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PubMed:10194443 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 18-57 DNA denotes megakaryocytic glycoprotein IX promoter
T2 65-99 protein denotes oncogenic Ets transcription factor
T3 100-105 protein denotes Fli-1
T4 107-127 protein denotes Glycoprotein (GP) IX
T5 148-171 protein denotes von Willebrand receptor
T6 173-182 protein denotes GPIb-V-IX
T7 211-220 cell_type denotes platelets
T8 302-315 DNA denotes GPIX promoter
T9 411-422 protein denotes Ets protein
T10 441-454 DNA denotes GPIX promoter
T11 530-563 DNA denotes GPIX promoter/reporter constructs
T12 569-592 cell_line denotes 293T kidney fibroblasts
T13 600-623 DNA denotes Fli-1 expression vector
T14 657-662 protein denotes Fli-1
T15 685-698 DNA denotes GPIX promoter
T16 714-727 DNA denotes GPIX Ets site
T17 753-758 protein denotes Fli-1
T18 774-787 DNA denotes GPIX Ets site
T19 871-912 cell_type denotes hematopoietic human erythroleukemia cells
T20 946-951 protein denotes Fli-1
T21 987-996 DNA denotes GPIbalpha
T22 1026-1040 DNA denotes GPIIb promoter
T23 1073-1086 protein denotes Fli-1 protein
T24 1111-1120 cell_type denotes platelets
T25 1149-1154 protein denotes Fli-1
T26 1195-1209 cell_type denotes megakaryocytes
T27 1223-1236 cell_type denotes CD34(+) cells
T28 1254-1308 protein denotes megakaryocyte differentiation and proliferation factor
T29 1310-1324 protein denotes thrombopoietin
T30 1353-1358 protein denotes Fli-1
T31 1381-1403 DNA denotes lineage-specific genes

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-106 Sentence denotes Regulation of the megakaryocytic glycoprotein IX promoter by the oncogenic Ets transcription factor Fli-1.
S2 107-268 Sentence denotes Glycoprotein (GP) IX is a subunit of the von Willebrand receptor, GPIb-V-IX, which mediates adhesion of platelets to the subendothelium of damaged blood vessels.
S3 269-397 Sentence denotes Previous characterization of the GPIX promoter identified a functional Ets site that, when disrupted, reduced promoter activity.
S4 398-478 Sentence denotes However, the Ets protein(s) that regulated GPIX promoter expression was unknown.
S5 479-739 Sentence denotes In this study, transient cotransfection of several GPIX promoter/reporter constructs into 293T kidney fibroblasts with a Fli-1 expression vector shows that the oncogenic protein Fli-1 can transactivate the GPIX promoter when an intact GPIX Ets site is present.
S6 740-913 Sentence denotes In addition, Fli-1 binding of the GPIX Ets site was identified in antibody supershift experiments in nuclear extracts derived from hematopoietic human erythroleukemia cells.
S7 914-1041 Sentence denotes Comparative studies showed that Fli-1 was also able to transactivate the GPIbalpha and, to a lesser extent, the GPIIb promoter.
S8 1042-1121 Sentence denotes Immunoblot analysis identified Fli-1 protein in lysates derived from platelets.
S9 1122-1325 Sentence denotes In addition, expression of Fli-1 was identified immunohistochemically in megakaryocytes derived from CD34(+) cells treated with the megakaryocyte differentiation and proliferation factor, thrombopoietin.
S10 1326-1432 Sentence denotes These results suggest that Fli-1 is likely to regulate lineage-specific genes during megakaryocytopoiesis.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 61-105 NP denotes the oncogenic Ets transcription factor Fli-1
C3 144-171 NP denotes the von Willebrand receptor
C4 173-182 NP denotes GPIb-V-IX
C2 131-182 NP denotes a subunit of the von Willebrand receptor, GPIb-V-IX
C5 184-189 NP denotes which
C6 211-220 NP denotes platelets
C7 298-315 NP denotes the GPIX promoter
C8 327-348 NP denotes a functional Ets site
C9 349-353 NP denotes that
C10 407-425 NP denotes the Ets protein(s)
C11 426-430 NP denotes that
C12 635-662 NP denotes the oncogenic protein Fli-1
C13 681-698 NP denotes the GPIX promoter
C14 946-951 NP denotes Fli-1
C15 1111-1120 NP denotes platelets
C16 1149-1154 NP denotes Fli-1
C17 1288-1308 NP denotes proliferation factor
C18 1310-1324 NP denotes thrombopoietin
C19 1353-1358 NP denotes Fli-1
R1 C4 C3 coref-appos GPIb-V-IX,the von Willebrand receptor
R2 C5 C2 coref-relat which,"a subunit of the von Willebrand receptor, GPIb-V-IX"
R3 C9 C8 coref-relat that,a functional Ets site
R4 C11 C10 coref-relat that,the Ets protein(s)
R5 C12 C1 coref-ident the oncogenic protein Fli-1,the oncogenic Ets transcription factor Fli-1
R6 C13 C7 coref-ident the GPIX promoter,the GPIX promoter
R7 C14 C12 coref-ident Fli-1,the oncogenic protein Fli-1
R8 C15 C6 coref-ident platelets,platelets
R9 C16 C14 coref-ident Fli-1,Fli-1
R10 C18 C17 coref-appos thrombopoietin,proliferation factor
R11 C19 C16 coref-ident Fli-1,Fli-1

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 18-57 DNA_family_or_group denotes megakaryocytic glycoprotein IX promoter
T2 65-99 protein_family_or_group denotes oncogenic Ets transcription factor
T3 100-105 protein_molecule denotes Fli-1
T4 107-127 protein_molecule denotes Glycoprotein (GP) IX
T5 148-171 protein_complex denotes von Willebrand receptor
T6 173-182 protein_complex denotes GPIb-V-IX
T7 211-220 cell_type denotes platelets
T8 228-242 tissue denotes subendothelium
T9 246-267 body_part denotes damaged blood vessels
T10 302-315 DNA_domain_or_region denotes GPIX promoter
T11 379-396 other_name denotes promoter activity
T12 411-422 protein_family_or_group denotes Ets protein
T13 441-454 DNA_domain_or_region denotes GPIX promoter
T14 530-543 DNA_domain_or_region denotes GPIX promoter
T15 569-592 cell_line denotes 293T kidney fibroblasts
T16 600-605 protein_molecule denotes Fli-1
T17 657-662 protein_molecule denotes Fli-1
T18 685-698 DNA_domain_or_region denotes GPIX promoter
T19 714-727 DNA_domain_or_region denotes GPIX Ets site
T20 753-758 protein_molecule denotes Fli-1
T21 774-787 DNA_domain_or_region denotes GPIX Ets site
T22 841-857 cell_component denotes nuclear extracts
T23 871-912 cell_type denotes hematopoietic human erythroleukemia cells
T24 946-951 protein_molecule denotes Fli-1
T25 987-996 DNA_domain_or_region denotes GPIbalpha
T26 1026-1040 DNA_domain_or_region denotes GPIIb promoter
T27 1073-1078 protein_molecule denotes Fli-1
T28 1111-1120 cell_type denotes platelets
T29 1149-1154 protein_molecule denotes Fli-1
T30 1195-1209 cell_type denotes megakaryocytes
T31 1223-1236 cell_type denotes CD34(+) cells
T32 1254-1308 protein_family_or_group denotes megakaryocyte differentiation and proliferation factor
T33 1310-1324 protein_molecule denotes thrombopoietin
T34 1353-1358 protein_molecule denotes Fli-1
T35 1381-1403 DNA_family_or_group denotes lineage-specific genes
T36 1411-1431 other_name denotes megakaryocytopoiesis