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PubMed:10210321 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 41-46 protein denotes Spi-1
T2 48-53 protein denotes Fli-1
T3 59-79 DNA denotes megakaryocytic genes
T4 88-112 cell_line denotes Epo-dependent cell lines
T5 192-222 protein denotes thermosensitive SV40 T antigen
T6 229-255 cell_line denotes erythroleukemic cell lines
T7 287-326 protein denotes erythrocytic and megakaryocytic markers
T8 372-377 protein denotes Spi-1
T9 385-412 protein denotes Fli-1 transcription factors
T10 422-473 protein denotes transactivators of megakaryocyte-specific promoters
T11 541-555 cell_line denotes new cell lines
T12 668-692 cell_type denotes erythrocytic progenitors
T13 806-836 protein denotes thermosensitive SV40 T antigen
T14 932-974 cell_line denotes Ter 119 positive erythroid nucleated cells
T15 986-995 protein denotes T antigen
T16 1066-1112 cell_type denotes erythropoietin-dependent erythroid progenitors
T17 1166-1176 cell_line denotes cell lines
T18 1204-1253 protein denotes erythrocytic (globins) and megakaryocytic markers
T19 1255-1271 protein denotes glycoprotein IIb
T20 1273-1290 protein denotes platelet factor 4
T21 1303-1308 protein denotes Spi-1
T22 1313-1330 protein denotes Fli-1 transcripts
T23 1439-1450 DNA denotes globin gene
T24 1504-1509 protein denotes Spi-1
T25 1511-1516 protein denotes Fli-1
T26 1522-1542 DNA denotes megakaryocytic genes
T27 1549-1563 protein denotes erythropoietin
T28 1620-1641 DNA denotes Spi-1 and Fli-1 genes
T29 1670-1702 cell_line denotes Ter 119 positive cell population
T30 1752-1782 cell_line denotes normal Ter 119 erythroid cells
T31 1790-1812 cell_line denotes Ter 119 positive cells
T32 1865-1876 protein denotes beta-globin
T33 1906-1922 protein denotes glycoprotein IIb
T34 1927-1971 protein denotes platelet factor 4 megakaryocytic transcripts
T35 2043-2063 DNA denotes megakaryocytic genes
T36 2090-2108 cell_line denotes immortalized cells
T37 2165-2189 DNA denotes Spi-1 and/or Fli-1 genes

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-223 Sentence denotes Unexpected and coordinated expression of Spi-1, Fli-1, and megakaryocytic genes in four Epo-dependent cell lines established from transgenic mice displaying erythroid-specific expression of a thermosensitive SV40 T antigen.
S2 224-474 Sentence denotes Most erythroleukemic cell lines established in vitro coexpress erythrocytic and megakaryocytic markers that often are associated with expression of Spi-1 and/or Fli-1 transcription factors known as transactivators of megakaryocyte-specific promoters.
S3 475-693 Sentence denotes In the present study, we examined the possibility of establishing new cell lines keeping strictly erythroid-specific properties in vitro through the targeted and conditional immortalization of erythrocytic progenitors.
S4 694-837 Sentence denotes For that purpose, we established several lines of transgenic mice displaying erythroid-specific expression of a thermosensitive SV40 T antigen.
S5 838-996 Sentence denotes As expected, these transgenic mice developed splenomegaly due to the massive amplification of Ter 119 positive erythroid nucleated cells expressing T antigen.
S6 997-1357 Sentence denotes Despite this drastic effect in vivo, the in vitro immortalization of erythropoietin-dependent erythroid progenitors unexpectedly occurred at low frequency, and all four cell lines established expressed both erythrocytic (globins) and megakaryocytic markers (glycoprotein IIb, platelet factor 4) as well as Spi-1 and Fli-1 transcripts at permissive temperature.
S7 1358-1581 Sentence denotes Switching the cells to the nonpermissive temperature led to a marked increase in globin gene expression and concomitant decrease in expression of Spi-1, Fli-1, and megakaryocytic genes in an erythropoietin-dependent manner.
S8 1582-1737 Sentence denotes Interestingly, enhanced expression of Spi-1 and Fli-1 genes already was detected in the Ter 119 positive cell population of transgenic mice spleen in vivo.
S9 1738-1972 Sentence denotes However, like normal Ter 119 erythroid cells, these Ter 119 positive cells from transgenic mice still expressed high levels of beta-globin and very low or undetectable glycoprotein IIb and platelet factor 4 megakaryocytic transcripts.
S10 1973-2190 Sentence denotes Taken together, these data indicate that the unexpected expression of megakaryocytic genes is a specific property of immortalized cells that cannot be explained only by enhanced expression of Spi-1 and/or Fli-1 genes.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 59-79 NP denotes megakaryocytic genes
C1 41-79 NP denotes Spi-1, Fli-1, and megakaryocytic genes
C3 130-222 NP denotes transgenic mice displaying erythroid-specific expression of a thermosensitive SV40 T antigen
C4 287-326 NP denotes erythrocytic and megakaryocytic markers
C5 327-331 NP denotes that
C6 744-836 NP denotes transgenic mice displaying erythroid-specific expression of a thermosensitive SV40 T antigen
C7 851-872 NP denotes these transgenic mice
C9 1522-1542 NP denotes megakaryocytic genes
C8 1504-1542 NP denotes Spi-1, Fli-1, and megakaryocytic genes
C10 2043-2063 NP denotes megakaryocytic genes
C11 2067-2108 NP denotes a specific property of immortalized cells
C12 2109-2113 NP denotes that
R1 C5 C4 coref-relat that,erythrocytic and megakaryocytic markers
R2 C6 C3 coref-ident transgenic mice displaying erythroid-specific expression of a thermosensitive SV40 T antigen,transgenic mice displaying erythroid-specific expression of a thermosensitive SV40 T antigen
R3 C7 C6 coref-ident these transgenic mice,transgenic mice displaying erythroid-specific expression of a thermosensitive SV40 T antigen
R4 C9 C2 coref-ident megakaryocytic genes,megakaryocytic genes
R5 C8 C1 coref-ident "Spi-1, Fli-1, and megakaryocytic genes","Spi-1, Fli-1, and megakaryocytic genes"
R6 C10 C9 coref-ident megakaryocytic genes,megakaryocytic genes
R7 C12 C11 coref-relat that,a specific property of immortalized cells

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 15-37 other_name denotes coordinated expression
T2 41-46 protein_molecule denotes Spi-1
T3 48-53 protein_molecule denotes Fli-1
T4 59-79 DNA_family_or_group denotes megakaryocytic genes
T5 88-112 cell_line denotes Epo-dependent cell lines
T6 130-145 other_artificial_source denotes transgenic mice
T7 157-186 other_name denotes erythroid-specific expression
T8 192-222 protein_molecule denotes thermosensitive SV40 T antigen
T9 229-255 cell_line denotes erythroleukemic cell lines
T10 372-377 protein_molecule denotes Spi-1
T11 385-390 protein_molecule denotes Fli-1
T12 422-440 protein_family_or_group denotes transactivators of
T13 441-473 DNA_family_or_group denotes megakaryocyte-specific promoters
T14 541-555 cell_line denotes new cell lines
T15 573-602 other_name denotes erythroid-specific properties
T16 668-692 cell_type denotes erythrocytic progenitors
T17 744-759 other_artificial_source denotes transgenic mice
T18 771-800 other_name denotes erythroid-specific expression
T19 806-836 protein_molecule denotes thermosensitive SV40 T antigen
T20 857-872 other_artificial_source denotes transgenic mice
T21 883-895 other_name denotes splenomegaly
T22 907-928 other_name denotes massive amplification
T23 932-974 cell_line denotes Ter 119 positive erythroid nucleated cells
T24 986-995 protein_family_or_group denotes T antigen
T25 1038-1062 other_name denotes in vitro immortalization
T26 1066-1112 cell_type denotes erythropoietin-dependent erythroid progenitors
T27 1166-1176 cell_line denotes cell lines
T28 1255-1271 protein_family_or_group denotes glycoprotein IIb
T29 1273-1290 protein_molecule denotes platelet factor 4
T30 1303-1308 protein_molecule denotes Spi-1
T31 1313-1330 protein_family_or_group denotes Fli-1 transcripts
T32 1334-1356 other_name denotes permissive temperature
T33 1385-1410 other_name denotes nonpermissive temperature
T34 1439-1450 DNA_family_or_group denotes globin gene
T35 1504-1509 protein_molecule denotes Spi-1
T36 1511-1516 protein_molecule denotes Fli-1
T37 1522-1542 DNA_family_or_group denotes megakaryocytic genes
T38 1549-1563 protein_molecule denotes erythropoietin
T39 1597-1616 other_name denotes enhanced expression
T40 1670-1702 cell_line denotes Ter 119 positive cell population
T41 1706-1721 other_artificial_source denotes transgenic mice
T42 1752-1782 cell_line denotes normal Ter 119 erythroid cells
T43 1790-1812 cell_line denotes Ter 119 positive cells
T44 1818-1833 other_artificial_source denotes transgenic mice
T45 1865-1876 protein_molecule denotes beta-globin
T46 1906-1922 protein_family_or_group denotes glycoprotein IIb
T47 1927-1944 protein_molecule denotes platelet factor 4
T48 2043-2063 DNA_family_or_group denotes megakaryocytic genes
T49 2090-2108 cell_line denotes immortalized cells
T50 2142-2161 other_name denotes enhanced expression

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 287-299 HP_0001901 denotes erythrocytic
T2 668-680 HP_0001901 denotes erythrocytic
T3 883-895 HP_0001744 denotes splenomegaly
T4 1204-1216 HP_0001901 denotes erythrocytic