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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 177-368 DRI_Approach denotes Matrix metalloproteinases (MMPs) have been implicated as important factors in gliomas since they may both facilitate invasion into the surrounding brain and participate in neovascularization.
T2 369-631 DRI_Approach denotes We have tested the hypothesis that deregulated expression of gelatinase-A or B, or an activator of gelatinase-A, MT1-MMP, may contribute directly to human gliomas by quantifying the expression of these MMPs in 46 brain tumour specimens and seven control tissues.
T3 632-839 DRI_Background denotes Quantitative RT-PCR and gelatin zymography showed that gelatinase-A in glioma specimens was higher than in normal tissue; these were significantly elevated in low grade gliomas and remained elevated in GBMs.
T4 840-969 DRI_Background denotes Gelatinase-B transcript and activity levels were also higher than in normal brain and more strongly correlated with tumour grade.
T5 970-1093 DRI_Approach denotes We did not see a close relationship between the levels of expression of MT1-MMP mRNA and amounts of activated gelatinase-A.
T6 1094-1233 DRI_Background denotes In situ hybridization localized gelatinase-A and MT1-MMP transcripts to normal neuronal and glia, malignant glioma cells and blood vessels.
T7 1234-1415 DRI_Outcome denotes In contrast, gelatinase-B showed a more restricted pattern of expression; it was strongly expressed in blood vessels at proliferating margins, as well as tumour cells in some cases.
T8 1416-1523 DRI_Outcome denotes These data suggest that gelatinase-A, -B and MT1-MMP are important in the pathophysiology of human gliomas.
T9 1524-1705 DRI_Challenge denotes The primary role of gelatinase-B may lie in remodelling associated with neovascularization, whereas gelatinase-A and MT1-MMP may be involved in both glial invasion and angiogenesis.

c_corpus

Id Subject Object Predicate Lexical cue
T3 0-12 P08253 denotes Gelatinase-A
T4 0-12 Q90611 denotes Gelatinase-A
T6 0-12 PR:000010479 denotes Gelatinase-A
T7 0-12 P33436 denotes Gelatinase-A
T8 0-12 P33434 denotes Gelatinase-A
T9 0-12 P50757 denotes Gelatinase-A
T5 0-12 D020778 denotes Gelatinase-A
T10 14-17 CHEBI:340824 denotes MMP
T13 14-17 CHEBI:59761 denotes MMP
T14 14-19 PR:P08253 denotes MMP-2
T15 14-19 Q9GLE5 denotes MMP-2
T16 14-19 P08253 denotes MMP-2
T17 14-19 Q90611 denotes MMP-2
T19 14-19 PR:Q8MPP3 denotes MMP-2
T20 14-19 P33436 denotes MMP-2
T21 14-19 PR:Q90611 denotes MMP-2
T22 14-19 PR:P33436 denotes MMP-2
T23 14-19 PR:000010479 denotes MMP-2
T24 14-19 PR:P33434 denotes MMP-2
T25 14-19 P33434 denotes MMP-2
T26 14-19 P50757 denotes MMP-2
T18 14-19 GO:0004228 denotes MMP-2
T30 22-34 P14780 denotes gelatinase-B
T31 22-34 P41246 denotes gelatinase-B
T32 22-34 P41245 denotes gelatinase-B
T33 22-34 P50282 denotes gelatinase-B
T34 22-34 PR:000010491 denotes gelatinase-B
T35 22-34 P52176 denotes gelatinase-B
T36 22-34 O18733 denotes gelatinase-B
T29 22-34 D020780 denotes gelatinase-B
T37 36-39 CHEBI:340824 denotes MMP
T40 36-39 CHEBI:59761 denotes MMP
T41 36-41 PR:P50282 denotes MMP-9
T42 36-41 PR:P14780 denotes MMP-9
T43 36-41 P14780 denotes MMP-9
T44 36-41 PR:P41245 denotes MMP-9
T45 36-41 P41246 denotes MMP-9
T46 36-41 P41245 denotes MMP-9
T47 36-41 PR:P52176 denotes MMP-9
T48 36-41 P50282 denotes MMP-9
T50 36-41 PR:000010491 denotes MMP-9
T51 36-41 P52176 denotes MMP-9
T52 36-41 O18733 denotes MMP-9
T49 36-41 GO:0004229 denotes MMP-9
T53 47-55 UBERON:0000094 denotes membrane
T55 47-55 UBERON:0000158 denotes membrane
T54 47-55 GO:0016020 denotes membrane
T57 47-87 Q9XT90 denotes membrane type matrix metalloproteinase-1
T58 47-87 P50281 denotes membrane type matrix metalloproteinase-1
T59 47-87 Q9GLE4 denotes membrane type matrix metalloproteinase-1
T60 47-87 PR:000010474 denotes membrane type matrix metalloproteinase-1
T61 47-87 Q10739 denotes membrane type matrix metalloproteinase-1
T62 47-87 Q95220 denotes membrane type matrix metalloproteinase-1
T64 47-87 P53690 denotes membrane type matrix metalloproteinase-1
T63 47-87 D053511 denotes membrane type matrix metalloproteinase-1
T65 61-67 UBERON:0027368 denotes matrix
T66 61-87 GO:0004232 denotes matrix metalloproteinase-1
T68 61-87 GO:0051405 denotes matrix metalloproteinase-1
T101 89-92 CVCL_2501 denotes MT1
T86 89-92 GO:0047152 denotes MT1
T95 89-92 GO:0043791 denotes MT1
T104 89-92 GO:0043834 denotes MT1
T120 89-96 Q9XT90 denotes MT1-MMP
T121 89-96 P50281 denotes MT1-MMP
T122 89-96 Q9GLE4 denotes MT1-MMP
T123 89-96 PR:000010474 denotes MT1-MMP
T124 89-96 Q10739 denotes MT1-MMP
T125 89-96 Q95220 denotes MT1-MMP
T127 89-96 P53690 denotes MT1-MMP
T126 89-96 D053511 denotes MT1-MMP
T130 93-96 GO:0004235 denotes MMP
T133 158-175 D005910 denotes malignant gliomas
T134 158-175 D005910 denotes malignant gliomas
T137 184-202 D045726 denotes metalloproteinases
T138 204-208 D020782 denotes MMPs
T139 255-262 D005910 denotes gliomas
T140 255-262 D005910 denotes gliomas
T141 324-329 UBERON:6110636 denotes brain
T142 324-329 UBERON:0000955 denotes brain
T145 430-442 P08253 denotes gelatinase-A
T146 430-442 Q90611 denotes gelatinase-A
T148 430-442 PR:000010479 denotes gelatinase-A
T149 430-442 P33436 denotes gelatinase-A
T150 430-442 P33434 denotes gelatinase-A
T151 430-442 P50757 denotes gelatinase-A
T147 430-442 D020778 denotes gelatinase-A
T154 468-480 P08253 denotes gelatinase-A
T155 468-480 Q90611 denotes gelatinase-A
T157 468-480 PR:000010479 denotes gelatinase-A
T158 468-480 P33436 denotes gelatinase-A
T159 468-480 P33434 denotes gelatinase-A
T160 468-480 P50757 denotes gelatinase-A
T156 468-480 D020778 denotes gelatinase-A
T183 482-485 CVCL_2501 denotes MT1
T168 482-485 GO:0047152 denotes MT1
T177 482-485 GO:0043791 denotes MT1
T186 482-485 GO:0043834 denotes MT1
T202 482-489 Q9XT90 denotes MT1-MMP
T203 482-489 P50281 denotes MT1-MMP
T204 482-489 Q9GLE4 denotes MT1-MMP
T205 482-489 PR:000010474 denotes MT1-MMP
T206 482-489 Q10739 denotes MT1-MMP
T207 482-489 Q95220 denotes MT1-MMP
T209 482-489 P53690 denotes MT1-MMP
T208 482-489 D053511 denotes MT1-MMP
T212 486-489 GO:0004235 denotes MMP
T215 515-523 PR:P48775 denotes to human
T216 518-523 D006801 denotes human
T217 524-531 D005910 denotes gliomas
T218 524-531 D005910 denotes gliomas
T219 571-575 D020782 denotes MMPs
T220 582-587 UBERON:6110636 denotes brain
T221 582-587 UBERON:0000955 denotes brain
T222 648-651 Q41249 denotes PCR
T223 648-651 O66148 denotes PCR
T224 648-651 Q59987 denotes PCR
T225 648-651 Q01289 denotes PCR
T226 648-651 O80333 denotes PCR
T227 648-651 P15904 denotes PCR
T228 648-651 Q9SDT1 denotes PCR
T229 648-651 Q39617 denotes PCR
T230 656-663 4716 denotes gelatin
T231 656-663 D005780 denotes gelatin
T232 656-663 CHEBI:5291 denotes gelatin
T235 687-699 P08253 denotes gelatinase-A
T236 687-699 Q90611 denotes gelatinase-A
T238 687-699 PR:000010479 denotes gelatinase-A
T239 687-699 P33436 denotes gelatinase-A
T240 687-699 P33434 denotes gelatinase-A
T241 687-699 P50757 denotes gelatinase-A
T237 687-699 D020778 denotes gelatinase-A
T242 703-709 D005910 denotes glioma
T243 703-709 D005910 denotes glioma
T244 746-752 UBERON:0000479 denotes tissue
T245 801-808 D005910 denotes gliomas
T246 801-808 D005910 denotes gliomas
T250 840-852 P14780 denotes Gelatinase-B
T251 840-852 P41246 denotes Gelatinase-B
T252 840-852 P41245 denotes Gelatinase-B
T253 840-852 P50282 denotes Gelatinase-B
T254 840-852 PR:000010491 denotes Gelatinase-B
T255 840-852 P52176 denotes Gelatinase-B
T256 840-852 O18733 denotes Gelatinase-B
T249 840-852 D020780 denotes Gelatinase-B
T257 853-863 SO:0000673 denotes transcript
T258 916-921 UBERON:6110636 denotes brain
T259 916-921 UBERON:0000955 denotes brain
T282 1042-1045 CVCL_2501 denotes MT1
T267 1042-1045 GO:0047152 denotes MT1
T276 1042-1045 GO:0043791 denotes MT1
T285 1042-1045 GO:0043834 denotes MT1
T301 1042-1049 Q9XT90 denotes MT1-MMP
T302 1042-1049 P50281 denotes MT1-MMP
T303 1042-1049 Q9GLE4 denotes MT1-MMP
T304 1042-1049 PR:000010474 denotes MT1-MMP
T305 1042-1049 Q10739 denotes MT1-MMP
T306 1042-1049 Q95220 denotes MT1-MMP
T308 1042-1049 P53690 denotes MT1-MMP
T307 1042-1049 D053511 denotes MT1-MMP
T311 1046-1049 GO:0004235 denotes MMP
T316 1050-1054 SO:0000234 denotes mRNA
T314 1050-1054 D012333 denotes mRNA
T315 1050-1054 CHEBI:33699 denotes mRNA
T319 1080-1092 P08253 denotes gelatinase-A
T320 1080-1092 Q90611 denotes gelatinase-A
T322 1080-1092 PR:000010479 denotes gelatinase-A
T323 1080-1092 P33436 denotes gelatinase-A
T324 1080-1092 P33434 denotes gelatinase-A
T325 1080-1092 P50757 denotes gelatinase-A
T321 1080-1092 D020778 denotes gelatinase-A
T328 1126-1138 P08253 denotes gelatinase-A
T329 1126-1138 Q90611 denotes gelatinase-A
T331 1126-1138 PR:000010479 denotes gelatinase-A
T332 1126-1138 P33436 denotes gelatinase-A
T333 1126-1138 P33434 denotes gelatinase-A
T334 1126-1138 P50757 denotes gelatinase-A
T330 1126-1138 D020778 denotes gelatinase-A
T357 1143-1146 CVCL_2501 denotes MT1
T342 1143-1146 GO:0047152 denotes MT1
T351 1143-1146 GO:0043791 denotes MT1
T360 1143-1146 GO:0043834 denotes MT1
T376 1143-1150 Q9XT90 denotes MT1-MMP
T377 1143-1150 P50281 denotes MT1-MMP
T378 1143-1150 Q9GLE4 denotes MT1-MMP
T379 1143-1150 PR:000010474 denotes MT1-MMP
T380 1143-1150 Q10739 denotes MT1-MMP
T381 1143-1150 Q95220 denotes MT1-MMP
T383 1143-1150 P53690 denotes MT1-MMP
T382 1143-1150 D053511 denotes MT1-MMP
T386 1147-1150 GO:0004235 denotes MMP
T389 1192-1208 D005910 denotes malignant glioma
T390 1192-1208 D005910 denotes malignant glioma
T393 1219-1232 UBERON:0004537 denotes blood vessels
T397 1247-1259 P14780 denotes gelatinase-B
T398 1247-1259 P41246 denotes gelatinase-B
T399 1247-1259 P41245 denotes gelatinase-B
T400 1247-1259 P50282 denotes gelatinase-B
T401 1247-1259 PR:000010491 denotes gelatinase-B
T402 1247-1259 P52176 denotes gelatinase-B
T403 1247-1259 O18733 denotes gelatinase-B
T396 1247-1259 D020780 denotes gelatinase-B
T404 1337-1350 UBERON:0004537 denotes blood vessels
T405 1368-1375 UBERON:0004879 denotes margins
T408 1440-1452 P08253 denotes gelatinase-A
T409 1440-1452 Q90611 denotes gelatinase-A
T411 1440-1452 PR:000010479 denotes gelatinase-A
T412 1440-1452 P33436 denotes gelatinase-A
T413 1440-1452 P33434 denotes gelatinase-A
T414 1440-1452 P50757 denotes gelatinase-A
T410 1440-1452 D020778 denotes gelatinase-A
T437 1461-1464 CVCL_2501 denotes MT1
T422 1461-1464 GO:0047152 denotes MT1
T431 1461-1464 GO:0043791 denotes MT1
T440 1461-1464 GO:0043834 denotes MT1
T456 1461-1468 Q9XT90 denotes MT1-MMP
T457 1461-1468 P50281 denotes MT1-MMP
T458 1461-1468 Q9GLE4 denotes MT1-MMP
T459 1461-1468 PR:000010474 denotes MT1-MMP
T460 1461-1468 Q10739 denotes MT1-MMP
T461 1461-1468 Q95220 denotes MT1-MMP
T463 1461-1468 P53690 denotes MT1-MMP
T462 1461-1468 D053511 denotes MT1-MMP
T466 1465-1468 GO:0004235 denotes MMP
T469 1509-1514 D006801 denotes human
T470 1515-1522 D005910 denotes gliomas
T471 1515-1522 D005910 denotes gliomas
T475 1544-1556 P14780 denotes gelatinase-B
T476 1544-1556 P41246 denotes gelatinase-B
T477 1544-1556 P41245 denotes gelatinase-B
T478 1544-1556 P50282 denotes gelatinase-B
T479 1544-1556 PR:000010491 denotes gelatinase-B
T480 1544-1556 P52176 denotes gelatinase-B
T481 1544-1556 O18733 denotes gelatinase-B
T474 1544-1556 D020780 denotes gelatinase-B
T484 1624-1636 P08253 denotes gelatinase-A
T485 1624-1636 Q90611 denotes gelatinase-A
T487 1624-1636 PR:000010479 denotes gelatinase-A
T488 1624-1636 P33436 denotes gelatinase-A
T489 1624-1636 P33434 denotes gelatinase-A
T490 1624-1636 P50757 denotes gelatinase-A
T486 1624-1636 D020778 denotes gelatinase-A
T513 1641-1644 CVCL_2501 denotes MT1
T498 1641-1644 GO:0047152 denotes MT1
T507 1641-1644 GO:0043791 denotes MT1
T516 1641-1644 GO:0043834 denotes MT1
T532 1641-1648 Q9XT90 denotes MT1-MMP
T533 1641-1648 P50281 denotes MT1-MMP
T534 1641-1648 Q9GLE4 denotes MT1-MMP
T535 1641-1648 PR:000010474 denotes MT1-MMP
T536 1641-1648 Q10739 denotes MT1-MMP
T537 1641-1648 Q95220 denotes MT1-MMP
T539 1641-1648 P53690 denotes MT1-MMP
T538 1641-1648 D053511 denotes MT1-MMP
T542 1645-1648 GO:0004235 denotes MMP
T545 1692-1704 GO:0001525 denotes angiogenesis

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 158-175 DiseaseOrPhenotypicFeature denotes malignant gliomas 0100342
T2 703-709 DiseaseOrPhenotypicFeature denotes glioma 0021042|0100342
T4 791-808 DiseaseOrPhenotypicFeature denotes low grade gliomas 0021637
T5 1192-1208 DiseaseOrPhenotypicFeature denotes malignant glioma 0100342

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-176 DRI_Background denotes Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas.
T2 177-368 DRI_Approach denotes Matrix metalloproteinases (MMPs) have been implicated as important factors in gliomas since they may both facilitate invasion into the surrounding brain and participate in neovascularization.
T3 369-631 DRI_Approach denotes We have tested the hypothesis that deregulated expression of gelatinase-A or B, or an activator of gelatinase-A, MT1-MMP, may contribute directly to human gliomas by quantifying the expression of these MMPs in 46 brain tumour specimens and seven control tissues.
T4 632-839 DRI_Background denotes Quantitative RT-PCR and gelatin zymography showed that gelatinase-A in glioma specimens was higher than in normal tissue; these were significantly elevated in low grade gliomas and remained elevated in GBMs.
T5 840-969 DRI_Background denotes Gelatinase-B transcript and activity levels were also higher than in normal brain and more strongly correlated with tumour grade.
T6 970-1093 DRI_Approach denotes We did not see a close relationship between the levels of expression of MT1-MMP mRNA and amounts of activated gelatinase-A.
T7 1094-1233 DRI_Background denotes In situ hybridization localized gelatinase-A and MT1-MMP transcripts to normal neuronal and glia, malignant glioma cells and blood vessels.
T8 1234-1415 DRI_Outcome denotes In contrast, gelatinase-B showed a more restricted pattern of expression; it was strongly expressed in blood vessels at proliferating margins, as well as tumour cells in some cases.
T9 1416-1523 DRI_Outcome denotes These data suggest that gelatinase-A, -B and MT1-MMP are important in the pathophysiology of human gliomas.
T10 1524-1705 DRI_Challenge denotes The primary role of gelatinase-B may lie in remodelling associated with neovascularization, whereas gelatinase-A and MT1-MMP may be involved in both glial invasion and angiogenesis.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10206300-0#0#12#gene4313 0-12 gene4313 denotes Gelatinase-A
10206300-0#14#19#gene4313 14-19 gene4313 denotes MMP-2
10206300-0#22#34#gene4318 22-34 gene4318 denotes gelatinase-B
10206300-0#36#41#gene4318 36-41 gene4318 denotes MMP-9
10206300-0#47#87#gene4323 47-87 gene4323 denotes membrane type matrix metalloproteinase-1
10206300-0#89#96#gene4323 89-96 gene4323 denotes MT1-MMP
10206300-0#158#175#diseaseC0555198 158-175 diseaseC0555198 denotes malignant gliomas
10206300-8#24#36#gene4313 1440-1452 gene4313 denotes gelatinase-A
10206300-8#45#52#gene4323 1461-1468 gene4323 denotes MT1-MMP
10206300-8#99#106#diseaseC0017638 1515-1522 diseaseC0017638 denotes gliomas
0#12#gene4313158#175#diseaseC0555198 10206300-0#0#12#gene4313 10206300-0#158#175#diseaseC0555198 associated_with Gelatinase-A,malignant gliomas
14#19#gene4313158#175#diseaseC0555198 10206300-0#14#19#gene4313 10206300-0#158#175#diseaseC0555198 associated_with MMP-2,malignant gliomas
22#34#gene4318158#175#diseaseC0555198 10206300-0#22#34#gene4318 10206300-0#158#175#diseaseC0555198 associated_with gelatinase-B,malignant gliomas
36#41#gene4318158#175#diseaseC0555198 10206300-0#36#41#gene4318 10206300-0#158#175#diseaseC0555198 associated_with MMP-9,malignant gliomas
47#87#gene4323158#175#diseaseC0555198 10206300-0#47#87#gene4323 10206300-0#158#175#diseaseC0555198 associated_with membrane type matrix metalloproteinase-1,malignant gliomas
89#96#gene4323158#175#diseaseC0555198 10206300-0#89#96#gene4323 10206300-0#158#175#diseaseC0555198 associated_with MT1-MMP,malignant gliomas
24#36#gene431399#106#diseaseC0017638 10206300-8#24#36#gene4313 10206300-8#99#106#diseaseC0017638 associated_with gelatinase-A,gliomas
45#52#gene432399#106#diseaseC0017638 10206300-8#45#52#gene4323 10206300-8#99#106#diseaseC0017638 associated_with MT1-MMP,gliomas

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1461-1468 gene:4323 denotes MT1-MMP
T1 1515-1522 disease:C0017638 denotes gliomas
R1 T0 T1 associated_with MT1-MMP,gliomas

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 255-262 HP_0009733 denotes gliomas
T2 524-531 HP_0009733 denotes gliomas
T3 588-594 HP_0002664 denotes tumour
T4 703-709 HP_0009733 denotes glioma
T5 801-808 HP_0009733 denotes gliomas
T6 956-962 HP_0002664 denotes tumour
T7 1202-1208 HP_0009733 denotes glioma
T8 1388-1394 HP_0002664 denotes tumour
T9 1515-1522 HP_0009733 denotes gliomas