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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 31-36 protein denotes IL-12
T2 41-45 protein denotes IL-2
T3 55-91 protein denotes p38 mitogen-activated protein kinase
T4 164-169 protein denotes IL-12
T5 174-178 protein denotes IL-2
T6 193-226 cell_type denotes mitogen- or CD3-activated T cells
T7 251-260 protein denotes IFN-gamma
T8 271-282 cell_type denotes tumor cells
T9 354-361 cell_type denotes T cells
T10 398-403 protein denotes IL-12
T11 408-412 protein denotes IL-2
T12 440-447 cell_type denotes T cells
T13 482-491 protein denotes cytokines
T14 536-548 cell_type denotes CD8+ T cells
T15 550-564 cell_type denotes CD8+CD18bright
T16 610-615 protein denotes IL-12
T17 620-624 protein denotes IL-2
T18 685-690 protein denotes IL-12
T19 695-699 protein denotes IL-2
T20 703-725 cell_type denotes CD8+CD18bright T cells
T21 764-778 protein denotes stress kinases
T22 780-822 protein denotes p38 mitogen-activated protein (MAP) kinase
T23 827-887 protein denotes stress-activated protein kinase (SAPK)/Jun N-terminal kinase
T24 924-962 protein denotes extracellular signal-regulated kinases
T25 995-999 protein denotes IL-2
T26 1004-1009 protein denotes IL-12
T27 1058-1063 protein denotes STAT1
T28 1068-1073 protein denotes STAT3
T29 1121-1126 protein denotes IL-12
T30 1130-1134 protein denotes IL-2
T31 1155-1159 protein denotes STAT
T32 1334-1339 protein denotes STAT1
T33 1344-1349 protein denotes STAT3
T34 1361-1366 protein denotes IL-12
T35 1371-1375 protein denotes IL-2
T36 1421-1426 protein denotes IL-12
T37 1431-1435 protein denotes IL-2
T38 1622-1627 protein denotes IL-12
T39 1632-1636 protein denotes IL-2
T40 1706-1713 cell_type denotes T cells
T41 1717-1722 protein denotes IL-12
T42 1727-1731 protein denotes IL-2
T43 1773-1787 protein denotes p38 MAP kinase
T44 1792-1809 protein denotes Janus kinase/STAT

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-163 Sentence denotes The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation.
S2 164-283 Sentence denotes IL-12 and IL-2 can stimulate mitogen- or CD3-activated T cells to proliferate, produce IFN-gamma, and kill tumor cells.
S3 284-413 Sentence denotes The magnitude of these functional responses is greatly augmented when T cells are activated by the combination of IL-12 and IL-2.
S4 414-625 Sentence denotes Although peripheral blood T cells are largely unresponsive to these cytokines without prior activation, a small subset of CD8+ T cells (CD8+CD18bright) is strongly activated by the combination of IL-12 and IL-2.
S5 626-963 Sentence denotes In this report we show that the functional synergy between IL-12 and IL-2 in CD8+CD18bright T cells correlates with the activation of the stress kinases, p38 mitogen-activated protein (MAP) kinase and stress-activated protein kinase (SAPK)/Jun N-terminal kinase, but not with the activation of the extracellular signal-regulated kinases.
S6 964-1141 Sentence denotes The functional synergy between IL-2 and IL-12 is also associated with a prominent increase in STAT1 and STAT3 serine phosphorylation over that observed with IL-12 or IL-2 alone.
S7 1142-1244 Sentence denotes By contrast, STAT tyrosine phosphorylation is not augmented over that seen with either cytokine alone.
S8 1245-1484 Sentence denotes A specific inhibitor of p38 MAP kinase completely inhibits the serine phosphorylation of STAT1 and STAT3 induced by IL-12 and IL-2 and abrogates the functional synergy between IL-12 and IL-2 without affecting STAT tyrosine phosphorylation.
S9 1485-1637 Sentence denotes This suggests that p38 MAP kinase may play an important role in regulating STAT serine phosphorylation in response to the combination of IL-12 and IL-2.
S10 1638-1829 Sentence denotes Furthermore, these findings indicate that the optimal activation of T cells by IL-12 and IL-2 may depend on an interaction between the p38 MAP kinase and Janus kinase/STAT signaling pathways.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 31-45 NP denotes IL-12 and IL-2
C1 0-45 NP denotes The functional synergy between IL-12 and IL-2
C3 55-91 NP denotes p38 mitogen-activated protein kinase
C4 135-162 NP denotes STAT serine phosphorylation
C5 164-178 NP denotes IL-12 and IL-2
C6 354-361 NP denotes T cells
C8 398-412 NP denotes IL-12 and IL-2
C7 379-412 NP denotes the combination of IL-12 and IL-2
C9 476-491 NP denotes these cytokines
C11 610-624 NP denotes IL-12 and IL-2
C10 591-624 NP denotes the combination of IL-12 and IL-2
C12 685-699 NP denotes IL-12 and IL-2
C13 760-778 NP denotes the stress kinases
C15 780-822 NP denotes p38 mitogen-activated protein (MAP) kinase
C14 780-887 NP denotes p38 mitogen-activated protein (MAP) kinase and stress-activated protein kinase (SAPK)/Jun N-terminal kinase
C17 995-1009 NP denotes IL-2 and IL-12
C16 964-1009 NP denotes The functional synergy between IL-2 and IL-12
C18 1058-1096 NP denotes STAT1 and STAT3 serine phosphorylation
C19 1102-1106 NP denotes that
C20 1121-1140 NP denotes IL-12 or IL-2 alone
C21 1155-1184 NP denotes STAT tyrosine phosphorylation
C22 1207-1211 NP denotes that
C23 1222-1243 NP denotes either cytokine alone
C24 1269-1283 NP denotes p38 MAP kinase
C25 1361-1375 NP denotes IL-12 and IL-2
C27 1421-1435 NP denotes IL-12 and IL-2
C26 1390-1435 NP denotes the functional synergy between IL-12 and IL-2
C28 1454-1483 NP denotes STAT tyrosine phosphorylation
C29 1504-1518 NP denotes p38 MAP kinase
C30 1560-1587 NP denotes STAT serine phosphorylation
C32 1622-1636 NP denotes IL-12 and IL-2
C31 1603-1636 NP denotes the combination of IL-12 and IL-2
C33 1706-1713 NP denotes T cells
C34 1717-1731 NP denotes IL-12 and IL-2
R1 C5 C2 coref-ident IL-12 and IL-2,IL-12 and IL-2
R2 C8 C5 coref-ident IL-12 and IL-2,IL-12 and IL-2
R3 C9 C8 coref-ident these cytokines,IL-12 and IL-2
R4 C11 C9 coref-ident IL-12 and IL-2,these cytokines
R5 C10 C7 coref-ident the combination of IL-12 and IL-2,the combination of IL-12 and IL-2
R6 C12 C11 coref-ident IL-12 and IL-2,IL-12 and IL-2
R7 C15 C3 coref-ident p38 mitogen-activated protein (MAP) kinase,p38 mitogen-activated protein kinase
R8 C14 C13 coref-appos p38 mitogen-activated protein (MAP) kinase and stress-activated protein kinase (SAPK)/Jun N-terminal kinase,the stress kinases
R9 C17 C12 coref-ident IL-2 and IL-12,IL-12 and IL-2
R10 C16 C1 coref-ident The functional synergy between IL-2 and IL-12,The functional synergy between IL-12 and IL-2
R11 C18 C4 coref-ident STAT1 and STAT3 serine phosphorylation,STAT serine phosphorylation
R12 C19 C18 coref-pron that,STAT1 and STAT3 serine phosphorylation
R13 C22 C21 coref-pron that,STAT tyrosine phosphorylation
R14 C23 C20 coref-ident either cytokine alone,IL-12 or IL-2 alone
R15 C24 C15 coref-ident p38 MAP kinase,p38 mitogen-activated protein (MAP) kinase
R16 C25 C17 coref-ident IL-12 and IL-2,IL-2 and IL-12
R17 C27 C25 coref-ident IL-12 and IL-2,IL-12 and IL-2
R18 C26 C16 coref-ident the functional synergy between IL-12 and IL-2,The functional synergy between IL-2 and IL-12
R19 C28 C21 coref-ident STAT tyrosine phosphorylation,STAT tyrosine phosphorylation
R20 C29 C24 coref-ident p38 MAP kinase,p38 MAP kinase
R21 C30 C18 coref-ident STAT serine phosphorylation,STAT1 and STAT3 serine phosphorylation
R22 C32 C27 coref-ident IL-12 and IL-2,IL-12 and IL-2
R23 C31 C10 coref-ident the combination of IL-12 and IL-2,the combination of IL-12 and IL-2
R24 C33 C6 coref-ident T cells,T cells
R25 C34 C32 coref-ident IL-12 and IL-2,IL-12 and IL-2

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 31-36 protein_molecule denotes IL-12
T2 41-45 protein_molecule denotes IL-2
T3 55-91 protein_molecule denotes p38 mitogen-activated protein kinase
T4 135-139 other_name denotes STAT
T5 140-146 amino_acid_monomer denotes serine
T6 164-169 protein_molecule denotes IL-12
T7 174-178 protein_molecule denotes IL-2
T8 251-260 protein_molecule denotes IFN-gamma
T9 271-282 cell_type denotes tumor cells
T10 354-361 cell_type denotes T cells
T11 398-403 protein_molecule denotes IL-12
T12 408-412 protein_molecule denotes IL-2
T13 440-447 cell_type denotes T cells
T14 482-491 protein_family_or_group denotes cytokines
T15 536-548 cell_type denotes CD8+ T cells
T16 550-564 cell_type denotes CD8+CD18bright
T17 610-615 protein_molecule denotes IL-12
T18 620-624 protein_molecule denotes IL-2
T19 685-690 protein_molecule denotes IL-12
T20 695-699 protein_molecule denotes IL-2
T21 703-725 cell_type denotes CD8+CD18bright T cells
T22 764-778 protein_family_or_group denotes stress kinases
T23 780-822 protein_molecule denotes p38 mitogen-activated protein (MAP) kinase
T24 827-887 protein_molecule denotes stress-activated protein kinase (SAPK)/Jun N-terminal kinase
T25 924-962 protein_family_or_group denotes extracellular signal-regulated kinases
T26 995-999 protein_molecule denotes IL-2
T27 1004-1009 protein_molecule denotes IL-12
T28 1058-1063 protein_molecule denotes STAT1
T29 1068-1073 protein_molecule denotes STAT3
T30 1074-1080 amino_acid_monomer denotes serine
T31 1121-1126 protein_molecule denotes IL-12
T32 1130-1134 protein_molecule denotes IL-2
T33 1155-1159 protein_family_or_group denotes STAT
T34 1160-1168 amino_acid_monomer denotes tyrosine
T35 1308-1314 amino_acid_monomer denotes serine
T36 1334-1339 protein_molecule denotes STAT1
T37 1344-1349 protein_molecule denotes STAT3
T38 1361-1366 protein_molecule denotes IL-12
T39 1371-1375 protein_molecule denotes IL-2
T40 1421-1426 protein_molecule denotes IL-12
T41 1431-1435 protein_molecule denotes IL-2
T42 1459-1467 amino_acid_monomer denotes tyrosine
T43 1560-1564 other_name denotes STAT
T44 1565-1571 amino_acid_monomer denotes serine
T45 1622-1627 protein_molecule denotes IL-12
T46 1632-1636 protein_molecule denotes IL-2
T47 1706-1713 cell_type denotes T cells
T48 1717-1722 protein_molecule denotes IL-12
T49 1727-1731 protein_molecule denotes IL-2
T50 1773-1787 protein_molecule denotes p38 MAP kinase
T51 1792-1809 protein_molecule denotes Janus kinase/STAT

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 271-276 HP_0002664 denotes tumor