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PubMed:10202937 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 71-76 protein denotes STAT1
T2 415-420 protein denotes STAT1
T3 461-492 protein denotes lymphocyte-activating cytokines
T4 507-518 protein denotes interferons
T5 763-771 protein denotes cytokine
T6 794-799 protein denotes STAT1
T7 804-809 protein denotes STAT1
T8 842-881 cell_type denotes normal resting or activated lymphocytes
T9 926-939 protein denotes STAT1 protein
T10 968-973 protein denotes STATs
T11 988-993 protein denotes STAT1
T12 1122-1127 protein denotes STAT1
T13 1231-1236 protein denotes STAT1

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10202937-3#0#5#gene6772 415-420 gene6772 denotes STAT1
10202937-3#240#256#diseaseC0042769 655-671 diseaseC0042769 denotes viral infections
0#5#gene6772240#256#diseaseC0042769 10202937-3#0#5#gene6772 10202937-3#240#256#diseaseC0042769 associated_with STAT1,viral infections

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-87 Sentence denotes Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling.
S2 88-228 Sentence denotes Fludarabine is a nucleoside analog used in the treatment of hematologic malignancies that can induce severe and prolonged immunosuppression.
S3 229-414 Sentence denotes Although it can be incorporated into the DNA of dividing cells, fludarabine is also a potent inhibitor of cells with a low growth fraction, thus it must have other mechanisms of action.
S4 415-672 Sentence denotes STAT1, which is activated in response to many lymphocyte-activating cytokines including the interferons, is essential for cell-mediated immunity, as the absence of this protein is associated with prominent defects in the ability to control viral infections.
S5 673-882 Sentence denotes Here we show that fludarabine, but not the immunosuppressant cyclosporine A, inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes.
S6 883-974 Sentence denotes Fludarabine caused a specific depletion of STAT1 protein (and mRNA) but not of other STATs.
S7 975-1064 Sentence denotes This loss of STAT1 was also seen in cells from patients treated with fludarabine in vivo.
S8 1065-1224 Sentence denotes Brief exposure to fludarabine led to a sustained loss of STAT1, analogous to the prolonged period of immunosuppression induced by exposure to the drug in vivo.
S9 1225-1330 Sentence denotes Thus, STAT1 may be a useful target in the development of new immunosuppressive and antineoplastic agents.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 88-99 NP denotes Fludarabine
C2 148-172 NP denotes hematologic malignancies
C3 173-177 NP denotes that
C4 238-240 NP denotes it
C5 293-304 NP denotes fludarabine
C6 374-376 NP denotes it
C7 415-420 NP denotes STAT1
C8 422-427 NP denotes which
C9 579-591 NP denotes this protein
C10 691-702 NP denotes fludarabine
C11 794-799 NP denotes STAT1
C12 883-894 NP denotes Fludarabine
C13 988-993 NP denotes STAT1
C14 1044-1055 NP denotes fludarabine
C15 1083-1094 NP denotes fludarabine
C16 1122-1127 NP denotes STAT1
C17 1207-1215 NP denotes the drug
C18 1231-1236 NP denotes STAT1
R1 C3 C2 coref-relat that,hematologic malignancies
R2 C4 C1 coref-pron it,Fludarabine
R3 C5 C1 coref-ident fludarabine,Fludarabine
R4 C6 C5 coref-pron it,fludarabine
R5 C8 C7 coref-relat which,STAT1
R6 C9 C7 coref-ident this protein,STAT1
R7 C10 C5 coref-ident fludarabine,fludarabine
R8 C11 C9 coref-ident STAT1,this protein
R9 C12 C10 coref-ident Fludarabine,fludarabine
R10 C13 C11 coref-ident STAT1,STAT1
R11 C14 C12 coref-ident fludarabine,Fludarabine
R12 C15 C14 coref-ident fludarabine,fludarabine
R13 C16 C13 coref-ident STAT1,STAT1
R14 C17 C15 coref-ident the drug,fludarabine
R15 C18 C16 coref-ident STAT1,STAT1

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-11 other_organic_compound denotes Fludarabine
T2 71-76 protein_molecule denotes STAT1
T3 88-99 other_organic_compound denotes Fludarabine
T4 105-122 other_organic_compound denotes nucleoside analog
T5 148-172 other_name denotes hematologic malignancies
T6 200-227 other_name denotes prolonged immunosuppression
T7 293-304 other_organic_compound denotes fludarabine
T8 348-367 other_name denotes low growth fraction
T9 415-420 protein_molecule denotes STAT1
T10 461-492 protein_family_or_group denotes lymphocyte-activating cytokines
T11 507-518 protein_family_or_group denotes interferons
T12 537-559 other_name denotes cell-mediated immunity
T13 655-671 other_name denotes viral infections
T14 691-702 other_organic_compound denotes fludarabine
T15 716-733 other_organic_compound denotes immunosuppressant
T16 734-748 other_organic_compound denotes cyclosporine A
T17 763-771 protein_family_or_group denotes cytokine
T18 794-799 protein_molecule denotes STAT1
T19 804-809 protein_molecule denotes STAT1
T20 883-894 other_organic_compound denotes Fludarabine
T21 926-931 protein_molecule denotes STAT1
T22 968-973 protein_family_or_group denotes STATs
T23 988-993 protein_molecule denotes STAT1
T24 1022-1030 multi_cell denotes patients
T25 1044-1055 other_organic_compound denotes fludarabine
T26 1083-1094 other_organic_compound denotes fludarabine
T27 1122-1127 protein_molecule denotes STAT1
T28 1166-1183 other_name denotes immunosuppression
T29 1231-1236 protein_molecule denotes STAT1

DisGeNET

Id Subject Object Predicate Lexical cue
T0 415-420 gene:6772 denotes STAT1
T1 655-671 disease:C0042769 denotes viral infections
R1 T0 T1 associated_with STAT1,viral infections