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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-174 Sentence denotes Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid.
T2 175-275 Sentence denotes The therapeutic potential of drugs that block the induction of cyclooxygenase-2 has been emphasized.
T3 276-788 Sentence denotes When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethyl-benzoic acid (triflusal) and its deacetylated metabolite 2-hydroxy-4-trifluoromethylbenzoic acid (HTB)] were compared with aspirin and sodium salicylate as cyclooxygenase-2 (COX-2) inhibitors, we observed that in bacterial lipopolysaccharide-activated human blood, triflusal, aspirin, and HTB, but not sodium salicylate, inhibited COX-2-mediated prostaglandin E2 (PGE2) production (IC50 = 0.16, 0.18, 0.39, and >10 mM, respectively).
T4 789-857 Sentence denotes However, only triflusal and aspirin inhibited purified COX-2 enzyme.
T5 858-1077 Sentence denotes To test this apparent discrepancy, we realized that HTB and triflusal (but neither aspirin nor salicylate) produced a concentration-dependent inhibition of COX-2 protein expression in peripheral human mononuclear cells.
T6 1078-1334 Sentence denotes This observation was further confirmed in a rat air pouch model in vivo, in which both aspirin and triflusal inhibited PGE2 production (ID50 = 18.9 and 11.4 mg/kg p.o., respectively) but only triflusal-treated animals showed a decrease in COX-2 expression.
T7 1335-1553 Sentence denotes This different behavior may be, at least in part, due to the ability of HTB and triflusal to block the activation of the transcription factor nuclear factor-kappaB to a higher extent than aspirin and sodium salicylate.
T8 1554-1763 Sentence denotes Thus, in addition to inhibiting the COX-2 activity at therapeutic concentrations, triflusal is able to block through its metabolite HTB the expression of new enzyme, and hence the resumption of PGE2 synthesis.
T9 1764-1990 Sentence denotes Triflusal and HTB may exert beneficial effects in processes in which de novo COX-2 expression is involved and, in a broader sense, in pathological situations in which genes under nuclear factor-kappaB control are up-regulated.
T1 0-174 Sentence denotes Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid.
T2 175-275 Sentence denotes The therapeutic potential of drugs that block the induction of cyclooxygenase-2 has been emphasized.
T3 276-788 Sentence denotes When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethyl-benzoic acid (triflusal) and its deacetylated metabolite 2-hydroxy-4-trifluoromethylbenzoic acid (HTB)] were compared with aspirin and sodium salicylate as cyclooxygenase-2 (COX-2) inhibitors, we observed that in bacterial lipopolysaccharide-activated human blood, triflusal, aspirin, and HTB, but not sodium salicylate, inhibited COX-2-mediated prostaglandin E2 (PGE2) production (IC50 = 0.16, 0.18, 0.39, and >10 mM, respectively).
T4 789-857 Sentence denotes However, only triflusal and aspirin inhibited purified COX-2 enzyme.
T5 858-1077 Sentence denotes To test this apparent discrepancy, we realized that HTB and triflusal (but neither aspirin nor salicylate) produced a concentration-dependent inhibition of COX-2 protein expression in peripheral human mononuclear cells.
T6 1078-1334 Sentence denotes This observation was further confirmed in a rat air pouch model in vivo, in which both aspirin and triflusal inhibited PGE2 production (ID50 = 18.9 and 11.4 mg/kg p.o., respectively) but only triflusal-treated animals showed a decrease in COX-2 expression.
T7 1335-1553 Sentence denotes This different behavior may be, at least in part, due to the ability of HTB and triflusal to block the activation of the transcription factor nuclear factor-kappaB to a higher extent than aspirin and sodium salicylate.
T8 1554-1763 Sentence denotes Thus, in addition to inhibiting the COX-2 activity at therapeutic concentrations, triflusal is able to block through its metabolite HTB the expression of new enzyme, and hence the resumption of PGE2 synthesis.
T9 1764-1990 Sentence denotes Triflusal and HTB may exert beneficial effects in processes in which de novo COX-2 expression is involved and, in a broader sense, in pathological situations in which genes under nuclear factor-kappaB control are up-regulated.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-30 protein denotes cyclooxygenase-2
T2 238-254 protein denotes cyclooxygenase-2
T3 511-527 protein denotes cyclooxygenase-2
T4 835-856 protein denotes purified COX-2 enzyme
T5 1014-1019 protein denotes COX-2
T6 1042-1076 cell_type denotes peripheral human mononuclear cells
T7 1317-1322 protein denotes COX-2
T8 1477-1498 protein denotes nuclear factor-kappaB
T9 1841-1846 protein denotes COX-2
T10 1943-1964 protein denotes nuclear factor-kappaB

semrep-sample

Id Subject Object Predicate Lexical cue
E1-ti-1 14-30 cui:C0387583 denotes cyclooxygenase-2
E2-ti-1 31-41 cui:C0185117 denotes expression
E3-ti-1 63-74 cui:C0243072 denotes derivatives
E4-ti-1 78-88 cui:C0036075 denotes salicylate
E5-ti-1 90-99 cui:C0077126 denotes triflusal
E6-ti-1 122-132 cui:C0870883 denotes metabolite
E7-ti-1 134-173 cui:C0048733 denotes 2-hydroxy-4-trifluoromethylbenzoic acid
T1 0-10 INHIBITS denotes Inhibition
E1-ab-1 179-190 cui:C0302350 denotes therapeutic
E2-ab-1 191-200 cui:C0237399 denotes potential
E3-ab-1 204-209 cui:C0013227 denotes drugs
E4-ab-1 225-234 cui:C0857127 denotes induction
E5-ab-1 238-254 cui:C0387583 denotes cyclooxygenase-2
E1-ab-2 281-284 cui:C0205448 denotes two
E2-ab-2 303-313 cui:C0036075 denotes salicylate
E3-ab-2 314-325 cui:C0243072 denotes derivatives
E4-ab-2 355-367 cui:C0053225 denotes benzoic acid
E5-ab-2 369-378 cui:C0077126 denotes triflusal
E6-ab-2 401-411 cui:C0870883 denotes metabolite
E7-ab-2 414-451 cui:C0020317 denotes hydroxy-4-trifluoromethylbenzoic acid
E8-ab-2 478-485 cui:C0004057 denotes aspirin
E9-ab-2 490-507 cui:C0037549 denotes sodium salicylate
E10-ab-2 511-546 cui:C1257954 denotes cyclooxygenase-2 (COX-2) inhibitors
E11-ab-2 568-577 cui:C0521009 denotes bacterial
E12-ab-2 578-596 cui:C0023810 denotes lipopolysaccharide
E13-ab-2 597-606 cui:C1515877 denotes activated
E14-ab-2 607-612 cui:C0020114 denotes human
E15-ab-2 613-618 cui:C0005767 denotes blood
E16-ab-2 620-629 cui:C0077126 denotes triflusal
E17-ab-2 631-638 cui:C0004057 denotes aspirin
E18-ab-2 644-647 cui:C0020317 denotes HTB
E19-ab-2 653-656 cui:C1518422 denotes not
E20-ab-2 657-674 cui:C0037549 denotes sodium salicylate
E21-ab-2 686-691 cui:C0387583 denotes COX-2
E22-ab-2 692-700 cui:C0086597 denotes mediated
E23-ab-2 701-735 cui:C1514503 denotes prostaglandin E2 (PGE2) production
E24-ab-2 737-741 cui:C0600495 denotes IC50
T2 464-472 compared_with denotes compared
T3 355-378 ISA denotes benzoic acid (triflusal
T4 355-378 ISA denotes benzoic acid (triflusal
T5 355-378 ISA denotes benzoic acid (triflusal
T6 565-567 LOCATION_OF denotes in
T7 676-685 DISRUPTS denotes inhibited
T8 676-685 DISRUPTS denotes inhibited
T9 355-378 compared_with denotes benzoic acid (triflusal
E1-ab-3 803-812 cui:C0077126 denotes triflusal
E2-ab-3 817-824 cui:C0004057 denotes aspirin
E3-ab-3 844-849 cui:C0387583 denotes COX-2
E4-ab-3 850-856 cui:C0014442 denotes enzyme
T10 825-834 INHIBITS denotes inhibited
T11 825-834 INHIBITS denotes inhibited
E1-ab-4 871-879 cui:C0750489 denotes apparent
E2-ab-4 880-891 cui:C1290905 denotes discrepancy
E3-ab-4 910-913 cui:C0020317 denotes HTB
E4-ab-4 918-927 cui:C0077126 denotes triflusal
E5-ab-4 941-948 cui:C0004057 denotes aspirin
E6-ab-4 953-963 cui:C0036075 denotes salicylate
E7-ab-4 1014-1019 cui:C0387583 denotes COX-2
E8-ab-4 1020-1038 cui:C1171362 denotes protein expression
E9-ab-4 1042-1052 cui:C0205100 denotes peripheral
E10-ab-4 1053-1058 cui:C0020114 denotes human
E11-ab-4 1059-1076 cui:C0806987 denotes mononuclear cells
T12 1053-1076 PART_OF denotes human mononuclear cells
T13 1039-1041 LOCATION_OF denotes in
E1-ab-5 1099-1106 cui:C1517331 denotes further
E2-ab-5 1122-1125 cui:C0034693 denotes rat
E3-ab-5 1126-1129 cui:C0001861 denotes air
E4-ab-5 1136-1141 cui:C0026336 denotes model
E5-ab-5 1165-1172 cui:C0004057 denotes aspirin
E6-ab-5 1177-1186 cui:C0077126 denotes triflusal
E7-ab-5 1197-1212 cui:C1514503 denotes PGE2 production
E8-ab-5 1270-1279 cui:C0077126 denotes triflusal
E9-ab-5 1280-1287 cui:C1522326 denotes treated
E10-ab-5 1288-1295 cui:C0003062 denotes animals
E11-ab-5 1305-1313 cui:C0547047 denotes decrease
E12-ab-5 1317-1322 cui:C0387583 denotes COX-2
E13-ab-5 1323-1333 cui:C0185117 denotes expression
T14 1187-1196 DISRUPTS denotes inhibited
T15 1187-1196 DISRUPTS denotes inhibited
E1-ab-6 1340-1349 cui:C1547020 denotes different
E2-ab-6 1350-1358 cui:C0004927 denotes behavior
E3-ab-6 1379-1383 cui:C0449719 denotes part
E4-ab-6 1396-1403 cui:C0085732 denotes ability
E5-ab-6 1407-1410 cui:C0020317 denotes HTB
E6-ab-6 1415-1424 cui:C0077126 denotes triflusal
E7-ab-6 1456-1476 cui:C0040648 denotes transcription factor
E8-ab-6 1477-1484 cui:C0521447 denotes nuclear
E9-ab-6 1504-1510 cui:C0205250 denotes higher
E10-ab-6 1511-1517 cui:C0439792 denotes extent
E11-ab-6 1523-1530 cui:C0004057 denotes aspirin
E12-ab-6 1535-1552 cui:C0037549 denotes sodium salicylate
E1-ab-7 1563-1571 cui:C0442796 denotes addition
E2-ab-7 1575-1585 cui:C0311403 denotes inhibiting
E3-ab-7 1590-1595 cui:C0387583 denotes COX-2
E4-ab-7 1596-1604 cui:C0439167 denotes activity
E5-ab-7 1608-1619 cui:C0302350 denotes therapeutic
E6-ab-7 1620-1634 cui:C0086045 denotes concentrations
E7-ab-7 1636-1645 cui:C0077126 denotes triflusal
E8-ab-7 1649-1653 cui:C1299581 denotes able
E9-ab-7 1675-1685 cui:C0870883 denotes metabolite
E10-ab-7 1686-1689 cui:C0020317 denotes HTB
E11-ab-7 1694-1704 cui:C0185117 denotes expression
E12-ab-7 1708-1711 cui:C0205314 denotes new
E13-ab-7 1712-1718 cui:C0014442 denotes enzyme
E14-ab-7 1748-1752 cui:C0012472 denotes PGE2
E15-ab-7 1753-1762 cui:C0869032 denotes synthesis
T16 1636-1689 ISA denotes triflusal is able to block through its metabolite HTB
T17 1657-1662 INHIBITS denotes block
T18 1636-1689 INHIBITS denotes triflusal is able to block through its metabolite HTB
E1-ab-8 1764-1773 cui:C0077126 denotes Triflusal
E2-ab-8 1778-1781 cui:C0020317 denotes HTB
E3-ab-8 1803-1810 cui:C1280500 denotes effects
E4-ab-8 1814-1823 cui:C1522240 denotes processes
E5-ab-8 1833-1840 cui:C1515568 denotes de novo
E6-ab-8 1841-1846 cui:C0387583 denotes COX-2
E7-ab-8 1847-1857 cui:C0185117 denotes expression
E8-ab-8 1880-1887 cui:C0332464 denotes broader
E9-ab-8 1898-1910 cui:C1521733 denotes pathological
E10-ab-8 1931-1936 cui:C0017337 denotes genes
E11-ab-8 1943-1950 cui:C0521447 denotes nuclear
E12-ab-8 1951-1957 cui:C1521761 denotes factor
E13-ab-8 1965-1972 cui:C0243148 denotes control
T19 1824-1826 COEXISTS_WITH denotes in
T20 1824-1826 COEXISTS_WITH denotes in
R1 E4-ti-1 T1 subjectOf salicylate,Inhibition
R2 E1-ti-1 T1 objectOf cyclooxygenase-2,Inhibition
R3 E7-ab-2 T2 subjectOf hydroxy-4-trifluoromethylbenzoic acid,compared
R4 E8-ab-2 T2 objectOf aspirin,compared
R5 E5-ab-2 T3 subjectOf triflusal,benzoic acid (triflusal
R6 E4-ab-2 T3 objectOf benzoic acid,benzoic acid (triflusal
R7 E5-ab-2 T4 subjectOf triflusal,benzoic acid (triflusal
R8 E18-ab-2 T4 objectOf HTB,benzoic acid (triflusal
R9 E5-ab-2 T5 subjectOf triflusal,benzoic acid (triflusal
R10 E7-ab-2 T5 objectOf hydroxy-4-trifluoromethylbenzoic acid,benzoic acid (triflusal
R11 E15-ab-2 T6 subjectOf blood,in
R12 E10-ab-2 T6 objectOf cyclooxygenase-2 (COX-2) inhibitors,in
R13 E20-ab-2 T7 subjectOf sodium salicylate,inhibited
R14 E23-ab-2 T7 objectOf prostaglandin E2 (PGE2) production,inhibited
R15 E9-ab-2 T8 subjectOf sodium salicylate,inhibited
R16 E23-ab-2 T8 objectOf prostaglandin E2 (PGE2) production,inhibited
R17 E5-ab-2 T9 subjectOf triflusal,benzoic acid (triflusal
R18 E8-ab-2 T9 objectOf aspirin,benzoic acid (triflusal
R19 E2-ab-3 T10 subjectOf aspirin,inhibited
R20 E3-ab-3 T10 objectOf COX-2,inhibited
R21 E1-ab-3 T11 subjectOf triflusal,inhibited
R22 E3-ab-3 T11 objectOf COX-2,inhibited
R23 E11-ab-4 T12 subjectOf mononuclear cells,human mononuclear cells
R24 E10-ab-4 T12 objectOf human,human mononuclear cells
R25 E11-ab-4 T13 subjectOf mononuclear cells,in
R26 E7-ab-4 T13 objectOf COX-2,in
R27 E6-ab-5 T14 subjectOf triflusal,inhibited
R28 E7-ab-5 T14 objectOf PGE2 production,inhibited
R29 E5-ab-5 T15 subjectOf aspirin,inhibited
R30 E7-ab-5 T15 objectOf PGE2 production,inhibited
R31 E7-ab-7 T16 subjectOf triflusal,triflusal is able to block through its metabolite HTB
R32 E10-ab-7 T16 objectOf HTB,triflusal is able to block through its metabolite HTB
R33 E7-ab-7 T17 subjectOf triflusal,block
R34 E10-ab-7 T17 objectOf HTB,block
R35 E7-ab-7 T18 subjectOf triflusal,triflusal is able to block through its metabolite HTB
R36 E7-ab-7 T18 objectOf triflusal,triflusal is able to block through its metabolite HTB
R37 E2-ab-8 T19 subjectOf HTB,in
R38 E6-ab-8 T19 objectOf COX-2,in
R39 E1-ab-8 T20 subjectOf Triflusal,in
R40 E6-ab-8 T20 objectOf COX-2,in

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-174 Sentence denotes Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid.
S2 175-275 Sentence denotes The therapeutic potential of drugs that block the induction of cyclooxygenase-2 has been emphasized.
S3 276-788 Sentence denotes When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethyl-benzoic acid (triflusal) and its deacetylated metabolite 2-hydroxy-4-trifluoromethylbenzoic acid (HTB)] were compared with aspirin and sodium salicylate as cyclooxygenase-2 (COX-2) inhibitors, we observed that in bacterial lipopolysaccharide-activated human blood, triflusal, aspirin, and HTB, but not sodium salicylate, inhibited COX-2-mediated prostaglandin E2 (PGE2) production (IC50 = 0.16, 0.18, 0.39, and >10 mM, respectively).
S4 789-857 Sentence denotes However, only triflusal and aspirin inhibited purified COX-2 enzyme.
S5 858-1077 Sentence denotes To test this apparent discrepancy, we realized that HTB and triflusal (but neither aspirin nor salicylate) produced a concentration-dependent inhibition of COX-2 protein expression in peripheral human mononuclear cells.
S6 1078-1334 Sentence denotes This observation was further confirmed in a rat air pouch model in vivo, in which both aspirin and triflusal inhibited PGE2 production (ID50 = 18.9 and 11.4 mg/kg p.o., respectively) but only triflusal-treated animals showed a decrease in COX-2 expression.
S7 1335-1553 Sentence denotes This different behavior may be, at least in part, due to the ability of HTB and triflusal to block the activation of the transcription factor nuclear factor-kappaB to a higher extent than aspirin and sodium salicylate.
S8 1554-1763 Sentence denotes Thus, in addition to inhibiting the COX-2 activity at therapeutic concentrations, triflusal is able to block through its metabolite HTB the expression of new enzyme, and hence the resumption of PGE2 synthesis.
S9 1764-1990 Sentence denotes Triflusal and HTB may exert beneficial effects in processes in which de novo COX-2 expression is involved and, in a broader sense, in pathological situations in which genes under nuclear factor-kappaB control are up-regulated.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 90-99 NP denotes triflusal
C3 105-108 NP denotes its
C2 105-132 NP denotes its deacetylated metabolite
C4 134-173 NP denotes 2-hydroxy-4-trifluoromethylbenzoic acid
C5 204-209 NP denotes drugs
C6 210-214 NP denotes that
C7 238-254 NP denotes cyclooxygenase-2
C8 620-629 NP denotes triflusal
C9 631-638 NP denotes aspirin
C10 644-647 NP denotes HTB
C11 657-674 NP denotes sodium salicylate
C12 798-824 NP denotes only triflusal and aspirin
C14 910-913 NP denotes HTB
C15 918-927 NP denotes triflusal
C13 910-927 NP denotes HTB and triflusal
C16 1014-1038 NP denotes COX-2 protein expression
C17 1120-1149 NP denotes a rat air pouch model in vivo
C18 1154-1159 NP denotes which
C19 1160-1186 NP denotes both aspirin and triflusal
C20 1317-1333 NP denotes COX-2 expression
C22 1407-1410 NP denotes HTB
C23 1415-1424 NP denotes triflusal
C21 1407-1424 NP denotes HTB and triflusal
C24 1523-1530 NP denotes aspirin
C25 1535-1552 NP denotes sodium salicylate
C26 1636-1645 NP denotes triflusal
C28 1671-1674 NP denotes its
C27 1671-1689 NP denotes its metabolite HTB
C30 1764-1773 NP denotes Triflusal
C31 1778-1781 NP denotes HTB
C29 1764-1781 NP denotes Triflusal and HTB
C32 1814-1823 NP denotes processes
C33 1827-1832 NP denotes which
C34 1898-1921 NP denotes pathological situations
C35 1925-1930 NP denotes which
R1 C3 C7 coref-pron its,cyclooxygenase-2
R2 C4 C2 coref-appos 2-hydroxy-4-trifluoromethylbenzoic acid,its deacetylated metabolite
R3 C6 C5 coref-relat that,drugs
R4 C8 C1 coref-ident triflusal,triflusal
R5 C10 C2 coref-ident HTB,its deacetylated metabolite
R6 C14 C10 coref-ident HTB,HTB
R7 C15 C8 coref-ident triflusal,triflusal
R8 C18 C17 coref-relat which,a rat air pouch model in vivo
R9 C19 C12 coref-ident both aspirin and triflusal,only triflusal and aspirin
R10 C20 C16 coref-ident COX-2 expression,COX-2 protein expression
R11 C22 C14 coref-ident HTB,HTB
R12 C23 C15 coref-ident triflusal,triflusal
R13 C21 C13 coref-ident HTB and triflusal,HTB and triflusal
R14 C24 C9 coref-ident aspirin,aspirin
R15 C25 C11 coref-ident sodium salicylate,sodium salicylate
R16 C26 C23 coref-ident triflusal,triflusal
R17 C28 C7 coref-pron its,cyclooxygenase-2
R18 C27 C22 coref-ident its metabolite HTB,HTB
R19 C30 C26 coref-ident Triflusal,triflusal
R20 C31 C27 coref-ident HTB,its metabolite HTB
R21 C29 C21 coref-ident Triflusal and HTB,HTB and triflusal
R22 C33 C32 coref-relat which,processes
R23 C35 C34 coref-relat which,pathological situations

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-30 protein_molecule denotes cyclooxygenase-2
T2 45-74 other_organic_compound denotes 4-trifluoromethyl derivatives
T3 78-88 other_organic_compound denotes salicylate
T4 90-99 other_organic_compound denotes triflusal
T5 109-132 other_organic_compound denotes deacetylated metabolite
T6 134-173 other_organic_compound denotes 2-hydroxy-4-trifluoromethylbenzoic acid
T7 238-254 protein_molecule denotes cyclooxygenase-2
T8 285-325 other_organic_compound denotes 4-trifluoromethyl salicylate derivatives
T9 327-367 other_organic_compound denotes 2-acetoxy-4-trifluoromethyl-benzoic acid
T10 369-378 other_organic_compound denotes triflusal
T11 388-411 other_organic_compound denotes deacetylated metabolite
T12 412-451 other_organic_compound denotes 2-hydroxy-4-trifluoromethylbenzoic acid
T13 453-456 other_organic_compound denotes HTB
T14 511-527 protein_molecule denotes cyclooxygenase-2
T15 568-618 tissue denotes bacterial lipopolysaccharide-activated human blood
T16 620-629 other_organic_compound denotes triflusal
T17 631-638 other_organic_compound denotes aspirin
T18 644-647 other_organic_compound denotes HTB
T19 657-674 other_organic_compound denotes sodium salicylate
T20 686-717 other_organic_compound denotes COX-2-mediated prostaglandin E2
T21 719-723 other_organic_compound denotes PGE2
T22 803-812 other_organic_compound denotes triflusal
T23 817-824 other_organic_compound denotes aspirin
T24 835-856 protein_molecule denotes purified COX-2 enzyme
T25 910-913 other_organic_compound denotes HTB
T26 918-927 other_organic_compound denotes triflusal
T27 941-948 other_organic_compound denotes aspirin
T28 953-963 other_organic_compound denotes salicylate
T29 1014-1019 protein_molecule denotes COX-2
T30 1042-1076 cell_type denotes peripheral human mononuclear cells
T31 1122-1141 other_name denotes rat air pouch model
T32 1165-1172 other_organic_compound denotes aspirin
T33 1177-1186 other_organic_compound denotes triflusal
T34 1197-1201 other_organic_compound denotes PGE2
T35 1270-1279 other_organic_compound denotes triflusal
T36 1317-1322 protein_molecule denotes COX-2
T37 1407-1410 other_organic_compound denotes HTB
T38 1415-1424 other_organic_compound denotes triflusal
T39 1477-1498 protein_complex denotes nuclear factor-kappaB
T40 1523-1530 other_organic_compound denotes aspirin
T41 1535-1552 other_organic_compound denotes sodium salicylate
T42 1590-1604 other_name denotes COX-2 activity
T43 1636-1645 other_organic_compound denotes triflusal
T44 1686-1689 other_organic_compound denotes HTB
T45 1748-1752 other_organic_compound denotes PGE2
T46 1764-1773 other_organic_compound denotes Triflusal
T47 1778-1781 other_organic_compound denotes HTB
T48 1841-1846 protein_molecule denotes COX-2
T49 1943-1964 protein_complex denotes nuclear factor-kappaB

metamap-sample

Id Subject Object Predicate Lexical cue
T1 1842-1847 C0387583 denotes OX-2
T2 1591-1596 C0387583 denotes OX-2
T3 1015-1020 C0387583 denotes OX-2
T4 845-850 C0387583 denotes OX-2
T5 687-692 C0387583 denotes OX-2-
T6 239-254 C0387583 denotes yclooxygenase-2
T7 15-31 C0387583 denotes yclooxygenase-2
T8 135-174 C0048733 denotes -hydroxy-4-trifluoromethylbenzoic acid.
T9 1765-1774 C0077126 denotes riflusal
T10 1637-1646 C0077126 denotes riflusal
T11 1416-1425 C0077126 denotes riflusal
T12 919-928 C0077126 denotes riflusal
T13 804-813 C0077126 denotes riflusal
T14 328-368 C0077126 denotes -acetoxy-4-trifluoromethyl-benzoic acid
T15 91-100 C0077126 denotes riflusal,
T16 1524-1531 C0004057 denotes spirin
T17 1166-1173 C0004057 denotes spirin
T18 942-949 C0004057 denotes spirin
T19 818-825 C0004057 denotes spirin
T20 954-964 C0036075 denotes alicylate)
T21 304-314 C0036075 denotes alicylate
T22 79-89 C0036075 denotes alicylate,
T23 315-325 C0243072 denotes erivatives
T24 64-75 C0243072 denotes erivatives
T25 1001-1011 C0021469 denotes nhibition
T26 1-11 C0021469 denotes nhibition
T27 1676-1686 C0870883 denotes etabolite
T28 402-412 C0870883 denotes etabolite
T29 123-133 C0870883 denotes etabolite,
T30 1848-1858 C0185117 denotes xpression
T31 1695-1705 C0185117 denotes xpression
T32 1324-1334 C0185117 denotes xpression.
T33 1029-1039 C0185117 denotes xpression
T34 32-42 C0185117 denotes xpression
T35 1842-1847 C1367485 denotes OX-2
T36 1591-1596 C1367485 denotes OX-2
T37 1015-1020 C1367485 denotes OX-2
T38 845-850 C1367485 denotes OX-2
T39 687-692 C1367485 denotes OX-2-
T40 239-254 C1367485 denotes yclooxygenase-2
T41 15-31 C1367485 denotes yclooxygenase-2
T42 1536-1553 C0037549 denotes odium salicylate.
T43 1749-1753 C0012472 denotes GE2
T44 1198-1202 C0012472 denotes GE2
T45 702-717 C0012472 denotes rostaglandin E2
T46 1054-1059 C0086418 denotes uman
T47 608-613 C0086418 denotes uman
T48 1779-1782 C0001128 denotes TB
T49 1687-1690 C0001128 denotes TB
T50 1408-1411 C0001128 denotes TB
T51 911-914 C0001128 denotes TB
T52 645-648 C0001128 denotes TB,
T53 448-452 C0001128 denotes cid
T54 1123-1126 C0034721 denotes at
T55 1650-1654 C0085732 denotes ble
T56 1397-1404 C0085732 denotes bility
T57 1779-1782 C0700307 denotes TB
T58 1687-1690 C0700307 denotes TB
T59 1408-1411 C0700307 denotes TB
T60 911-914 C0700307 denotes TB
T61 645-648 C0700307 denotes TB,
T62 415-422 C0700307 denotes ydroxy-
T63 1318-1323 C0033551 denotes OX-2
T64 1932-1937 C0017337 denotes enes
T65 1084-1095 C0700325 denotes bservation
T66 1127-1130 C0001861 denotes ir
T67 614-619 C0005768 denotes lood,
T68 579-597 C0023810 denotes ipopolysaccharide-
T69 1188-1197 C0311403 denotes nhibited
T70 826-835 C0311403 denotes nhibited
T71 677-686 C0311403 denotes nhibited
T72 1576-1586 C3463820 denotes nhibiting
T73 1713-1719 C0014442 denotes nzyme,
T74 851-857 C0014442 denotes nzyme.
T75 1889-1894 C0036658 denotes ense,
T76 1318-1323 C1565860 denotes OX-2
T77 1658-1663 C2828370 denotes lock
T78 1429-1434 C2828370 denotes lock
T79 216-221 C2828370 denotes lock
T80 1749-1753 C3539520 denotes GE2
T81 1198-1202 C3539520 denotes GE2
T82 716-717 C3539520 denotes 2
T83 1981-1990 C0851285 denotes egulated.
T84 738-742 C0600495 denotes C50
T85 1457-1477 C0040648 denotes ranscription factor
T86 1198-1213 C1514503 denotes GE2 production
T87 1203-1213 C0033268 denotes roduction
T88 726-736 C0033268 denotes roduction
T89 1439-1449 C1879547 denotes ctivation
T90 598-607 C1879547 denotes ctivated
T91 1266-1270 C0205171 denotes nly
T92 799-803 C0205171 denotes nly
T93 1609-1620 C0302350 denotes herapeutic
T94 180-191 C0302350 denotes herapeutic
T95 1351-1359 C0004927 denotes ehavior
T96 1289-1296 C0003062 denotes nimals
T97 1754-1763 C0220781 denotes ynthesis.
T98 1787-1791 C0015264 denotes xert
T99 1100-1106 C1517331 denotes urther
T100 1143-1150 C1515655 denotes n vivo,
T101 1862-1869 C1314939 denotes nvolved
T102 552-559 C1441672 denotes bserved
T103 1380-1384 C1709471 denotes art,
T104 862-866 C0392366 denotes est
T105 859-861 C1883351 denotes o
T106 1297-1303 C1547282 denotes howed
T107 1371-1376 C0547044 denotes east
T108 881-892 C1290905 denotes iscrepancy,
T109 1512-1518 C0439792 denotes xtent
T110 1060-1077 C0806987 denotes ononuclear cells.
T111 1978-1980 C1282911 denotes p-
T112 1966-1973 C2587213 denotes ontrol
T113 1060-1071 C1513475 denotes ononuclear
T114 465-473 C1707455 denotes ompared
T115 1804-1811 C1280500 denotes ffects
T116 226-235 C0205263 denotes nduction
T117 192-201 C3245505 denotes otential
T118 1306-1314 C0392756 denotes ecrease
T119 1597-1605 C1561536 denotes ctivity
T120 569-578 C0521009 denotes acterial
T121 1108-1117 C0750484 denotes onfirmed
T122 1137-1142 C3161035 denotes odel
T123 1131-1136 C1706199 denotes ouch
T124 1341-1350 C1705242 denotes ifferent
T125 1899-1911 C1521733 denotes athological
T126 872-879 C0750489 denotes pparent
T127 1834-1841 C1515568 denotes e novo
T128 1505-1511 C0205250 denotes igher
T129 1881-1888 C0332464 denotes roader
T130 654-657 C1518422 denotes ot
T131 1236-1241 C0439272 denotes g/kg
T132 1043-1053 C0205100 denotes eripheral
T133 836-844 C1998793 denotes urified
T134 1281-1288 C1522326 denotes reated
T135 282-285 C0205448 denotes wo
T136 693-701 C0127400 denotes ediated
T137 1749-1763 C1157324 denotes GE2 synthesis.
T138 1709-1711 C0205314 denotes ew
T139 205-210 C0013227 denotes rugs
T140 1621-1635 C0086045 denotes oncentrations,
T141 977-990 C1446561 denotes oncentration-
T142 991-1000 C0851827 denotes ependent
T143 1471-1477 C1521761 denotes actor
T144 1815-1824 C1522240 denotes rocesses