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PubMed:10098606 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 47-107 protein denotes human pterin carbinolamine dehydratase/dimerization cofactor
T2 111-115 protein denotes HNF1
T3 117-171 protein denotes Pterin carbinolamine dehydratase/dimerization cofactor
T4 175-179 protein denotes HNF1
T5 181-189 protein denotes PCD/DCoH
T6 196-217 protein denotes dual-function protein
T7 249-260 protein denotes dehydratase
T8 284-303 protein denotes tetrahydrobiopterin
T9 322-354 protein denotes aromatic amino acid hydroxylases
T10 390-411 protein denotes dimerization cofactor
T11 415-419 protein denotes HNF1
T12 466-470 protein denotes HNF1
T13 583-591 protein denotes PCD/DCoH
T14 875-885 cell_line denotes HeLa cells
T15 898-902 protein denotes HNF1
T16 928-939 cell_type denotes fibroblasts
T17 963-982 protein denotes tetrahydrobiopterin
T18 1002-1016 protein denotes human PCD/DCoH
T19 1034-1050 cell_type denotes nonhepatic cells
T20 1172-1185 cell_type denotes keratinocytes
T21 1190-1201 cell_type denotes fibroblasts
T22 1207-1231 protein denotes hepatic PCD/DCoH protein
T23 1270-1306 cell_type denotes normal human epidermal keratinocytes
T24 1311-1329 cell_type denotes dermal fibroblasts
T25 1346-1375 DNA denotes 5' and 3' untranslated region
T26 1377-1380 DNA denotes UTR
T27 1385-1412 protein denotes human keratinocyte PCD/DCoH
T28 1448-1480 DNA denotes GC-rich 5' untranslated sequence
T29 1500-1514 protein denotes liver PCD/DCoH
T30 1587-1593 DNA denotes 5' UTR
T31 1675-1689 protein denotes human PCD/DCoH
T32 1725-1744 protein denotes tetrahydrobiopterin
T33 1763-1767 protein denotes HNF1

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-116 Sentence denotes Characterization of expression of the gene for human pterin carbinolamine dehydratase/dimerization cofactor of HNF1.
S2 117-218 Sentence denotes Pterin carbinolamine dehydratase/dimerization cofactor of HNF1 (PCD/DCoH) is a dual-function protein.
S3 219-355 Sentence denotes In the cytoplasm it acts as a dehydratase in the regeneration of tetrahydrobiopterin, the cofactor for aromatic amino acid hydroxylases.
S4 356-471 Sentence denotes In the nucleus, it functions as a dimerization cofactor of HNF1 and increases the transcriptional activity of HNF1.
S5 472-576 Sentence denotes To deepen our understanding of this protein, we characterized its expression in human tissues and cells.
S6 577-766 Sentence denotes Human PCD/DCoH was present predominantly in liver and kidney, with significant amounts in testis and ovary, trace amounts in lung, and undetectable levels in whole brain, heart, and spleen.
S7 767-823 Sentence denotes It was expressed in all of the cells that were examined.
S8 824-983 Sentence denotes Importantly, it was also present in the nucleus of HeLa cells, which lack HNF1, and in the cytoplasm of fibroblasts that have little or no tetrahydrobiopterin.
S9 984-1100 Sentence denotes The expression of human PCD/DCoH in the liver and nonhepatic cells was compared at both the mRNA and protein levels.
S10 1101-1330 Sentence denotes Although the mRNA level in liver was only fourfold higher than that in keratinocytes and fibroblasts, the hepatic PCD/DCoH protein level was 20-fold higher than that in normal human epidermal keratinocytes and dermal fibroblasts.
S11 1331-1515 Sentence denotes Cloning of the 5' and 3' untranslated region (UTR) of human keratinocyte PCD/DCoH revealed that it has 53 bp more of GC-rich 5' untranslated sequence than the published liver PCD/DCoH.
S12 1516-1653 Sentence denotes In vitro transcription and translation analysis showed that the longer 5' UTR resulted in about a 35% decrease in translation efficiency.
S13 1654-1815 Sentence denotes These data show that human PCD/DCoH is not only present in cells where tetrahydrobiopterin is synthesized or HNF1 is present but is a widely distributed protein.
S14 1816-1962 Sentence denotes Its differential expression in different tissues and cells is regulated not only at the transcriptional level but also at the translational level.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 111-115 NP denotes HNF1
C1 47-115 NP denotes human pterin carbinolamine dehydratase/dimerization cofactor of HNF1
C4 175-179 NP denotes HNF1
C3 117-190 NP denotes Pterin carbinolamine dehydratase/dimerization cofactor of HNF1 (PCD/DCoH)
C5 236-238 NP denotes it
C6 284-303 NP denotes tetrahydrobiopterin
C7 305-354 NP denotes the cofactor for aromatic amino acid hydroxylases
C8 372-374 NP denotes it
C9 415-419 NP denotes HNF1
C10 466-470 NP denotes HNF1
C11 503-515 NP denotes this protein
C12 534-537 NP denotes its
C13 577-591 NP denotes Human PCD/DCoH
C14 621-626 NP denotes liver
C15 767-769 NP denotes It
C16 787-803 NP denotes all of the cells
C17 804-808 NP denotes that
C18 837-839 NP denotes it
C19 875-885 NP denotes HeLa cells
C20 887-892 NP denotes which
C21 898-902 NP denotes HNF1
C22 928-939 NP denotes fibroblasts
C23 940-944 NP denotes that
C24 1002-1016 NP denotes human PCD/DCoH
C25 1020-1029 NP denotes the liver
C26 1110-1124 NP denotes the mRNA level
C27 1128-1133 NP denotes liver
C28 1164-1168 NP denotes that
C29 1385-1412 NP denotes human keratinocyte PCD/DCoH
C30 1427-1429 NP denotes it
C31 1675-1689 NP denotes human PCD/DCoH
C32 1713-1718 NP denotes cells
C33 1719-1724 NP denotes where
C34 1725-1744 NP denotes tetrahydrobiopterin
C35 1763-1767 NP denotes HNF1
C36 1816-1819 NP denotes Its
R1 C4 C2 coref-ident HNF1,HNF1
R2 C5 C3 coref-pron it,Pterin carbinolamine dehydratase/dimerization cofactor of HNF1 (PCD/DCoH)
R3 C7 C6 coref-appos the cofactor for aromatic amino acid hydroxylases,tetrahydrobiopterin
R4 C8 C3 coref-pron it,Pterin carbinolamine dehydratase/dimerization cofactor of HNF1 (PCD/DCoH)
R5 C9 C4 coref-ident HNF1,HNF1
R6 C10 C9 coref-ident HNF1,HNF1
R7 C11 C3 coref-ident this protein,Pterin carbinolamine dehydratase/dimerization cofactor of HNF1 (PCD/DCoH)
R8 C12 C11 coref-pron its,this protein
R9 C13 C1 coref-ident Human PCD/DCoH,human pterin carbinolamine dehydratase/dimerization cofactor of HNF1
R10 C15 C13 coref-pron It,Human PCD/DCoH
R11 C17 C16 coref-relat that,all of the cells
R12 C18 C13 coref-pron it,Human PCD/DCoH
R13 C20 C19 coref-relat which,HeLa cells
R14 C21 C10 coref-ident HNF1,HNF1
R15 C23 C22 coref-relat that,fibroblasts
R16 C24 C13 coref-ident human PCD/DCoH,Human PCD/DCoH
R17 C25 C14 coref-ident the liver,liver
R18 C27 C25 coref-ident liver,the liver
R19 C28 C26 coref-pron that,the mRNA level
R20 C30 C29 coref-pron it,human keratinocyte PCD/DCoH
R21 C31 C24 coref-ident human PCD/DCoH,human PCD/DCoH
R22 C33 C32 coref-relat where,cells
R23 C34 C6 coref-ident tetrahydrobiopterin,tetrahydrobiopterin
R24 C35 C21 coref-ident HNF1,HNF1
R25 C36 C31 coref-pron Its,human PCD/DCoH

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 47-107 protein_family_or_group denotes human pterin carbinolamine dehydratase/dimerization cofactor
T2 111-115 protein_molecule denotes HNF1
T3 117-171 protein_family_or_group denotes Pterin carbinolamine dehydratase/dimerization cofactor
T4 175-179 protein_molecule denotes HNF1
T5 181-189 protein_molecule denotes PCD/DCoH
T6 196-217 protein_family_or_group denotes dual-function protein
T7 249-260 protein_family_or_group denotes dehydratase
T8 284-303 protein_molecule denotes tetrahydrobiopterin
T9 322-354 protein_family_or_group denotes aromatic amino acid hydroxylases
T10 390-411 protein_family_or_group denotes dimerization cofactor
T11 415-419 protein_molecule denotes HNF1
T12 466-470 protein_molecule denotes HNF1
T13 552-565 tissue denotes human tissues
T14 583-591 protein_molecule denotes PCD/DCoH
T15 621-626 body_part denotes liver
T16 631-637 body_part denotes kidney
T17 667-673 body_part denotes testis
T18 678-683 body_part denotes ovary
T19 702-706 body_part denotes lung
T20 735-746 body_part denotes whole brain
T21 748-753 body_part denotes heart
T22 759-765 body_part denotes spleen
T23 875-885 cell_line denotes HeLa cells
T24 898-902 protein_molecule denotes HNF1
T25 915-924 cell_component denotes cytoplasm
T26 928-939 cell_type denotes fibroblasts
T27 963-982 protein_molecule denotes tetrahydrobiopterin
T28 1002-1007 protein_molecule denotes human
T29 1008-1016 protein_molecule denotes PCD/DCoH
T30 1024-1029 body_part denotes liver
T31 1034-1050 cell_type denotes nonhepatic cells
T32 1128-1133 body_part denotes liver
T33 1172-1185 cell_type denotes keratinocytes
T34 1190-1201 cell_type denotes fibroblasts
T35 1207-1214 protein_molecule denotes hepatic
T36 1215-1223 protein_molecule denotes PCD/DCoH
T37 1270-1306 cell_type denotes normal human epidermal keratinocytes
T38 1311-1317 cell_type denotes dermal
T39 1318-1329 cell_type denotes fibroblasts
T40 1346-1375 DNA_domain_or_region denotes 5' and 3' untranslated region
T41 1377-1380 DNA_domain_or_region denotes UTR
T42 1385-1403 cell_type denotes human keratinocyte
T43 1404-1412 protein_molecule denotes PCD/DCoH
T44 1448-1480 DNA_domain_or_region denotes GC-rich 5' untranslated sequence
T45 1500-1505 body_part denotes liver
T46 1506-1514 protein_molecule denotes PCD/DCoH
T47 1516-1538 other_name denotes In vitro transcription
T48 1543-1563 other_name denotes translation analysis
T49 1587-1589 DNA_domain_or_region denotes 5'
T50 1590-1593 DNA_domain_or_region denotes UTR
T51 1675-1680 protein_molecule denotes human
T52 1681-1689 protein_molecule denotes PCD/DCoH
T53 1725-1744 protein_molecule denotes tetrahydrobiopterin
T54 1763-1767 protein_molecule denotes HNF1
T55 1904-1925 other_name denotes transcriptional level
T56 1942-1961 other_name denotes translational level