PubMed:10096561
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 15-19 | protein | denotes | CD40 |
| T2 | 76-98 | cell_type | denotes | cytotoxic T lymphocyte |
| T3 | 182-186 | protein | denotes | CD40 |
| T4 | 324-328 | protein | denotes | CD40 |
| T5 | 392-396 | protein | denotes | CD40 |
| T6 | 427-446 | cell_line | denotes | human MM cell lines |
| T7 | 517-527 | cell_line | denotes | cell lines |
| T8 | 566-570 | protein | denotes | CD40 |
| T9 | 581-585 | protein | denotes | CD40 |
| T10 | 618-622 | protein | denotes | CD40 |
| T11 | 655-664 | protein | denotes | IFN-gamma |
| T12 | 669-696 | protein | denotes | tumor necrosis factor-alpha |
| T13 | 708-730 | protein | denotes | interleukin (IL)-1beta |
| T14 | 734-738 | protein | denotes | CD40 |
| T15 | 751-755 | protein | denotes | CD40 |
| T16 | 774-806 | cell_line | denotes | CD40L-transfected murine L-cells |
| T17 | 823-843 | protein | denotes | CD40L fusion protein |
| T18 | 877-910 | protein | denotes | intercellular adhesion molecule-1 |
| T19 | 915-949 | protein | denotes | MHC class I and class II molecules |
| T20 | 973-977 | protein | denotes | IL-6 |
| T21 | 979-983 | protein | denotes | IL-8 |
| T22 | 985-1008 | protein | denotes | tumor necrosis factor-a |
| T23 | 1014-1062 | protein | denotes | granulocyte macrophage colony-stimulating factor |
| T24 | 1106-1126 | protein | denotes | transcription factor |
| T25 | 1127-1148 | protein | denotes | nuclear factor kappaB |
| T26 | 1163-1167 | protein | denotes | CD40 |
| T27 | 1182-1217 | cell_line | denotes | HLA-A2+, MelanA/MART1+ MM cell line |
| T28 | 1269-1320 | cell_line | denotes | HLA-A2-restricted, MelanA/MART-1-specific CTL clone |
| T29 | 1331-1335 | protein | denotes | CD40 |
| T30 | 1420-1424 | protein | denotes | CD40 |
| T31 | 1424-1430 | protein | denotes | -CD40L |
| T32 | 1535-1539 | protein | denotes | CD40 |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-136 | Sentence | denotes | Stimulation of CD40 on immunogenic human malignant melanomas augments their cytotoxic T lymphocyte-mediated lysis and induces apoptosis. |
| S2 | 137-222 | Sentence | denotes | Here, we report the functional expression of CD40 on human malignant melanomas (MMs). |
| S3 | 223-391 | Sentence | denotes | Comparison of tumor specimen from MM precursor lesions, primary tumors, and metastases revealed that CD40 surface expression is down-regulated during tumor progression. |
| S4 | 392-580 | Sentence | denotes | CD40 expression was confirmed in 7 human MM cell lines established from immunogenic primary tumors or metastases, whereas 11 cell lines established from advanced stages were CD40 negative. |
| S5 | 581-750 | Sentence | denotes | CD40 expression could be enhanced in CD40-positive MM by stimulation with IFN-gamma and tumor necrosis factor-alpha but not by interleukin (IL)-1beta or CD40 triggering. |
| S6 | 751-1149 | Sentence | denotes | CD40 ligation on MM by CD40L-transfected murine L-cells or by a soluble CD40L fusion protein up-regulated their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6, IL-8, tumor necrosis factor-a, and granulocyte macrophage colony-stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB. |
| S7 | 1150-1321 | Sentence | denotes | Furthermore, CD40 ligation of a HLA-A2+, MelanA/MART1+ MM cell line enhanced its susceptibility to specific lysis by a HLA-A2-restricted, MelanA/MART-1-specific CTL clone. |
| S8 | 1322-1391 | Sentence | denotes | Finally, CD40 ligation induced growth inhibition and apoptosis in MM. |
| S9 | 1392-1571 | Sentence | denotes | These results indicate that CD40-CD40L interactions may play an important role in augmenting antitumor immunity and inducing apoptosis in some CD40-positive immunogenic human MMs. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 15-19 | NP | denotes | CD40 |
| C2 | 23-60 | NP | denotes | immunogenic human malignant melanomas |
| C3 | 70-75 | NP | denotes | their |
| C4 | 126-135 | NP | denotes | apoptosis |
| C5 | 182-186 | NP | denotes | CD40 |
| C6 | 190-221 | NP | denotes | human malignant melanomas (MMs) |
| C7 | 299-309 | NP | denotes | metastases |
| C8 | 392-407 | NP | denotes | CD40 expression |
| C9 | 494-504 | NP | denotes | metastases |
| C10 | 581-596 | NP | denotes | CD40 expression |
| C11 | 768-770 | NP | denotes | MM |
| C12 | 857-862 | NP | denotes | their |
| C13 | 954-959 | NP | denotes | their |
| C14 | 1163-1217 | NP | denotes | CD40 ligation of a HLA-A2+, MelanA/MART1+ MM cell line |
| C15 | 1227-1230 | NP | denotes | its |
| C16 | 1375-1384 | NP | denotes | apoptosis |
| C17 | 1388-1390 | NP | denotes | MM |
| C18 | 1517-1526 | NP | denotes | apoptosis |
| R1 | C3 | C2 | coref-pron | their,immunogenic human malignant melanomas |
| R2 | C5 | C1 | coref-ident | CD40,CD40 |
| R3 | C6 | C2 | coref-ident | human malignant melanomas (MMs),immunogenic human malignant melanomas |
| R4 | C9 | C7 | coref-ident | metastases,metastases |
| R5 | C10 | C8 | coref-ident | CD40 expression,CD40 expression |
| R6 | C11 | C6 | coref-ident | MM,human malignant melanomas (MMs) |
| R7 | C12 | C11 | coref-pron | their,MM |
| R8 | C13 | C11 | coref-pron | their,MM |
| R9 | C15 | C14 | coref-pron | its,"CD40 ligation of a HLA-A2+, MelanA/MART1+ MM cell line" |
| R10 | C16 | C4 | coref-ident | apoptosis,apoptosis |
| R11 | C17 | C11 | coref-ident | MM,MM |
| R12 | C18 | C16 | coref-ident | apoptosis,apoptosis |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 15-19 | protein_molecule | denotes | CD40 |
| T2 | 23-60 | tissue | denotes | immunogenic human malignant melanomas |
| T3 | 76-98 | cell_type | denotes | cytotoxic T lymphocyte |
| T4 | 126-135 | other_name | denotes | apoptosis |
| T5 | 182-186 | protein_molecule | denotes | CD40 |
| T6 | 190-215 | tissue | denotes | human malignant melanomas |
| T7 | 217-220 | tissue | denotes | MMs |
| T8 | 237-251 | tissue | denotes | tumor specimen |
| T9 | 257-277 | tissue | denotes | MM precursor lesions |
| T10 | 279-293 | tissue | denotes | primary tumors |
| T11 | 299-309 | other_name | denotes | metastases |
| T12 | 324-328 | protein_molecule | denotes | CD40 |
| T13 | 373-390 | other_name | denotes | tumor progression |
| T14 | 392-396 | protein_molecule | denotes | CD40 |
| T15 | 427-446 | cell_line | denotes | human MM cell lines |
| T16 | 464-475 | tissue | denotes | immunogenic |
| T17 | 476-490 | tissue | denotes | primary tumors |
| T18 | 494-504 | other_name | denotes | metastases |
| T19 | 517-527 | cell_line | denotes | cell lines |
| T20 | 566-570 | protein_molecule | denotes | CD40 |
| T21 | 581-585 | protein_molecule | denotes | CD40 |
| T22 | 618-622 | protein_molecule | denotes | CD40 |
| T23 | 655-664 | protein_molecule | denotes | IFN-gamma |
| T24 | 669-696 | protein_molecule | denotes | tumor necrosis factor-alpha |
| T25 | 708-730 | protein_molecule | denotes | interleukin (IL)-1beta |
| T26 | 734-738 | protein_molecule | denotes | CD40 |
| T27 | 751-755 | protein_molecule | denotes | CD40 |
| T28 | 768-770 | tissue | denotes | MM |
| T29 | 774-779 | protein_molecule | denotes | CD40L |
| T30 | 823-828 | protein_molecule | denotes | CD40L |
| T31 | 877-910 | protein_molecule | denotes | intercellular adhesion molecule-1 |
| T32 | 973-977 | protein_molecule | denotes | IL-6 |
| T33 | 979-983 | protein_molecule | denotes | IL-8 |
| T34 | 985-1008 | protein_molecule | denotes | tumor necrosis factor-a |
| T35 | 1014-1062 | protein_molecule | denotes | granulocyte macrophage colony-stimulating factor |
| T36 | 1106-1126 | protein_family_or_group | denotes | transcription factor |
| T37 | 1127-1148 | protein_complex | denotes | nuclear factor kappaB |
| T38 | 1163-1167 | protein_molecule | denotes | CD40 |
| T39 | 1182-1204 | cell_line | denotes | HLA-A2+, MelanA/MART1+ |
| T40 | 1205-1207 | tissue | denotes | MM |
| T41 | 1269-1320 | cell_line | denotes | HLA-A2-restricted, MelanA/MART-1-specific CTL clone |
| T42 | 1331-1335 | protein_molecule | denotes | CD40 |
| T43 | 1353-1370 | other_name | denotes | growth inhibition |
| T44 | 1375-1384 | other_name | denotes | apoptosis |
| T45 | 1388-1390 | tissue | denotes | MM |
| T46 | 1420-1424 | protein_molecule | denotes | CD40 |
| T47 | 1424-1430 | protein_molecule | denotes | -CD40L |
| T48 | 1485-1503 | other_name | denotes | antitumor immunity |
| T49 | 1517-1526 | other_name | denotes | apoptosis |
| T50 | 1535-1539 | protein_molecule | denotes | CD40 |
| T51 | 1567-1570 | tissue | denotes | MMs |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 196-215 | HP_0002861 | denotes | malignant melanomas |
| T2 | 206-215 | HP_0002861 | denotes | melanomas |
| T3 | 237-242 | HP_0002664 | denotes | tumor |
| T4 | 287-293 | HP_0002664 | denotes | tumors |
| T5 | 373-378 | HP_0002664 | denotes | tumor |
| T6 | 484-490 | HP_0002664 | denotes | tumors |
| T7 | 669-674 | HP_0002664 | denotes | tumor |
| T8 | 985-990 | HP_0002664 | denotes | tumor |