PubMed:10101602
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 27-38 | cell_type | denotes | lymphocytes |
| T2 | 287-308 | cell_type | denotes | normal lymphoid cells |
| T3 | 454-478 | cell_type | denotes | malignant lymphoid cells |
| T4 | 544-566 | protein | denotes | intracellular receptor |
| T5 | 584-612 | protein | denotes | steroid receptor superfamily |
| T6 | 618-641 | protein | denotes | glucocorticoid receptor |
| T7 | 643-645 | protein | denotes | GR |
| T8 | 668-670 | protein | denotes | GR |
| T9 | 771-792 | protein | denotes | transcription factors |
| T10 | 819-830 | cell_type | denotes | lymphocytes |
| T11 | 962-964 | protein | denotes | GR |
| T12 | 966-975 | protein | denotes | I kappa B |
| T13 | 977-982 | protein | denotes | c-jun |
| T14 | 1001-1017 | protein | denotes | survival factors |
| T15 | 1019-1023 | protein | denotes | AP-1 |
| T16 | 1025-1030 | protein | denotes | c-Myc |
| T17 | 1132-1137 | protein | denotes | Nur77 |
| T18 | 1142-1144 | protein | denotes | GR |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-95 | Sentence | denotes | [Induction of apoptosis in lymphocytes by glucocorticoids: between physiology and pharmacology] |
| S2 | 97-246 | Sentence | denotes | Glucocorticoids are physiological molecules that are also extensively used in clinics as anti-inflammatory, immunosuppressive or anti-tumoral agents. |
| S3 | 247-367 | Sentence | denotes | Glucocorticoids can induce apoptosis on normal lymphoid cells and play a key role in the physiology of thymic selection. |
| S4 | 368-479 | Sentence | denotes | In clinics these molecules are also used for their potencies in inducing apoptosis of malignant lymphoid cells. |
| S5 | 480-647 | Sentence | denotes | Glucocorticoids are mediating their effects after binding to an intracellular receptor belonging to the steroid receptor superfamily: the glucocorticoid receptor (GR). |
| S6 | 648-793 | Sentence | denotes | Once activated, the GR, can mediate his effects through direct binding on the DNA or via protein/protein interactions with transcription factors. |
| S7 | 794-1032 | Sentence | denotes | Depending on the type of lymphocytes, the mechanism of apoptosis induced by glucocorticoids fall roughly in two categories: induction of "death genes" by the activated GR (I kappa B, c-jun) or repression of survival factors (AP-1, c-Myc). |
| S8 | 1033-1145 | Sentence | denotes | In the case of thymic selection the mechanism is more subtle depending on the mutual repression of Nur77 and GR. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 97-112 | NP | denotes | Glucocorticoids |
| C2 | 117-140 | NP | denotes | physiological molecules |
| C3 | 141-145 | NP | denotes | that |
| C4 | 175-182 | NP | denotes | clinics |
| C5 | 247-262 | NP | denotes | Glucocorticoids |
| C6 | 274-283 | NP | denotes | apoptosis |
| C7 | 350-366 | NP | denotes | thymic selection |
| C8 | 371-378 | NP | denotes | clinics |
| C9 | 379-394 | NP | denotes | these molecules |
| C10 | 413-418 | NP | denotes | their |
| C11 | 480-495 | NP | denotes | Glucocorticoids |
| C12 | 510-515 | NP | denotes | their |
| C13 | 580-612 | NP | denotes | the steroid receptor superfamily |
| C14 | 614-646 | NP | denotes | the glucocorticoid receptor (GR) |
| C15 | 664-670 | NP | denotes | the GR |
| C16 | 684-687 | NP | denotes | his |
| C17 | 849-858 | NP | denotes | apoptosis |
| C18 | 870-885 | NP | denotes | glucocorticoids |
| C19 | 902-916 | NP | denotes | two categories |
| C20 | 918-1031 | NP | denotes | induction of "death genes" by the activated GR (I kappa B, c-jun) or repression of survival factors (AP-1, c-Myc) |
| C21 | 1048-1064 | NP | denotes | thymic selection |
| C22 | 1142-1144 | NP | denotes | GR |
| R1 | C3 | C2 | coref-relat | that,physiological molecules |
| R2 | C5 | C1 | coref-ident | Glucocorticoids,Glucocorticoids |
| R3 | C8 | C4 | coref-ident | clinics,clinics |
| R4 | C9 | C5 | coref-ident | these molecules,Glucocorticoids |
| R5 | C10 | C9 | coref-pron | their,these molecules |
| R6 | C11 | C9 | coref-ident | Glucocorticoids,these molecules |
| R7 | C12 | C11 | coref-pron | their,Glucocorticoids |
| R8 | C14 | C13 | coref-appos | the glucocorticoid receptor (GR),the steroid receptor superfamily |
| R9 | C15 | C14 | coref-ident | the GR,the glucocorticoid receptor (GR) |
| R10 | C16 | C15 | coref-pron | his,the GR |
| R11 | C17 | C6 | coref-ident | apoptosis,apoptosis |
| R12 | C18 | C11 | coref-ident | glucocorticoids,Glucocorticoids |
| R13 | C20 | C19 | coref-appos | "induction of ""death genes"" by the activated GR (I kappa B, c-jun) or repression of survival factors (AP-1, c-Myc)",two categories |
| R14 | C21 | C7 | coref-ident | thymic selection,thymic selection |
| R15 | C22 | C15 | coref-ident | GR,the GR |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 27-38 | cell_type | denotes | lymphocytes |
| T2 | 42-57 | lipid | denotes | glucocorticoids |
| T3 | 97-112 | lipid | denotes | Glucocorticoids |
| T4 | 247-262 | lipid | denotes | Glucocorticoids |
| T5 | 274-283 | other_name | denotes | apoptosis |
| T6 | 287-308 | cell_type | denotes | normal lymphoid cells |
| T7 | 350-366 | other_name | denotes | thymic selection |
| T8 | 441-450 | other_name | denotes | apoptosis |
| T9 | 454-478 | cell_type | denotes | malignant lymphoid cells |
| T10 | 480-495 | lipid | denotes | Glucocorticoids |
| T11 | 544-566 | protein_family_or_group | denotes | intracellular receptor |
| T12 | 584-612 | protein_family_or_group | denotes | steroid receptor superfamily |
| T13 | 618-641 | protein_family_or_group | denotes | glucocorticoid receptor |
| T14 | 643-645 | protein_family_or_group | denotes | GR |
| T15 | 668-670 | protein_family_or_group | denotes | GR |
| T16 | 737-765 | other_name | denotes | protein/protein interactions |
| T17 | 771-792 | protein_family_or_group | denotes | transcription factors |
| T18 | 819-830 | cell_type | denotes | lymphocytes |
| T19 | 849-858 | other_name | denotes | apoptosis |
| T20 | 870-885 | lipid | denotes | glucocorticoids |
| T21 | 962-964 | protein_family_or_group | denotes | GR |
| T22 | 966-975 | protein_molecule | denotes | I kappa B |
| T23 | 977-982 | protein_molecule | denotes | c-jun |
| T24 | 1001-1017 | protein_family_or_group | denotes | survival factors |
| T25 | 1019-1023 | protein_molecule | denotes | AP-1 |
| T26 | 1025-1030 | protein_molecule | denotes | c-Myc |
| T27 | 1048-1064 | other_name | denotes | thymic selection |
| T28 | 1111-1128 | other_name | denotes | mutual repression |
| T29 | 1132-1137 | protein_molecule | denotes | Nur77 |
| T30 | 1142-1144 | protein_family_or_group | denotes | GR |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 231-238 | HP_0002664 | denotes | tumoral |