PubMed:10196365 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	208-237	HP_0002344	denotes	progressive neurodegeneration
T2	220-237	HP_0002180	denotes	neurodegeneration
T3	509-521	HP_0001371	denotes	contractions
T4	612-637	HP_0012433	denotes	abnormal social behaviour
T5	662-679	HP_0002180	denotes	neurodegeneration
T6	723-735	HP_0000737	denotes	irritability
T7	740-750	HP_0000718	denotes	aggression

Id	Subject	Object	Predicate	Lexical cue
T1	128-238	DRI_Challenge	denotes	Huntington's disease (HD) is a dominant disorder characterized by premature and progressive neurodegeneration.
T2	239-406	DRI_Approach	denotes	In order to generate an accurate model of the disease, we introduced an HD-like mutation (an extended stretch of 72-80 CAG repeats) into the endogenous mouse Hdh gene.
T3	407-560	DRI_Background	denotes	Analysis of the mutation in vivo reveals significant levels of germline instability, with expansions, contractions and sex-of-origin effects in evidence.
T4	561-680	DRI_Challenge	denotes	Mice expressing full-length mutant protein display abnormal social behaviour in the absence of acute neurodegeneration.
T5	681-945	DRI_Challenge	denotes	Given that psychiatric changes, including irritability and aggression, are common findings in HD patients, our data are consistent with the hypothesis that some clinical features of HD may be caused by pathological processes that precede gross neuronal cell death.
T6	946-1144	DRI_Challenge	denotes	This implies that effective treatment of HD may require an understanding and amelioration of these dysfunctional processes, rather than simply preventing the premature death of neurons in the brain.
T7	1145-1279	DRI_Outcome	denotes	These mice should facilitate the investigation of the molecular mechanisms that underpin the pathway from genotype to phenotype in HD.