | C1456820 | denotes | NF-alpha |
| T22 | 358-367 | C1456820 | denotes | NF-alpha |
| T23 | 159-186 | C1456820 | denotes | umor necrosis factor alpha |
| T25 | 2013-691 | C0026473 | denotes | |
| T26 | 2013-691 | C0026473 | denotes | |
| T27 | 2013-691 | C0026473 | denotes | |
| T28 | 2013-691 | C0026473 | denotes | |
| T29 | 2013-691 | C0026473 | denotes | |
| T30 | 2013-691 | C0026473 | denotes | |
| T31 | 682-691 | C0026473 | denotes | onocytes. |
| T32 | 286-295 | C0026473 | denotes | onocytes |
| T34 | 2013-691 | C0079904 | denotes | |
| T35 | 2013-691 | C0079904 | denotes | |
| T36 | 2013-691 | C0079904 | denotes | |
| T37 | 2013-691 | C0079904 | denotes | |
| T38 | 2013-691 | C0079904 | denotes | |
| T39 | 2013-691 | C0079904 | denotes | |
| T40 | 629-638 | C0079904 | denotes | F-kappaB |
| T41 | 319-341 | C0079904 | denotes | uclear factor-kappa B |
| T45 | 2013-691 | C1283071 | denotes | |
| T46 | 2013-691 | C1283071 | denotes | |
| T47 | 2013-691 | C1283071 | denotes | |
| T48 | 2013-691 | C1283071 | denotes | |
| T49 | 665-672 | C1283071 | denotes | elease |
| T50 | 368-375 | C1283071 | denotes | elease. |
| T52 | 2013-691 | C1879547 | denotes | |
| T53 | 2013-691 | C1879547 | denotes | |
| T54 | 2013-691 | C1879547 | denotes | |
| T55 | 2013-691 | C1879547 | denotes | |
| T56 | 305-315 | C1879547 | denotes | ctivation |
| T58 | 2013-691 | C2003941 | denotes | |
| T59 | 2013-691 | C2003941 | denotes | |
| T60 | 2013-691 | C2003941 | denotes | |
| T61 | 655-664 | C2003941 | denotes | NF-alpha |
| T63 | 2013-691 | C0205263 | denotes | |
| T64 | 2013-691 | C0205263 | denotes | |
| T65 | 2013-691 | C0205263 | denotes | |
| T66 | 2013-691 | C0205263 | denotes | |
| T67 | 2013-691 | C0205263 | denotes | |
| T68 | 621-628 | C0205263 | denotes | nduced |
| T69 | 494-501 | C0205263 | denotes | nduced |
| T71 | 2013-691 | C2697656 | denotes | |
| T72 | 2013-691 | C2697656 | denotes | |
| T73 | 2013-691 | C2697656 | denotes | |
| T74 | 2013-691 | C2697656 | denotes | |
| T75 | 2013-691 | C2697656 | denotes | |
| T76 | 2013-691 | C2697656 | denotes | |
| T77 | 617-620 | C2697656 | denotes | PS- |
| T78 | 490-493 | C2697656 | denotes | PS- |
| T79 | 252-255 | C2697656 | denotes | PS) |
| T81 | 2013-691 | C0039654 | denotes | |
| T82 | 2013-691 | C0039654 | denotes | |
| T83 | 2013-691 | C0061202 | denotes | |
| T84 | 2013-691 | C0061202 | denotes | |
| T85 | 2013-691 | C1148673 | denotes | |
| T86 | 2013-691 | C1148673 | denotes | |
| T87 | 2013-691 | C1148673 | denotes | |
| T88 | 639-650 | C1148673 | denotes | NA binding |
| T89 | 2013-691 | C0256431 | denotes | |
| T90 | 2013-691 | C0256431 | denotes | |
| T91 | 2013-691 | C0033640 | denotes | |
| T92 | 227-239 | C0036983 | denotes | eptic shock. |
| T93 | 2013-691 | C0014441 | denotes | |
| T94 | 2013-691 | C0075193 | denotes | |
| T95 | 464-472 | C0041485 | denotes | yrosine |
| T96 | 2013-691 | C1628982 | denotes | |
| T97 | 570-580 | C1628982 | denotes | nhibition |
| T98 | 241-250 | C0014264 | denotes | ndotoxin |
| T99 | 2013-691 | C0949632 | denotes | |
| T100 | 257-276 | C0037083 | denotes | ignal transduction |
| T101 | 2013-691 | C0220825 | denotes | |
| T102 | 2013-691 | C0036720 | denotes | |
| T103 | 2013-691 | C0040005 | denotes | |
| T104 | 2013-691 | C2825142 | denotes | |
| T105 | 2013-691 | C2825142 | denotes | |
| T106 | 2013-691 | C2825142 | denotes | |
| T107 | 2013-691 | C1819464 | denotes | |
| T108 | 2013-691 | C0025664 | denotes | |
| T109 | 2013-691 | C0750540 | denotes | |
| T110 | 2013-691 | C0750540 | denotes | |
| T111 | 2013-691 | C0205370 | denotes | |
| T112 | 2013-691 | C0205370 | denotes | |
| T113 | 2013-691 | C1552740 | denotes | |
| T114 | 2013-691 | C1552740 | denotes | |
| T115 | 2013-691 | C0332161 | denotes | |
| T116 | 158-146 | C1706907 | denotes | |
| T117 | 2013-691 | C1707478 | denotes | |
| T118 | 2013-691 | C0600138 | denotes | |
| T119 | 2013-691 | C0332120 | denotes | |
| T120 | 2013-691 | C0205217 | denotes | |
| T121 | 2013-691 | C0311403 | denotes | |
| T122 | 2013-691 | C0520510 | denotes | |
| T123 | 2013-691 | C1999230 | denotes | |
| T124 | 608-615 | C0392756 | denotes | ecrease |
| T125 | 2013-691 | C1705535 | denotes | |
| T126 | 386-393 | C0947630 | denotes | tudies |
| T127 | 2013-691 | C1150572 | denotes | |
| T128 | 2013-691 | C0679994 | denotes | |
| T129 | 2013-691 | C1948023 | denotes | |
| T130 | 2013-691 | C0332291 | denotes | |
| T131 | 2013-691 | C0444706 | denotes | |
| T132 | 2013-691 | C1301751 | denotes | |
| T133 | 215-223 | C1363844 | denotes | ediator |
| T134 | 2013-691 | C1521840 | denotes | |
| T135 | 2013-691 | C1551058 | denotes | |
| T136 | 296-301 | C0181586 | denotes | eads |
| T137 | 2013-691 | C1515981 | denotes | |
| T138 | 2013-691 | C1705810 | denotes | |
| T139 | 2013-691 | C1514555 | denotes | |
| T140 | 377-385 | C1552607 | denotes | revious |
| T141 | 2013-691 | C0085999 | denotes | |
| T142 | 2013-691 | C0439851 | denotes | |
| T143 | 2013-691 | C1301808 | denotes | |
| T144 | 2013-691 | C0333348 | denotes | |
| T145 | 2013-691 | C3245505 | denotes | |
| T146 | 2013-691 | C0302350 | denotes | |
| T147 | 2013-691 | C0430400 | denotes | |
| T148 | 2013-691 | C1550101 | denotes |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 158-163 | HP_0002664 | denotes | Tumor |