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PubMed:10206993 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes Differential mechanisms of recognition and activation of interleukin-8 receptor subtypes.
T2 90-204 Sentence denotes We have probed an epitope sequence (His18-Pro19-Lys20-Phe21) in interleukin-8 (IL-8) by site-directed mutagenesis.
T3 205-407 Sentence denotes This work shows that single and double Ala substitutions of His18 and Phe21 in IL-8 reduced up to 77-fold the binding affinity to IL-8 receptor subtypes A (CXCR1) and B (CXCR2) and to the Duffy antigen.
T4 408-519 Sentence denotes These Ala mutants triggered neutrophil degranulation and induced calcium responses mediated by CXCR1 and CXCR2.
T5 520-717 Sentence denotes Single Asp or Ser substitutions, H18D, F21D, F21S, and double substitutions, H18A/F21D, H18A/F21S, and H18D/F21D, reduced up to 431-fold the binding affinity to CXCR1, CXCR2, and the Duffy antigen.
T6 718-874 Sentence denotes Interestingly, double mutants with charged residue substitutions failed to trigger degranulation or to induce wild-type calcium responses mediated by CXCR1.
T7 875-990 Sentence denotes Except for the H18A and F21A mutants, all other IL-8 mutants failed to induce superoxide production in neutrophils.
T8 991-1109 Sentence denotes This study demonstrates that IL-8 recognizes and activates CXCR1, CXCR2, and the Duffy antigen by distinct mechanisms.

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 597-601 http://www.glycoepitope.jp/epitopes/AN0030 denotes H18A
T2 608-612 http://www.glycoepitope.jp/epitopes/AN0030 denotes H18A
T3 890-894 http://www.glycoepitope.jp/epitopes/AN0030 denotes H18A

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 57-79 protein denotes interleukin-8 receptor
T2 154-167 protein denotes interleukin-8
T3 169-173 protein denotes IL-8
T4 284-288 protein denotes IL-8
T5 335-359 protein denotes IL-8 receptor subtypes A
T6 361-366 protein denotes CXCR1
T7 375-380 protein denotes CXCR2
T8 393-406 protein denotes Duffy antigen
T9 503-508 protein denotes CXCR1
T10 513-518 protein denotes CXCR2
T11 681-686 protein denotes CXCR1
T12 688-693 protein denotes CXCR2
T13 703-716 protein denotes Duffy antigen
T14 868-873 protein denotes CXCR1
T15 923-927 protein denotes IL-8
T16 1020-1024 protein denotes IL-8
T17 1050-1055 protein denotes CXCR1
T18 1057-1062 protein denotes CXCR2
T19 1072-1085 protein denotes Duffy antigen

AIMed

Id Subject Object Predicate Lexical cue
T1 57-70 protein denotes interleukin-8
T2 154-167 protein denotes interleukin-8
T3 169-173 protein denotes IL-8
T4 284-288 protein denotes IL-8
T5 335-359 protein denotes IL-8 receptor subtypes A
T6 361-366 protein denotes CXCR1
T7 375-380 protein denotes CXCR2
T8 393-406 protein denotes Duffy antigen
T9 503-508 protein denotes CXCR1
T10 513-518 protein denotes CXCR2
T11 681-686 protein denotes CXCR1
T12 688-693 protein denotes CXCR2
T13 703-716 protein denotes Duffy antigen
T14 868-873 protein denotes CXCR1
T15 923-927 protein denotes IL-8
T16 1020-1024 protein denotes IL-8
T17 1050-1055 protein denotes CXCR1
T18 1057-1062 protein denotes CXCR2
T19 1072-1085 protein denotes Duffy antigen

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 436-446 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T2 978-989 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 436-446 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T2 978-989 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775