PubMed:10200294
Annnotations
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 67-72 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
| T2 | 209-212 | DiseaseOrPhenotypicFeature | denotes | LPS | 0019508 |
| T3 | 288-293 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
| T4 | 701-704 | DiseaseOrPhenotypicFeature | denotes | LPS | 0019508 |
| T5 | 1252-1255 | DiseaseOrPhenotypicFeature | denotes | LPS | 0019508 |
| T6 | 1299-1302 | DiseaseOrPhenotypicFeature | denotes | LPS | 0019508 |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 8-55 | protein | denotes | lipopolysaccharide-induced transcription factor |
| T2 | 67-94 | protein | denotes | tumor necrosis factor alpha |
| T3 | 240-249 | cell_type | denotes | monocytes |
| T4 | 254-265 | cell_type | denotes | macrophages |
| T5 | 288-315 | protein | denotes | tumor necrosis factor alpha |
| T6 | 317-326 | protein | denotes | TNF-alpha |
| T7 | 407-416 | protein | denotes | TNF-alpha |
| T8 | 446-455 | protein | denotes | TNF-alpha |
| T9 | 517-531 | protein | denotes | nuclear factor |
| T10 | 548-557 | protein | denotes | TNF-alpha |
| T11 | 613-622 | protein | denotes | NF-kappaB |
| T12 | 724-742 | protein | denotes | DNA-binding domain |
| T13 | 776-800 | DNA | denotes | human TNF-alpha promoter |
| T14 | 861-870 | protein | denotes | NF-kappaB |
| T15 | 870-884 | DNA | denotes | -binding sites |
| T16 | 941-955 | protein | denotes | 60-kDa protein |
| T17 | 998-1021 | protein | denotes | amino-terminal sequence |
| T18 | 1048-1065 | DNA | denotes | degenerate probes |
| T19 | 1096-1107 | cell_line | denotes | THP-1 cells |
| T20 | 1117-1127 | DNA | denotes | cDNA clone |
| T21 | 1196-1206 | DNA | denotes | cDNA clone |
| T22 | 1270-1281 | cell_line | denotes | THP-1 cells |
| T23 | 1299-1327 | protein | denotes | LPS-induced TNF-alpha factor |
| T24 | 1329-1334 | protein | denotes | LITAF |
| T25 | 1351-1361 | RNA | denotes | LITAF mRNA |
| T26 | 1376-1387 | cell_line | denotes | THP-1 cells |
| T27 | 1415-1424 | protein | denotes | TNF-alpha |
| T28 | 1479-1489 | RNA | denotes | LITAF mRNA |
| T29 | 1534-1561 | cell_type | denotes | peripheral blood leukocytes |
| T30 | 1681-1686 | protein | denotes | LITAF |
| T31 | 1697-1721 | DNA | denotes | chromosome 16p12-16p13.3 |
| T32 | 1761-1766 | protein | denotes | LITAF |
| T33 | 1816-1836 | DNA | denotes | human TNF-alpha gene |
| T34 | 1877-1886 | protein | denotes | TNF-alpha |
semrep-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| E1-ti-1 | 2-7 | cui:C0679622 | denotes | novel |
| E2-ti-1 | 8-26 | cui:C0023810 | denotes | lipopolysaccharide |
| E3-ti-1 | 27-34 | cui:C0205263 | denotes | induced |
| E4-ti-1 | 35-55 | cui:C0040648 | denotes | transcription factor |
| E5-ti-1 | 67-94 | cui:C1448177 | denotes | tumor necrosis factor alpha |
| E6-ti-1 | 95-110 | cui:C0017262 | denotes | gene expression |
| E7-ti-1 | 112-129 | cui:C0009017 | denotes | molecular cloning |
| E8-ti-1 | 165-176 | cui:C0008633 | denotes | chromosomal |
| E9-ti-1 | 177-187 | cui:C1516050 | denotes | assignment |
| T1 | 56-66 | INTERACTS_WITH | denotes | regulating |
| E1-ab-1 | 189-207 | cui:C0023810 | denotes | Lipopolysaccharide |
| E2-ab-1 | 219-225 | cui:C0237399 | denotes | potent |
| E3-ab-1 | 226-236 | cui:C0175727 | denotes | stimulator |
| E4-ab-1 | 240-249 | cui:C0026473 | denotes | monocytes |
| E5-ab-1 | 254-265 | cui:C0024432 | denotes | macrophages |
| E6-ab-1 | 275-284 | cui:C0015283 | denotes | secretion |
| E7-ab-1 | 288-315 | cui:C1456820 | denotes | tumor necrosis factor alpha |
| E8-ab-1 | 338-360 | cui:C0243042 | denotes | inflammatory mediators |
| E1-ab-2 | 384-391 | cui:C1280500 | denotes | effects |
| E2-ab-2 | 399-403 | cui:C1167395 | denotes | host |
| E3-ab-2 | 407-416 | cui:C1456820 | denotes | TNF-alpha |
| E4-ab-2 | 446-455 | cui:C1456820 | denotes | TNF-alpha |
| E5-ab-2 | 456-471 | cui:C0017262 | denotes | gene expression |
| E1-ab-3 | 503-509 | cui:C0349590 | denotes | nature |
| E2-ab-3 | 517-524 | cui:C0521447 | denotes | nuclear |
| E3-ab-3 | 525-531 | cui:C1521761 | denotes | factor |
| E4-ab-3 | 540-547 | cui:C0243148 | denotes | control |
| E5-ab-3 | 548-557 | cui:C1448177 | denotes | TNF-alpha |
| E6-ab-3 | 558-576 | cui:C0040649 | denotes | gene transcription |
| E7-ab-3 | 580-586 | cui:C0020114 | denotes | humans |
| E8-ab-3 | 613-622 | cui:C0079904 | denotes | NF-kappaB |
| T2 | 577-579 | PROCESS_OF | denotes | in |
| E1-ab-4 | 647-655 | cui:C0205156 | denotes | previous |
| E2-ab-4 | 656-663 | cui:C0008972 | denotes | studies |
| E3-ab-4 | 678-688 | cui:C0024432 | denotes | macrophage |
| E4-ab-4 | 689-697 | cui:C0871261 | denotes | response |
| E5-ab-4 | 701-704 | cui:C0023810 | denotes | LPS |
| E6-ab-4 | 718-723 | cui:C0679622 | denotes | novel |
| E7-ab-4 | 724-742 | cui:C1511662 | denotes | DNA-binding domain |
| E8-ab-4 | 776-781 | cui:C0020114 | denotes | human |
| E9-ab-4 | 782-791 | cui:C0027540 | denotes | TNF-alpha |
| E10-ab-4 | 782-791 | cui:C1521761 | denotes | TNF-alpha |
| E11-ab-4 | 782-791 | cui:C0439095 | denotes | TNF-alpha |
| E12-ab-4 | 782-800 | cui:C0041370 | denotes | TNF-alpha promoter |
| E13-ab-4 | 815-830 | cui:C0040649 | denotes | transcriptional |
| E14-ab-4 | 831-839 | cui:C0439167 | denotes | activity |
| E15-ab-4 | 855-860 | cui:C0205309 | denotes | known |
| E16-ab-4 | 861-870 | cui:C0079904 | denotes | NF-kappaB |
| E17-ab-4 | 871-884 | cui:C0005456 | denotes | binding sites |
| T3 | 776-791 | PROCESS_OF | denotes | human TNF-alpha |
| T4 | 782-791 | AFFECTS | denotes | TNF-alpha |
| E1-ab-5 | 904-907 | cui:C0012854 | denotes | DNA |
| E2-ab-5 | 944-947 | cui:C1532717 | denotes | kDa |
| E3-ab-5 | 948-963 | cui:C0033618 | denotes | protein binding |
| E4-ab-5 | 972-980 | cui:C0486805 | denotes | fragment |
| E5-ab-5 | 1004-1012 | cui:C0205088 | denotes | terminal |
| E6-ab-5 | 1013-1021 | cui:C1519249 | denotes | sequence |
| E7-ab-5 | 1059-1065 | cui:C0182400 | denotes | probes |
| E8-ab-5 | 1078-1090 | cui:C0751608 | denotes | cDNA library |
| E9-ab-5 | 1096-1101 | entrez:2736 | denotes | THP-1 |
| E10-ab-5 | 1102-1107 | cui:C0007634 | denotes | cells |
| T5 | 1091-1095 | LOCATION_OF | denotes | from |
| E1-ab-6 | 1111-1116 | cui:C0679622 | denotes | novel |
| E2-ab-6 | 1117-1121 | cui:C0006556 | denotes | cDNA |
| E3-ab-6 | 1122-1127 | cui:C1522642 | denotes | clone |
| E1-ab-7 | 1196-1200 | cui:C0006556 | denotes | cDNA |
| E2-ab-7 | 1201-1206 | cui:C1522642 | denotes | clone |
| E3-ab-7 | 1225-1234 | cui:C0857127 | denotes | induction |
| E4-ab-7 | 1252-1255 | cui:C0023810 | denotes | LPS |
| E5-ab-7 | 1270-1275 | entrez:2736 | denotes | THP-1 |
| E6-ab-7 | 1276-1281 | cui:C0007634 | denotes | cells |
| T6 | 1256-1266 | AUGMENTS | denotes | activation |
| E1-ab-8 | 1294-1298 | cui:C0027365 | denotes | name |
| E2-ab-8 | 1299-1302 | cui:C0023810 | denotes | LPS |
| E3-ab-8 | 1303-1310 | cui:C0205263 | denotes | induced |
| E4-ab-8 | 1311-1320 | cui:C1456820 | denotes | TNF-alpha |
| E5-ab-8 | 1329-1334 | entrez:9516 | denotes | LITAF |
| E1-ab-9 | 1351-1356 | entrez:9516 | denotes | LITAF |
| E2-ab-9 | 1357-1372 | cui:C1515670 | denotes | mRNA expression |
| E3-ab-9 | 1376-1381 | entrez:2736 | denotes | THP-1 |
| E4-ab-9 | 1382-1387 | cui:C0007634 | denotes | cells |
| E5-ab-9 | 1415-1424 | cui:C1448177 | denotes | TNF-alpha |
| E6-ab-9 | 1425-1436 | cui:C1519595 | denotes | transcripts |
| T7 | 1373-1375 | LOCATION_OF | denotes | in |
| E1-ab-10 | 1441-1449 | cui:C0442796 | denotes | addition |
| E2-ab-10 | 1451-1455 | cui:C0205250 | denotes | high |
| E3-ab-10 | 1465-1475 | cui:C0185117 | denotes | expression |
| E4-ab-10 | 1479-1484 | entrez:9516 | denotes | LITAF |
| E5-ab-10 | 1485-1489 | cui:C0035696 | denotes | mRNA |
| E6-ab-10 | 1524-1532 | cui:C0032043 | denotes | placenta |
| E7-ab-10 | 1534-1550 | cui:C0229664 | denotes | peripheral blood |
| E8-ab-10 | 1551-1561 | cui:C0023516 | denotes | leukocytes |
| E9-ab-10 | 1563-1574 | cui:C0024204 | denotes | lymph nodes |
| E10-ab-10 | 1584-1590 | cui:C0037993 | denotes | spleen |
| T8 | 1517-1519 | LOCATION_OF | denotes | in |
| T9 | 1517-1519 | LOCATION_OF | denotes | in |
| T10 | 1517-1519 | LOCATION_OF | denotes | in |
| T11 | 1517-1519 | LOCATION_OF | denotes | in |
| E1-ab-11 | 1601-1612 | cui:C0008633 | denotes | chromosomal |
| E2-ab-11 | 1613-1625 | cui:C1524110 | denotes | localization |
| E3-ab-11 | 1632-1644 | cui:C0016315 | denotes | fluorescence |
| E4-ab-11 | 1653-1666 | cui:C0020202 | denotes | hybridization |
| E5-ab-11 | 1681-1686 | entrez:9516 | denotes | LITAF |
| E6-ab-11 | 1697-1707 | cui:C0008633 | denotes | chromosome |
| E7-ab-11 | 1708-1713 | cui:C1520681 | denotes | 16p12 |
| E8-ab-11 | 1714-1721 | cui:C1520688 | denotes | 16p13.3 |
| T12 | 1645-1647 | PROCESS_OF | denotes | in |
| T13 | 1687-1693 | PART_OF | denotes | mapped |
| E1-ab-12 | 1739-1747 | cui:C0243095 | denotes | findings |
| E2-ab-12 | 1761-1766 | entrez:9516 | denotes | LITAF |
| E3-ab-12 | 1786-1790 | cui:C0035820 | denotes | role |
| E4-ab-12 | 1822-1831 | cui:C1448177 | denotes | TNF-alpha |
| E5-ab-12 | 1816-1836 | cui:C0314604 | denotes | human TNF-alpha gene |
| E6-ab-12 | 1852-1855 | cui:C0205314 | denotes | new |
| E7-ab-12 | 1856-1865 | cui:C0441712 | denotes | mechanism |
| E8-ab-12 | 1877-1886 | cui:C1448177 | denotes | TNF-alpha |
| E9-ab-12 | 1887-1902 | cui:C0017262 | denotes | gene expression |
| T14 | 1798-1808 | STIMULATES | denotes | activation |
| R1 | E4-ti-1 | T1 | subjectOf | transcription factor,regulating |
| R2 | E5-ti-1 | T1 | objectOf | tumor necrosis factor alpha,regulating |
| R3 | E6-ab-3 | T2 | subjectOf | gene transcription,in |
| R4 | E7-ab-3 | T2 | objectOf | humans,in |
| R5 | E9-ab-4 | T3 | subjectOf | TNF-alpha,human TNF-alpha |
| R6 | E8-ab-4 | T3 | objectOf | human,human TNF-alpha |
| R7 | E5-ab-4 | T4 | subjectOf | LPS,TNF-alpha |
| R8 | E9-ab-4 | T4 | objectOf | TNF-alpha,TNF-alpha |
| R9 | E10-ab-5 | T5 | subjectOf | cells,from |
| R10 | E8-ab-5 | T5 | objectOf | cDNA library,from |
| R11 | E4-ab-7 | T6 | subjectOf | LPS,activation |
| R12 | E6-ab-7 | T6 | objectOf | cells,activation |
| R13 | E4-ab-9 | T7 | subjectOf | cells,in |
| R14 | E1-ab-9 | T7 | objectOf | LITAF,in |
| R15 | E6-ab-10 | T8 | subjectOf | placenta,in |
| R16 | E4-ab-10 | T8 | objectOf | LITAF,in |
| R17 | E10-ab-10 | T9 | subjectOf | spleen,in |
| R18 | E4-ab-10 | T9 | objectOf | LITAF,in |
| R19 | E9-ab-10 | T10 | subjectOf | lymph nodes,in |
| R20 | E4-ab-10 | T10 | objectOf | LITAF,in |
| R21 | E8-ab-10 | T11 | subjectOf | leukocytes,in |
| R22 | E4-ab-10 | T11 | objectOf | LITAF,in |
| R23 | E3-ab-11 | T12 | subjectOf | fluorescence,in |
| R24 | E4-ab-11 | T12 | objectOf | hybridization,in |
| R25 | E5-ab-11 | T13 | subjectOf | LITAF,mapped |
| R26 | E8-ab-11 | T13 | objectOf | 16p13.3,mapped |
| R27 | E2-ab-12 | T14 | subjectOf | LITAF,activation |
| R28 | E4-ab-12 | T14 | objectOf | TNF-alpha,activation |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-188 | Sentence | denotes | A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment. |
| S2 | 189-361 | Sentence | denotes | Lipopolysaccharide (LPS) is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor alpha (TNF-alpha) and other inflammatory mediators. |
| S3 | 362-498 | Sentence | denotes | Given the deleterious effects to the host of TNF-alpha, it has been postulated that TNF-alpha gene expression must be tightly regulated. |
| S4 | 499-642 | Sentence | denotes | The nature of the nuclear factor(s) that control TNF-alpha gene transcription in humans remains obscure, although NF-kappaB has been suggested. |
| S5 | 643-885 | Sentence | denotes | Our previous studies pertaining to macrophage response to LPS identified a novel DNA-binding domain located from -550 to -487 in the human TNF-alpha promoter that contains transcriptional activity, but lacks any known NF-kappaB-binding sites. |
| S6 | 886-1108 | Sentence | denotes | We have used this DNA fragment to isolate and purify a 60-kDa protein binding to this fragment and obtained its amino-terminal sequence, which was used to design degenerate probes to screen a cDNA library from THP-1 cells. |
| S7 | 1109-1170 | Sentence | denotes | A novel cDNA clone (1.8 kb) was isolated and fully sequenced. |
| S8 | 1171-1336 | Sentence | denotes | Characterization of this cDNA clone revealed that its induction was dependent on LPS activation of THP-1 cells; hence, the name LPS-induced TNF-alpha factor (LITAF). |
| S9 | 1337-1437 | Sentence | denotes | Inhibition of LITAF mRNA expression in THP-1 cells resulted in a reduction of TNF-alpha transcripts. |
| S10 | 1438-1591 | Sentence | denotes | In addition, high level of expression of LITAF mRNA was observed predominantly in the placenta, peripheral blood leukocytes, lymph nodes, and the spleen. |
| S11 | 1592-1722 | Sentence | denotes | Finally, chromosomal localization using fluorescence in situ hybridization revealed that LITAF mapped to chromosome 16p12-16p13.3. |
| S12 | 1723-1903 | Sentence | denotes | Together, these findings suggest that LITAF plays an important role in the activation of the human TNF-alpha gene and proposes a new mechanism to control TNF-alpha gene expression. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 67-110 | NP | denotes | tumor necrosis factor alpha gene expression |
| C2 | 189-213 | NP | denotes | Lipopolysaccharide (LPS) |
| C3 | 288-327 | NP | denotes | tumor necrosis factor alpha (TNF-alpha) |
| C4 | 407-416 | NP | denotes | TNF-alpha |
| C5 | 446-471 | NP | denotes | TNF-alpha gene expression |
| C6 | 513-534 | NP | denotes | the nuclear factor(s) |
| C7 | 535-539 | NP | denotes | that |
| C8 | 701-704 | NP | denotes | LPS |
| C10 | 772-800 | NP | denotes | the human TNF-alpha promoter |
| C11 | 801-805 | NP | denotes | that |
| C9 | 716-884 | NP | denotes | a novel DNA-binding domain located from -550 to -487 in the human TNF-alpha promoter that contains transcriptional activity, but lacks any known NF-kappaB-binding sites |
| C12 | 899-916 | NP | denotes | this DNA fragment |
| C13 | 967-980 | NP | denotes | this fragment |
| C15 | 994-997 | NP | denotes | its |
| C14 | 994-1021 | NP | denotes | its amino-terminal sequence |
| C16 | 1023-1028 | NP | denotes | which |
| C17 | 1096-1107 | NP | denotes | THP-1 cells |
| C18 | 1109-1136 | NP | denotes | A novel cDNA clone (1.8 kb) |
| C19 | 1191-1206 | NP | denotes | this cDNA clone |
| C20 | 1221-1224 | NP | denotes | its |
| C21 | 1270-1282 | NP | denotes | THP-1 cells; |
| C22 | 1290-1335 | NP | denotes | the name LPS-induced TNF-alpha factor (LITAF) |
| C23 | 1376-1387 | NP | denotes | THP-1 cells |
| C24 | 1681-1686 | NP | denotes | LITAF |
| C25 | 1761-1766 | NP | denotes | LITAF |
| C26 | 1877-1902 | NP | denotes | TNF-alpha gene expression |
| R1 | C4 | C3 | coref-ident | TNF-alpha,tumor necrosis factor alpha (TNF-alpha) |
| R2 | C5 | C1 | coref-ident | TNF-alpha gene expression,tumor necrosis factor alpha gene expression |
| R3 | C7 | C6 | coref-relat | that,the nuclear factor(s) |
| R4 | C8 | C2 | coref-ident | LPS,Lipopolysaccharide (LPS) |
| R5 | C11 | C10 | coref-relat | that,the human TNF-alpha promoter |
| R6 | C12 | C9 | coref-ident | this DNA fragment,"a novel DNA-binding domain located from -550 to -487 in the human TNF-alpha promoter that contains transcriptional activity, but lacks any known NF-kappaB-binding sites" |
| R7 | C13 | C12 | coref-ident | this fragment,this DNA fragment |
| R8 | C15 | C13 | coref-pron | its,this fragment |
| R9 | C16 | C14 | coref-relat | which,its amino-terminal sequence |
| R10 | C19 | C18 | coref-ident | this cDNA clone,A novel cDNA clone (1.8 kb) |
| R11 | C20 | C19 | coref-pron | its,this cDNA clone |
| R12 | C21 | C17 | coref-ident | THP-1 cells;,THP-1 cells |
| R13 | C23 | C21 | coref-ident | THP-1 cells,THP-1 cells; |
| R14 | C24 | C22 | coref-ident | LITAF,the name LPS-induced TNF-alpha factor (LITAF) |
| R15 | C25 | C24 | coref-ident | LITAF,LITAF |
| R16 | C26 | C5 | coref-ident | TNF-alpha gene expression,TNF-alpha gene expression |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 8-55 | protein_family_or_group | denotes | lipopolysaccharide-induced transcription factor |
| T2 | 67-94 | protein_molecule | denotes | tumor necrosis factor alpha |
| T3 | 112-129 | other_name | denotes | molecular cloning |
| T4 | 131-141 | other_name | denotes | sequencing |
| T5 | 143-159 | other_name | denotes | characterization |
| T6 | 165-187 | other_name | denotes | chromosomal assignment |
| T7 | 189-207 | lipid | denotes | Lipopolysaccharide |
| T8 | 209-212 | lipid | denotes | LPS |
| T9 | 240-249 | cell_type | denotes | monocytes |
| T10 | 254-265 | cell_type | denotes | macrophages |
| T11 | 288-315 | protein_molecule | denotes | tumor necrosis factor alpha |
| T12 | 317-326 | protein_molecule | denotes | TNF-alpha |
| T13 | 338-360 | other_name | denotes | inflammatory mediators |
| T14 | 407-416 | protein_molecule | denotes | TNF-alpha |
| T15 | 446-455 | protein_molecule | denotes | TNF-alpha |
| T16 | 517-531 | protein_family_or_group | denotes | nuclear factor |
| T17 | 548-557 | protein_molecule | denotes | TNF-alpha |
| T18 | 613-622 | protein_complex | denotes | NF-kappaB |
| T19 | 701-704 | lipid | denotes | LPS |
| T20 | 724-742 | protein_domain_or_region | denotes | DNA-binding domain |
| T21 | 776-781 | DNA_domain_or_region | denotes | human |
| T22 | 782-791 | protein_molecule | denotes | TNF-alpha |
| T23 | 815-839 | other_name | denotes | transcriptional activity |
| T24 | 861-870 | protein_complex | denotes | NF-kappaB |
| T25 | 870-884 | DNA_domain_or_region | denotes | -binding sites |
| T26 | 941-955 | protein_molecule | denotes | 60-kDa protein |
| T27 | 998-1021 | protein_domain_or_region | denotes | amino-terminal sequence |
| T28 | 1048-1065 | DNA_molecule | denotes | degenerate probes |
| T29 | 1078-1090 | other_name | denotes | cDNA library |
| T30 | 1096-1107 | cell_line | denotes | THP-1 cells |
| T31 | 1117-1127 | DNA_molecule | denotes | cDNA clone |
| T32 | 1196-1206 | DNA_molecule | denotes | cDNA clone |
| T33 | 1252-1255 | lipid | denotes | LPS |
| T34 | 1270-1281 | cell_line | denotes | THP-1 cells |
| T35 | 1299-1302 | lipid | denotes | LPS |
| T36 | 1311-1320 | protein_molecule | denotes | TNF-alpha |
| T37 | 1329-1334 | protein_molecule | denotes | LITAF |
| T38 | 1351-1356 | protein_molecule | denotes | LITAF |
| T39 | 1376-1387 | cell_line | denotes | THP-1 cells |
| T40 | 1415-1424 | protein_molecule | denotes | TNF-alpha |
| T41 | 1479-1484 | protein_molecule | denotes | LITAF |
| T42 | 1524-1532 | body_part | denotes | placenta |
| T43 | 1534-1561 | cell_type | denotes | peripheral blood leukocytes |
| T44 | 1563-1574 | body_part | denotes | lymph nodes |
| T45 | 1584-1590 | body_part | denotes | spleen |
| T46 | 1601-1625 | other_name | denotes | chromosomal localization |
| T47 | 1632-1666 | other_name | denotes | fluorescence in situ hybridization |
| T48 | 1681-1686 | protein_molecule | denotes | LITAF |
| T49 | 1697-1721 | DNA_domain_or_region | denotes | chromosome 16p12-16p13.3 |
| T50 | 1761-1766 | protein_molecule | denotes | LITAF |
| T51 | 1816-1821 | DNA_domain_or_region | denotes | human |
| T52 | 1822-1831 | protein_molecule | denotes | TNF-alpha |
| T53 | 1877-1886 | protein_molecule | denotes | TNF-alpha |
metamap-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 166-177 | C0008633 | denotes | hromosomal |
| T2 | 1416-1425 | C1456820 | denotes | NF-alpha |
| T3 | 783-792 | C1456820 | denotes | NF-alpha |
| T4 | 549-558 | C1456820 | denotes | NF-alpha |
| T5 | 289-316 | C1456820 | denotes | umor necrosis factor alpha |
| T6 | 1253-1256 | C0023810 | denotes | PS |
| T7 | 702-705 | C0023810 | denotes | PS |
| T8 | 190-208 | C0023810 | denotes | ipopolysaccharide |
| T9 | 9-27 | C0023810 | denotes | ipopolysaccharide- |
| T10 | 113-130 | C0009017 | denotes | olecular cloning, |
| T11 | 36-56 | C0040648 | denotes | ranscription factor |
| T12 | 1888-1903 | C0017262 | denotes | ene expression. |
| T13 | 457-472 | C0017262 | denotes | ene expression |
| T14 | 96-111 | C0017262 | denotes | ene expression: |
| T15 | 132-142 | C1553778 | denotes | equencing, |
| T16 | 1172-1188 | C1880022 | denotes | haracterization |
| T17 | 144-160 | C1880022 | denotes | haracterization, |
| T18 | 178-188 | C1516050 | denotes | ssignment. |
| T19 | 1226-1235 | C0205263 | denotes | nduction |
| T20 | 28-35 | C0205263 | denotes | nduced |
| T21 | 1853-1856 | C0205314 | denotes | ew |
| T22 | 1112-1117 | C0205314 | denotes | ovel |
| T23 | 719-724 | C0205314 | denotes | ovel |
| T24 | 3-8 | C0205314 | denotes | ovel |
| T25 | 1817-1822 | C0086418 | denotes | uman |
| T26 | 777-782 | C0086418 | denotes | uman |
| T27 | 581-587 | C0086418 | denotes | umans |
| T28 | 1197-1201 | C0006556 | denotes | DNA |
| T29 | 1118-1122 | C0006556 | denotes | DNA |
| T30 | 816-831 | C0040649 | denotes | ranscriptional |
| T31 | 559-577 | C0040649 | denotes | ene transcription |
| T32 | 564-577 | C0040649 | denotes | ranscription |
| T33 | 1633-1667 | C0162789 | denotes | luorescence in situ hybridization |
| T34 | 679-689 | C0024432 | denotes | acrophage |
| T35 | 255-266 | C0024432 | denotes | acrophages, |
| T36 | 1552-1562 | C0023516 | denotes | eukocytes, |
| T37 | 1546-1562 | C0023516 | denotes | lood leukocytes, |
| T38 | 1817-1832 | C1448177 | denotes | uman TNF-alpha |
| T39 | 777-792 | C1448177 | denotes | uman TNF-alpha |
| T40 | 1762-1767 | C1424587 | denotes | ITAF |
| T41 | 1682-1687 | C1424587 | denotes | ITAF |
| T42 | 1480-1485 | C1424587 | denotes | ITAF |
| T43 | 1352-1357 | C1424587 | denotes | ITAF |
| T44 | 1300-1328 | C1424587 | denotes | PS-induced TNF-alpha factor |
| T45 | 1330-1335 | C1424587 | denotes | ITAF) |
| T46 | 1202-1206 | C0009013 | denotes | lone |
| T47 | 1123-1127 | C0009013 | denotes | lone |
| T48 | 276-285 | C0036536 | denotes | ecretion |
| T49 | 1295-1299 | C0027365 | denotes | ame |
| T50 | 241-250 | C0026473 | denotes | onocytes |
| T51 | 1585-1591 | C0037993 | denotes | pleen. |
| T52 | 1564-1575 | C0024204 | denotes | ymph nodes, |
| T53 | 614-623 | C0079904 | denotes | F-kappaB |
| T54 | 1338-1348 | C0021467 | denotes | nhibition |
| T55 | 1486-1490 | C0035696 | denotes | RNA |
| T56 | 905-908 | C0012854 | denotes | NA |
| T57 | 489-498 | C0851285 | denotes | egulated. |
| T58 | 1377-1380 | C1705396 | denotes | HP- |
| T59 | 1271-1274 | C1705396 | denotes | HP- |
| T60 | 1097-1100 | C1705396 | denotes | HP- |
| T61 | 1668-1676 | C0443289 | denotes | evealed |
| T62 | 1208-1216 | C0443289 | denotes | evealed |
| T63 | 1079-1091 | C0751608 | denotes | DNA library |
| T64 | 1749-1756 | C1705535 | denotes | uggest |
| T65 | 633-642 | C1705535 | denotes | uggested. |
| T66 | 1161-1170 | C1519249 | denotes | equenced. |
| T67 | 1014-1022 | C1519249 | denotes | equence, |
| T68 | 1870-1877 | C1882979 | denotes | ontrol |
| T69 | 541-548 | C1882979 | denotes | ontrol |
| T70 | 1383-1388 | C0007634 | denotes | ells |
| T71 | 1103-1108 | C0007634 | denotes | ells. |
| T72 | 1823-1832 | C2003941 | denotes | NF-alpha |
| T73 | 783-792 | C2003941 | denotes | NF-alpha |
| T74 | 1525-1533 | C0032043 | denotes | lacenta, |
| T75 | 1442-1450 | C1883712 | denotes | ddition, |
| T76 | 1142-1150 | C1548221 | denotes | solated |
| T77 | 268-275 | C0678227 | denotes | ausing |
| T78 | 807-814 | C2700400 | denotes | ontains |
| T79 | 1042-1047 | C1707689 | denotes | esign |
| T80 | 1768-1773 | C0600138 | denotes | lays |
| T81 | 363-368 | C1442162 | denotes | iven |
| T82 | 921-928 | C1875400 | denotes | solate |
| T83 | 706-716 | C0205396 | denotes | dentified |
| T84 | 846-851 | C0332268 | denotes | acks |
| T85 | 1495-1503 | C1441672 | denotes | bserved |
| T86 | 986-994 | C1301820 | denotes | btained |
| T87 | 1070-1076 | C0220908 | denotes | creen |
| T88 | 1724-1732 | C1883357 | denotes | ogether, |
| T89 | 1627-1632 | C1524063 | denotes | sing |
| T90 | 1740-1748 | C2607943 | denotes | indings |
| T91 | 1602-1626 | C1657114 | denotes | hromosomal localization |
| T92 | 933-939 | C1998793 | denotes | urify |
| T93 | 1535-1551 | C0229664 | denotes | eripheral blood |
| T94 | 862-879 | C1523084 | denotes | F-kappaB-binding |
| T95 | 832-840 | C0441655 | denotes | ctivity, |
| T96 | 339-351 | C0333348 | denotes | nflammatory |
| T97 | 352-361 | C0127400 | denotes | ediators. |
| T98 | 657-664 | C0947630 | denotes | tudies |
| T99 | 1857-1866 | C0441712 | denotes | echanism |
| T100 | 1535-1545 | C0205100 | denotes | eripheral |
| T101 | 1060-1066 | C0182400 | denotes | robes |
| T102 | 880-885 | C0205145 | denotes | ites. |
| T103 | 793-801 | C0086860 | denotes | romoter |
| T104 | 1715-1722 | C1520688 | denotes | 6p13.3. |
| T105 | 690-698 | C2911692 | denotes | esponse |
| T106 | 227-237 | C0175727 | denotes | timulator |
| T107 | 1709-1714 | C1520681 | denotes | 6p12- |
| T108 | 504-510 | C1262865 | denotes | ature |
| T109 | 1452-1456 | C1299351 | denotes | igh |
| T110 | 1457-1462 | C0441889 | denotes | evel |
| T111 | 957-964 | C1145667 | denotes | inding |
| T112 | 1240-1249 | C0851827 | denotes | ependent |
| T113 | 1403-1412 | C0441610 | denotes | eduction |
| T114 | 1426-1437 | C1519595 | denotes | ranscripts. |
| T115 | 385-392 | C1280500 | denotes | ffects |
| T116 | 1787-1791 | C1705810 | denotes | ole |
| T117 | 1389-1397 | C2825142 | denotes | esulted |
| T118 | 648-655 | C0205156 | denotes | revious |
| T119 | 1130-1131 | C2827734 | denotes | . |
| T120 | 1005-1013 | C0205088 | denotes | erminal |
| T121 | 1049-1059 | C1880269 | denotes | egenerate |
| T122 | 856-861 | C0205309 | denotes | nown |
| T123 | 526-532 | C1521761 | denotes | actor( |
| T124 | 518-525 | C0521447 | denotes | uclear |
| T125 | 1823-1837 | C1537647 | denotes | NF-alpha gene |
| T126 | 945-948 | C1532717 | denotes | Da |
| T127 | 400-404 | C1167395 | denotes | ost |
| T128 | 1799-1809 | C1879547 | denotes | ctivation |
| T129 | 220-226 | C3245505 | denotes | otent |
bionlp-st-gro-2013-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 8-26 | OrganicChemical | denotes | lipopolysaccharide |
| T3 | 35-55 | TranscriptionFactor | denotes | transcription factor |
| T5 | 67-94 | Protein | denotes | tumor necrosis factor alpha |
| T7 | 189-207 | OrganicChemical | denotes | Lipopolysaccharide |
| T8 | 209-212 | OrganicChemical | denotes | LPS |
| T10 | 240-249 | Cell | denotes | monocytes |
| T11 | 254-265 | Cell | denotes | macrophages |
| T12 | 317-326 | Protein | denotes | TNF-alpha |
| T14 | 338-360 | MolecularEntity | denotes | inflammatory mediators |
| T15 | 407-416 | Protein | denotes | TNF-alpha |
| T16 | 446-455 | Protein | denotes | TNF-alpha |
| T19 | 517-534 | Protein | denotes | nuclear factor(s) |
| T21 | 548-562 | Gene | denotes | TNF-alpha gene |
| T23 | 580-586 | Eukaryote | denotes | humans |
| T24 | 613-622 | Protein | denotes | NF-kappaB |
| T25 | 678-688 | Cell | denotes | macrophage |
| T27 | 701-704 | OrganicChemical | denotes | LPS |
| T28 | 724-742 | DNABindingDomainOfProtein | denotes | DNA-binding domain |
| T29 | 776-781 | Eukaryote | denotes | human |
| T30 | 782-791 | Gene | denotes | TNF-alpha |
| T31 | 792-800 | Promoter | denotes | promoter |
| T33 | 861-870 | Protein | denotes | NF-kappaB |
| T34 | 871-884 | BindingSiteOfProtein | denotes | binding sites |
| T35 | 904-916 | DNAFragment | denotes | DNA fragment |
| T36 | 948-955 | Protein | denotes | protein |
| T38 | 972-980 | DNAFragment | denotes | fragment |
| T39 | 1078-1090 | DNA | denotes | cDNA library |
| T40 | 1096-1107 | Cell | denotes | THP-1 cells |
| T41 | 1117-1127 | DNA | denotes | cDNA clone |
| T42 | 1196-1206 | DNA | denotes | cDNA clone |
| T44 | 1252-1255 | OrganicChemical | denotes | LPS |
| T46 | 1270-1281 | Cell | denotes | THP-1 cells |
| T47 | 1299-1327 | Protein | denotes | LPS-induced TNF-alpha factor |
| T48 | 1329-1334 | Protein | denotes | LITAF |
| T50 | 1351-1356 | Protein | denotes | LITAF |
| T51 | 1357-1361 | MessengerRNA | denotes | mRNA |
| T53 | 1376-1387 | Cell | denotes | THP-1 cells |
| T55 | 1415-1424 | Protein | denotes | TNF-alpha |
| T56 | 1425-1436 | Transcript | denotes | transcripts |
| T58 | 1479-1484 | Protein | denotes | LITAF |
| T59 | 1485-1489 | MessengerRNA | denotes | mRNA |
| T60 | 1524-1532 | Tissue | denotes | placenta |
| T61 | 1534-1561 | Cell | denotes | peripheral blood leukocytes |
| T62 | 1563-1574 | Tissue | denotes | lymph nodes |
| T63 | 1584-1590 | Tissue | denotes | spleen |
| T64 | 1601-1612 | Chromosome | denotes | chromosomal |
| T66 | 1681-1686 | Gene | denotes | LITAF |
| T67 | 1697-1721 | Chromosome | denotes | chromosome 16p12-16p13.3 |
| T68 | 1761-1766 | Protein | denotes | LITAF |
| T70 | 1816-1821 | Eukaryote | denotes | human |
| T71 | 1822-1836 | Gene | denotes | TNF-alpha gene |
| T73 | 1877-1886 | Protein | denotes | TNF-alpha |
| T32 | 815-839 | TranscriptionFactorActivity | denotes | transcriptional activity |
| E1 | 27-34 | PositiveRegulation | denotes | induced |
| E2 | 56-66 | RegulatoryProcess | denotes | regulating |
| E3 | 95-110 | GeneExpression | denotes | gene expression |
| E4 | 456-471 | GeneExpression | denotes | gene expression |
| E5 | 488-497 | RegulatoryProcess | denotes | regulated |
| E6 | 540-547 | RegulatoryProcess | denotes | control |
| E7 | 563-576 | Transcription | denotes | transcription |
| E8 | 689-697 | ResponseProcess | denotes | response |
| E10 | 956-963 | BindingOfProteinToDNA | denotes | binding |
| E11 | 1225-1234 | Increase | denotes | induction |
| E12 | 1256-1266 | PositiveRegulation | denotes | activation |
| E13 | 1337-1347 | NegativeRegulation | denotes | Inhibition |
| E14 | 1362-1372 | TranscriptionOfGene | denotes | expression |
| E15 | 1402-1411 | Decrease | denotes | reduction |
| E18 | 1798-1808 | PositiveRegulation | denotes | activation |
| E19 | 1869-1876 | RegulatoryProcess | denotes | control |
| E20 | 1887-1902 | GeneExpression | denotes | gene expression |
| E21 | 226-236 | PositiveRegulation | denotes | stimulator |
| E22 | 275-284 | Transport | denotes | secretion |
| E9 | 1451-1475 | PositiveRegulationOfTranscriptionOfGene | denotes | high level of expression |
| E16 | 226-236 | PositiveRegulation | denotes | stimulator |
| E17 | 275-284 | Transport | denotes | secretion |
| R1 | T30 | T29 | fromSpecies | TNF-alpha,human |
| R2 | T30 | T31 | hasPart | TNF-alpha,promoter |
| R7 | T51 | T50 | encodes | mRNA,LITAF |
| R8 | E14 | T53 | locatedIn | expression,THP-1 cells |
| R14 | T59 | T58 | encodes | mRNA,LITAF |
| R16 | T66 | T67 | locatedIn | LITAF,chromosome 16p12-16p13.3 |
| R17 | T71 | T70 | fromSpecies | TNF-alpha gene,human |
| R18 | E7 | T23 | fromSpecies | transcription,humans |
| R3 | T39 | T40 | locatedIn | cDNA library,THP-1 cells |
| R4 | T56 | T55 | encodes | transcripts,TNF-alpha |
| R5 | E9 | T60 | locatedIn | high level of expression,placenta |
| R6 | E9 | T61 | locatedIn | high level of expression,peripheral blood leukocytes |
| R9 | E9 | T62 | locatedIn | high level of expression,lymph nodes |
| R10 | E9 | T63 | locatedIn | high level of expression,spleen |
| R12 | T1 | E1 | hasAgent | lipopolysaccharide,induced |
| R13 | T3 | E1 | hasPatient | transcription factor,induced |
| R14 | T3 | E2 | hasAgent | transcription factor,regulating |
| R15 | E3 | E2 | hasPatient | gene expression,regulating |
| R16 | T5 | E3 | hasPatient | tumor necrosis factor alpha,gene expression |
| R17 | T16 | E4 | hasPatient | TNF-alpha,gene expression |
| R18 | E4 | E5 | hasPatient | gene expression,regulated |
| R19 | T19 | E6 | hasAgent | nuclear factor(s),control |
| R20 | E7 | E6 | hasPatient | transcription,control |
| R21 | T21 | E7 | hasPatient | TNF-alpha gene,transcription |
| R22 | T27 | E8 | hasAgent | LPS,response |
| R24 | T25 | E8 | hasPatient | macrophage,response |
| R25 | T36 | E10 | hasAgent | protein,binding |
| R26 | T38 | E10 | hasPatient | fragment,binding |
| R27 | E12 | E11 | hasAgent | activation,induction |
| R28 | T42 | E11 | hasPatient | cDNA clone,induction |
| R29 | T44 | E12 | hasAgent | LPS,activation |
| R31 | T46 | E12 | hasPatient | THP-1 cells,activation |
| R32 | E14 | E13 | hasPatient | expression,Inhibition |
| R33 | T51 | E14 | hasPatient | mRNA,expression |
| R34 | E13 | E15 | hasAgent | Inhibition,reduction |
| R35 | T56 | E15 | hasPatient | transcripts,reduction |
| R36 | T71 | E18 | hasPatient | TNF-alpha gene,activation |
| R37 | E20 | E19 | hasPatient | gene expression,control |
| R38 | T73 | E20 | hasPatient | TNF-alpha,gene expression |
| R39 | T7 | E21 | hasAgent | Lipopolysaccharide,stimulator |
| R40 | T10 | E21 | hasPatient | monocytes,stimulator |
| R41 | T12 | E22 | hasPatient | TNF-alpha,secretion |
| R42 | T59 | E9 | hasPatient | mRNA,high level of expression |
| R43 | T7 | E16 | hasAgent | Lipopolysaccharide,stimulator |
| R44 | T11 | E16 | hasPatient | macrophages,stimulator |
| R45 | T14 | E17 | hasPatient | inflammatory mediators,secretion |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 288-293 | HP_0002664 | denotes | tumor |