PubMed:10187778
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 61-64 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T3 | 139-142 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T5 | 190-193 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T7 | 376-379 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T9 | 388-391 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T11 | 461-464 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T13 | 500-503 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T15 | 698-701 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T17 | 708-711 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T19 | 766-769 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T21 | 778-781 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T23 | 833-836 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T25 | 889-892 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T27 | 899-902 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T29 | 998-1001 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T31 | 1022-1028 | Glycan_Motif | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
| T32 | 1034-1037 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T34 | 1124-1127 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T36 | 1179-1182 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T38 | 1191-1194 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T40 | 1202-1205 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T42 | 1237-1240 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T44 | 1325-1328 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T46 | 1383-1386 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T48 | 1463-1469 | Glycan_Motif | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
| T49 | 1569-1572 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T51 | 1650-1653 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-90 | Sentence | denotes | Structural basis for the resistance of Tay-Sachs ganglioside GM2 to enzymatic degradation. |
| T2 | 91-454 | Sentence | denotes | To understand the reason why, in the absence of GM2 activator protein, the GalNAc and the NeuAc in GM2 (GalNAcbeta1-->4(NeuAcalpha2-->3)Galbeta1-->4Glcbet a1-1'Cer) are refractory to beta-hexosaminidase A and sialidase, respectively, we have recently synthesized a linkage analogue of GM2 named 6'GM2 (GalNAcbeta1-->6(NeuAcalpha2-->3)Galbeta1-->4Glcbet a1-1'Cer). |
| T3 | 455-627 | Sentence | denotes | While GM2 has GalNAcbeta1-->4Gal linkage, 6'-GM2 has GalNAcbeta1-->6Gal linkage (Ishida, H., Ito, Y., Tanahashi, E., Li, Y.-T., Kiso, M., and Hasegawa, A. (1997) Carbohydr. |
| T4 | 628-632 | Sentence | denotes | Res. |
| T5 | 633-647 | Sentence | denotes | 302, 223-227). |
| T6 | 648-837 | Sentence | denotes | We have studied the enzymatic susceptibilities of GM2 and 6'GM2, as well as that of the oligosaccharides derived from GM2, asialo-GM2 (GalNAcbeta1-->4Galbeta1--> 4Glcbeta1-1'Cer) and 6'GM2. |
| T7 | 838-976 | Sentence | denotes | In addition, the conformational properties of both GM2 and 6'GM2 were analyzed using NMR spectroscopy and molecular mechanics computation. |
| T8 | 977-1138 | Sentence | denotes | In sharp contrast to GM2, the GalNAc and the Neu5Ac of 6'GM2 were readily hydrolyzed by beta-hexosaminidase A and sialidase, respectively, without GM2 activator. |
| T9 | 1139-1280 | Sentence | denotes | Among the oligosaccharides derived from GM2, asialo-GM2, and 6'GM2, only the oligosaccharide from GM2 was resistant to beta-hexosaminidase A. |
| T10 | 1281-1513 | Sentence | denotes | Conformational analyses revealed that while GM2 has a compact and rigid oligosaccharide head group, 6'GM2 has an open spatial arrangement of the sugar units, with the GalNAc and the Neu5Ac freely accessible to external interactions. |
| T11 | 1514-1670 | Sentence | denotes | These results strongly indicate that the resistance of GM2 to enzymatic hydrolysis is because of the specific rigid conformation of the GM2 oligosaccharide. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 61-64 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T2 | 61-64 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T3 | 139-142 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T4 | 139-142 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T5 | 190-193 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T6 | 190-193 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T7 | 376-379 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T8 | 376-379 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T9 | 388-391 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T10 | 388-391 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T11 | 461-464 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T12 | 461-464 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T13 | 500-503 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T14 | 500-503 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T15 | 698-701 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T16 | 698-701 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T17 | 708-711 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T18 | 708-711 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T19 | 766-769 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T20 | 766-769 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T21 | 778-781 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T22 | 778-781 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T23 | 833-836 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T24 | 833-836 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T25 | 889-892 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T26 | 889-892 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T27 | 899-902 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T28 | 899-902 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T29 | 998-1001 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T30 | 998-1001 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T31 | 1022-1028 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T32 | 1034-1037 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T33 | 1034-1037 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T34 | 1124-1127 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T35 | 1124-1127 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T36 | 1179-1182 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T37 | 1179-1182 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T38 | 1191-1194 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T39 | 1191-1194 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T40 | 1202-1205 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T41 | 1202-1205 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T42 | 1237-1240 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T43 | 1237-1240 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T44 | 1325-1328 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T45 | 1325-1328 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T46 | 1383-1386 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T47 | 1383-1386 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T48 | 1463-1469 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T49 | 1569-1572 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T50 | 1569-1572 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T51 | 1650-1653 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T52 | 1650-1653 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1369-1373 | http://purl.obolibrary.org/obo/MAT_0000294 | denotes | head |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1347-1352 | HP_0002063 | denotes | rigid |
| T2 | 1624-1629 | HP_0002063 | denotes | rigid |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 61-64 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T2 | 139-142 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T3 | 166-172 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T4 | 181-186 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T5 | 190-193 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T6 | 376-379 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T7 | 388-391 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T8 | 461-464 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T9 | 500-503 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T10 | 698-701 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T11 | 708-711 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T12 | 766-769 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T13 | 778-781 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T14 | 833-836 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T15 | 889-892 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T16 | 899-902 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T17 | 998-1001 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T18 | 1007-1013 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T19 | 1022-1028 | Glycan | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T20 | 1034-1037 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T21 | 1124-1127 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T22 | 1179-1182 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T23 | 1191-1194 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T24 | 1202-1205 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T25 | 1237-1240 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T26 | 1325-1328 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T27 | 1383-1386 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T28 | 1448-1454 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T29 | 1463-1469 | Glycan | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T30 | 1569-1572 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T31 | 1650-1653 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 1369-1373 | Body_part | denotes | head | http://purl.obolibrary.org/obo/UBERON_0000033 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1369-1373 | Body_part | denotes | head | http://purl.obolibrary.org/obo/MAT_0000294 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-90 | Sentence | denotes | Structural basis for the resistance of Tay-Sachs ganglioside GM2 to enzymatic degradation. |
| T2 | 91-454 | Sentence | denotes | To understand the reason why, in the absence of GM2 activator protein, the GalNAc and the NeuAc in GM2 (GalNAcbeta1-->4(NeuAcalpha2-->3)Galbeta1-->4Glcbet a1-1'Cer) are refractory to beta-hexosaminidase A and sialidase, respectively, we have recently synthesized a linkage analogue of GM2 named 6'GM2 (GalNAcbeta1-->6(NeuAcalpha2-->3)Galbeta1-->4Glcbet a1-1'Cer). |
| T3 | 455-627 | Sentence | denotes | While GM2 has GalNAcbeta1-->4Gal linkage, 6'-GM2 has GalNAcbeta1-->6Gal linkage (Ishida, H., Ito, Y., Tanahashi, E., Li, Y.-T., Kiso, M., and Hasegawa, A. (1997) Carbohydr. |
| T4 | 628-632 | Sentence | denotes | Res. |
| T5 | 633-647 | Sentence | denotes | 302, 223-227). |
| T6 | 648-837 | Sentence | denotes | We have studied the enzymatic susceptibilities of GM2 and 6'GM2, as well as that of the oligosaccharides derived from GM2, asialo-GM2 (GalNAcbeta1-->4Galbeta1--> 4Glcbeta1-1'Cer) and 6'GM2. |
| T7 | 838-976 | Sentence | denotes | In addition, the conformational properties of both GM2 and 6'GM2 were analyzed using NMR spectroscopy and molecular mechanics computation. |
| T8 | 977-1138 | Sentence | denotes | In sharp contrast to GM2, the GalNAc and the Neu5Ac of 6'GM2 were readily hydrolyzed by beta-hexosaminidase A and sialidase, respectively, without GM2 activator. |
| T9 | 1139-1280 | Sentence | denotes | Among the oligosaccharides derived from GM2, asialo-GM2, and 6'GM2, only the oligosaccharide from GM2 was resistant to beta-hexosaminidase A. |
| T10 | 1281-1513 | Sentence | denotes | Conformational analyses revealed that while GM2 has a compact and rigid oligosaccharide head group, 6'GM2 has an open spatial arrangement of the sugar units, with the GalNAc and the Neu5Ac freely accessible to external interactions. |
| T11 | 1514-1670 | Sentence | denotes | These results strongly indicate that the resistance of GM2 to enzymatic hydrolysis is because of the specific rigid conformation of the GM2 oligosaccharide. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-90 | Sentence | denotes | Structural basis for the resistance of Tay-Sachs ganglioside GM2 to enzymatic degradation. |
| T2 | 91-454 | Sentence | denotes | To understand the reason why, in the absence of GM2 activator protein, the GalNAc and the NeuAc in GM2 (GalNAcbeta1-->4(NeuAcalpha2-->3)Galbeta1-->4Glcbet a1-1'Cer) are refractory to beta-hexosaminidase A and sialidase, respectively, we have recently synthesized a linkage analogue of GM2 named 6'GM2 (GalNAcbeta1-->6(NeuAcalpha2-->3)Galbeta1-->4Glcbet a1-1'Cer). |
| T3 | 455-647 | Sentence | denotes | While GM2 has GalNAcbeta1-->4Gal linkage, 6'-GM2 has GalNAcbeta1-->6Gal linkage (Ishida, H., Ito, Y., Tanahashi, E., Li, Y.-T., Kiso, M., and Hasegawa, A. (1997) Carbohydr. Res. 302, 223-227). |
| T4 | 648-837 | Sentence | denotes | We have studied the enzymatic susceptibilities of GM2 and 6'GM2, as well as that of the oligosaccharides derived from GM2, asialo-GM2 (GalNAcbeta1-->4Galbeta1--> 4Glcbeta1-1'Cer) and 6'GM2. |
| T5 | 838-976 | Sentence | denotes | In addition, the conformational properties of both GM2 and 6'GM2 were analyzed using NMR spectroscopy and molecular mechanics computation. |
| T6 | 977-1138 | Sentence | denotes | In sharp contrast to GM2, the GalNAc and the Neu5Ac of 6'GM2 were readily hydrolyzed by beta-hexosaminidase A and sialidase, respectively, without GM2 activator. |
| T7 | 1139-1513 | Sentence | denotes | Among the oligosaccharides derived from GM2, asialo-GM2, and 6'GM2, only the oligosaccharide from GM2 was resistant to beta-hexosaminidase A. Conformational analyses revealed that while GM2 has a compact and rigid oligosaccharide head group, 6'GM2 has an open spatial arrangement of the sugar units, with the GalNAc and the Neu5Ac freely accessible to external interactions. |
| T8 | 1514-1670 | Sentence | denotes | These results strongly indicate that the resistance of GM2 to enzymatic hydrolysis is because of the specific rigid conformation of the GM2 oligosaccharide. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 61-64 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T2 | 139-142 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T3 | 166-172 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T4 | 181-186 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T5 | 190-193 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T6 | 376-379 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T7 | 388-391 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T8 | 461-464 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T9 | 500-503 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T10 | 698-701 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T11 | 708-711 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T12 | 766-769 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T13 | 778-781 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T14 | 833-836 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T15 | 889-892 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T16 | 899-902 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T17 | 998-1001 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T18 | 1007-1013 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T19 | 1022-1028 | Glycan | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T20 | 1034-1037 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T21 | 1124-1127 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T22 | 1179-1182 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T23 | 1191-1194 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T24 | 1202-1205 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T25 | 1237-1240 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T26 | 1325-1328 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T27 | 1383-1386 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T28 | 1448-1454 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T29 | 1463-1469 | Glycan | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T30 | 1569-1572 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T31 | 1650-1653 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 1369-1373 | Body_part | denotes | head | http://purl.obolibrary.org/obo/UBERON_0000033 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1369-1373 | Body_part | denotes | head | http://purl.obolibrary.org/obo/MAT_0000294 |