PubMed:10094499 JSONTXT

{"project":"PennBioIE","denotations":[{"id":"T1","span":{"begin":101,"end":114},"obj":"protein"},{"id":"T2","span":{"begin":192,"end":205},"obj":"protein"},{"id":"T3","span":{"begin":378,"end":401},"obj":"protein"},{"id":"T4","span":{"begin":406,"end":426},"obj":"protein"},{"id":"T5","span":{"begin":526,"end":549},"obj":"protein"},{"id":"T6","span":{"begin":553,"end":573},"obj":"protein"},{"id":"T7","span":{"begin":765,"end":774},"obj":"protein"},{"id":"T8","span":{"begin":776,"end":784},"obj":"protein"},{"id":"T9","span":{"begin":786,"end":790},"obj":"protein"},{"id":"T10","span":{"begin":795,"end":799},"obj":"protein"},{"id":"T11","span":{"begin":825,"end":838},"obj":"protein"},{"id":"T12","span":{"begin":935,"end":948},"obj":"protein"},{"id":"T13","span":{"begin":974,"end":983},"obj":"protein"},{"id":"T14","span":{"begin":985,"end":993},"obj":"protein"},{"id":"T15","span":{"begin":998,"end":1002},"obj":"protein"},{"id":"T16","span":{"begin":1057,"end":1061},"obj":"protein"},{"id":"T17","span":{"begin":1082,"end":1095},"obj":"protein"},{"id":"T18","span":{"begin":1198,"end":1203},"obj":"protein"}],"text":"Differential effects of retinoic acid isomers on the expression of nuclear receptor co-regulators in neuroblastoma.\nRetinoic acid modulates growth and induces differentiation and apoptosis of neuroblastoma cells in vitro, with the all-trans and 9-cis isomers having different biological properties. Transcriptional activation in response to retinoic acid isomers is mediated by retinoic acid receptors and retinoid X receptors. The differential expression of co-activators and co-repressors which preferentially interact with retinoic acid receptors or retinoid X receptors may be a mechanism leading to different cellular responses to 9-cis and all-trans retinoic acid. To test this hypothesis, we have studied the expression of the nuclear receptor co-regulators TIF1alpha, TIF1beta, SUG1 and SMRT in the N-type and S-type neuroblastoma cell lines SH SY 5Y and SH S EP. Transcripts for all four co-regulators were expressed in these neuroblastoma cells. The expression of TIF1alpha, TIF1beta and SUG1 did not change in response to retinoic acid; however, SMRT was induced in both neuroblastoma cell lines, but particularly by all-trans retinoic acid in SH S EP cells. An additional co-activator, Trip3, was isolated by differential mRNA display and shown to be preferentially induced by 9-cis retinoic acid in SH SY 5Y and SH S EP cells. These data suggest that retinoic acid isomer-specific induction of nuclear receptor co-regulators may determine, in part, the differential biological effects of retinoic acid isomers."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"10094499-6#18#27#gene8805","span":{"begin":974,"end":983},"obj":"gene8805"},{"id":"10094499-6#42#46#gene5705","span":{"begin":998,"end":1002},"obj":"gene5705"},{"id":"10094499-6#101#105#gene9612","span":{"begin":1057,"end":1061},"obj":"gene9612"},{"id":"10094499-6#126#139#diseaseC0027819","span":{"begin":1082,"end":1095},"obj":"diseaseC0027819"},{"id":"10094499-6#126#139#diseaseC0700095","span":{"begin":1082,"end":1095},"obj":"diseaseC0700095"},{"id":"10094499-6#126#139#diseaseC0027819","span":{"begin":1082,"end":1095},"obj":"diseaseC0027819"},{"id":"10094499-6#126#139#diseaseC0700095","span":{"begin":1082,"end":1095},"obj":"diseaseC0700095"},{"id":"10094499-6#126#139#diseaseC0027819","span":{"begin":1082,"end":1095},"obj":"diseaseC0027819"},{"id":"10094499-6#126#139#diseaseC0700095","span":{"begin":1082,"end":1095},"obj":"diseaseC0700095"}],"relations":[{"id":"18#27#gene8805126#139#diseaseC0027819","pred":"associated_with","subj":"10094499-6#18#27#gene8805","obj":"10094499-6#126#139#diseaseC0027819"},{"id":"18#27#gene8805126#139#diseaseC0700095","pred":"associated_with","subj":"10094499-6#18#27#gene8805","obj":"10094499-6#126#139#diseaseC0700095"},{"id":"18#27#gene8805126#139#diseaseC0027819","pred":"associated_with","subj":"10094499-6#18#27#gene8805","obj":"10094499-6#126#139#diseaseC0027819"},{"id":"18#27#gene8805126#139#diseaseC0700095","pred":"associated_with","subj":"10094499-6#18#27#gene8805","obj":"10094499-6#126#139#diseaseC0700095"},{"id":"18#27#gene8805126#139#diseaseC0027819","pred":"associated_with","subj":"10094499-6#18#27#gene8805","obj":"10094499-6#126#139#diseaseC0027819"},{"id":"18#27#gene8805126#139#diseaseC0700095","pred":"associated_with","subj":"10094499-6#18#27#gene8805","obj":"10094499-6#126#139#diseaseC0700095"},{"id":"42#46#gene5705126#139#diseaseC0027819","pred":"associated_with","subj":"10094499-6#42#46#gene5705","obj":"10094499-6#126#139#diseaseC0027819"},{"id":"42#46#gene5705126#139#diseaseC0700095","pred":"associated_with","subj":"10094499-6#42#46#gene5705","obj":"10094499-6#126#139#diseaseC0700095"},{"id":"42#46#gene5705126#139#diseaseC0027819","pred":"associated_with","subj":"10094499-6#42#46#gene5705","obj":"10094499-6#126#139#diseaseC0027819"},{"id":"42#46#gene5705126#139#diseaseC0700095","pred":"associated_with","subj":"10094499-6#42#46#gene5705","obj":"10094499-6#126#139#diseaseC0700095"},{"id":"42#46#gene5705126#139#diseaseC0027819","pred":"associated_with","subj":"10094499-6#42#46#gene5705","obj":"10094499-6#126#139#diseaseC0027819"},{"id":"42#46#gene5705126#139#diseaseC0700095","pred":"associated_with","subj":"10094499-6#42#46#gene5705","obj":"10094499-6#126#139#diseaseC0700095"},{"id":"101#105#gene9612126#139#diseaseC0027819","pred":"associated_with","subj":"10094499-6#101#105#gene9612","obj":"10094499-6#126#139#diseaseC0027819"},{"id":"101#105#gene9612126#139#diseaseC0700095","pred":"associated_with","subj":"10094499-6#101#105#gene9612","obj":"10094499-6#126#139#diseaseC0700095"},{"id":"101#105#gene9612126#139#diseaseC0027819","pred":"associated_with","subj":"10094499-6#101#105#gene9612","obj":"10094499-6#126#139#diseaseC0027819"},{"id":"101#105#gene9612126#139#diseaseC0700095","pred":"associated_with","subj":"10094499-6#101#105#gene9612","obj":"10094499-6#126#139#diseaseC0700095"},{"id":"101#105#gene9612126#139#diseaseC0027819","pred":"associated_with","subj":"10094499-6#101#105#gene9612","obj":"10094499-6#126#139#diseaseC0027819"},{"id":"101#105#gene9612126#139#diseaseC0700095","pred":"associated_with","subj":"10094499-6#101#105#gene9612","obj":"10094499-6#126#139#diseaseC0700095"}],"text":"Differential effects of retinoic acid isomers on the expression of nuclear receptor co-regulators in neuroblastoma.\nRetinoic acid modulates growth and induces differentiation and apoptosis of neuroblastoma cells in vitro, with the all-trans and 9-cis isomers having different biological properties. Transcriptional activation in response to retinoic acid isomers is mediated by retinoic acid receptors and retinoid X receptors. The differential expression of co-activators and co-repressors which preferentially interact with retinoic acid receptors or retinoid X receptors may be a mechanism leading to different cellular responses to 9-cis and all-trans retinoic acid. To test this hypothesis, we have studied the expression of the nuclear receptor co-regulators TIF1alpha, TIF1beta, SUG1 and SMRT in the N-type and S-type neuroblastoma cell lines SH SY 5Y and SH S EP. Transcripts for all four co-regulators were expressed in these neuroblastoma cells. The expression of TIF1alpha, TIF1beta and SUG1 did not change in response to retinoic acid; however, SMRT was induced in both neuroblastoma cell lines, but particularly by all-trans retinoic acid in SH S EP cells. An additional co-activator, Trip3, was isolated by differential mRNA display and shown to be preferentially induced by 9-cis retinoic acid in SH SY 5Y and SH S EP cells. These data suggest that retinoic acid isomer-specific induction of nuclear receptor co-regulators may determine, in part, the differential biological effects of retinoic acid isomers."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":795,"end":799},"obj":"gene:9612"},{"id":"T1","span":{"begin":825,"end":838},"obj":"disease:C0027819"},{"id":"T2","span":{"begin":795,"end":799},"obj":"gene:9612"},{"id":"T3","span":{"begin":825,"end":838},"obj":"disease:C0700095"},{"id":"T4","span":{"begin":998,"end":1002},"obj":"gene:5705"},{"id":"T5","span":{"begin":1082,"end":1095},"obj":"disease:C0027819"},{"id":"T6","span":{"begin":974,"end":983},"obj":"gene:8805"},{"id":"T7","span":{"begin":1082,"end":1095},"obj":"disease:C0700095"},{"id":"T8","span":{"begin":974,"end":983},"obj":"gene:8805"},{"id":"T9","span":{"begin":1082,"end":1095},"obj":"disease:C0027819"},{"id":"T10","span":{"begin":998,"end":1002},"obj":"gene:5705"},{"id":"T11","span":{"begin":1082,"end":1095},"obj":"disease:C0700095"},{"id":"T12","span":{"begin":1057,"end":1061},"obj":"gene:9612"},{"id":"T13","span":{"begin":1082,"end":1095},"obj":"disease:C0027819"},{"id":"T14","span":{"begin":1057,"end":1061},"obj":"gene:9612"},{"id":"T15","span":{"begin":1082,"end":1095},"obj":"disease:C0700095"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"},{"id":"R7","pred":"associated_with","subj":"T12","obj":"T13"},{"id":"R8","pred":"associated_with","subj":"T14","obj":"T15"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Differential effects of retinoic acid isomers on the expression of nuclear receptor co-regulators in neuroblastoma.\nRetinoic acid modulates growth and induces differentiation and apoptosis of neuroblastoma cells in vitro, with the all-trans and 9-cis isomers having different biological properties. Transcriptional activation in response to retinoic acid isomers is mediated by retinoic acid receptors and retinoid X receptors. The differential expression of co-activators and co-repressors which preferentially interact with retinoic acid receptors or retinoid X receptors may be a mechanism leading to different cellular responses to 9-cis and all-trans retinoic acid. To test this hypothesis, we have studied the expression of the nuclear receptor co-regulators TIF1alpha, TIF1beta, SUG1 and SMRT in the N-type and S-type neuroblastoma cell lines SH SY 5Y and SH S EP. Transcripts for all four co-regulators were expressed in these neuroblastoma cells. The expression of TIF1alpha, TIF1beta and SUG1 did not change in response to retinoic acid; however, SMRT was induced in both neuroblastoma cell lines, but particularly by all-trans retinoic acid in SH S EP cells. An additional co-activator, Trip3, was isolated by differential mRNA display and shown to be preferentially induced by 9-cis retinoic acid in SH SY 5Y and SH S EP cells. These data suggest that retinoic acid isomer-specific induction of nuclear receptor co-regulators may determine, in part, the differential biological effects of retinoic acid isomers."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":192,"end":205},"obj":"HP_0003006"},{"id":"T2","span":{"begin":825,"end":838},"obj":"HP_0003006"},{"id":"T3","span":{"begin":935,"end":948},"obj":"HP_0003006"},{"id":"T4","span":{"begin":1082,"end":1095},"obj":"HP_0003006"}],"text":"Differential effects of retinoic acid isomers on the expression of nuclear receptor co-regulators in neuroblastoma.\nRetinoic acid modulates growth and induces differentiation and apoptosis of neuroblastoma cells in vitro, with the all-trans and 9-cis isomers having different biological properties. Transcriptional activation in response to retinoic acid isomers is mediated by retinoic acid receptors and retinoid X receptors. The differential expression of co-activators and co-repressors which preferentially interact with retinoic acid receptors or retinoid X receptors may be a mechanism leading to different cellular responses to 9-cis and all-trans retinoic acid. To test this hypothesis, we have studied the expression of the nuclear receptor co-regulators TIF1alpha, TIF1beta, SUG1 and SMRT in the N-type and S-type neuroblastoma cell lines SH SY 5Y and SH S EP. Transcripts for all four co-regulators were expressed in these neuroblastoma cells. The expression of TIF1alpha, TIF1beta and SUG1 did not change in response to retinoic acid; however, SMRT was induced in both neuroblastoma cell lines, but particularly by all-trans retinoic acid in SH S EP cells. An additional co-activator, Trip3, was isolated by differential mRNA display and shown to be preferentially induced by 9-cis retinoic acid in SH SY 5Y and SH S EP cells. These data suggest that retinoic acid isomer-specific induction of nuclear receptor co-regulators may determine, in part, the differential biological effects of retinoic acid isomers."}