PubMed:10187841
Annnotations
GlyCosmos6-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 23-29 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T2 | 77-81 | Body_part | denotes | cell | http://purl.obolibrary.org/obo/CL_0000000 |
| T3 | 122-128 | Body_part | denotes | Tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T4 | 217-221 | Body_part | denotes | cell | http://purl.obolibrary.org/obo/CL_0000000 |
| T5 | 1127-1131 | Body_part | denotes | cell | http://purl.obolibrary.org/obo/CL_0000000 |
| T6 | 1132-1139 | Body_part | denotes | surface | http://purl.obolibrary.org/obo/UBERON_0002416 |
| T7 | 1307-1311 | Body_part | denotes | cell | http://purl.obolibrary.org/obo/CL_0000000 |
| T8 | 1312-1319 | Body_part | denotes | surface | http://purl.obolibrary.org/obo/UBERON_0002416 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-121 | Sentence | denotes | Reactive site-modified tissue inhibitor of metalloproteinases-2 inhibits the cell-mediated activation of progelatinase A. |
| T2 | 122-261 | Sentence | denotes | Tissue inhibitor of metalloproteinases-2 (TIMP-2) is supposed to play a regulatory role in the cell-mediated activation of progelatinase A. |
| T3 | 262-432 | Sentence | denotes | To investigate the mechanism of the regulation, we prepared and characterized a chemically modified TIMP-2, and examined its effects on the activation of progelatinase A. |
| T4 | 433-553 | Sentence | denotes | We found that treatment of TIMP-2 with cyanate ion led to loss of inhibitory activity toward matrilysin or gelatinase A. |
| T5 | 554-746 | Sentence | denotes | Structural and functional analyses of the modified TIMP-2 showed that carbamylation of the alpha-amino group of the NH2-terminal Cys1 of TIMP-2 led to complete loss of the inhibitory activity. |
| T6 | 747-1031 | Sentence | denotes | When the reactive-site modified TIMP-2 was added to culture medium of concanavalin A-stimulated HT1080 cells, the conversion of endogenous progelatinase A to the intermediate form was partially inhibited, whereas that of the intermediate form to the mature one was strongly inhibited. |
| T7 | 1032-1140 | Sentence | denotes | The reactive site-modified TIMP-2 also prevented an accumulation of active gelatinase A on the cell surface. |
| T8 | 1141-1426 | Sentence | denotes | We speculate that occupation of the hemopexin-like domain of gelatinase A by the reactive site-modified TIMP-2 makes it unable for gelatinase A to be retained on the cell surface, thus preventing the autocatalytic conversion of the intermediate form of gelatinase A to its mature form. |
GlyCosmos6-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 77-81 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T2 | 91-101 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T3 | 217-221 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T4 | 231-241 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T5 | 402-412 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T6 | 510-518 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T7 | 737-745 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T8 | 843-855 | http://purl.obolibrary.org/obo/CLO_0052210 | denotes | HT1080 cells |
| T9 | 843-855 | http://purl.obolibrary.org/obo/CLO_0052211 | denotes | HT1080 cells |
| T10 | 843-849 | http://purl.obolibrary.org/obo/CLO_0004266 | denotes | HT1080 |
| T11 | 843-849 | http://purl.obolibrary.org/obo/CLO_0004276 | denotes | HT1080 |
| T12 | 850-855 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T13 | 1100-1106 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T14 | 1127-1131 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T15 | 1307-1311 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
2015-BEL-Sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1032-1139 | cat(p(HGNC:TIMP2)) decreases cat(p(HGNC:MMP2)) | denotes | The reactive site-modified TIMP-2 also prevented an accumulation of active gelatinase A on the cell surface |
2015-BEL-Sample-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| BEL:20000058 | 1032-1139 | cat(p(HGNC:TIMP2)) decreases cat(p(HGNC:MMP2)) | denotes | The reactive site-modified TIMP-2 also prevented an accumulation of active gelatinase A on the cell surface |
| BEL:20030278 | 1032-1139 | cat(p(HGNC:TIMP2)) decreases cat(p(HGNC:MMP2)) | denotes | The reactive site-modified TIMP-2 also prevented an accumulation of active gelatinase A on the cell surface |