PubMed:10101249
Annnotations
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 225-233 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
| T2 | 265-269 | Body_part | denotes | bone | http://purl.obolibrary.org/obo/MAT_0000299 |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-18 | protein | denotes | Vitamin D receptor |
| T2 | 19-41 | DNA | denotes | 3'-untranslated region |
| T3 | 130-159 | DNA | denotes | vitamin D receptor (VDR) gene |
| T4 | 328-339 | protein | denotes | VDR protein |
| T5 | 526-529 | protein | denotes | VDR |
| T6 | 530-536 | DNA | denotes | 3'-UTR |
| T7 | 706-723 | DNA | denotes | sequence variants |
| T8 | 874-904 | DNA | denotes | message-destabilizing elements |
| T9 | 931-937 | DNA | denotes | 3'-UTR |
| T10 | 945-968 | RNA | denotes | vitamin D receptor mRNA |
| T11 | 991-1001 | DNA | denotes | VDR 3'-UTR |
| T12 | 1051-1089 | DNA | denotes | heterologous beta-globin reporter gene |
| T13 | 1172-1182 | DNA | denotes | VDR 3'-UTR |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 10101249-1#39#57#gene7421 | 130-148 | gene7421 | denotes | vitamin D receptor |
| 10101249-1#59#62#gene7421 | 150-153 | gene7421 | denotes | VDR |
| 10101249-1#134#149#diseaseC0376358 | 225-240 | diseaseC0376358 | denotes | prostate cancer |
| 10101249-1#134#149#diseaseC0600139 | 225-240 | diseaseC0600139 | denotes | prostate cancer |
| 10101249-1#134#149#diseaseC0376358 | 225-240 | diseaseC0376358 | denotes | prostate cancer |
| 10101249-1#134#149#diseaseC0600139 | 225-240 | diseaseC0600139 | denotes | prostate cancer |
| 39#57#gene7421134#149#diseaseC0376358 | 10101249-1#39#57#gene7421 | 10101249-1#134#149#diseaseC0376358 | associated_with | vitamin D receptor,prostate cancer |
| 39#57#gene7421134#149#diseaseC0600139 | 10101249-1#39#57#gene7421 | 10101249-1#134#149#diseaseC0600139 | associated_with | vitamin D receptor,prostate cancer |
| 39#57#gene7421134#149#diseaseC0376358 | 10101249-1#39#57#gene7421 | 10101249-1#134#149#diseaseC0376358 | associated_with | vitamin D receptor,prostate cancer |
| 39#57#gene7421134#149#diseaseC0600139 | 10101249-1#39#57#gene7421 | 10101249-1#134#149#diseaseC0600139 | associated_with | vitamin D receptor,prostate cancer |
| 59#62#gene7421134#149#diseaseC0376358 | 10101249-1#59#62#gene7421 | 10101249-1#134#149#diseaseC0376358 | associated_with | VDR,prostate cancer |
| 59#62#gene7421134#149#diseaseC0600139 | 10101249-1#59#62#gene7421 | 10101249-1#134#149#diseaseC0600139 | associated_with | VDR,prostate cancer |
| 59#62#gene7421134#149#diseaseC0376358 | 10101249-1#59#62#gene7421 | 10101249-1#134#149#diseaseC0376358 | associated_with | VDR,prostate cancer |
| 59#62#gene7421134#149#diseaseC0600139 | 10101249-1#59#62#gene7421 | 10101249-1#134#149#diseaseC0600139 | associated_with | VDR,prostate cancer |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-90 | Sentence | denotes | Vitamin D receptor 3'-untranslated region polymorphisms: lack of effect on mRNA stability. |
| S2 | 91-285 | Sentence | denotes | Allelic variation at the 3'-end of the vitamin D receptor (VDR) gene has been associated with a 3-5-fold increased risk of developing prostate cancer and with differences in bone mineralization. |
| S3 | 286-464 | Sentence | denotes | This genetic diversity does not alter the VDR protein structurally, but instead may be a marker(s) of other, nearby polymorphisms that influence message stability or translation. |
| S4 | 465-661 | Sentence | denotes | The work reported here was instigated to identify additional VDR 3'-UTR polymorphisms that may have functional significance and to then test whether these genetic variants alter message stability. |
| S5 | 662-814 | Sentence | denotes | Initially, four novel, frequently occurring sequence variants were identified that associated with two common haplotypes that were described previously. |
| S6 | 815-969 | Sentence | denotes | These common sequence variants were not found within three message-destabilizing elements that we mapped within the 3'-UTR of the vitamin D receptor mRNA. |
| S7 | 970-1112 | Sentence | denotes | Furthermore, the two VDR 3'-UTR haplotypes conferred an identical half-life on a heterologous beta-globin reporter gene, in an in vitro assay. |
| S8 | 1113-1218 | Sentence | denotes | We therefore conclude that common polymorphisms within the VDR 3'-UTR do not influence message stability. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 388-415 | NP | denotes | other, nearby polymorphisms |
| C2 | 416-420 | NP | denotes | that |
| C4 | 515-550 | NP | denotes | additional VDR 3'-UTR polymorphisms |
| C5 | 551-555 | NP | denotes | that |
| C3 | 515-588 | NP | denotes | additional VDR 3'-UTR polymorphisms that may have functional significance |
| C6 | 614-636 | NP | denotes | these genetic variants |
| C7 | 643-660 | NP | denotes | message stability |
| C8 | 673-723 | NP | denotes | four novel, frequently occurring sequence variants |
| C9 | 740-744 | NP | denotes | that |
| C11 | 761-782 | NP | denotes | two common haplotypes |
| C12 | 783-787 | NP | denotes | that |
| C10 | 761-813 | NP | denotes | two common haplotypes that were described previously |
| C13 | 815-845 | NP | denotes | These common sequence variants |
| C14 | 868-904 | NP | denotes | three message-destabilizing elements |
| C15 | 905-909 | NP | denotes | that |
| C16 | 983-1012 | NP | denotes | the two VDR 3'-UTR haplotypes |
| C17 | 1200-1217 | NP | denotes | message stability |
| R1 | C2 | C1 | coref-relat | that,"other, nearby polymorphisms" |
| R2 | C5 | C4 | coref-relat | that,additional VDR 3'-UTR polymorphisms |
| R3 | C6 | C3 | coref-ident | these genetic variants,additional VDR 3'-UTR polymorphisms that may have functional significance |
| R4 | C9 | C8 | coref-pron | that,"four novel, frequently occurring sequence variants" |
| R5 | C12 | C11 | coref-relat | that,two common haplotypes |
| R6 | C13 | C8 | coref-ident | These common sequence variants,"four novel, frequently occurring sequence variants" |
| R7 | C15 | C14 | coref-relat | that,three message-destabilizing elements |
| R8 | C16 | C10 | coref-ident | the two VDR 3'-UTR haplotypes,two common haplotypes that were described previously |
| R9 | C17 | C7 | coref-ident | message stability,message stability |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-18 | protein_family_or_group | denotes | Vitamin D receptor |
| T2 | 19-41 | DNA_domain_or_region | denotes | 3'-untranslated region |
| T3 | 75-89 | other_name | denotes | mRNA stability |
| T4 | 130-159 | DNA_domain_or_region | denotes | vitamin D receptor (VDR) gene |
| T5 | 196-210 | other_name | denotes | increased risk |
| T6 | 225-240 | other_name | denotes | prostate cancer |
| T7 | 265-284 | other_name | denotes | bone mineralization |
| T8 | 328-339 | protein_molecule | denotes | VDR protein |
| T9 | 526-529 | protein_family_or_group | denotes | VDR |
| T10 | 530-536 | DNA_domain_or_region | denotes | 3'-UTR |
| T11 | 643-660 | other_name | denotes | message stability |
| T12 | 706-723 | DNA_family_or_group | denotes | sequence variants |
| T13 | 874-904 | DNA_family_or_group | denotes | message-destabilizing elements |
| T14 | 931-937 | DNA_domain_or_region | denotes | 3'-UTR |
| T15 | 945-968 | RNA_family_or_group | denotes | vitamin D receptor mRNA |
| T16 | 991-1001 | DNA_domain_or_region | denotes | VDR 3'-UTR |
| T17 | 1051-1089 | DNA_domain_or_region | denotes | heterologous beta-globin reporter gene |
| T18 | 1097-1111 | other_name | denotes | in vitro assay |
| T19 | 1172-1182 | DNA_domain_or_region | denotes | VDR 3'-UTR |
| T20 | 1200-1217 | other_name | denotes | message stability |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 150-153 | gene:1594 | denotes | VDR |
| T1 | 225-240 | disease:C0376358 | denotes | prostate cancer |
| T2 | 150-153 | gene:1594 | denotes | VDR |
| T3 | 225-240 | disease:C0600139 | denotes | prostate cancer |
| T4 | 150-153 | gene:7421 | denotes | VDR |
| T5 | 225-240 | disease:C0376358 | denotes | prostate cancer |
| T6 | 150-153 | gene:7421 | denotes | VDR |
| T7 | 225-240 | disease:C0600139 | denotes | prostate cancer |
| R1 | T0 | T1 | associated_with | VDR,prostate cancer |
| R2 | T2 | T3 | associated_with | VDR,prostate cancer |
| R3 | T4 | T5 | associated_with | VDR,prostate cancer |
| R4 | T6 | T7 | associated_with | VDR,prostate cancer |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 225-240 | HP_0012125 | denotes | prostate cancer |
| T2 | 234-240 | HP_0002664 | denotes | cancer |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 225-240 | Disease | denotes | prostate cancer | http://purl.obolibrary.org/obo/MONDO_0008315 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 225-233 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
| T2 | 265-269 | Body_part | denotes | bone | http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 225-240 | Phenotype | denotes | prostate cancer | HP:0012125 |