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PubMed:10096574 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 60-83 protein denotes glucocorticoid receptor
T2 98-120 cell_type denotes human leukemic T cells
T3 168-191 protein denotes glucocorticoid receptor
T4 193-195 protein denotes GR
T5 240-242 protein denotes GR
T6 285-307 cell_type denotes human leukemic T cells
T7 485-502 DNA denotes wild-type GR gene
T8 526-557 DNA denotes tetracycline-regulated promoter
T9 586-616 cell_line denotes glucocorticoid-resistant cells
T10 657-670 cell_line denotes Transfectants
T11 791-793 protein denotes GR
T12 808-845 cell_line denotes glucocorticoid-sensitive 6TG1.1 cells
T13 1071-1078 RNA denotes GR mRNA
T14 1205-1217 cell_line denotes 6TG1.1 cells
T15 1444-1446 protein denotes GR
T16 1519-1551 cell_line denotes glucocorticoid-sensitive T cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-121 Sentence denotes Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells.
S2 122-374 Sentence denotes In contrast to the negative autoregulation of glucocorticoid receptor (GR) expression seen in most cells and tissues, GR expression is positively autoregulated in human leukemic T cells and in other cells sensitive to glucocorticoid-induced cell death.
S3 375-656 Sentence denotes To determine whether positive autoregulation is a necessary component of glucocorticoid-induced cell death, a wild-type GR gene under the control of a tetracycline-regulated promoter was stably transfected into glucocorticoid-resistant cells lacking endogenous functional receptor.
S4 657-871 Sentence denotes Transfectants grown in the presence of tetracycline contained about 15,000 receptors/cell, a value approximately equal to basal level GR expression in glucocorticoid-sensitive 6TG1.1 cells before steroid treatment.
S5 872-1038 Sentence denotes Under these conditions, dexamethasone had a minimal effect on cell growth, elicited little internucleosomal DNA fragmentation, and induced no cell cycle perturbation.
S6 1039-1246 Sentence denotes In the absence of tetracycline, GR mRNA and protein expression increased 2-3-fold, and cells expressed 48,000 receptors, a level nearly equivalent to that present in 6TG1.1 cells after 18 h of autoinduction.
S7 1247-1394 Sentence denotes Under these conditions, dexamethasone markedly inhibited cell growth, caused G1 arrest, and induced significant internucleosomal DNA fragmentation.
S8 1395-1626 Sentence denotes These studies therefore suggest that basal level GR expression is inadequate to mediate glucocorticoid-induced apoptosis in glucocorticoid-sensitive T cells and that positive autoregulation is a necessary component of this process.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-33 NP denotes Glucocorticoid-induced cell death
C2 60-94 NP denotes glucocorticoid receptor expression
C3 98-120 NP denotes human leukemic T cells
C4 168-207 NP denotes glucocorticoid receptor (GR) expression
C5 240-253 NP denotes GR expression
C6 285-307 NP denotes human leukemic T cells
C7 340-373 NP denotes glucocorticoid-induced cell death
C8 396-419 NP denotes positive autoregulation
C9 448-481 NP denotes glucocorticoid-induced cell death
C10 696-708 NP denotes tetracycline
C11 725-746 NP denotes 15,000 receptors/cell
C12 748-870 NP denotes a value approximately equal to basal level GR expression in glucocorticoid-sensitive 6TG1.1 cells before steroid treatment
C13 896-909 NP denotes dexamethasone
C14 934-945 NP denotes cell growth
C15 1057-1069 NP denotes tetracycline
C16 1160-1167 NP denotes a level
C17 1189-1193 NP denotes that
C18 1271-1284 NP denotes dexamethasone
C19 1304-1315 NP denotes cell growth
C20 1561-1584 NP denotes positive autoregulation
R1 C4 C2 coref-ident glucocorticoid receptor (GR) expression,glucocorticoid receptor expression
R2 C5 C4 coref-ident GR expression,glucocorticoid receptor (GR) expression
R3 C6 C3 coref-ident human leukemic T cells,human leukemic T cells
R4 C7 C1 coref-ident glucocorticoid-induced cell death,Glucocorticoid-induced cell death
R5 C9 C7 coref-ident glucocorticoid-induced cell death,glucocorticoid-induced cell death
R6 C12 C11 coref-appos a value approximately equal to basal level GR expression in glucocorticoid-sensitive 6TG1.1 cells before steroid treatment,"15,000 receptors/cell"
R7 C15 C10 coref-ident tetracycline,tetracycline
R8 C17 C16 coref-pron that,a level
R9 C18 C13 coref-ident dexamethasone,dexamethasone
R10 C19 C14 coref-ident cell growth,cell growth
R11 C20 C8 coref-ident positive autoregulation,positive autoregulation

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-14 lipid denotes Glucocorticoid
T2 60-83 protein_family_or_group denotes glucocorticoid receptor
T3 98-120 cell_type denotes human leukemic T cells
T4 168-191 protein_family_or_group denotes glucocorticoid receptor
T5 193-195 protein_family_or_group denotes GR
T6 240-242 protein_family_or_group denotes GR
T7 285-307 cell_type denotes human leukemic T cells
T8 340-373 other_name denotes glucocorticoid-induced cell death
T9 448-481 other_name denotes glucocorticoid-induced cell death
T10 485-494 DNA_domain_or_region denotes wild-type
T11 495-497 protein_family_or_group denotes GR
T12 526-538 other_organic_compound denotes tetracycline
T13 586-616 cell_line denotes glucocorticoid-resistant cells
T14 657-670 cell_line denotes Transfectants
T15 696-708 other_organic_compound denotes tetracycline
T16 779-790 other_name denotes basal level
T17 791-793 protein_family_or_group denotes GR
T18 808-845 cell_line denotes glucocorticoid-sensitive 6TG1.1 cells
T19 853-870 other_name denotes steroid treatment
T20 896-909 lipid denotes dexamethasone
T21 963-997 other_name denotes internucleosomal DNA fragmentation
T22 1014-1037 other_name denotes cell cycle perturbation
T23 1057-1069 other_organic_compound denotes tetracycline
T24 1071-1078 RNA_family_or_group denotes GR mRNA
T25 1083-1101 other_name denotes protein expression
T26 1205-1217 cell_line denotes 6TG1.1 cells
T27 1271-1284 lipid denotes dexamethasone
T28 1304-1315 other_name denotes cell growth
T29 1359-1393 other_name denotes internucleosomal DNA fragmentation
T30 1444-1446 protein_family_or_group denotes GR
T31 1483-1515 other_name denotes glucocorticoid-induced apoptosis
T32 1519-1551 cell_line denotes glucocorticoid-sensitive T cells