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PMID_GLOBAL

Id Subject Object Predicate Lexical cue
T1 0-120 Sentence denotes SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation.
T2 121-334 Sentence denotes T lymphocytes express several low molecular weight transmembrane adaptor proteins that recruit src homology (SH)2 domain-containing intracellular molecules to the cell membrane via tyrosine-based signaling motifs.
T3 335-443 Sentence denotes We describe here a novel molecule of this group termed SIT (SHP2 interacting transmembrane adaptor protein).
T4 444-528 Sentence denotes SIT is a disulfide-linked homodimeric glycoprotein that is expressed in lymphocytes.
T5 529-728 Sentence denotes After tyrosine phosphorylation by src and possibly syk protein tyrosine kinases SIT recruits the SH2 domain-containing tyrosine phosphatase SHP2 via an immunoreceptor tyrosine-based inhibition motif.
T6 729-1000 Sentence denotes Overexpression of SIT in Jurkat cells downmodulates T cell receptor- and phytohemagglutinin-mediated activation of the nuclear factor of activated T cells (NF-AT) by interfering with signaling processes that are probably located upstream of activation of phospholipase C.
T7 1001-1217 Sentence denotes However, binding of SHP2 to SIT is not required for inhibition of NF-AT induction, suggesting that SIT not only regulates NF-AT activity but also controls NF-AT unrelated pathways of T cell activation involving SHP2.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-46 protein denotes SHP2-interacting transmembrane adaptor protein
T2 48-51 protein denotes SIT
T3 62-84 protein denotes disulfide-linked dimer
T4 121-134 cell_type denotes T lymphocytes
T5 151-202 protein denotes low molecular weight transmembrane adaptor proteins
T6 216-276 protein denotes src homology (SH)2 domain-containing intracellular molecules
T7 390-393 protein denotes SIT
T8 395-441 protein denotes SHP2 interacting transmembrane adaptor protein
T9 444-447 protein denotes SIT
T10 453-494 protein denotes disulfide-linked homodimeric glycoprotein
T11 516-527 cell_type denotes lymphocytes
T12 563-566 protein denotes src
T13 580-583 protein denotes syk
T14 584-608 protein denotes protein tyrosine kinases
T15 609-612 protein denotes SIT
T16 626-668 protein denotes SH2 domain-containing tyrosine phosphatase
T17 669-673 protein denotes SHP2
T18 747-750 protein denotes SIT
T19 754-766 cell_line denotes Jurkat cells
T20 848-883 protein denotes nuclear factor of activated T cells
T21 885-890 protein denotes NF-AT
T22 984-999 protein denotes phospholipase C
T23 1021-1025 protein denotes SHP2
T24 1029-1032 protein denotes SIT
T25 1067-1072 protein denotes NF-AT
T26 1100-1103 protein denotes SIT
T27 1123-1128 protein denotes NF-AT
T28 1156-1161 protein denotes NF-AT
T29 1212-1216 protein denotes SHP2

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-120 Sentence denotes SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation.
S2 121-334 Sentence denotes T lymphocytes express several low molecular weight transmembrane adaptor proteins that recruit src homology (SH)2 domain-containing intracellular molecules to the cell membrane via tyrosine-based signaling motifs.
S3 335-443 Sentence denotes We describe here a novel molecule of this group termed SIT (SHP2 interacting transmembrane adaptor protein).
S4 444-528 Sentence denotes SIT is a disulfide-linked homodimeric glycoprotein that is expressed in lymphocytes.
S5 529-728 Sentence denotes After tyrosine phosphorylation by src and possibly syk protein tyrosine kinases SIT recruits the SH2 domain-containing tyrosine phosphatase SHP2 via an immunoreceptor tyrosine-based inhibition motif.
S6 729-1000 Sentence denotes Overexpression of SIT in Jurkat cells downmodulates T cell receptor- and phytohemagglutinin-mediated activation of the nuclear factor of activated T cells (NF-AT) by interfering with signaling processes that are probably located upstream of activation of phospholipase C.
S7 1001-1217 Sentence denotes However, binding of SHP2 to SIT is not required for inhibition of NF-AT induction, suggesting that SIT not only regulates NF-AT activity but also controls NF-AT unrelated pathways of T cell activation involving SHP2.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-52 NP denotes SHP2-interacting transmembrane adaptor protein (SIT)
C3 96-119 NP denotes human T cell activation
C2 54-119 NP denotes a novel disulfide-linked dimer regulating human T cell activation
C5 143-202 NP denotes several low molecular weight transmembrane adaptor proteins
C6 203-207 NP denotes that
C4 143-333 NP denotes several low molecular weight transmembrane adaptor proteins that recruit src homology (SH)2 domain-containing intracellular molecules to the cell membrane via tyrosine-based signaling motifs
C8 372-382 NP denotes this group
C7 352-382 NP denotes a novel molecule of this group
C9 390-442 NP denotes SIT (SHP2 interacting transmembrane adaptor protein)
C10 444-447 NP denotes SIT
C11 451-494 NP denotes a disulfide-linked homodimeric glycoprotein
C12 495-499 NP denotes that
C13 609-612 NP denotes SIT
C14 622-673 NP denotes the SH2 domain-containing tyrosine phosphatase SHP2
C15 747-750 NP denotes SIT
C16 912-931 NP denotes signaling processes
C17 932-936 NP denotes that
C18 1021-1025 NP denotes SHP2
C19 1029-1032 NP denotes SIT
C20 1100-1103 NP denotes SIT
C21 1184-1201 NP denotes T cell activation
C22 1212-1216 NP denotes SHP2
R1 C2 C1 coref-appos a novel disulfide-linked dimer regulating human T cell activation,SHP2-interacting transmembrane adaptor protein (SIT)
R2 C6 C5 coref-relat that,several low molecular weight transmembrane adaptor proteins
R3 C8 C4 coref-ident this group,several low molecular weight transmembrane adaptor proteins that recruit src homology (SH)2 domain-containing intracellular molecules to the cell membrane via tyrosine-based signaling motifs
R4 C7 C1 coref-ident a novel molecule of this group,SHP2-interacting transmembrane adaptor protein (SIT)
R5 C9 C7 coref-ident SIT (SHP2 interacting transmembrane adaptor protein),a novel molecule of this group
R6 C10 C9 coref-ident SIT,SIT (SHP2 interacting transmembrane adaptor protein)
R7 C12 C11 coref-relat that,a disulfide-linked homodimeric glycoprotein
R8 C13 C10 coref-ident SIT,SIT
R9 C15 C13 coref-ident SIT,SIT
R10 C17 C16 coref-relat that,signaling processes
R11 C18 C14 coref-ident SHP2,the SH2 domain-containing tyrosine phosphatase SHP2
R12 C19 C15 coref-ident SIT,SIT
R13 C20 C19 coref-ident SIT,SIT
R14 C21 C3 coref-ident T cell activation,human T cell activation
R15 C22 C18 coref-ident SHP2,SHP2

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-46 protein_molecule denotes SHP2-interacting transmembrane adaptor protein
T2 48-51 protein_molecule denotes SIT
T3 62-84 protein_complex denotes disulfide-linked dimer
T4 96-119 other_name denotes human T cell activation
T5 121-134 cell_type denotes T lymphocytes
T6 151-202 protein_family_or_group denotes low molecular weight transmembrane adaptor proteins
T7 216-241 protein_domain_or_region denotes src homology (SH)2 domain
T8 390-393 protein_molecule denotes SIT
T9 395-441 protein_molecule denotes SHP2 interacting transmembrane adaptor protein
T10 444-447 protein_molecule denotes SIT
T11 453-494 protein_molecule denotes disulfide-linked homodimeric glycoprotein
T12 516-527 cell_type denotes lymphocytes
T13 535-559 other_name denotes tyrosine phosphorylation
T14 563-566 protein_molecule denotes src
T15 580-583 protein_molecule denotes syk
T16 584-608 protein_family_or_group denotes protein tyrosine kinases
T17 609-612 protein_molecule denotes SIT
T18 626-636 protein_domain_or_region denotes SH2 domain
T19 669-673 protein_molecule denotes SHP2
T20 747-750 protein_molecule denotes SIT
T21 754-766 cell_line denotes Jurkat cells
T22 848-875 protein_molecule denotes nuclear factor of activated
T23 876-883 cell_type denotes T cells
T24 885-890 protein_molecule denotes NF-AT
T25 984-999 protein_molecule denotes phospholipase C
T26 1021-1025 protein_molecule denotes SHP2
T27 1029-1032 protein_molecule denotes SIT
T28 1067-1072 protein_molecule denotes NF-AT
T29 1100-1103 protein_molecule denotes SIT
T30 1123-1128 protein_molecule denotes NF-AT
T31 1156-1161 protein_molecule denotes NF-AT
T32 1184-1201 other_name denotes T cell activation
T33 1212-1216 protein_molecule denotes SHP2

bionlp-st-gro-2013-training

Id Subject Object Predicate Lexical cue
T2 48-51 Protein denotes SIT
T4 96-101 Eukaryote denotes human
T5 102-108 Cell denotes T cell
T7 121-134 Cell denotes T lymphocytes
T9 172-202 Protein denotes transmembrane adaptor proteins
T12 267-276 MolecularEntity denotes molecules
T13 284-297 CellComponent denotes cell membrane
T15 327-333 ProteinDomain denotes motifs
T16 390-393 Protein denotes SIT
T18 444-447 Protein denotes SIT
T21 516-527 Cell denotes lymphocytes
T22 535-543 AminoAcid denotes tyrosine
T24 563-566 Protein denotes src
T28 609-612 Protein denotes SIT
T33 669-673 Enzyme denotes SHP2
T34 696-704 AminoAcid denotes tyrosine
T35 711-727 ProteinDomain denotes inhibition motif
T37 747-750 Protein denotes SIT
T38 754-766 Cell denotes Jurkat cells
T40 781-787 Cell denotes T cell
T41 788-796 Protein denotes receptor
T42 802-820 Protein denotes phytohemagglutinin
T46 885-890 Protein denotes NF-AT
T50 984-999 Enzyme denotes phospholipase C
T52 1021-1025 Protein denotes SHP2
T53 1029-1032 Protein denotes SIT
T55 1067-1072 Protein denotes NF-AT
T57 1100-1103 Protein denotes SIT
T59 1123-1128 Protein denotes NF-AT
T61 1156-1161 Protein denotes NF-AT
T63 1184-1190 Cell denotes T cell
T65 1212-1216 Protein denotes SHP2
T11 229-241 ProteinDomain denotes (SH)2 domain
T66 482-494 Protein denotes glycoprotein
T25 580-608 Enzyme denotes syk protein tyrosine kinases
T26 626-668 Enzyme denotes SH2 domain-containing tyrosine phosphatase
T27 681-695 Protein denotes immunoreceptor
E1 85-95 RegulatoryProcess denotes regulating
E2 109-119 PositiveRegulation denotes activation
E3 135-142 GeneExpression denotes express
E4 208-215 Localization denotes recruit
E5 503-512 GeneExpression denotes expressed
E6 544-559 Phosphorylation denotes phosphorylation
E7 613-621 Localization denotes recruits
E9 729-743 PositiveRegulationOfGeneExpression denotes Overexpression
E10 767-780 Decrease denotes downmodulates
E11 821-829 RegulatoryProcess denotes mediated
E12 830-840 PositiveRegulation denotes activation
E13 895-906 Affecting denotes interfering
E14 912-931 SignalingPathway denotes signaling processes
E15 970-980 PositiveRegulation denotes activation
E16 1010-1017 BindingToProtein denotes binding
E17 1053-1063 NegativeRegulation denotes inhibition
E18 1073-1082 Increase denotes induction
E19 1113-1122 RegulatoryProcess denotes regulates
E20 1147-1155 RegulatoryProcess denotes controls
E21 1172-1180 SignalingPathway denotes pathways
E22 1191-1201 PositiveRegulation denotes activation
E23 302-326 SignalingPathway denotes tyrosine-based signaling
E24 470-481 Homodimerization denotes homodimeric
E8 821-829 RegulatoryProcess denotes mediated
R1 T5 T4 fromSpecies T cell,human
R2 E3 T7 locatedIn express,T lymphocytes
R4 E5 T21 locatedIn expressed,lymphocytes
R7 E9 T38 locatedIn Overexpression,Jurkat cells
R8 T41 T40 locatedIn receptor,T cell
R10 E14 E15 precedes signaling processes,activation
R3 T12 T11 hasPart molecules,(SH)2 domain
R5 T2 E1 hasAgent SIT,regulating
R6 E2 E1 hasPatient activation,regulating
R7 T5 E2 hasPatient T cell,activation
R8 T9 E3 hasPatient transmembrane adaptor proteins,express
R9 T9 E4 hasAgent transmembrane adaptor proteins,recruit
R10 T12 E4 hasPatient molecules,recruit
R11 T18 E5 hasPatient SIT,expressed
R12 T24 E6 hasAgent src,phosphorylation
R13 T22 E6 hasPatient tyrosine,phosphorylation
R14 T28 E7 hasAgent SIT,recruits
R15 T26 E7 hasPatient SH2 domain-containing tyrosine phosphatase,recruits
R16 T37 E9 hasPatient SIT,Overexpression
R17 E9 E10 hasAgent Overexpression,downmodulates
R18 E12 E10 hasPatient activation,downmodulates
R19 T41 E11 hasAgent receptor,mediated
R20 E12 E11 hasPatient activation,mediated
R21 T46 E12 hasPatient NF-AT,activation
R22 E14 E13 hasAgent signaling processes,interfering
R23 T50 E15 hasPatient phospholipase C,activation
R24 T53 E16 hasPatient SIT,binding
R25 T52 E16 hasPatient SHP2,binding
R26 E18 E17 hasPatient induction,inhibition
R27 T55 E18 hasPatient NF-AT,induction
R28 T57 E19 hasAgent SIT,regulates
R29 T59 E19 hasPatient NF-AT,regulates
R30 T57 E20 hasAgent SIT,controls
R31 E21 E20 hasPatient pathways,controls
R32 T63 E22 hasPatient T cell,activation
R33 T66 E24 hasPatient glycoprotein,homodimeric
R34 T42 E8 hasAgent phytohemagglutinin,mediated
R35 E12 E8 hasPatient activation,mediated