PubMed:10205587 JSONTXT

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"10205587-0#27#35#geners1042714","span":{"begin":27,"end":35},"obj":"geners1042714"},{"id":"10205587-0#77#84#diseaseC0028754","span":{"begin":77,"end":84},"obj":"diseaseC0028754"}],"relations":[{"id":"27#35#geners104271477#84#diseaseC0028754","pred":"associated_with","subj":"10205587-0#27#35#geners1042714","obj":"10205587-0#77#84#diseaseC0028754"}],"text":"The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females.\nOBJECTIVES: To investigate the role of a polymorphism in codon 27 (Gln27Glu) of the beta 2-adrenoceptor gene for obesity in males compared to previously investigated females with an association of this polymorphism to obesity.\nDESIGN: Population-based study.\nSETTING: Medical department at a University Hospital.\nSUBJECTS: A total of 138 non-related Swedish males with body mass indexes (BMI) in the range 19.4-53.4 kg m-2 were recruited as: healthy volunteers, healthy obese subjects and subjects undergoing surgery for uncomplicated gallstone or abdominal hernia. In order to investigate the impact of gender, the results were compared with a subset of an earlier investigated female population of 109 Swedish females. Obesity was defined as a BMI \u003e 27 kg m-2.\nMAIN OUTCOME MEASURES: Genotype examination of beta 2-adrenoceptor polymorphism in codon 27 with polymerase chain reaction and restriction fragment length polymorphism.\nRESULTS: The allele frequency of Gln27 and Glu27 did not differ between males and females when obese and non-obese subjects were investigated together. However, in obese males, the frequency of the Glu27 allele was significantly decreased (P = 0.034), whereas the frequency of this allele was increased in obese females (P = 0.013). No impact of the female androgen status on the distribution of the Gln27Glu polymorphism could be demonstrated in the obese females.\nCONCLUSION: A positive association between obesity and the Glu27 genetic variant in the beta 2-adrenoceptor exists in females, whereas in males there is a negative correlation between Glu27 and obesity. The findings suggest that different genetic factors contribute to obesity in males and females."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"10205587-0#36#55#gene154","span":{"begin":36,"end":55},"obj":"gene154"},{"id":"10205587-0#77#84#diseaseC0028754","span":{"begin":77,"end":84},"obj":"diseaseC0028754"}],"relations":[{"id":"36#55#gene15477#84#diseaseC0028754","pred":"associated_with","subj":"10205587-0#36#55#gene154","obj":"10205587-0#77#84#diseaseC0028754"}],"text":"The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females.\nOBJECTIVES: To investigate the role of a polymorphism in codon 27 (Gln27Glu) of the beta 2-adrenoceptor gene for obesity in males compared to previously investigated females with an association of this polymorphism to obesity.\nDESIGN: Population-based study.\nSETTING: Medical department at a University Hospital.\nSUBJECTS: A total of 138 non-related Swedish males with body mass indexes (BMI) in the range 19.4-53.4 kg m-2 were recruited as: healthy volunteers, healthy obese subjects and subjects undergoing surgery for uncomplicated gallstone or abdominal hernia. In order to investigate the impact of gender, the results were compared with a subset of an earlier investigated female population of 109 Swedish females. Obesity was defined as a BMI \u003e 27 kg m-2.\nMAIN OUTCOME MEASURES: Genotype examination of beta 2-adrenoceptor polymorphism in codon 27 with polymerase chain reaction and restriction fragment length polymorphism.\nRESULTS: The allele frequency of Gln27 and Glu27 did not differ between males and females when obese and non-obese subjects were investigated together. However, in obese males, the frequency of the Glu27 allele was significantly decreased (P = 0.034), whereas the frequency of this allele was increased in obese females (P = 0.013). No impact of the female androgen status on the distribution of the Gln27Glu polymorphism could be demonstrated in the obese females.\nCONCLUSION: A positive association between obesity and the Glu27 genetic variant in the beta 2-adrenoceptor exists in females, whereas in males there is a negative correlation between Glu27 and obesity. The findings suggest that different genetic factors contribute to obesity in males and females."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":194,"end":213},"obj":"gene:154"},{"id":"T1","span":{"begin":223,"end":230},"obj":"disease:C0028754"},{"id":"T2","span":{"begin":194,"end":213},"obj":"gene:154"},{"id":"T3","span":{"begin":328,"end":335},"obj":"disease:C0028754"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females.\nOBJECTIVES: To investigate the role of a polymorphism in codon 27 (Gln27Glu) of the beta 2-adrenoceptor gene for obesity in males compared to previously investigated females with an association of this polymorphism to obesity.\nDESIGN: Population-based study.\nSETTING: Medical department at a University Hospital.\nSUBJECTS: A total of 138 non-related Swedish males with body mass indexes (BMI) in the range 19.4-53.4 kg m-2 were recruited as: healthy volunteers, healthy obese subjects and subjects undergoing surgery for uncomplicated gallstone or abdominal hernia. In order to investigate the impact of gender, the results were compared with a subset of an earlier investigated female population of 109 Swedish females. Obesity was defined as a BMI \u003e 27 kg m-2.\nMAIN OUTCOME MEASURES: Genotype examination of beta 2-adrenoceptor polymorphism in codon 27 with polymerase chain reaction and restriction fragment length polymorphism.\nRESULTS: The allele frequency of Gln27 and Glu27 did not differ between males and females when obese and non-obese subjects were investigated together. However, in obese males, the frequency of the Glu27 allele was significantly decreased (P = 0.034), whereas the frequency of this allele was increased in obese females (P = 0.013). No impact of the female androgen status on the distribution of the Gln27Glu polymorphism could be demonstrated in the obese females.\nCONCLUSION: A positive association between obesity and the Glu27 genetic variant in the beta 2-adrenoceptor exists in females, whereas in males there is a negative correlation between Glu27 and obesity. The findings suggest that different genetic factors contribute to obesity in males and females."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":223,"end":230},"obj":"HP_0001513"},{"id":"T2","span":{"begin":328,"end":335},"obj":"HP_0001513"}],"text":"The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females.\nOBJECTIVES: To investigate the role of a polymorphism in codon 27 (Gln27Glu) of the beta 2-adrenoceptor gene for obesity in males compared to previously investigated females with an association of this polymorphism to obesity.\nDESIGN: Population-based study.\nSETTING: Medical department at a University Hospital.\nSUBJECTS: A total of 138 non-related Swedish males with body mass indexes (BMI) in the range 19.4-53.4 kg m-2 were recruited as: healthy volunteers, healthy obese subjects and subjects undergoing surgery for uncomplicated gallstone or abdominal hernia. In order to investigate the impact of gender, the results were compared with a subset of an earlier investigated female population of 109 Swedish females. Obesity was defined as a BMI \u003e 27 kg m-2.\nMAIN OUTCOME MEASURES: Genotype examination of beta 2-adrenoceptor polymorphism in codon 27 with polymerase chain reaction and restriction fragment length polymorphism.\nRESULTS: The allele frequency of Gln27 and Glu27 did not differ between males and females when obese and non-obese subjects were investigated together. However, in obese males, the frequency of the Glu27 allele was significantly decreased (P = 0.034), whereas the frequency of this allele was increased in obese females (P = 0.013). No impact of the female androgen status on the distribution of the Gln27Glu polymorphism could be demonstrated in the obese females.\nCONCLUSION: A positive association between obesity and the Glu27 genetic variant in the beta 2-adrenoceptor exists in females, whereas in males there is a negative correlation between Glu27 and obesity. The findings suggest that different genetic factors contribute to obesity in males and females."}