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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-36 protein denotes p38 mitogen-activated protein kinase
T2 68-71 protein denotes TCR
T3 71-76 protein denotes /CD28
T4 94-116 cell_type denotes primary murine T cells
T5 183-186 protein denotes TCR
T6 206-233 protein denotes CD28 costimulatory receptor
T7 306-338 protein denotes mitogen-activated protein kinase
T8 340-344 protein denotes MAPK
T9 360-381 cell_type denotes primary mouse T cells
T10 416-436 cell_type denotes human Jurkat T cells
T11 452-460 protein denotes p38 MAPK
T12 470-493 protein denotes Jun NH2-terminal kinase
T13 495-498 protein denotes JNK
T14 550-558 protein denotes anti-CD3
T15 562-571 protein denotes anti-CD28
T16 575-592 cell_type denotes murine thymocytes
T17 597-612 cell_type denotes splenic T cells
T18 623-631 protein denotes p38 MAPK
T19 684-692 protein denotes CD3/CD28
T20 752-755 protein denotes TCR
T21 756-764 protein denotes CD3/CD28
T22 799-807 protein denotes p38 MAPK
T23 898-901 protein denotes JNK
T24 984-988 protein denotes IL-2
T25 990-994 protein denotes IL-4
T26 1000-1009 protein denotes IFN-gamma
T27 1026-1029 protein denotes CD3
T28 1034-1037 protein denotes CD3
T29 1037-1042 protein denotes /CD28
T30 1086-1110 protein denotes c-Jun and ATF-2 proteins
T31 1135-1143 protein denotes p38 MAPK
T32 1194-1202 protein denotes p38 MAPK
T33 1276-1297 cell_type denotes primary mouse T cells
T34 1338-1343 protein denotes c-Jun
T35 1375-1379 protein denotes AP-1
T36 1431-1438 cell_type denotes T cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-117 Sentence denotes p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells.
S2 118-234 Sentence denotes Optimal T cell activation requires two signals, one generated by TCR and another by the CD28 costimulatory receptor.
S3 235-382 Sentence denotes In this study, we investigated the regulation of costimulation-induced mitogen-activated protein kinase (MAPK) activation in primary mouse T cells.
S4 383-613 Sentence denotes In contrast to that reported for human Jurkat T cells, we found that p38 MAPK, but not Jun NH2-terminal kinase (JNK), is weakly activated upon stimulation with either anti-CD3 or anti-CD28 in murine thymocytes and splenic T cells.
S5 614-784 Sentence denotes However, p38 MAPK is activated strongly and synergistically by either CD3/CD28 coligation or PMA/Ca2+ ionophore stimulation, which mimics TCR-CD3/CD28-mediated signaling.
S6 785-872 Sentence denotes Activation of p38 MAPK correlates closely with the stimulation of T cell proliferation.
S7 873-944 Sentence denotes In contrast, PMA-induced JNK activation is inhibited by Ca2+ ionophore.
S8 945-1163 Sentence denotes T cell proliferation and production of IL-2, IL-4, and IFN-gamma induced by both CD3 and CD3/CD28 ligation and the nuclear expression of the c-Jun and ATF-2 proteins are each blocked by the p38 MAPK inhibitor SB203580.
S9 1164-1484 Sentence denotes Our findings demonstrate that p38 MAPK 1) plays an important role in signal integration during costimulation of primary mouse T cells, 2) may be involved in the induction of c-Jun activation and augmentation of AP-1 transcriptional activity, and 3) regulates whether T cells enter a state of functional unresponsiveness.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-36 NP denotes p38 mitogen-activated protein kinase
C2 94-116 NP denotes primary murine T cells
C3 153-164 NP denotes two signals
C4 166-233 NP denotes one generated by TCR and another by the CD28 costimulatory receptor
C5 360-381 NP denotes primary mouse T cells
C6 416-436 NP denotes human Jurkat T cells
C7 452-460 NP denotes p38 MAPK
C8 623-631 NP denotes p38 MAPK
C9 707-737 NP denotes PMA/Ca2+ ionophore stimulation
C10 739-744 NP denotes which
C11 799-807 NP denotes p38 MAPK
C12 1194-1202 NP denotes p38 MAPK
C13 1276-1297 NP denotes primary mouse T cells
C14 1431-1438 NP denotes T cells
R1 C4 C3 coref-appos one generated by TCR and another by the CD28 costimulatory receptor,two signals
R2 C5 C2 coref-ident primary mouse T cells,primary murine T cells
R3 C7 C1 coref-ident p38 MAPK,p38 mitogen-activated protein kinase
R4 C8 C7 coref-ident p38 MAPK,p38 MAPK
R5 C10 C9 coref-relat which,PMA/Ca2+ ionophore stimulation
R6 C11 C8 coref-ident p38 MAPK,p38 MAPK
R7 C12 C11 coref-ident p38 MAPK,p38 MAPK
R8 C13 C5 coref-ident primary mouse T cells,primary mouse T cells
R9 C14 C6 coref-ident T cells,human Jurkat T cells

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-3 protein_molecule denotes p38
T2 68-71 protein_family_or_group denotes TCR
T3 71-76 protein_molecule denotes /CD28
T4 94-116 cell_type denotes primary murine T cells
T5 118-143 other_name denotes Optimal T cell activation
T6 183-186 protein_family_or_group denotes TCR
T7 206-233 protein_molecule denotes CD28 costimulatory receptor
T8 284-305 other_name denotes costimulation-induced
T9 306-338 protein_molecule denotes mitogen-activated protein kinase
T10 340-344 protein_family_or_group denotes MAPK
T11 360-381 cell_type denotes primary mouse T cells
T12 416-436 cell_type denotes human Jurkat T cells
T13 452-460 protein_molecule denotes p38 MAPK
T14 470-493 protein_molecule denotes Jun NH2-terminal kinase
T15 495-498 protein_molecule denotes JNK
T16 550-558 protein_family_or_group denotes anti-CD3
T17 562-571 protein_family_or_group denotes anti-CD28
T18 575-592 cell_type denotes murine thymocytes
T19 597-612 cell_type denotes splenic T cells
T20 623-631 protein_molecule denotes p38 MAPK
T21 684-692 protein_complex denotes CD3/CD28
T22 707-737 other_name denotes PMA/Ca2+ ionophore stimulation
T23 752-755 protein_family_or_group denotes TCR
T24 756-764 protein_complex denotes CD3/CD28
T25 799-807 protein_molecule denotes p38 MAPK
T26 851-871 other_name denotes T cell proliferation
T27 886-897 other_name denotes PMA-induced
T28 898-901 protein_molecule denotes JNK
T29 929-943 other_organic_compound denotes Ca2+ ionophore
T30 945-965 other_name denotes T cell proliferation
T31 984-988 protein_molecule denotes IL-2
T32 990-994 protein_molecule denotes IL-4
T33 1000-1009 protein_molecule denotes IFN-gamma
T34 1026-1029 protein_molecule denotes CD3
T35 1034-1037 protein_molecule denotes CD3
T36 1037-1042 protein_molecule denotes /CD28
T37 1060-1078 other_name denotes nuclear expression
T38 1135-1143 protein_molecule denotes p38 MAPK
T39 1154-1162 other_organic_compound denotes SB203580
T40 1194-1202 protein_molecule denotes p38 MAPK
T41 1276-1297 cell_type denotes primary mouse T cells
T42 1338-1343 protein_molecule denotes c-Jun
T43 1375-1379 protein_molecule denotes AP-1
T44 1431-1438 cell_type denotes T cells
T45 1456-1483 other_name denotes functional unresponsiveness