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PubMed:10197731 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 27-47 protein denotes tyrosine phosphatase
T2 80-88 protein denotes NFkappaB
T3 103-116 cell_type denotes T lymphocytes
T4 152-165 protein denotes IkappaB-alpha
T5 199-221 protein denotes Nuclear Factor kappa B
T6 223-231 protein denotes NFkappaB
T7 334-341 cell_type denotes T cells
T8 379-388 protein denotes TNF-alpha
T9 431-449 protein denotes p65-50 heterodimer
T10 493-500 cell_type denotes T cells
T11 595-603 protein denotes NFkappaB
T12 617-626 protein denotes TNF-alpha
T13 635-642 cell_type denotes T cells
T14 666-691 protein denotes PAO-sensitive phosphatase
T15 717-725 protein denotes NFkappaB
T16 746-759 cell_type denotes human T cells
T17 844-855 protein denotes phosphatase
T18 908-911 protein denotes TNF
T19 956-963 cell_type denotes T cells
T20 1053-1066 protein denotes IkappaB-alpha
T21 1082-1101 cell_type denotes TNF-treated T cells
T22 1177-1190 protein denotes IkappaB-alpha
T23 1366-1379 protein denotes IkappaB-alpha
T24 1392-1395 protein denotes TNF
T25 1448-1458 protein denotes proteasome

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-198 Sentence denotes Studies into the effect of tyrosine phosphatase inhibitor phenylarsine oxide on NFkappaB activation in T lymphocytes during aging: evidence for altered IkappaB-alpha phosphorylation and degradation.
S2 199-320 Sentence denotes Nuclear Factor kappa B (NFkappaB) is a critical regulator of several genes involved in immune and inflammatory responses.
S3 321-518 Sentence denotes Treatment of T cells with a variety of stimuli, including TNF-alpha, leads to the translocation of the active p65-50 heterodimer to the nucleus, albeit at a lower level in T cells from the elderly.
S4 519-760 Sentence denotes We demonstrate here that pretreatment with PAO results in the inhibition of NFkappaB induction in TNF-alpha treated T cells, suggesting a role for PAO-sensitive phosphatase in the activation of the NFkappaB via this pathway in human T cells.
S5 761-856 Sentence denotes Furthermore, it demonstrates that aging does not influence the sensitivity of this phosphatase.
S6 857-1002 Sentence denotes Treatment with DMP prior to treatment with PAO and TNF abolishes the inhibition induced by PAO, in T cells from both young and old donors, alike.
S7 1003-1255 Sentence denotes Finally, we demonstrate that a failure to degrade IkappaB-alpha in cytosols of TNF-treated T cells pretreated with PAO is due to its interference with the phosphorylation of IkappaB-alpha and not due to its inhibitory effect on proteasomal degradation.
S8 1256-1479 Sentence denotes These data collectively suggest that PAO interferes with the phosphorylation and the regulated degradation of IkappaB-alpha, induced by TNF, without affecting the chymotryptic activity of the proteasome, independent of age.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 27-76 NP denotes tyrosine phosphatase inhibitor phenylarsine oxide
C2 103-116 NP denotes T lymphocytes
C3 124-129 NP denotes aging
C4 199-232 NP denotes Nuclear Factor kappa B (NFkappaB)
C5 334-341 NP denotes T cells
C6 562-565 NP denotes PAO
C7 666-691 NP denotes PAO-sensitive phosphatase
C8 713-725 NP denotes the NFkappaB
C9 746-759 NP denotes human T cells
C10 795-800 NP denotes aging
C11 839-855 NP denotes this phosphatase
C12 900-903 NP denotes PAO
C13 908-911 NP denotes TNF
C14 948-951 NP denotes PAO
C15 1118-1121 NP denotes PAO
C16 1132-1135 NP denotes its
C17 1177-1190 NP denotes IkappaB-alpha
C18 1206-1209 NP denotes its
C19 1293-1296 NP denotes PAO
C20 1366-1379 NP denotes IkappaB-alpha
C21 1392-1395 NP denotes TNF
R1 C5 C2 coref-ident T cells,T lymphocytes
R2 C6 C1 coref-ident PAO,tyrosine phosphatase inhibitor phenylarsine oxide
R3 C8 C4 coref-ident the NFkappaB,Nuclear Factor kappa B (NFkappaB)
R4 C9 C5 coref-ident human T cells,T cells
R5 C10 C3 coref-ident aging,aging
R6 C11 C7 coref-ident this phosphatase,PAO-sensitive phosphatase
R7 C12 C6 coref-ident PAO,PAO
R8 C14 C12 coref-ident PAO,PAO
R9 C15 C14 coref-ident PAO,PAO
R10 C16 C15 coref-pron its,PAO
R11 C18 C15 coref-pron its,PAO
R12 C19 C15 coref-ident PAO,PAO
R13 C20 C17 coref-ident IkappaB-alpha,IkappaB-alpha
R14 C21 C13 coref-ident TNF,TNF

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 27-35 amino_acid_monomer denotes tyrosine
T2 58-76 other_organic_compound denotes phenylarsine oxide
T3 80-88 protein_complex denotes NFkappaB
T4 103-116 cell_type denotes T lymphocytes
T5 152-165 protein_molecule denotes IkappaB-alpha
T6 199-221 protein_complex denotes Nuclear Factor kappa B
T7 223-231 protein_complex denotes NFkappaB
T8 334-341 cell_type denotes T cells
T9 379-388 protein_molecule denotes TNF-alpha
T10 431-449 protein_complex denotes p65-50 heterodimer
T11 457-464 cell_component denotes nucleus
T12 493-500 cell_type denotes T cells
T13 562-565 other_organic_compound denotes PAO
T14 595-603 protein_complex denotes NFkappaB
T15 617-626 protein_molecule denotes TNF-alpha
T16 635-642 cell_type denotes T cells
T17 666-669 other_organic_compound denotes PAO
T18 717-725 protein_complex denotes NFkappaB
T19 746-759 cell_type denotes human T cells
T20 844-855 protein_family_or_group denotes phosphatase
T21 872-875 other_organic_compound denotes DMP
T22 900-903 other_organic_compound denotes PAO
T23 908-911 protein_family_or_group denotes TNF
T24 948-951 other_organic_compound denotes PAO
T25 956-963 cell_type denotes T cells
T26 1053-1066 protein_molecule denotes IkappaB-alpha
T27 1082-1085 protein_family_or_group denotes TNF
T28 1094-1101 cell_type denotes T cells
T29 1118-1121 other_organic_compound denotes PAO
T30 1158-1173 other_name denotes phosphorylation
T31 1177-1190 protein_molecule denotes IkappaB-alpha
T32 1231-1254 other_name denotes proteasomal degradation
T33 1293-1296 other_organic_compound denotes PAO
T34 1341-1362 other_name denotes regulated degradation
T35 1366-1379 protein_molecule denotes IkappaB-alpha
T36 1392-1395 protein_family_or_group denotes TNF
T37 1419-1440 other_name denotes chymotryptic activity
T38 1448-1458 protein_complex denotes proteasome