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sentences

Id Subject Object Predicate Lexical cue
T1 0-137 Sentence denotes SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.
T2 138-252 Sentence denotes SPI-B is a B lymphocyte-specific Ets transcription factor that shares a high degree of similarity with PU.1/SPI-1.
T3 253-437 Sentence denotes In direct contrast to PU.1(-/-) mice that die in utero and lack monocytes, neutrophils, B cells, and T cells, Spi-B-/- mice are viable and exhibit a severe B cell proliferation defect.
T4 438-620 Sentence denotes Since PU.1 is expressed at wild type levels in Spi-B-/- B cells, the mutant mice provide genetic evidence that SPI-B and PU.1 have at least some non-redundant roles in B lymphocytes.
T5 621-757 Sentence denotes To begin to understand the molecular basis for these defects, we delineated functional domains of SPI-B for comparison to those of PU.1.
T6 758-887 Sentence denotes By using a heterologous co-transfection system, we identified two independent transactivation domains in the N terminus of SPI-B.
T7 888-1100 Sentence denotes Interestingly, only one of these domains (amino acids 31-61), a proline/serine/threonine-rich region, unique among Ets proteins, is necessary for transactivation of the immunoglobulin lambda light chain enhancer.
T8 1101-1208 Sentence denotes This transactivation motif is in marked contrast to PU.1, which contains acidic and glutamine-rich domains.
T9 1209-1339 Sentence denotes In addition, we describe a functional PU.1 site within the c-FES promoter which SPI-B fails to bind efficiently and transactivate.
T10 1340-1497 Sentence denotes Finally, we show that SPI-B interacts with the PU.1 cofactors Pip, TBP, c-Jun and with lower affinity to nuclear factor interleukin-6beta and retinoblastoma.
T11 1498-1654 Sentence denotes Taken together, these data suggest that SPI-B binds DNA with a different affinity for certain sites than PU.1 and harbors different transactivation domains.
T12 1655-1797 Sentence denotes We conclude that SPI-B may activate unique target genes in B lymphocytes and interact with unique, although currently unidentified, cofactors.

relna

Id Subject Object Predicate Lexical cue
T1 0-5 DNA denotes SPI-B
T2 132-136 DNA denotes PU.1
T3 138-143 DNA denotes SPI-B
T4 241-245 DNA denotes PU.1
T5 246-251 DNA denotes SPI-1
T6 275-279 DNA denotes PU.1
T7 363-368 DNA denotes Spi-B
T8 444-448 DNA denotes PU.1
T9 549-554 DNA denotes SPI-B
T10 559-563 DNA denotes PU.1
T11 719-724 DNA denotes SPI-B
T12 752-756 DNA denotes PU.1
T13 881-886 DNA denotes SPI-B
T14 1153-1157 DNA denotes PU.1
T15 1247-1251 DNA denotes PU.1
T16 1268-1273 Protein denotes c-FES
T17 1289-1294 DNA denotes SPI-B
T18 1362-1367 DNA denotes SPI-B
T19 1387-1391 DNA denotes PU.1
T20 1402-1405 Protein denotes Pip
T21 1407-1410 DNA denotes TBP
T22 1412-1417 DNA denotes c-Jun
T23 1538-1543 DNA denotes SPI-B
T24 1603-1607 DNA denotes PU.1
T25 1672-1677 DNA denotes SPI-B
R0 T18 T20 linked SPI-B,Pip

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1482-1496 HP_0009919 denotes retinoblastoma

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1482-1496 Phenotype denotes retinoblastoma HP:0009919

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1482-1496 Disease denotes retinoblastoma http://purl.obolibrary.org/obo/MONDO_0008380

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 285-289 OrganismTaxon denotes mice 10088
T2 372-376 OrganismTaxon denotes mice 10088
T3 514-518 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 149-161 Body_part denotes B lymphocyte http://purl.obolibrary.org/obo/CL_0000236
T2 317-326 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T4 328-339 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T5 409-415 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T6 606-619 Body_part denotes B lymphocytes http://purl.obolibrary.org/obo/CL_0000236
T7 1072-1078 Body_part denotes lambda http://purl.obolibrary.org/obo/UBERON_0013424
T8 1714-1727 Body_part denotes B lymphocytes http://purl.obolibrary.org/obo/CL_0000236

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 149-161 Cell denotes B lymphocyte http://purl.obolibrary.org/obo/CL:0000236
T2 151-161 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T3 317-326 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T5 328-339 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T6 341-348 Cell denotes B cells http://purl.obolibrary.org/obo/CL:0000236
T7 354-361 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T8 409-415 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T9 494-501 Cell denotes B cells http://purl.obolibrary.org/obo/CL:0000236
T10 606-619 Cell denotes B lymphocytes http://purl.obolibrary.org/obo/CL:0000236
T11 1714-1727 Cell denotes B lymphocytes http://purl.obolibrary.org/obo/CL:0000236