PubMed:10208461
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-5 | protein | denotes | Bcl-6 |
| T2 | 166-189 | cell_type | denotes | intrafollicular T-cells |
| T3 | 296-314 | protein | denotes | Bcl-6 gene product |
| T4 | 318-340 | protein | denotes | nuclear phosphoprotein |
| T5 | 372-377 | protein | denotes | Bcl-6 |
| T6 | 428-433 | protein | denotes | Bcl-6 |
| T7 | 459-487 | cell_type | denotes | germinal center (GC) B-cells |
| T8 | 506-538 | cell_type | denotes | CD3/CD4+ intrafollicular T cells |
| T9 | 579-592 | protein | denotes | Bcl-6 protein |
| T10 | 610-627 | cell_type | denotes | CD3+/CD4+ T cells |
| T11 | 847-855 | cell_type | denotes | GC cells |
| T12 | 943-948 | protein | denotes | Bcl-6 |
| T13 | 1132-1137 | protein | denotes | Bcl-6 |
| T14 | 1336-1346 | protein | denotes | Bcl-6/CD20 |
| T15 | 1348-1357 | protein | denotes | Bcl-6/CD3 |
| T16 | 1363-1373 | protein | denotes | Bcl-6/CD57 |
| T17 | 1455-1460 | protein | denotes | Bcl-6 |
| T18 | 1542-1554 | cell_type | denotes | Bcl-6+ cells |
| T19 | 1844-1856 | cell_type | denotes | Bcl-6+ cells |
| T20 | 1981-2009 | cell_type | denotes | interfollicular Bcl-6+ cells |
| T21 | 2070-2098 | cell_type | denotes | interfollicular Bcl-6+ cells |
| T22 | 2115-2145 | cell_type | denotes | Bcl6+/CD3+/CD20-/CD57- T cells |
| T23 | 2157-2185 | cell_type | denotes | CD3+ intrafollicular T cells |
| T24 | 2262-2273 | cell_type | denotes | CD57+ cells |
| T25 | 2292-2297 | protein | denotes | Bcl-6 |
| T26 | 2391-2396 | protein | denotes | Bcl-6 |
| T27 | 2573-2578 | protein | denotes | Bcl-6 |
| T28 | 2611-2639 | cell_type | denotes | Intrafollicular CD3+ T cells |
| T29 | 2678-2683 | protein | denotes | Bcl-6 |
| T30 | 2751-2768 | cell_type | denotes | Bcl-6+/CD3+ cells |
| T31 | 2805-2828 | cell_type | denotes | intrafollicular T cells |
| T32 | 2852-2885 | cell_type | denotes | Interfollicular Bcl-6+/CD3+ cells |
| T33 | 2991-3018 | cell_type | denotes | Intrafollicular CD57+ cells |
| T34 | 3037-3042 | protein | denotes | Bcl-6 |
| T35 | 3076-3109 | cell_type | denotes | intrafollicular T-cell population |
| T36 | 3157-3162 | protein | denotes | Bcl-6 |
| T37 | 3192-3197 | protein | denotes | Bcl-6 |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-279 | Sentence | denotes | Bcl-6 expression in reactive follicular hyperplasia, follicular lymphoma, and angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers: heterogeneity of intrafollicular T-cells and their altered distribution in the pathogenesis of angioimmunoblastic T-cell lymphoma. |
| S2 | 280-397 | Sentence | denotes | BACKGROUND: The Bcl-6 gene product, a nuclear phosphoprotein, is expressed independently of Bcl-6 gene rearrangement. |
| S3 | 398-539 | Sentence | denotes | In lymph nodes, expression of Bcl-6 protein is restricted to germinal center (GC) B-cells and 10% to 15% of CD3/CD4+ intrafollicular T cells. |
| S4 | 540-628 | Sentence | denotes | Interfollicular cells are negative for Bcl-6 protein, except for rare CD3+/CD4+ T cells. |
| S5 | 629-893 | Sentence | denotes | Recently, we reported cases of angioimmunoblastic T-cell lymphoma (AITL) with hyperplastic GCs (AITL/GC), and observed that borders of enlarged GCs were ill defined, with features suggestive of an outward migration of GC cells to surrounding interfollicular zones. |
| S6 | 894-1043 | Sentence | denotes | This prompted a study of follicular borders with Bcl-6 staining in reactive follicular hyperplasias and follicular lymphomas to compare with AITL/GC. |
| S7 | 1044-1138 | Sentence | denotes | MATERIALS AND METHODS: Formalin-fixed paraffin sections were used for immunostaining of Bcl-6. |
| S8 | 1139-1315 | Sentence | denotes | Six cases of AITL/GC, 12 nonspecific reactive follicular hyperplasia (FH), 7 HIV adenopathy, 10 follicular lymphoma (FL), and 8 typical AITL (ie, AITL without GC) were studied. |
| S9 | 1316-1406 | Sentence | denotes | Double staining for Bcl-6/CD20, Bcl-6/CD3, and Bcl-6/CD57 was performed in selected cases. |
| S10 | 1407-1594 | Sentence | denotes | RESULTS: In FH and HIV adenopathy, staining for Bcl-6 revealed densely populated GCs with well-defined and regular GC borders, whereas Bcl-6+ cells were rare in the interfollicular areas. |
| S11 | 1595-1758 | Sentence | denotes | An occasional GC with an ill-defined border was invariably surrounded by a broad mantle zone; those with indistinct mantle zones had well-defined, regular borders. |
| S12 | 1759-1886 | Sentence | denotes | In FL, follicles were densely populated, and their borders were irregular, with some Bcl-6+ cells in the interfollicular zones. |
| S13 | 1887-2033 | Sentence | denotes | In AITL/GC, GCs were less dense, GC borders were ill defined and irregular, and the number of interfollicular Bcl-6+ cells was markedly increased. |
| S14 | 2034-2146 | Sentence | denotes | Double staining revealed that these interfollicular Bcl-6+ cells in AITL/GC were Bcl6+/CD3+/CD20-/CD57- T cells. |
| S15 | 2147-2245 | Sentence | denotes | Moreover, CD3+ intrafollicular T cells were depleted in AITL/GC, whereas they were abundant in FH. |
| S16 | 2246-2333 | Sentence | denotes | Intrafollicular CD57+ cells did not stain for Bcl-6, and were also depleted in AITL/GC. |
| S17 | 2334-2435 | Sentence | denotes | In typical AITL, some neoplastic cells were positive for Bcl-6, showing variable degrees of staining. |
| S18 | 2436-2606 | Sentence | denotes | CONCLUSIONS: (1) GCs of AITL/GC differed from those of other reactive follicular hyperplasias and follicular lymphomas, and staining for Bcl-6 was useful to discern them. |
| S19 | 2607-2847 | Sentence | denotes | (2) Intrafollicular CD3+ T cells, many of which were also positive for Bcl-6, were markedly depleted in AITL/GC, with increased interfollicular Bcl-6+/CD3+ cells, suggesting an outward migration of intrafollicular T cells in this condition. |
| S20 | 2848-2986 | Sentence | denotes | (3) Interfollicular Bcl-6+/CD3+ cells in AITL/GC were too numerous to be accounted for by migration alone, suggesting local proliferation. |
| S21 | 2987-3110 | Sentence | denotes | (4) Intrafollicular CD57+ cells were negative for Bcl-6, indicating heterogeneity of the intrafollicular T-cell population. |
| S22 | 3111-3223 | Sentence | denotes | (5) Some neoplastic cells in AITL stained for Bcl-6, suggesting up-regulation of Bcl-6 expression in this tumor. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 20-51 | NP | denotes | reactive follicular hyperplasia |
| C2 | 53-72 | NP | denotes | follicular lymphoma |
| C3 | 78-147 | NP | denotes | angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers |
| C4 | 166-189 | NP | denotes | intrafollicular T-cells |
| C5 | 194-199 | NP | denotes | their |
| C6 | 244-278 | NP | denotes | angioimmunoblastic T-cell lymphoma |
| C7 | 292-314 | NP | denotes | The Bcl-6 gene product |
| C8 | 316-340 | NP | denotes | a nuclear phosphoprotein |
| C9 | 428-441 | NP | denotes | Bcl-6 protein |
| C10 | 579-592 | NP | denotes | Bcl-6 protein |
| C11 | 660-733 | NP | denotes | angioimmunoblastic T-cell lymphoma (AITL) with hyperplastic GCs (AITL/GC) |
| C12 | 961-993 | NP | denotes | reactive follicular hyperplasias |
| C13 | 998-1018 | NP | denotes | follicular lymphomas |
| C14 | 1035-1042 | NP | denotes | AITL/GC |
| C15 | 1132-1137 | NP | denotes | Bcl-6 |
| C16 | 1152-1159 | NP | denotes | AITL/GC |
| C17 | 1419-1421 | NP | denotes | FH |
| C19 | 1455-1460 | NP | denotes | Bcl-6 |
| C18 | 1442-1460 | NP | denotes | staining for Bcl-6 |
| C20 | 1568-1593 | NP | denotes | the interfollicular areas |
| C21 | 1766-1775 | NP | denotes | follicles |
| C22 | 1804-1809 | NP | denotes | their |
| C23 | 1860-1885 | NP | denotes | the interfollicular zones |
| C24 | 1890-1897 | NP | denotes | AITL/GC |
| C25 | 2102-2109 | NP | denotes | AITL/GC |
| C26 | 2157-2185 | NP | denotes | CD3+ intrafollicular T cells |
| C27 | 2203-2210 | NP | denotes | AITL/GC |
| C28 | 2220-2224 | NP | denotes | they |
| C29 | 2242-2244 | NP | denotes | FH |
| C30 | 2246-2273 | NP | denotes | Intrafollicular CD57+ cells |
| C31 | 2292-2297 | NP | denotes | Bcl-6 |
| C32 | 2325-2332 | NP | denotes | AITL/GC |
| C33 | 2391-2396 | NP | denotes | Bcl-6 |
| C34 | 2453-2456 | NP | denotes | GCs |
| C35 | 2460-2467 | NP | denotes | AITL/GC |
| C36 | 2482-2487 | NP | denotes | those |
| C38 | 2573-2578 | NP | denotes | Bcl-6 |
| C37 | 2560-2578 | NP | denotes | staining for Bcl-6 |
| C39 | 2611-2639 | NP | denotes | Intrafollicular CD3+ T cells |
| C40 | 2649-2654 | NP | denotes | which |
| C41 | 2678-2683 | NP | denotes | Bcl-6 |
| C42 | 2711-2718 | NP | denotes | AITL/GC |
| C43 | 2805-2828 | NP | denotes | intrafollicular T cells |
| C44 | 2889-2896 | NP | denotes | AITL/GC |
| C45 | 2991-3018 | NP | denotes | Intrafollicular CD57+ cells |
| C46 | 3037-3042 | NP | denotes | Bcl-6 |
| C47 | 3140-3144 | NP | denotes | AITL |
| C48 | 3157-3162 | NP | denotes | Bcl-6 |
| R1 | C5 | C4 | coref-pron | their,intrafollicular T-cells |
| R2 | C8 | C7 | coref-appos | a nuclear phosphoprotein,The Bcl-6 gene product |
| R3 | C10 | C9 | coref-ident | Bcl-6 protein,Bcl-6 protein |
| R4 | C11 | C3 | coref-ident | angioimmunoblastic T-cell lymphoma (AITL) with hyperplastic GCs (AITL/GC),angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers |
| R5 | C12 | C1 | coref-ident | reactive follicular hyperplasias,reactive follicular hyperplasia |
| R6 | C13 | C2 | coref-ident | follicular lymphomas,follicular lymphoma |
| R7 | C14 | C11 | coref-ident | AITL/GC,angioimmunoblastic T-cell lymphoma (AITL) with hyperplastic GCs (AITL/GC) |
| R8 | C15 | C10 | coref-ident | Bcl-6,Bcl-6 protein |
| R9 | C16 | C14 | coref-ident | AITL/GC,AITL/GC |
| R10 | C19 | C15 | coref-ident | Bcl-6,Bcl-6 |
| R11 | C22 | C21 | coref-pron | their,follicles |
| R12 | C23 | C20 | coref-ident | the interfollicular zones,the interfollicular areas |
| R13 | C24 | C16 | coref-ident | AITL/GC,AITL/GC |
| R14 | C25 | C24 | coref-ident | AITL/GC,AITL/GC |
| R15 | C27 | C25 | coref-ident | AITL/GC,AITL/GC |
| R16 | C28 | C26 | coref-pron | they,CD3+ intrafollicular T cells |
| R17 | C29 | C17 | coref-ident | FH,FH |
| R18 | C31 | C19 | coref-ident | Bcl-6,Bcl-6 |
| R19 | C32 | C27 | coref-ident | AITL/GC,AITL/GC |
| R20 | C33 | C31 | coref-ident | Bcl-6,Bcl-6 |
| R21 | C35 | C32 | coref-ident | AITL/GC,AITL/GC |
| R22 | C36 | C34 | coref-pron | those,GCs |
| R23 | C38 | C33 | coref-ident | Bcl-6,Bcl-6 |
| R24 | C37 | C18 | coref-ident | staining for Bcl-6,staining for Bcl-6 |
| R25 | C39 | C26 | coref-ident | Intrafollicular CD3+ T cells,CD3+ intrafollicular T cells |
| R26 | C40 | C39 | coref-pron | which,Intrafollicular CD3+ T cells |
| R27 | C41 | C38 | coref-ident | Bcl-6,Bcl-6 |
| R28 | C42 | C35 | coref-ident | AITL/GC,AITL/GC |
| R29 | C43 | C4 | coref-ident | intrafollicular T cells,intrafollicular T-cells |
| R30 | C44 | C42 | coref-ident | AITL/GC,AITL/GC |
| R31 | C45 | C30 | coref-ident | Intrafollicular CD57+ cells,Intrafollicular CD57+ cells |
| R32 | C46 | C41 | coref-ident | Bcl-6,Bcl-6 |
| R33 | C47 | C6 | coref-ident | AITL,angioimmunoblastic T-cell lymphoma |
| R34 | C48 | C46 | coref-ident | Bcl-6,Bcl-6 |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-5 | protein_molecule | denotes | Bcl-6 |
| T2 | 29-51 | other_name | denotes | follicular hyperplasia |
| T3 | 53-72 | other_name | denotes | follicular lymphoma |
| T4 | 78-112 | other_name | denotes | angioimmunoblastic T-cell lymphoma |
| T5 | 118-147 | tissue | denotes | hyperplastic germinal centers |
| T6 | 166-189 | cell_type | denotes | intrafollicular T-cells |
| T7 | 244-278 | other_name | denotes | angioimmunoblastic T-cell lymphoma |
| T8 | 296-301 | protein_molecule | denotes | Bcl-6 |
| T9 | 318-340 | protein_family_or_group | denotes | nuclear phosphoprotein |
| T10 | 372-377 | protein_molecule | denotes | Bcl-6 |
| T11 | 401-412 | body_part | denotes | lymph nodes |
| T12 | 428-433 | protein_molecule | denotes | Bcl-6 |
| T13 | 459-487 | cell_type | denotes | germinal center (GC) B-cells |
| T14 | 506-538 | cell_type | denotes | CD3/CD4+ intrafollicular T cells |
| T15 | 579-584 | protein_molecule | denotes | Bcl-6 |
| T16 | 610-627 | cell_type | denotes | CD3+/CD4+ T cells |
| T17 | 660-694 | other_name | denotes | angioimmunoblastic T-cell lymphoma |
| T18 | 696-700 | other_name | denotes | AITL |
| T19 | 707-723 | tissue | denotes | hyperplastic GCs |
| T20 | 725-732 | other_name | denotes | AITL/GC |
| T21 | 764-776 | tissue | denotes | enlarged GCs |
| T22 | 847-855 | cell_type | denotes | GC cells |
| T23 | 871-892 | tissue | denotes | interfollicular zones |
| T24 | 919-937 | tissue | denotes | follicular borders |
| T25 | 943-948 | protein_molecule | denotes | Bcl-6 |
| T26 | 970-993 | other_name | denotes | follicular hyperplasias |
| T27 | 998-1018 | other_name | denotes | follicular lymphomas |
| T28 | 1035-1039 | other_name | denotes | AITL |
| T29 | 1067-1099 | other_organic_compound | denotes | Formalin-fixed paraffin sections |
| T30 | 1114-1128 | other_name | denotes | immunostaining |
| T31 | 1132-1137 | protein_molecule | denotes | Bcl-6 |
| T32 | 1152-1159 | other_name | denotes | AITL/GC |
| T33 | 1185-1207 | other_name | denotes | follicular hyperplasia |
| T34 | 1209-1211 | other_name | denotes | FH |
| T35 | 1216-1230 | other_name | denotes | HIV adenopathy |
| T36 | 1235-1254 | other_name | denotes | follicular lymphoma |
| T37 | 1275-1279 | other_name | denotes | AITL |
| T38 | 1285-1289 | other_name | denotes | AITL |
| T39 | 1298-1300 | tissue | denotes | GC |
| T40 | 1336-1341 | protein_molecule | denotes | Bcl-6 |
| T41 | 1348-1353 | protein_molecule | denotes | Bcl-6 |
| T42 | 1363-1368 | protein_molecule | denotes | Bcl-6 |
| T43 | 1419-1421 | other_name | denotes | FH |
| T44 | 1426-1440 | other_name | denotes | HIV adenopathy |
| T45 | 1455-1460 | protein_molecule | denotes | Bcl-6 |
| T46 | 1488-1491 | tissue | denotes | GCs |
| T47 | 1522-1532 | tissue | denotes | GC borders |
| T48 | 1542-1547 | protein_molecule | denotes | Bcl-6 |
| T49 | 1572-1593 | tissue | denotes | interfollicular areas |
| T50 | 1609-1611 | tissue | denotes | GC |
| T51 | 1700-1723 | tissue | denotes | indistinct mantle zones |
| T52 | 1844-1849 | protein_molecule | denotes | Bcl-6 |
| T53 | 1864-1885 | tissue | denotes | interfollicular zones |
| T54 | 1890-1894 | other_name | denotes | AITL |
| T55 | 1899-1902 | tissue | denotes | GCs |
| T56 | 1920-1930 | tissue | denotes | GC borders |
| T57 | 1981-1996 | cell_type | denotes | interfollicular |
| T58 | 1997-2002 | protein_molecule | denotes | Bcl-6 |
| T59 | 2070-2085 | cell_type | denotes | interfollicular |
| T60 | 2086-2091 | protein_molecule | denotes | Bcl-6 |
| T61 | 2102-2106 | other_name | denotes | AITL |
| T62 | 2115-2145 | cell_type | denotes | Bcl6+/CD3+/CD20-/CD57- T cells |
| T63 | 2157-2185 | cell_type | denotes | CD3+ intrafollicular T cells |
| T64 | 2203-2207 | other_name | denotes | AITL |
| T65 | 2242-2244 | other_name | denotes | FH |
| T66 | 2262-2273 | cell_type | denotes | CD57+ cells |
| T67 | 2292-2297 | protein_molecule | denotes | Bcl-6 |
| T68 | 2325-2329 | other_name | denotes | AITL |
| T69 | 2345-2349 | other_name | denotes | AITL |
| T70 | 2391-2396 | protein_molecule | denotes | Bcl-6 |
| T71 | 2453-2456 | tissue | denotes | GCs |
| T72 | 2460-2467 | other_name | denotes | AITL/GC |
| T73 | 2506-2529 | other_name | denotes | follicular hyperplasias |
| T74 | 2534-2554 | other_name | denotes | follicular lymphomas |
| T75 | 2573-2578 | protein_molecule | denotes | Bcl-6 |
| T76 | 2611-2639 | cell_type | denotes | Intrafollicular CD3+ T cells |
| T77 | 2678-2683 | protein_molecule | denotes | Bcl-6 |
| T78 | 2711-2715 | other_name | denotes | AITL |
| T79 | 2751-2756 | protein_molecule | denotes | Bcl-6 |
| T80 | 2805-2828 | cell_type | denotes | intrafollicular T cells |
| T81 | 2852-2867 | cell_type | denotes | Interfollicular |
| T82 | 2868-2873 | protein_molecule | denotes | Bcl-6 |
| T83 | 2889-2896 | other_name | denotes | AITL/GC |
| T84 | 2991-3018 | cell_type | denotes | Intrafollicular CD57+ cells |
| T85 | 3037-3042 | protein_molecule | denotes | Bcl-6 |
| T86 | 3076-3109 | cell_type | denotes | intrafollicular T-cell population |
| T87 | 3140-3144 | other_name | denotes | AITL |
| T88 | 3157-3162 | protein_molecule | denotes | Bcl-6 |
| T89 | 3192-3197 | protein_molecule | denotes | Bcl-6 |
| T90 | 3217-3222 | tissue | denotes | tumor |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T4 | 1009-1018 | HP_0002665 | denotes | lymphomas |
| T3 | 970-993 | HP_0002729 | denotes | follicular hyperplasias |
| T2 | 686-694 | HP_0002665 | denotes | lymphoma |
| T1 | 679-694 | HP_0012190 | denotes | T-cell lymphoma |