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PubMed:10195428 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 4-40 protein denotes Epstein-Barr virus nuclear antigen 2
T2 42-47 protein denotes EBNA2
T3 73-85 cell_type denotes B lymphocyte
T4 128-145 protein denotes type I interferon
T5 149-178 cell_line denotes Burkitt's lymphoma cell lines
T6 180-216 protein denotes Epstein-Barr virus nuclear antigen 2
T7 218-223 protein denotes EBNA2
T8 310-328 protein denotes type I interferons
T9 330-344 protein denotes IFN-alpha/beta
T10 403-408 protein denotes EBNA2
T11 431-434 protein denotes IFN
T12 447-476 cell_line denotes Burkitt's lymphoma cell lines
T13 492-497 protein denotes EBNA2
T14 570-590 DNA denotes IFN-stimulated genes
T15 592-596 DNA denotes ISGs
T16 632-641 DNA denotes promoters
T17 653-691 DNA denotes interferon-stimulated response element
T18 693-697 DNA denotes ISRE
T19 706-738 DNA denotes gamma interferon activation site
T20 740-743 DNA denotes GAS
T21 818-822 DNA denotes ISGs
T22 839-844 protein denotes EBNA2
T23 982-987 protein denotes EBNA2
T24 1036-1059 DNA denotes RBP-Jkappa binding site
T25 1100-1105 protein denotes EBNA2
T26 1116-1121 protein denotes EBNA2
T27 1165-1182 DNA denotes IFN-beta promoter
T28 1195-1232 cell_line denotes EBV-negative Burkitt's lymphoma cells
T29 1256-1265 DNA denotes EBV genes
T30 1305-1313 protein denotes IFN-beta

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10195428-2#84#87#gene3439 431-434 gene3439 denotes IFN
10195428-2#84#87#gene3447 431-434 gene3447 denotes IFN
10195428-2#100#118#diseaseC0006413 447-465 diseaseC0006413 denotes Burkitt's lymphoma
10195428-6#49#57#gene3456 1165-1173 gene3456 denotes IFN-beta
10195428-6#92#110#diseaseC0006413 1208-1226 diseaseC0006413 denotes Burkitt's lymphoma
84#87#gene3439100#118#diseaseC0006413 10195428-2#84#87#gene3439 10195428-2#100#118#diseaseC0006413 associated_with IFN,Burkitt's lymphoma
84#87#gene3447100#118#diseaseC0006413 10195428-2#84#87#gene3447 10195428-2#100#118#diseaseC0006413 associated_with IFN,Burkitt's lymphoma
49#57#gene345692#110#diseaseC0006413 10195428-6#49#57#gene3456 10195428-6#92#110#diseaseC0006413 associated_with IFN-beta,Burkitt's lymphoma

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-179 Sentence denotes The Epstein-Barr virus nuclear antigen 2 (EBNA2), a protein required for B lymphocyte immortalization, induces the synthesis of type I interferon in Burkitt's lymphoma cell lines.
S2 180-346 Sentence denotes Epstein-Barr virus nuclear antigen 2 (EBNA2), a protein involved in cell transformation, interferes with the cellular response to type I interferons (IFN-alpha/beta).
S3 347-477 Sentence denotes We investigated the function of conditionally expressed EBNA2 in the context of the IFN response in Burkitt's lymphoma cell lines.
S4 478-745 Sentence denotes Expression of EBNA2 led to the transcriptional activation of both endogenous or transfected IFN-stimulated genes (ISGs), genes which contain within their promoters either the interferon-stimulated response element (ISRE) or the gamma interferon activation site (GAS).
S5 746-936 Sentence denotes In search of a molecular mechanism for the transcriptional induction of ISGs, we observed an EBNA2-dependent synthesis of IFN-beta mRNA at low levels and the secretion of low amounts of IFN.
S6 937-1115 Sentence denotes A transfected IFN-beta promoter responded to EBNA2 activation, and a sequence closely resembling a RBP-Jkappa binding site was pinpointed as a potential target of EBNA2 activity.
S7 1116-1324 Sentence denotes EBNA2-dependent transcriptional induction of the IFN-beta promoter occurred in EBV-negative Burkitt's lymphoma cells, indicating that other EBV genes were not required for the induction of IFN-beta synthesis.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-48 NP denotes The Epstein-Barr virus nuclear antigen 2 (EBNA2)
C2 50-101 NP denotes a protein required for B lymphocyte immortalization
C3 149-178 NP denotes Burkitt's lymphoma cell lines
C4 180-224 NP denotes Epstein-Barr virus nuclear antigen 2 (EBNA2)
C5 226-267 NP denotes a protein involved in cell transformation
C6 447-476 NP denotes Burkitt's lymphoma cell lines
C7 492-497 NP denotes EBNA2
C8 539-597 NP denotes both endogenous or transfected IFN-stimulated genes (ISGs)
C10 599-604 NP denotes genes
C11 605-610 NP denotes which
C12 626-631 NP denotes their
C9 599-744 NP denotes genes which contain within their promoters either the interferon-stimulated response element (ISRE) or the gamma interferon activation site (GAS)
C13 818-822 NP denotes ISGs
C14 937-968 NP denotes A transfected IFN-beta promoter
C15 1161-1182 NP denotes the IFN-beta promoter
R1 C2 C1 coref-appos a protein required for B lymphocyte immortalization,The Epstein-Barr virus nuclear antigen 2 (EBNA2)
R2 C4 C1 coref-ident Epstein-Barr virus nuclear antigen 2 (EBNA2),The Epstein-Barr virus nuclear antigen 2 (EBNA2)
R3 C5 C4 coref-appos a protein involved in cell transformation,Epstein-Barr virus nuclear antigen 2 (EBNA2)
R4 C6 C3 coref-ident Burkitt's lymphoma cell lines,Burkitt's lymphoma cell lines
R5 C7 C4 coref-ident EBNA2,Epstein-Barr virus nuclear antigen 2 (EBNA2)
R6 C11 C10 coref-relat which,genes
R7 C12 C8 coref-pron their,both endogenous or transfected IFN-stimulated genes (ISGs)
R8 C9 C8 coref-appos genes which contain within their promoters either the interferon-stimulated response element (ISRE) or the gamma interferon activation site (GAS),both endogenous or transfected IFN-stimulated genes (ISGs)
R9 C13 C9 coref-ident ISGs,genes which contain within their promoters either the interferon-stimulated response element (ISRE) or the gamma interferon activation site (GAS)
R10 C15 C14 coref-ident the IFN-beta promoter,A transfected IFN-beta promoter

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 4-22 virus denotes Epstein-Barr virus
T2 42-47 protein_molecule denotes EBNA2
T3 73-85 cell_type denotes B lymphocyte
T4 128-145 protein_family_or_group denotes type I interferon
T5 149-178 cell_line denotes Burkitt's lymphoma cell lines
T6 180-198 virus denotes Epstein-Barr virus
T7 218-223 protein_molecule denotes EBNA2
T8 310-328 protein_family_or_group denotes type I interferons
T9 330-344 protein_family_or_group denotes IFN-alpha/beta
T10 403-408 protein_molecule denotes EBNA2
T11 431-434 protein_family_or_group denotes IFN
T12 447-476 cell_line denotes Burkitt's lymphoma cell lines
T13 492-497 protein_molecule denotes EBNA2
T14 509-535 other_name denotes transcriptional activation
T15 570-590 DNA_family_or_group denotes IFN-stimulated genes
T16 592-596 DNA_family_or_group denotes ISGs
T17 632-641 DNA_domain_or_region denotes promoters
T18 653-691 DNA_domain_or_region denotes interferon-stimulated response element
T19 693-697 DNA_domain_or_region denotes ISRE
T20 706-738 DNA_domain_or_region denotes gamma interferon activation site
T21 740-743 DNA_domain_or_region denotes GAS
T22 789-814 other_name denotes transcriptional induction
T23 818-822 DNA_family_or_group denotes ISGs
T24 839-844 protein_molecule denotes EBNA2
T25 982-987 protein_molecule denotes EBNA2
T26 1036-1059 DNA_domain_or_region denotes RBP-Jkappa binding site
T27 1100-1105 protein_molecule denotes EBNA2
T28 1116-1121 protein_molecule denotes EBNA2
T29 1132-1157 other_name denotes transcriptional induction
T30 1165-1182 DNA_domain_or_region denotes IFN-beta promoter
T31 1195-1232 cell_line denotes EBV-negative Burkitt's lymphoma cells
T32 1256-1265 DNA_family_or_group denotes EBV genes
T33 1305-1313 protein_molecule denotes IFN-beta

DisGeNET

Id Subject Object Predicate Lexical cue
T0 431-434 gene:3439 denotes IFN
T1 457-465 disease:C0024299 denotes lymphoma
T2 431-434 gene:3447 denotes IFN
T3 457-465 disease:C0024299 denotes lymphoma
R1 T0 T1 associated_with IFN,lymphoma
R2 T2 T3 associated_with IFN,lymphoma

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 447-465 HP_0030080 denotes Burkitt's lymphoma
T2 457-465 HP_0002665 denotes lymphoma
T3 1208-1226 HP_0030080 denotes Burkitt's lymphoma
T4 1218-1226 HP_0002665 denotes lymphoma