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PubMed:10207061 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 235-237 DiseaseOrPhenotypicFeature denotes RA 0005272|0008383
T3 412-414 DiseaseOrPhenotypicFeature denotes RA 0005272|0008383
T5 847-849 DiseaseOrPhenotypicFeature denotes RA 0005272|0008383
T7 1187-1189 DiseaseOrPhenotypicFeature denotes RA 0005272|0008383
T9 2014-2016 DiseaseOrPhenotypicFeature denotes RA 0005272|0008383

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-19 protein denotes Retinoid X receptor
T2 21-24 protein denotes RXR
T3 74-77 protein denotes RXR
T4 260-263 protein denotes RAR
T5 268-311 protein denotes retinoid X receptor (RXR) nuclear receptors
T6 340-360 DNA denotes DNA target sequences
T7 364-376 protein denotes heterodimers
T8 378-385 protein denotes RXR-RAR
T9 390-400 protein denotes homodimers
T10 402-409 protein denotes RXR-RXR
T11 522-556 protein denotes COOH-terminally truncated RARalpha
T12 596-607 protein denotes RARalpha403
T13 649-697 cell_line denotes hematopoietic growth factor-dependent cell lines
T14 961-979 cell_type denotes MPRO promyelocytes
T15 999-1012 protein denotes interleukin-3
T16 1014-1018 protein denotes IL-3
T17 1042-1051 cell_type denotes EML cells
T18 1123-1126 protein denotes RXR
T19 1132-1135 protein denotes RAR
T20 1238-1256 protein denotes truncated RARalpha
T21 1340-1343 protein denotes RXR
T22 1369-1372 protein denotes RAR
T23 1440-1458 cell_type denotes MPRO promyelocytes
T24 1518-1539 DNA denotes DNA response elements
T25 1557-1577 protein denotes RAR-RXR heterodimers
T26 1590-1608 protein denotes RXR-RXR homodimers
T27 1615-1618 protein denotes RXR
T28 1650-1653 protein denotes RAR
T29 1736-1763 protein denotes RXR-RARalpha403 heterodimer
T30 1812-1821 cell_type denotes EML cells
T31 1844-1847 protein denotes RXR
T32 1900-1904 protein denotes IL-3
T33 1928-1937 cell_type denotes EML cells
T34 1945-1964 cell_type denotes granulocyte lineage
T35 1987-2012 DNA denotes RAR-RXR response elements
T36 2034-2042 protein denotes RARalpha
T37 2105-2114 cell_type denotes EML cells
T38 2159-2170 protein denotes coactivator
T39 2194-2230 protein denotes histone deacetylase (HDAC) inhibitor
T40 2267-2293 DNA denotes RXR-RAR reporter construct
T41 2313-2322 cell_type denotes EML cells
T42 2348-2366 cell_type denotes MPRO promyelocytes
T43 2399-2434 protein denotes HDAC-containing repressor complexes
T44 2477-2499 cell_type denotes hematopoietic lineages
T45 2553-2581 protein denotes RXR-RARalpha403 heterodimers

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-183 Sentence denotes Retinoid X receptor (RXR) agonist-induced activation of dominant-negative RXR-retinoic acid receptor alpha403 heterodimers is developmentally regulated during myeloid differentiation.
S2 184-411 Sentence denotes The multiple biologic activities of retinoic acid (RA) are mediated through RAR and retinoid X receptor (RXR) nuclear receptors that interact with specific DNA target sequences as heterodimers (RXR-RAR) or homodimers (RXR-RXR).
S3 412-781 Sentence denotes RA receptor activation appears critical to regulating important aspects of hematopoiesis, since transducing a COOH-terminally truncated RARalpha exhibiting dominant-negative activity (RARalpha403) into normal mouse bone marrow generates hematopoietic growth factor-dependent cell lines frozen at the multipotent progenitor (EML) or committed promyelocyte (MPRO) stages.
S4 782-1088 Sentence denotes Nevertheless, relatively high, pharmacological concentrations of RA (1 to 10 microM) overcome these differentiation blocks and induce terminal granulocytic differentiation of the MPRO promyelocytes while potentiating interleukin-3 (IL-3)-induced commitment of EML cells to the granulocyte/monocyte lineage.
S5 1089-1305 Sentence denotes In the present study, we utilized RXR- and RAR-specific agonists and antagonists to determine how RA overcomes the dominant-negative activity of the truncated RARalpha in these different myeloid developmental stages.
S6 1306-1609 Sentence denotes Unexpectedly, we observed that an RXR-specific, rather than an RAR-specific, agonist induces terminal granulocytic differentiation of MPRO promyelocytes, and this differentiation is associated with activation of DNA response elements corresponding to RAR-RXR heterodimers rather than RXR-RXR homodimers.
S7 1610-1764 Sentence denotes This RXR agonist activity is blocked by RAR-specific antagonists, suggesting extensive cross-talk between the partners of the RXR-RARalpha403 heterodimer.
S8 1765-2013 Sentence denotes In contrast, in the more immature, multipotent EML cells we observed that this RXR-specific agonist is inactive either in potentiating IL-3-mediated commitment of EML cells to the granulocyte lineage or in transactivating RAR-RXR response elements.
S9 2014-2180 Sentence denotes RA-triggered GALdbd-RARalpha hybrid activity in these cells indicates that the multipotent EML cells harbor substantial nuclear hormone receptor coactivator activity.
S10 2181-2648 Sentence denotes However, the histone deacetylase (HDAC) inhibitor trichostatin A readily activates an RXR-RAR reporter construct in the multipotent EML cells but not in the committed MPRO promyelocytes, indicating that differences in HDAC-containing repressor complexes in these two closely related but distinct hematopoietic lineages might account for the differential activation of the RXR-RARalpha403 heterodimers that we observed at these different stages of myeloid development.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 56-122 NP denotes dominant-negative RXR-retinoic acid receptor alpha403 heterodimers
C2 220-238 NP denotes retinoic acid (RA)
C3 260-311 NP denotes RAR and retinoid X receptor (RXR) nuclear receptors
C4 312-316 NP denotes that
C5 364-386 NP denotes heterodimers (RXR-RAR)
C6 390-410 NP denotes homodimers (RXR-RXR)
C7 847-849 NP denotes RA
C8 916-979 NP denotes terminal granulocytic differentiation of the MPRO promyelocytes
C9 1042-1051 NP denotes EML cells
C10 1187-1189 NP denotes RA
C11 1399-1458 NP denotes terminal granulocytic differentiation of MPRO promyelocytes
C12 1464-1484 NP denotes this differentiation
C13 1557-1577 NP denotes RAR-RXR heterodimers
C14 1590-1608 NP denotes RXR-RXR homodimers
C15 1732-1763 NP denotes the RXR-RARalpha403 heterodimer
C16 1928-1937 NP denotes EML cells
C17 2062-2073 NP denotes these cells
C19 2549-2581 NP denotes the RXR-RARalpha403 heterodimers
C18 2518-2581 NP denotes the differential activation of the RXR-RARalpha403 heterodimers
C20 2582-2586 NP denotes that
R1 C4 C3 coref-relat that,RAR and retinoid X receptor (RXR) nuclear receptors
R2 C7 C2 coref-ident RA,retinoic acid (RA)
R3 C10 C7 coref-ident RA,RA
R4 C11 C8 coref-ident terminal granulocytic differentiation of MPRO promyelocytes,terminal granulocytic differentiation of the MPRO promyelocytes
R5 C12 C11 coref-ident this differentiation,terminal granulocytic differentiation of MPRO promyelocytes
R6 C13 C5 coref-ident RAR-RXR heterodimers,heterodimers (RXR-RAR)
R7 C14 C6 coref-ident RXR-RXR homodimers,homodimers (RXR-RXR)
R8 C15 C1 coref-ident the RXR-RARalpha403 heterodimer,dominant-negative RXR-retinoic acid receptor alpha403 heterodimers
R9 C16 C9 coref-ident EML cells,EML cells
R10 C17 C16 coref-ident these cells,EML cells
R11 C19 C15 coref-ident the RXR-RARalpha403 heterodimers,the RXR-RARalpha403 heterodimer
R12 C20 C18 coref-relat that,the differential activation of the RXR-RARalpha403 heterodimers

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-19 protein_molecule denotes Retinoid X receptor
T2 21-24 protein_molecule denotes RXR
T3 74-77 protein_molecule denotes RXR
T4 159-182 other_name denotes myeloid differentiation
T5 188-216 other_name denotes multiple biologic activities
T6 220-233 other_organic_compound denotes retinoic acid
T7 235-237 other_organic_compound denotes RA
T8 260-263 protein_family_or_group denotes RAR
T9 268-289 protein_molecule denotes retinoid X receptor (
T10 289-292 protein_molecule denotes RXR
T11 340-360 DNA_domain_or_region denotes DNA target sequences
T12 364-376 protein_complex denotes heterodimers
T13 378-385 protein_complex denotes RXR-RAR
T14 390-400 protein_complex denotes homodimers
T15 402-409 protein_complex denotes RXR-RXR
T16 412-414 other_organic_compound denotes RA
T17 487-500 other_name denotes hematopoiesis
T18 522-556 protein_molecule denotes COOH-terminally truncated RARalpha
T19 596-607 protein_molecule denotes RARalpha403
T20 614-638 tissue denotes normal mouse bone marrow
T21 649-697 cell_line denotes hematopoietic growth factor-dependent cell lines
T22 813-843 other_name denotes pharmacological concentrations
T23 847-849 other_organic_compound denotes RA
T24 916-953 other_name denotes terminal granulocytic differentiation
T25 961-979 cell_type denotes MPRO promyelocytes
T26 999-1012 protein_molecule denotes interleukin-3
T27 1014-1018 protein_molecule denotes IL-3
T28 1042-1051 cell_type denotes EML cells
T29 1123-1126 protein_molecule denotes RXR
T30 1132-1135 protein_family_or_group denotes RAR
T31 1145-1153 other_organic_compound denotes agonists
T32 1158-1169 other_organic_compound denotes antagonists
T33 1187-1189 other_organic_compound denotes RA
T34 1204-1230 other_name denotes dominant-negative activity
T35 1238-1256 protein_family_or_group denotes truncated RARalpha
T36 1276-1304 other_name denotes myeloid developmental stages
T37 1340-1343 protein_molecule denotes RXR
T38 1369-1372 protein_family_or_group denotes RAR
T39 1399-1436 other_name denotes terminal granulocytic differentiation
T40 1440-1458 cell_type denotes MPRO promyelocytes
T41 1518-1539 DNA_domain_or_region denotes DNA response elements
T42 1557-1577 protein_complex denotes RAR-RXR heterodimers
T43 1590-1597 protein_complex denotes RXR-RXR
T44 1615-1618 protein_molecule denotes RXR
T45 1650-1653 protein_family_or_group denotes RAR
T46 1736-1739 protein_molecule denotes RXR
T47 1739-1751 protein_molecule denotes -RARalpha403
T48 1812-1821 cell_type denotes EML cells
T49 1844-1847 protein_molecule denotes RXR
T50 1900-1904 protein_molecule denotes IL-3
T51 1928-1937 cell_type denotes EML cells
T52 1945-1964 cell_type denotes granulocyte lineage
T53 1987-2012 DNA_family_or_group denotes RAR-RXR response elements
T54 2014-2016 other_organic_compound denotes RA
T55 2034-2042 protein_molecule denotes RARalpha
T56 2105-2114 cell_type denotes EML cells
T57 2134-2158 other_name denotes nuclear hormone receptor
T58 2159-2170 protein_family_or_group denotes coactivator
T59 2194-2230 protein_family_or_group denotes histone deacetylase (HDAC) inhibitor
T60 2231-2245 other_organic_compound denotes trichostatin A
T61 2267-2274 protein_complex denotes RXR-RAR
T62 2313-2322 cell_type denotes EML cells
T63 2348-2366 cell_type denotes MPRO promyelocytes
T64 2399-2434 protein_complex denotes HDAC-containing repressor complexes
T65 2477-2499 cell_type denotes hematopoietic lineages
T66 2553-2581 protein_complex denotes RXR-RARalpha403 heterodimers
T67 2628-2647 other_name denotes myeloid development