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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-81 Sentence denotes Essential role of alveolar macrophages in intrapulmonary activation of NF-kappaB.
T2 82-304 Sentence denotes Acute inflammatory injury in rat lung induced by deposition of immunoglobulin G immune complexes requires expression of cytokines and chemokines as well as activation of the transcription factor nuclear factor (NF)-kappaB.
T3 305-407 Sentence denotes There is little direct evidence regarding the role of alveolar macrophages in these activation events.
T4 408-560 Sentence denotes In the present studies, rat lungs were depleted of alveolar macrophages by airway instillation of liposome-encapsulated dichloromethylene diphosphonate.
T5 561-715 Sentence denotes These procedures, which greatly reduced the number of retrievable alveolar macrophages, suppressed activation of lung NF-kappaB in the inflammatory model.
T6 716-887 Sentence denotes In addition, bronchoalveolar lavage levels of tumor necrosis factor-alpha (TNF-alpha) and the CXC chemokine, macrophage inflammatory protein-2, were substantially reduced.
T7 888-1076 Sentence denotes In parallel, upregulation of the lung vascular adhesion molecule, intercellular adhesion molecule-1, was greatly reduced by intrapulmonary instillation of phosphonate-containing liposomes.
T8 1077-1167 Sentence denotes Neutrophil accumulation and development of lung injury were also substantially diminished.
T9 1168-1293 Sentence denotes Lung instillation of TNF-alpha in alveolar macrophage-depleted rats restored the NF-kappaB activation response in whole lung.
T10 1294-1517 Sentence denotes These data suggest that, in this inflammatory model, initial activation of NF-kappaB occurs in alveolar macrophages and the ensuing production of TNF-alpha may propagate NF-kappaB activation to other cell types in the lung.
T1 0-81 Sentence denotes Essential role of alveolar macrophages in intrapulmonary activation of NF-kappaB.
T2 82-304 Sentence denotes Acute inflammatory injury in rat lung induced by deposition of immunoglobulin G immune complexes requires expression of cytokines and chemokines as well as activation of the transcription factor nuclear factor (NF)-kappaB.
T3 305-407 Sentence denotes There is little direct evidence regarding the role of alveolar macrophages in these activation events.
T4 408-560 Sentence denotes In the present studies, rat lungs were depleted of alveolar macrophages by airway instillation of liposome-encapsulated dichloromethylene diphosphonate.
T5 561-715 Sentence denotes These procedures, which greatly reduced the number of retrievable alveolar macrophages, suppressed activation of lung NF-kappaB in the inflammatory model.
T6 716-887 Sentence denotes In addition, bronchoalveolar lavage levels of tumor necrosis factor-alpha (TNF-alpha) and the CXC chemokine, macrophage inflammatory protein-2, were substantially reduced.
T7 888-1076 Sentence denotes In parallel, upregulation of the lung vascular adhesion molecule, intercellular adhesion molecule-1, was greatly reduced by intrapulmonary instillation of phosphonate-containing liposomes.
T8 1077-1167 Sentence denotes Neutrophil accumulation and development of lung injury were also substantially diminished.
T9 1168-1293 Sentence denotes Lung instillation of TNF-alpha in alveolar macrophage-depleted rats restored the NF-kappaB activation response in whole lung.
T10 1294-1517 Sentence denotes These data suggest that, in this inflammatory model, initial activation of NF-kappaB occurs in alveolar macrophages and the ensuing production of TNF-alpha may propagate NF-kappaB activation to other cell types in the lung.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 18-38 cell_type denotes alveolar macrophages
T2 71-80 protein denotes NF-kappaB
T3 145-178 protein denotes immunoglobulin G immune complexes
T4 202-211 protein denotes cytokines
T5 216-226 protein denotes chemokines
T6 256-276 protein denotes transcription factor
T7 277-303 protein denotes nuclear factor (NF)-kappaB
T8 359-379 cell_type denotes alveolar macrophages
T9 459-479 cell_type denotes alveolar macrophages
T10 627-647 cell_type denotes alveolar macrophages
T11 674-688 protein denotes lung NF-kappaB
T12 762-789 protein denotes tumor necrosis factor-alpha
T13 791-800 protein denotes TNF-alpha
T14 810-823 protein denotes CXC chemokine
T15 825-858 protein denotes macrophage inflammatory protein-2
T16 921-952 protein denotes lung vascular adhesion molecule
T17 954-987 protein denotes intercellular adhesion molecule-1
T18 1189-1198 protein denotes TNF-alpha
T19 1249-1258 protein denotes NF-kappaB
T20 1369-1378 protein denotes NF-kappaB
T21 1389-1409 cell_type denotes alveolar macrophages
T22 1440-1449 protein denotes TNF-alpha
T23 1464-1473 protein denotes NF-kappaB

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-81 Sentence denotes Essential role of alveolar macrophages in intrapulmonary activation of NF-kappaB.
S2 82-304 Sentence denotes Acute inflammatory injury in rat lung induced by deposition of immunoglobulin G immune complexes requires expression of cytokines and chemokines as well as activation of the transcription factor nuclear factor (NF)-kappaB.
S3 305-407 Sentence denotes There is little direct evidence regarding the role of alveolar macrophages in these activation events.
S4 408-560 Sentence denotes In the present studies, rat lungs were depleted of alveolar macrophages by airway instillation of liposome-encapsulated dichloromethylene diphosphonate.
S5 561-715 Sentence denotes These procedures, which greatly reduced the number of retrievable alveolar macrophages, suppressed activation of lung NF-kappaB in the inflammatory model.
S6 716-887 Sentence denotes In addition, bronchoalveolar lavage levels of tumor necrosis factor-alpha (TNF-alpha) and the CXC chemokine, macrophage inflammatory protein-2, were substantially reduced.
S7 888-1076 Sentence denotes In parallel, upregulation of the lung vascular adhesion molecule, intercellular adhesion molecule-1, was greatly reduced by intrapulmonary instillation of phosphonate-containing liposomes.
S8 1077-1167 Sentence denotes Neutrophil accumulation and development of lung injury were also substantially diminished.
S9 1168-1293 Sentence denotes Lung instillation of TNF-alpha in alveolar macrophage-depleted rats restored the NF-kappaB activation response in whole lung.
S10 1294-1517 Sentence denotes These data suggest that, in this inflammatory model, initial activation of NF-kappaB occurs in alveolar macrophages and the ensuing production of TNF-alpha may propagate NF-kappaB activation to other cell types in the lung.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 18-38 NP denotes alveolar macrophages
C2 71-80 NP denotes NF-kappaB
C3 111-119 NP denotes rat lung
C5 252-303 NP denotes the transcription factor nuclear factor (NF)-kappaB
C4 238-303 NP denotes activation of the transcription factor nuclear factor (NF)-kappaB
C6 359-379 NP denotes alveolar macrophages
C7 432-441 NP denotes rat lungs
C8 459-479 NP denotes alveolar macrophages
C9 561-577 NP denotes These procedures
C10 579-584 NP denotes which
C11 692-714 NP denotes the inflammatory model
C12 762-801 NP denotes tumor necrosis factor-alpha (TNF-alpha)
C13 806-823 NP denotes the CXC chemokine
C14 825-858 NP denotes macrophage inflammatory protein-2
C15 917-952 NP denotes the lung vascular adhesion molecule
C16 954-987 NP denotes intercellular adhesion molecule-1
C17 1189-1198 NP denotes TNF-alpha
C18 1322-1345 NP denotes this inflammatory model
C19 1369-1378 NP denotes NF-kappaB
C20 1389-1409 NP denotes alveolar macrophages
C21 1440-1449 NP denotes TNF-alpha
C22 1464-1484 NP denotes NF-kappaB activation
R1 C5 C2 coref-ident the transcription factor nuclear factor (NF)-kappaB,NF-kappaB
R2 C6 C1 coref-ident alveolar macrophages,alveolar macrophages
R3 C7 C3 coref-ident rat lungs,rat lung
R4 C8 C6 coref-ident alveolar macrophages,alveolar macrophages
R5 C10 C9 coref-relat which,These procedures
R6 C14 C13 coref-appos macrophage inflammatory protein-2,the CXC chemokine
R7 C16 C15 coref-appos intercellular adhesion molecule-1,the lung vascular adhesion molecule
R8 C17 C12 coref-ident TNF-alpha,tumor necrosis factor-alpha (TNF-alpha)
R9 C18 C11 coref-ident this inflammatory model,the inflammatory model
R10 C19 C5 coref-ident NF-kappaB,the transcription factor nuclear factor (NF)-kappaB
R11 C20 C8 coref-ident alveolar macrophages,alveolar macrophages
R12 C21 C17 coref-ident TNF-alpha,TNF-alpha
R13 C22 C4 coref-ident NF-kappaB activation,activation of the transcription factor nuclear factor (NF)-kappaB

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 18-38 cell_type denotes alveolar macrophages
T2 42-67 other_name denotes intrapulmonary activation
T3 71-80 protein_complex denotes NF-kappaB
T4 82-107 other_name denotes Acute inflammatory injury
T5 111-119 body_part denotes rat lung
T6 145-178 protein_complex denotes immunoglobulin G immune complexes
T7 202-211 protein_family_or_group denotes cytokines
T8 216-226 protein_family_or_group denotes chemokines
T9 256-276 protein_family_or_group denotes transcription factor
T10 277-303 protein_complex denotes nuclear factor (NF)-kappaB
T11 359-379 cell_type denotes alveolar macrophages
T12 432-441 body_part denotes rat lungs
T13 459-479 cell_type denotes alveolar macrophages
T14 506-559 other_organic_compound denotes liposome-encapsulated dichloromethylene diphosphonate
T15 627-647 cell_type denotes alveolar macrophages
T16 674-678 protein_complex denotes lung
T17 679-688 protein_complex denotes NF-kappaB
T18 762-789 protein_molecule denotes tumor necrosis factor-alpha
T19 791-800 protein_molecule denotes TNF-alpha
T20 810-823 protein_molecule denotes CXC chemokine
T21 825-858 protein_molecule denotes macrophage inflammatory protein-2
T22 921-952 protein_molecule denotes lung vascular adhesion molecule
T23 954-987 protein_molecule denotes intercellular adhesion molecule-1
T24 1012-1039 other_name denotes intrapulmonary instillation
T25 1043-1075 cell_component denotes phosphonate-containing liposomes
T26 1189-1198 protein_molecule denotes TNF-alpha
T27 1202-1235 other_artificial_source denotes alveolar macrophage-depleted rats
T28 1249-1258 protein_complex denotes NF-kappaB
T29 1282-1292 body_part denotes whole lung
T30 1327-1345 other_name denotes inflammatory model
T31 1369-1378 protein_complex denotes NF-kappaB
T32 1389-1409 cell_type denotes alveolar macrophages
T33 1440-1449 protein_molecule denotes TNF-alpha
T34 1464-1473 protein_complex denotes NF-kappaB
T35 1512-1516 body_part denotes lung

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 762-767 HP_0002664 denotes tumor