PubMed:10196286 JSONTXT

{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":17,"end":22},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":293,"end":298},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005070"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0005070"}],"text":"Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP.\nThe STP oncoproteins of the herpesvirus saimiri (HVS) subgroup A strain 11 and subgroup C strain 488 are now found to be stably associated with tumor necrosis factor receptor-associated factor (TRAF) 1, 2, or 3. Mutational analyses identified residues of PXQXT/S in STP-A11 as critical for TRAF association. In addition, a somewhat divergent region of STP-C488 is critical for TRAF association. Mutational analysis also revealed that STP-C488 induced NF-kappaB activation that was correlated with its ability to associate with TRAFs. The HVS STP-C488 P10--\u003eR mutant was deficient in human T-lymphocyte transformation to interleukin-2-independent growth but showed wild-type phenotype for marmoset T-lymphocyte transformation in vitro and in vivo. The STP-C488 P10--\u003eR mutant was also defective in Rat-1 fibroblast transformation, and fibroblast cell transformation was blocked by a TRAF2 dominant-negative mutant. These data implicate TRAFs in STP-C488-mediated transformation of human lymphocytes and rodent fibroblasts. Other factors are implicated in immortalization of common marmoset T lymphocytes and may also be critical in the transformation of human lymphocytes and rodent fibroblasts."}

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":8,"end":66},"obj":"protein"},{"id":"T2","span":{"begin":70,"end":79},"obj":"protein"},{"id":"T3","span":{"begin":95,"end":105},"obj":"cell_type"},{"id":"T4","span":{"begin":144,"end":147},"obj":"protein"},{"id":"T5","span":{"begin":153,"end":169},"obj":"protein"},{"id":"T6","span":{"begin":293,"end":359},"obj":"protein"},{"id":"T7","span":{"begin":404,"end":411},"obj":"protein"},{"id":"T8","span":{"begin":415,"end":422},"obj":"protein"},{"id":"T9","span":{"begin":439,"end":443},"obj":"protein"},{"id":"T10","span":{"begin":501,"end":509},"obj":"protein"},{"id":"T11","span":{"begin":526,"end":530},"obj":"protein"},{"id":"T12","span":{"begin":583,"end":591},"obj":"protein"},{"id":"T13","span":{"begin":600,"end":609},"obj":"protein"},{"id":"T14","span":{"begin":676,"end":681},"obj":"protein"},{"id":"T15","span":{"begin":691,"end":699},"obj":"protein"},{"id":"T16","span":{"begin":900,"end":923},"obj":"protein"},{"id":"T17","span":{"begin":1031,"end":1036},"obj":"protein"},{"id":"T18","span":{"begin":1084,"end":1089},"obj":"protein"},{"id":"T19","span":{"begin":1093,"end":1101},"obj":"protein"},{"id":"T20","span":{"begin":1129,"end":1146},"obj":"cell_type"},{"id":"T21","span":{"begin":1158,"end":1169},"obj":"cell_type"},{"id":"T22","span":{"begin":1222,"end":1251},"obj":"cell_type"},{"id":"T23","span":{"begin":1302,"end":1319},"obj":"cell_type"},{"id":"T24","span":{"begin":1324,"end":1342},"obj":"cell_type"}],"text":"Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP.\nThe STP oncoproteins of the herpesvirus saimiri (HVS) subgroup A strain 11 and subgroup C strain 488 are now found to be stably associated with tumor necrosis factor receptor-associated factor (TRAF) 1, 2, or 3. Mutational analyses identified residues of PXQXT/S in STP-A11 as critical for TRAF association. In addition, a somewhat divergent region of STP-C488 is critical for TRAF association. Mutational analysis also revealed that STP-C488 induced NF-kappaB activation that was correlated with its ability to associate with TRAFs. The HVS STP-C488 P10--\u003eR mutant was deficient in human T-lymphocyte transformation to interleukin-2-independent growth but showed wild-type phenotype for marmoset T-lymphocyte transformation in vitro and in vivo. The STP-C488 P10--\u003eR mutant was also defective in Rat-1 fibroblast transformation, and fibroblast cell transformation was blocked by a TRAF2 dominant-negative mutant. These data implicate TRAFs in STP-C488-mediated transformation of human lymphocytes and rodent fibroblasts. Other factors are implicated in immortalization of common marmoset T lymphocytes and may also be critical in the transformation of human lymphocytes and rodent fibroblasts."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":148},"obj":"Sentence"},{"id":"S2","span":{"begin":149,"end":360},"obj":"Sentence"},{"id":"S3","span":{"begin":361,"end":456},"obj":"Sentence"},{"id":"S4","span":{"begin":457,"end":543},"obj":"Sentence"},{"id":"S5","span":{"begin":544,"end":682},"obj":"Sentence"},{"id":"S6","span":{"begin":683,"end":895},"obj":"Sentence"},{"id":"S7","span":{"begin":896,"end":1062},"obj":"Sentence"},{"id":"S8","span":{"begin":1063,"end":1170},"obj":"Sentence"},{"id":"S9","span":{"begin":1171,"end":1343},"obj":"Sentence"}],"text":"Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP.\nThe STP oncoproteins of the herpesvirus saimiri (HVS) subgroup A strain 11 and subgroup C strain 488 are now found to be stably associated with tumor necrosis factor receptor-associated factor (TRAF) 1, 2, or 3. Mutational analyses identified residues of PXQXT/S in STP-A11 as critical for TRAF association. In addition, a somewhat divergent region of STP-C488 is critical for TRAF association. Mutational analysis also revealed that STP-C488 induced NF-kappaB activation that was correlated with its ability to associate with TRAFs. The HVS STP-C488 P10--\u003eR mutant was deficient in human T-lymphocyte transformation to interleukin-2-independent growth but showed wild-type phenotype for marmoset T-lymphocyte transformation in vitro and in vivo. The STP-C488 P10--\u003eR mutant was also defective in Rat-1 fibroblast transformation, and fibroblast cell transformation was blocked by a TRAF2 dominant-negative mutant. These data implicate TRAFs in STP-C488-mediated transformation of human lymphocytes and rodent fibroblasts. Other factors are implicated in immortalization of common marmoset T lymphocytes and may also be critical in the transformation of human lymphocytes and rodent fibroblasts."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":8,"end":66},"obj":"NP"},{"id":"C2","span":{"begin":361,"end":380},"obj":"NP"},{"id":"C3","span":{"begin":439,"end":455},"obj":"NP"},{"id":"C4","span":{"begin":501,"end":509},"obj":"NP"},{"id":"C5","span":{"begin":526,"end":542},"obj":"NP"},{"id":"C6","span":{"begin":544,"end":563},"obj":"NP"},{"id":"C7","span":{"begin":583,"end":591},"obj":"NP"},{"id":"C8","span":{"begin":600,"end":620},"obj":"NP"},{"id":"C9","span":{"begin":621,"end":625},"obj":"NP"},{"id":"C10","span":{"begin":646,"end":649},"obj":"NP"},{"id":"C11","span":{"begin":676,"end":681},"obj":"NP"},{"id":"C12","span":{"begin":1129,"end":1169},"obj":"NP"},{"id":"C13","span":{"begin":1302,"end":1342},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C5","obj":"C3"},{"id":"R2","pred":"coref-ident","subj":"C6","obj":"C2"},{"id":"R3","pred":"coref-ident","subj":"C7","obj":"C4"},{"id":"R4","pred":"coref-relat","subj":"C9","obj":"C8"},{"id":"R5","pred":"coref-pron","subj":"C10","obj":"C7"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C1"},{"id":"R7","pred":"coref-ident","subj":"C13","obj":"C12"}],"text":"Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP.\nThe STP oncoproteins of the herpesvirus saimiri (HVS) subgroup A strain 11 and subgroup C strain 488 are now found to be stably associated with tumor necrosis factor receptor-associated factor (TRAF) 1, 2, or 3. Mutational analyses identified residues of PXQXT/S in STP-A11 as critical for TRAF association. In addition, a somewhat divergent region of STP-C488 is critical for TRAF association. Mutational analysis also revealed that STP-C488 induced NF-kappaB activation that was correlated with its ability to associate with TRAFs. The HVS STP-C488 P10--\u003eR mutant was deficient in human T-lymphocyte transformation to interleukin-2-independent growth but showed wild-type phenotype for marmoset T-lymphocyte transformation in vitro and in vivo. The STP-C488 P10--\u003eR mutant was also defective in Rat-1 fibroblast transformation, and fibroblast cell transformation was blocked by a TRAF2 dominant-negative mutant. These data implicate TRAFs in STP-C488-mediated transformation of human lymphocytes and rodent fibroblasts. Other factors are implicated in immortalization of common marmoset T lymphocytes and may also be critical in the transformation of human lymphocytes and rodent fibroblasts."}

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{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":293,"end":298},"obj":"HP_0002664"}],"text":"Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP.\nThe STP oncoproteins of the herpesvirus saimiri (HVS) subgroup A strain 11 and subgroup C strain 488 are now found to be stably associated with tumor necrosis factor receptor-associated factor (TRAF) 1, 2, or 3. Mutational analyses identified residues of PXQXT/S in STP-A11 as critical for TRAF association. In addition, a somewhat divergent region of STP-C488 is critical for TRAF association. Mutational analysis also revealed that STP-C488 induced NF-kappaB activation that was correlated with its ability to associate with TRAFs. The HVS STP-C488 P10--\u003eR mutant was deficient in human T-lymphocyte transformation to interleukin-2-independent growth but showed wild-type phenotype for marmoset T-lymphocyte transformation in vitro and in vivo. The STP-C488 P10--\u003eR mutant was also defective in Rat-1 fibroblast transformation, and fibroblast cell transformation was blocked by a TRAF2 dominant-negative mutant. These data implicate TRAFs in STP-C488-mediated transformation of human lymphocytes and rodent fibroblasts. Other factors are implicated in immortalization of common marmoset T lymphocytes and may also be critical in the transformation of human lymphocytes and rodent fibroblasts."}