PubMed:10206991
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-103 | Sentence | denotes | Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. |
| T2 | 104-170 | Sentence | denotes | Mouse KCNK6 is a new subunit belonging to the TWIK channel family. |
| T3 | 171-295 | Sentence | denotes | This 335-amino acid polypeptide has four transmembrane segments, two pore-forming domains, and a Ca2+-binding EF-hand motif. |
| T4 | 296-386 | Sentence | denotes | Expression of KCNK6 transcripts is principally observed in eyes, lung, stomach and embryo. |
| T5 | 387-483 | Sentence | denotes | In the eyes, immunohistochemistry reveals protein expression only in some of the retina neurons. |
| T6 | 484-690 | Sentence | denotes | Although KCNK6 is able to dimerize as other functional two-P domain K+ channels when it is expressed in COS-7 cells, it remains in the endoplasmic reticulum and is unable to generate ionic channel activity. |
| T7 | 691-921 | Sentence | denotes | Deletions, mutations, and chimera constructions suggest that KCNK6 is not an intracellular channel but rather a subunit that needs to associate with a partner, which remains to be discovered, in order to reach the plasma membrane. |
| T8 | 922-978 | Sentence | denotes | A closely related human KCNK7-A subunit has been cloned. |
| T9 | 979-1128 | Sentence | denotes | KCNK7 displays an intriguing GLE sequence in its filter region instead of the G(Y/F/L)G sequence, which is considered to be the K+ channel signature. |
| T10 | 1129-1218 | Sentence | denotes | This subunit is alternatively spliced and gives rise to the shorter forms KCNK7-B and -C. |
| T11 | 1219-1288 | Sentence | denotes | None of the KCNK7 structures can generate channel activity by itself. |
| T12 | 1289-1407 | Sentence | denotes | The KCNK7 gene is situated on chromosome 11, in the q13 region, where several candidate diseases have been identified. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 284-288 | http://purl.obolibrary.org/obo/MAT_0000091 | denotes | hand |
| T2 | 355-359 | http://purl.obolibrary.org/obo/MAT_0000140 | denotes | eyes |
| T3 | 361-365 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
| T4 | 367-374 | http://purl.obolibrary.org/obo/MAT_0000051 | denotes | stomach |
| T5 | 379-385 | http://purl.obolibrary.org/obo/MAT_0000226 | denotes | embryo |
| T6 | 394-398 | http://purl.obolibrary.org/obo/MAT_0000140 | denotes | eyes |
| T7 | 468-474 | http://purl.obolibrary.org/obo/MAT_0000142 | denotes | retina |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 284-288 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/MAT_0000091 |
| T2 | 355-359 | Body_part | denotes | eyes | http://purl.obolibrary.org/obo/MAT_0000140 |
| T3 | 361-365 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
| T4 | 367-374 | Body_part | denotes | stomach | http://purl.obolibrary.org/obo/MAT_0000051 |
| T5 | 379-385 | Body_part | denotes | embryo | http://purl.obolibrary.org/obo/MAT_0000226 |
| T6 | 394-398 | Body_part | denotes | eyes | http://purl.obolibrary.org/obo/MAT_0000140 |
| T7 | 468-474 | Body_part | denotes | retina | http://purl.obolibrary.org/obo/MAT_0000142 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 17-22 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T3 | 58-63 | OrganismTaxon | denotes | human | 9606 |
| T4 | 104-109 | OrganismTaxon | denotes | Mouse | 10088|10090 |
| T6 | 940-945 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 88-92 | Body_part | denotes | pore | http://purl.obolibrary.org/obo/UBERON_0008915 |
| T2 | 212-225 | Body_part | denotes | transmembrane | http://purl.obolibrary.org/obo/GO_0016020 |
| T3 | 226-234 | Body_part | denotes | segments | http://purl.obolibrary.org/obo/UBERON_0000914 |
| T4 | 240-244 | Body_part | denotes | pore | http://purl.obolibrary.org/obo/UBERON_0008915 |
| T5 | 284-288 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
| T6 | 355-359 | Body_part | denotes | eyes | http://purl.obolibrary.org/obo/UBERON_0000019 |
| T7 | 361-365 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T8 | 367-374 | Body_part | denotes | stomach | http://purl.obolibrary.org/obo/UBERON_0000945 |
| T9 | 379-385 | Body_part | denotes | embryo | http://purl.obolibrary.org/obo/UBERON_0000922 |
| T10 | 394-398 | Body_part | denotes | eyes | http://purl.obolibrary.org/obo/UBERON_0000019 |
| T11 | 468-474 | Body_part | denotes | retina | http://purl.obolibrary.org/obo/UBERON_0000966 |
| T12 | 631-640 | Body_part | denotes | reticulum | http://purl.obolibrary.org/obo/UBERON_0007361 |
| T13 | 768-781 | Body_part | denotes | intracellular | http://purl.obolibrary.org/obo/GO_0005622 |
| T14 | 905-920 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T15 | 1319-1329 | Body_part | denotes | chromosome | http://purl.obolibrary.org/obo/GO_0005694 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 475-482 | Cell | denotes | neurons | http://purl.obolibrary.org/obo/CL:0000540 |