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PubMed:10103059 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 12-32 protein denotes transcription factor
T2 33-36 protein denotes SP1
T3 40-48 protein denotes caspases
T4 73-79 cell_type denotes B-cell
T5 185-205 cell_type denotes Autoreactive B-cells
T6 224-232 protein denotes anti-IgM
T7 265-278 protein denotes self-antigens
T8 314-320 cell_type denotes B-cell
T9 397-417 protein denotes transcription factor
T10 418-421 protein denotes SP1
T11 429-466 cell_line denotes human Burkitt lymphoma cell line BL60
T12 474-482 protein denotes anti-IgM
T13 572-578 protein denotes 68 kDa
T14 583-589 protein denotes 45 kDa
T15 699-723 protein denotes caspase 3-like proteases
T16 746-761 protein denotes recombinant SP1
T17 765-786 protein denotes recombinant caspase 3
T18 788-793 protein denotes CPP32
T19 798-807 protein denotes caspase 7
T20 809-814 protein denotes Mch 3
T21 880-901 protein denotes Recombinant caspase 6
T22 903-908 protein denotes Mch 2
T23 1007-1013 cell_type denotes B-cell
T24 1069-1072 protein denotes SP1
T25 1102-1105 protein denotes SP1
T26 1329-1332 protein denotes SP1
T27 1425-1428 protein denotes SP1
T28 1570-1573 protein denotes SP1
T29 1677-1697 protein denotes transcription factor
T30 1698-1701 protein denotes SP1
T31 1756-1780 protein denotes caspase 3-like proteases

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-90 Sentence denotes Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis.
S2 91-184 Sentence denotes Apoptosis is instrumental in the processes generating the diversity of the B-cell repertoire.
S3 185-361 Sentence denotes Autoreactive B-cells are eliminated by anti-IgM crosslinking after encountering self-antigens, but precise mechanisms leading to B-cell apoptosis are still not well understood.
S4 362-501 Sentence denotes We report here the cleavage of the transcription factor SP1 in the human Burkitt lymphoma cell line BL60 during anti-IgM-induced apoptosis.
S5 502-619 Sentence denotes Western blot analysis revealed two cleavage products of approximately 68 kDa and 45 kDa after induction of apoptosis.
S6 620-724 Sentence denotes Cleavage could be completely inhibited by zDEVD-fmk, an inhibitor specific for caspase 3-like proteases.
S7 725-879 Sentence denotes In-vitro cleavage of recombinant SP1 by recombinant caspase 3 (CPP32) or caspase 7 (Mch 3) results in similar cleavage products as those observed in vivo.
S8 880-1024 Sentence denotes Recombinant caspase 6 (Mch 2) primarily generates a 68-kDa cleavage product, as observed after calcium ionophore (CaI) induced B-cell apoptosis.
S9 1025-1082 Sentence denotes In contrast, caspase 1 (ICE) did not cleave SP1 in vitro.
S10 1083-1250 Sentence denotes The time course of SP1 cleavage during anti-IgM-induced apoptosis is paralleled by an increase of caspase activity measured by DEVD-p-nitroanilide (DEVD-pNA) cleavage.
S11 1251-1446 Sentence denotes DNA band-shift assays revealed a decrease in the intensity of the full length SP1/DNA complex and an increase in the intensity of a smaller complex due to the binding of one SP1 cleavage product.
S12 1447-1633 Sentence denotes By Edman sequencing we could identify a caspase 3 cleavage site after Asp584 (D584AQPQAGR), generating a 22-kDa C-terminal SP1 protein fragment which still contains the DNA binding site.
S13 1634-1830 Sentence denotes Our results show the cleavage of the human transcription factor SP1 in vivo and in vitro, underlining the central role of caspase 3-like proteases during the process of anti-IgM-induced apoptosis.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 12-36 NP denotes transcription factor SP1
C2 91-100 NP denotes Apoptosis
C3 393-421 NP denotes the transcription factor SP1
C4 474-500 NP denotes anti-IgM-induced apoptosis
C5 609-618 NP denotes apoptosis
C6 662-671 NP denotes zDEVD-fmk
C8 699-723 NP denotes caspase 3-like proteases
C7 673-723 NP denotes an inhibitor specific for caspase 3-like proteases
C9 1069-1072 NP denotes SP1
C10 1122-1148 NP denotes anti-IgM-induced apoptosis
C11 1550-1590 NP denotes a 22-kDa C-terminal SP1 protein fragment
C12 1591-1596 NP denotes which
C13 1667-1701 NP denotes the human transcription factor SP1
C14 1756-1780 NP denotes caspase 3-like proteases
C15 1803-1829 NP denotes anti-IgM-induced apoptosis
R1 C3 C1 coref-ident the transcription factor SP1,transcription factor SP1
R2 C5 C2 coref-ident apoptosis,Apoptosis
R3 C7 C6 coref-appos an inhibitor specific for caspase 3-like proteases,zDEVD-fmk
R4 C9 C3 coref-ident SP1,the transcription factor SP1
R5 C10 C4 coref-ident anti-IgM-induced apoptosis,anti-IgM-induced apoptosis
R6 C12 C11 coref-relat which,a 22-kDa C-terminal SP1 protein fragment
R7 C13 C9 coref-ident the human transcription factor SP1,SP1
R8 C14 C8 coref-ident caspase 3-like proteases,caspase 3-like proteases
R9 C15 C10 coref-ident anti-IgM-induced apoptosis,anti-IgM-induced apoptosis

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 12-32 protein_family_or_group denotes transcription factor
T2 33-36 protein_molecule denotes SP1
T3 40-48 protein_family_or_group denotes caspases
T4 56-72 other_name denotes anti-IgM-induced
T5 73-79 cell_type denotes B-cell
T6 91-100 other_name denotes Apoptosis
T7 166-183 other_name denotes B-cell repertoire
T8 185-205 cell_type denotes Autoreactive B-cells
T9 224-232 protein_family_or_group denotes anti-IgM
T10 265-278 protein_family_or_group denotes self-antigens
T11 314-320 cell_type denotes B-cell
T12 397-417 protein_family_or_group denotes transcription factor
T13 418-421 protein_molecule denotes SP1
T14 429-466 cell_line denotes human Burkitt lymphoma cell line BL60
T15 474-482 protein_family_or_group denotes anti-IgM
T16 572-578 protein_molecule denotes 68 kDa
T17 583-589 protein_molecule denotes 45 kDa
T18 609-618 other_name denotes apoptosis
T19 662-671 other_organic_compound denotes zDEVD-fmk
T20 699-723 protein_family_or_group denotes caspase 3-like proteases
T21 746-757 protein_molecule denotes recombinant
T22 758-761 protein_molecule denotes SP1
T23 765-786 protein_molecule denotes recombinant caspase 3
T24 788-793 protein_molecule denotes CPP32
T25 798-807 protein_molecule denotes caspase 7
T26 809-814 protein_molecule denotes Mch 3
T27 880-901 protein_molecule denotes Recombinant caspase 6
T28 903-908 protein_molecule denotes Mch 2
T29 1007-1013 cell_type denotes B-cell
T30 1014-1023 other_name denotes apoptosis
T31 1069-1072 protein_molecule denotes SP1
T32 1102-1105 protein_molecule denotes SP1
T33 1139-1148 other_name denotes apoptosis
T34 1329-1332 protein_molecule denotes SP1
T35 1425-1428 protein_molecule denotes SP1
T36 1570-1573 protein_molecule denotes SP1
T37 1677-1697 protein_family_or_group denotes transcription factor
T38 1698-1701 protein_molecule denotes SP1
T39 1756-1780 protein_family_or_group denotes caspase 3-like proteases
T40 1820-1829 other_name denotes apoptosis

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 435-451 HP_0030080 denotes Burkitt lymphoma
T2 443-451 HP_0002665 denotes lymphoma