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PubMed:10200007 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 22-50 RNA denotes glucocorticoid receptor mRNA
T2 109-126 cell_type denotes blood lymphocytes
T3 195-218 protein denotes glucocorticoid receptor
T4 220-222 protein denotes GR
T5 365-372 RNA denotes GR mRNA
T6 691-698 RNA denotes GR mRNA
T7 776-783 RNA denotes GR mRNA
T8 971-978 RNA denotes GR mRNA
T9 1052-1059 RNA denotes GR mRNA
T10 1162-1169 RNA denotes GR mRNA
T11 1223-1240 cell_type denotes blood lymphocytes
T12 1359-1366 RNA denotes GR mRNA
T13 2033-2035 protein denotes GR

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10200007-0#22#45#gene2908 22-45 gene2908 denotes glucocorticoid receptor
10200007-0#149#155#diseaseC0004096 149-155 diseaseC0004096 denotes asthma
10200007-10#279#306#gene5443 1761-1788 gene5443 denotes adrenocorticotropic hormone
10200007-10#237#246#diseaseC0032002 1719-1728 diseaseC0032002 denotes pituitary
22#45#gene2908149#155#diseaseC0004096 10200007-0#22#45#gene2908 10200007-0#149#155#diseaseC0004096 associated_with glucocorticoid receptor,asthma
279#306#gene5443237#246#diseaseC0032002 10200007-10#279#306#gene5443 10200007-10#237#246#diseaseC0032002 associated_with adrenocorticotropic hormone,pituitary

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-156 Sentence denotes In vivo modulation of glucocorticoid receptor mRNA by inhaled fluticasone propionate in bronchial mucosa and blood lymphocytes in subjects with mild asthma.
S2 157-304 Sentence denotes BACKGROUND: In vivo regulation of the glucocorticoid receptor (GR) by glucocorticoids provides a means of modulating sensitivity of targeted cells.
S3 305-444 Sentence denotes OBJECTIVE: We sought to determine the in vivo modulation of GR mRNA expression by fluticasone propionate (FP) in subjects with mild asthma.
S4 445-540 Sentence denotes METHODS: Ten atopic asthmatic subjects were treated with FP 250 microg twice daily for 4 weeks.
S5 541-706 Sentence denotes Before and after treatment, the patients underwent fiberoptic bronchoscopy with endobronchial biopsy and sampling of venous blood for measurements of GR mRNA levels.
S6 707-784 Sentence denotes A solution hybridization assay was used for quantitative analysis of GR mRNA.
S7 785-925 Sentence denotes In addition, a 24-hour urinary cortisol excretion and an adrenocorticotropic hormone test before and after treatment with FP were performed.
S8 926-999 Sentence denotes RESULTS: A high interindividual variation in GR mRNA expression was seen.
S9 1000-1204 Sentence denotes However, we detected a significant reduction of the GR mRNA levels in the endobronchial biopsy specimens after FP treatment (36.6 +/- 23.1 and 25.0 +/- 10.9 amol GR mRNA/microg RNA, respectively; P <.01).
S10 1205-1481 Sentence denotes In the peripheral blood lymphocytes an even more striking downregulation of the GR by its cognate ligand was documented (30.3 +/- 26.5 and 8.8 +/- 5 amol GR mRNA/microg RNA, respectively; P <.001), possibly reflecting differences in glucocorticoid sensitivity between tissues.
S11 1482-1834 Sentence denotes A small but significant reduction of the 24-hour urinary cortisol excretion was observed (233 +/- 109 and 157 +/- 66 nmol/L, respectively; P <.01), whereas the feedback regulation of glucocorticoid synthesis by means of the hypothalamic-pituitary-adrenal axis as assessed by the adrenocorticotropic hormone test remained normal after treatment with FP.
S12 1835-2036 Sentence denotes CONCLUSION: The results in this study confirm the potency of the inhaled corticosteroid FP and provide evidence for a considerable tissue-specific interindividual variation in the expression of the GR.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 22-50 NP denotes glucocorticoid receptor mRNA
C2 130-155 NP denotes subjects with mild asthma
C3 191-223 NP denotes the glucocorticoid receptor (GR)
C4 365-383 NP denotes GR mRNA expression
C5 387-414 NP denotes fluticasone propionate (FP)
C6 418-443 NP denotes subjects with mild asthma
C7 454-483 NP denotes Ten atopic asthmatic subjects
C8 569-581 NP denotes the patients
C9 691-705 NP denotes GR mRNA levels
C10 776-783 NP denotes GR mRNA
C12 907-909 NP denotes FP
C11 892-909 NP denotes treatment with FP
C13 971-989 NP denotes GR mRNA expression
C14 1048-1066 NP denotes the GR mRNA levels
C15 1111-1123 NP denotes FP treatment
C16 1281-1287 NP denotes the GR
C17 1291-1294 NP denotes its
C19 1831-1833 NP denotes FP
C18 1816-1833 NP denotes treatment with FP
C20 2029-2035 NP denotes the GR
R1 C6 C2 coref-ident subjects with mild asthma,subjects with mild asthma
R2 C8 C7 coref-ident the patients,Ten atopic asthmatic subjects
R3 C10 C1 coref-ident GR mRNA,glucocorticoid receptor mRNA
R4 C12 C5 coref-ident FP,fluticasone propionate (FP)
R5 C13 C4 coref-ident GR mRNA expression,GR mRNA expression
R6 C14 C9 coref-ident the GR mRNA levels,GR mRNA levels
R7 C15 C11 coref-ident FP treatment,treatment with FP
R8 C16 C3 coref-ident the GR,the glucocorticoid receptor (GR)
R9 C17 C16 coref-pron its,the GR
R10 C19 C12 coref-ident FP,FP
R11 C18 C15 coref-ident treatment with FP,FP treatment
R12 C20 C16 coref-ident the GR,the GR

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 22-45 protein_family_or_group denotes glucocorticoid receptor
T2 88-104 tissue denotes bronchial mucosa
T3 109-126 cell_type denotes blood lymphocytes
T4 144-155 other_name denotes mild asthma
T5 195-218 protein_family_or_group denotes glucocorticoid receptor
T6 220-222 protein_family_or_group denotes GR
T7 365-372 RNA_family_or_group denotes GR mRNA
T8 387-409 other_organic_compound denotes fluticasone propionate
T9 411-413 other_organic_compound denotes FP
T10 432-443 other_name denotes mild asthma
T11 465-483 multi_cell denotes asthmatic subjects
T12 502-504 other_organic_compound denotes FP
T13 592-615 other_name denotes fiberoptic bronchoscopy
T14 621-641 other_name denotes endobronchial biopsy
T15 658-670 tissue denotes venous blood
T16 691-698 RNA_family_or_group denotes GR mRNA
T17 776-783 RNA_family_or_group denotes GR mRNA
T18 808-815 other_name denotes urinary
T19 816-824 lipid denotes cortisol
T20 842-869 other_organic_compound denotes adrenocorticotropic hormone
T21 907-909 other_organic_compound denotes FP
T22 971-973 protein_family_or_group denotes GR
T23 1052-1059 RNA_family_or_group denotes GR mRNA
T24 1074-1094 other_name denotes endobronchial biopsy
T25 1111-1113 other_organic_compound denotes FP
T26 1162-1169 RNA_family_or_group denotes GR mRNA
T27 1223-1240 cell_type denotes blood lymphocytes
T28 1359-1366 RNA_family_or_group denotes GR mRNA
T29 1438-1464 other_name denotes glucocorticoid sensitivity
T30 1531-1538 other_name denotes urinary
T31 1539-1547 lipid denotes cortisol
T32 1665-1689 other_name denotes glucocorticoid synthesis
T33 1761-1793 other_name denotes adrenocorticotropic hormone test
T34 1831-1833 other_organic_compound denotes FP
T35 1908-1922 lipid denotes corticosteroid
T36 1923-1925 other_organic_compound denotes FP
T37 2033-2035 protein_family_or_group denotes GR

DisGeNET

Id Subject Object Predicate Lexical cue
T0 22-45 gene:2908 denotes glucocorticoid receptor
T1 149-155 disease:C0004096 denotes asthma
R1 T0 T1 associated_with glucocorticoid receptor,asthma